JP2015502547A5 - - Google Patents

Download PDF

Info

Publication number
JP2015502547A5
JP2015502547A5 JP2014547933A JP2014547933A JP2015502547A5 JP 2015502547 A5 JP2015502547 A5 JP 2015502547A5 JP 2014547933 A JP2014547933 A JP 2014547933A JP 2014547933 A JP2014547933 A JP 2014547933A JP 2015502547 A5 JP2015502547 A5 JP 2015502547A5
Authority
JP
Japan
Prior art keywords
antibody
antigen
multispecific
sample
multispecific antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014547933A
Other languages
English (en)
Japanese (ja)
Other versions
JP6203747B2 (ja
JP2015502547A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/075991 external-priority patent/WO2013092611A2/en
Publication of JP2015502547A publication Critical patent/JP2015502547A/ja
Publication of JP2015502547A5 publication Critical patent/JP2015502547A5/ja
Application granted granted Critical
Publication of JP6203747B2 publication Critical patent/JP6203747B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014547933A 2011-12-19 2012-12-18 多特異性結合体の遊離結合パートナーの検出方法 Active JP6203747B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11194350.2 2011-12-19
EP11194350 2011-12-19
PCT/EP2012/075991 WO2013092611A2 (en) 2011-12-19 2012-12-18 Method for the detection of free binding partner of a multispecific binder

Publications (3)

Publication Number Publication Date
JP2015502547A JP2015502547A (ja) 2015-01-22
JP2015502547A5 true JP2015502547A5 (enExample) 2016-02-04
JP6203747B2 JP6203747B2 (ja) 2017-09-27

Family

ID=47429825

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014547933A Active JP6203747B2 (ja) 2011-12-19 2012-12-18 多特異性結合体の遊離結合パートナーの検出方法

Country Status (10)

Country Link
US (1) US9671394B2 (enExample)
EP (1) EP2795335B1 (enExample)
JP (1) JP6203747B2 (enExample)
KR (1) KR20140099277A (enExample)
CN (1) CN104040350B (enExample)
BR (1) BR112014011535A2 (enExample)
CA (1) CA2853917A1 (enExample)
MX (1) MX349003B (enExample)
RU (1) RU2633488C2 (enExample)
WO (1) WO2013092611A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
CA2859268A1 (en) 2012-02-01 2013-08-08 F. Hoffmann-La Roche Ag Method for the detection of a binding partner of a multispecific binder
BR112015000665A2 (pt) 2012-07-13 2017-06-27 Hoffmann La Roche método para a determinação da quantidade de um anticorpo
EP3066469B1 (en) * 2013-11-05 2017-10-11 Roche Diagnostics GmbH A method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto
US10401368B2 (en) * 2014-03-20 2019-09-03 Pdl Biopharma, Inc. Antibodies and methods for the detection of cell death
WO2016097116A1 (en) 2014-12-18 2016-06-23 Roche Diagnostics Gmbh Methods for reducing interferences
EP3655779A1 (en) 2017-07-20 2020-05-27 CytomX Therapeutics, Inc. Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof
CN109358192B (zh) * 2018-02-08 2020-05-12 中国科学院上海药物研究所 一种去除抗药抗体检测样品中游离药物的装置和方法、该装置的制备方法及应用
WO2019235420A1 (ja) 2018-06-04 2019-12-12 中外製薬株式会社 複合体を検出する方法
EP3969908A1 (en) * 2019-05-13 2022-03-23 Regeneron Pharmaceuticals, Inc. Improved competitive ligand binding assays
EP3969907B1 (en) * 2019-05-13 2025-09-24 F. Hoffmann-La Roche AG Interference-suppressed pharmacokinetic immunoassay
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56128722A (en) * 1980-03-14 1981-10-08 Terumo Corp Removal of antiacetylcholinereceptor antibody and device therefor
US5219730A (en) 1982-09-28 1993-06-15 New York University Idiotype-anti-idiotype immunoassay
US4828981A (en) 1983-08-24 1989-05-09 Synbiotics Corporation Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents
EP0170302A1 (fr) 1984-06-27 1986-02-05 l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques
US4699880A (en) * 1984-09-25 1987-10-13 Immunomedics, Inc. Method of producing monoclonal anti-idiotype antibody
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
WO1987002778A1 (en) 1985-10-22 1987-05-07 Cooper-Lipotech Solid-phase liposome immunoassay system
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
ZA898290B (en) 1988-11-03 1991-06-26 Igen Inc Electrochemiluminescent assays
IL100866A (en) 1991-02-06 1995-10-31 Igen Inc Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
NZ255041A (en) 1992-07-13 1996-11-26 Bionebraska Inc Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
JPH11352129A (ja) * 1998-06-04 1999-12-24 Mizuho Medeii:Kk 検出装置及び検出方法
US6753189B1 (en) * 1998-06-04 2004-06-22 Mizuho Medy Co., Ltd. Detection apparatus and method for the same
AU774575C (en) * 1999-11-16 2005-09-08 Genentech Inc. Elisa for VEGF
EP1288308A1 (en) * 2001-08-28 2003-03-05 Roche Diagnostics GmbH A method for the determination of multiple analytes
GB0320459D0 (en) * 2003-09-01 2003-10-01 Selective Antibodies Ltd Assay methods and materials
DE102004052729A1 (de) * 2004-10-30 2006-05-04 Roche Diagnostics Gmbh Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten
EP1861708A2 (en) * 2005-03-08 2007-12-05 Tanox, Inc. Methods for determining the bivalency of protein and antibody therapeutics
MX2009003562A (es) * 2006-10-04 2009-04-15 Genentech Inc Ensayo elisa para la deteccion de vegf.
EP1917854A1 (en) 2006-11-06 2008-05-07 F. Hoffmann-La Roche Ag Method for producing anti idiotypic antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
PE20120591A1 (es) 2009-04-02 2012-05-23 Roche Glycart Ag Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla
CN102369214B (zh) 2009-04-07 2019-04-12 罗氏格黎卡特股份公司 三价、双特异性抗体
EP2435473B1 (en) 2009-05-27 2013-10-02 F.Hoffmann-La Roche Ag Tri- or tetraspecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US8703132B2 (en) 2009-06-18 2014-04-22 Hoffmann-La Roche, Inc. Bispecific, tetravalent antigen binding proteins
CN102207054B (zh) 2010-03-31 2013-03-13 比亚迪股份有限公司 一种混合动力车的爆震控制系统及方法
CN102207504A (zh) * 2011-03-23 2011-10-05 北京华创远航科技有限公司 一种酶联检测试剂盒及其制备方法

Similar Documents

Publication Publication Date Title
JP2015502547A5 (enExample)
RU2014133701A (ru) Способ детекции партнера по связыванию мультиспецифического связывающего агента
JP2018535404A5 (enExample)
WO2013092611A3 (en) Method for the detection of free binding partner of a multispecific binder
JP2012073260A5 (enExample)
JP2011217747A5 (enExample)
RU2015104737A (ru) Способ обнаружения мультиспецифического связывающего агента
WO2015017285A3 (en) Multiplex blocker beads for immunoassays
JP2017518366A5 (enExample)
NZ726258A (en) Antibodies and uses thereof to detect folate receptor 1
WO2010049672A3 (en) Methods and products for measuring free immunoglobulin light chain molecules
JP2017524725A5 (enExample)
NZ716369A (en) Anti-ox40 antibodies and methods of using the same
NZ602056A (en) Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ706232A (en) Anti-cd3 antibodies and uses thereof
RU2014146707A (ru) Антитела против тофацитиниба и их применение для лекарственного мониторинга
BR112013010213A2 (pt) anticorpos que unem ligantes solúveis de receptores de célula t
JP2015535828A5 (enExample)
NZ601615A (en) Antibodies that bind to lysyl oxidase-like 2 (loxl2) and methods of use therefor
JP2006502416A5 (enExample)
WO2013049704A3 (en) Method and system of particle-phage epitope complex
JP2015502356A5 (enExample)
JP2017026631A5 (enExample)
WO2013106778A3 (en) Non-equilibrium two-site assays for linear, ultrasensitive analyte detection
WO2018122205A3 (en) Novel biotin-specific monoclonal antibody and use thereof