CA2961004A1 - Recovery of aspartyl (asparaginyl) beta hydroxylase (haah) from an exosomal fraction of human sera from cancer patients - Google Patents
Recovery of aspartyl (asparaginyl) beta hydroxylase (haah) from an exosomal fraction of human sera from cancer patients Download PDFInfo
- Publication number
- CA2961004A1 CA2961004A1 CA2961004A CA2961004A CA2961004A1 CA 2961004 A1 CA2961004 A1 CA 2961004A1 CA 2961004 A CA2961004 A CA 2961004A CA 2961004 A CA2961004 A CA 2961004A CA 2961004 A1 CA2961004 A1 CA 2961004A1
- Authority
- CA
- Canada
- Prior art keywords
- haah
- exosomes
- serum
- elisa
- recovery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 29
- 201000011510 cancer Diseases 0.000 title claims abstract description 24
- 238000011084 recovery Methods 0.000 title description 7
- 108010025220 aspartic acid 2-oxoglutarate-dependent dioxygenase Proteins 0.000 title description 3
- 210000001808 exosome Anatomy 0.000 claims abstract description 53
- 238000000034 method Methods 0.000 claims abstract description 28
- 102100022108 Aspartyl/asparaginyl beta-hydroxylase Human genes 0.000 claims abstract 14
- 101000901030 Homo sapiens Aspartyl/asparaginyl beta-hydroxylase Proteins 0.000 claims abstract 14
- 238000002965 ELISA Methods 0.000 claims description 14
- 239000000523 sample Substances 0.000 claims description 8
- 239000012472 biological sample Substances 0.000 claims description 6
- 238000003118 sandwich ELISA Methods 0.000 claims description 3
- 102000004641 Fetal Proteins Human genes 0.000 claims description 2
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- 101001024605 Homo sapiens Next to BRCA1 gene 1 protein Proteins 0.000 claims description 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 2
- 108010036226 antigen CYFRA21.1 Proteins 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000011324 bead Substances 0.000 claims 4
- 239000003550 marker Substances 0.000 claims 1
- -1 Aspartyl-[Asparaginyl]- Chemical class 0.000 abstract description 2
- 210000002966 serum Anatomy 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 7
- 238000001514 detection method Methods 0.000 description 6
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
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- UAIUNKRWKOVEES-UHFFFAOYSA-N 3,3',5,5'-tetramethylbenzidine Chemical compound CC1=C(N)C(C)=CC(C=2C=C(C)C(N)=C(C)C=2)=C1 UAIUNKRWKOVEES-UHFFFAOYSA-N 0.000 description 1
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- 230000004614 tumor growth Effects 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462049582P | 2014-09-12 | 2014-09-12 | |
| US62/049,582 | 2014-09-12 | ||
| PCT/US2015/049976 WO2016040941A1 (en) | 2014-09-12 | 2015-09-14 | Recovery of aspartyl (asparaginyl) beta hydroxylase (haah) from an exosomal fraction of human sera from cancer patients |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2961004A1 true CA2961004A1 (en) | 2016-03-17 |
Family
ID=55454511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2961004A Abandoned CA2961004A1 (en) | 2014-09-12 | 2015-09-14 | Recovery of aspartyl (asparaginyl) beta hydroxylase (haah) from an exosomal fraction of human sera from cancer patients |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20160077098A1 (enExample) |
| EP (1) | EP3191841A4 (enExample) |
| JP (1) | JP6669731B2 (enExample) |
| CA (1) | CA2961004A1 (enExample) |
| WO (1) | WO2016040941A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190049455A1 (en) * | 2017-08-11 | 2019-02-14 | Panacea Pharmaceuticals Inc. | HAAH and MMP-9 are Complementary Cancer Biomarkers and Predictors of Metastasis when Combined |
| CN107907689A (zh) * | 2017-10-10 | 2018-04-13 | 北京大学 | 外泌体蛋白cd5l的检测方法 |
| CN111269986A (zh) * | 2020-03-24 | 2020-06-12 | 江西惠肽生物科技有限公司 | 外泌体中asph基因在肺癌早期诊断试剂盒中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6835370B2 (en) * | 1999-11-08 | 2004-12-28 | Rhode Island Hospital | Diagnosis and treatment of malignant neoplasms |
| WO2007087646A2 (en) * | 2006-01-27 | 2007-08-02 | Panacea Pharmaceuticals, Inc. | Methods of diagnosing, predicting therapeutic efficacy and screening for new therapeutic agents for leukemia |
| US20090298097A1 (en) * | 2007-07-17 | 2009-12-03 | Harris Pamela J | Methods for the diagnosis of lung cancer |
| EP3181705A1 (en) * | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| US20130178383A1 (en) * | 2008-11-12 | 2013-07-11 | David Spetzler | Vesicle isolation methods |
| CN103237901B (zh) * | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2827894A1 (en) * | 2011-02-22 | 2012-08-30 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers |
| KR20140136805A (ko) * | 2013-05-21 | 2014-12-01 | 건국대학교 산학협력단 | 신규한 인간 엑소좀 단백질 및 그 용도 |
-
2015
- 2015-09-14 JP JP2017513644A patent/JP6669731B2/ja not_active Expired - Fee Related
- 2015-09-14 US US14/853,254 patent/US20160077098A1/en not_active Abandoned
- 2015-09-14 CA CA2961004A patent/CA2961004A1/en not_active Abandoned
- 2015-09-14 WO PCT/US2015/049976 patent/WO2016040941A1/en not_active Ceased
- 2015-09-14 EP EP15839551.7A patent/EP3191841A4/en not_active Withdrawn
-
2017
- 2017-12-01 US US15/828,744 patent/US20210148915A9/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3191841A4 (en) | 2018-03-14 |
| JP6669731B2 (ja) | 2020-03-18 |
| WO2016040941A1 (en) | 2016-03-17 |
| US20210148915A9 (en) | 2021-05-20 |
| JP2017526931A (ja) | 2017-09-14 |
| EP3191841A1 (en) | 2017-07-19 |
| US20180203013A1 (en) | 2018-07-19 |
| US20160077098A1 (en) | 2016-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20200909 |
|
| FZDE | Discontinued |
Effective date: 20230124 |
|
| FZDE | Discontinued |
Effective date: 20230124 |