KR20140099277A - 다중특이적 결합제의 자유 결합 파트너의 검출 방법 - Google Patents
다중특이적 결합제의 자유 결합 파트너의 검출 방법 Download PDFInfo
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- KR20140099277A KR20140099277A KR1020147016700A KR20147016700A KR20140099277A KR 20140099277 A KR20140099277 A KR 20140099277A KR 1020147016700 A KR1020147016700 A KR 1020147016700A KR 20147016700 A KR20147016700 A KR 20147016700A KR 20140099277 A KR20140099277 A KR 20140099277A
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| JP2015507193A (ja) | 2012-02-01 | 2015-03-05 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 多重特異性結合物の結合パートナーを検出するための方法 |
| KR20150038046A (ko) | 2012-07-13 | 2015-04-08 | 에프. 호프만-라 로슈 아게 | 다중특이적 결합체의 탐지 방법 |
| CA2926306C (en) * | 2013-11-05 | 2022-12-06 | F. Hoffmann-La Roche Ag | A method for determining the total amount and/or concentration of an analyte in a sample |
| WO2015143277A1 (en) * | 2014-03-20 | 2015-09-24 | Wellstat Diagnostics, Llc | Antibodies and methods for the detection of cell death |
| WO2016097116A1 (en) * | 2014-12-18 | 2016-06-23 | Roche Diagnostics Gmbh | Methods for reducing interferences |
| AU2018304711B2 (en) | 2017-07-20 | 2025-04-10 | Cytomx Therapeutics, Inc. | Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof |
| CN109358192B (zh) * | 2018-02-08 | 2020-05-12 | 中国科学院上海药物研究所 | 一种去除抗药抗体检测样品中游离药物的装置和方法、该装置的制备方法及应用 |
| EP3805757A4 (en) | 2018-06-04 | 2022-03-23 | Chugai Seiyaku Kabushiki Kaisha | Method for detecting complex |
| MX2021013519A (es) * | 2019-05-13 | 2021-12-10 | Regeneron Pharma | Ensayos de union de ligandos competitivos mejorados. |
| EP3969907B1 (en) * | 2019-05-13 | 2025-09-24 | F. Hoffmann-La Roche AG | Interference-suppressed pharmacokinetic immunoassay |
| CN117805397A (zh) * | 2024-02-29 | 2024-04-02 | 军科正源（北京）药物研究有限责任公司 | 检测游离vegf的方法 |
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| JPS56128722A (en) * | 1980-03-14 | 1981-10-08 | Terumo Corp | Removal of antiacetylcholinereceptor antibody and device therefor |
| US5219730A (en) | 1982-09-28 | 1993-06-15 | New York University | Idiotype-anti-idiotype immunoassay |
| US4828981A (en) | 1983-08-24 | 1989-05-09 | Synbiotics Corporation | Immunoassays for determining Dirofilaria immitis infection using antiidiotype monoclonal antibody reagents |
| EP0170302A1 (fr) | 1984-06-27 | 1986-02-05 | l'Association internationale à but scientifique, dite: Institut international de pathologie cellulaire et moléculaire | Procédé de dosage immunologique d'une substance dans un échantillon liquide au moyen d'anticorps anti-idiotypiques |
| US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| WO1987002778A1 (en) | 1985-10-22 | 1987-05-07 | Cooper-Lipotech | Solid-phase liposome immunoassay system |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| KR0143993B1 (ko) | 1988-11-03 | 1998-07-15 | 리차아드 제이 매씨이 | 전기화학 발광성 분석 |
| IL100866A (en) | 1991-02-06 | 1995-10-31 | Igen Inc | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
| ATE225801T1 (de) | 1992-07-13 | 2002-10-15 | Bionebraska Inc | Verfahren zur modifizierung rekombinanter polypeptide |
| GB9316369D0 (en) * | 1993-08-06 | 1993-09-22 | Surface Active Ltd | Diagnostic method |
| US6753189B1 (en) * | 1998-06-04 | 2004-06-22 | Mizuho Medy Co., Ltd. | Detection apparatus and method for the same |
| JPH11352129A (ja) * | 1998-06-04 | 1999-12-24 | Mizuho Medeii:Kk | 検出装置及び検出方法 |
| JP4620312B2 (ja) * | 1999-11-16 | 2011-01-26 | ジェネンテック， インコーポレイテッド | Ｖｅｇｆに対するエライザ |
| EP1288308A1 (en) * | 2001-08-28 | 2003-03-05 | Roche Diagnostics GmbH | A method for the determination of multiple analytes |
| GB0320459D0 (en) | 2003-09-01 | 2003-10-01 | Selective Antibodies Ltd | Assay methods and materials |
| DE102004052729A1 (de) * | 2004-10-30 | 2006-05-04 | Roche Diagnostics Gmbh | Immunkomplex-spezifsicher Antikörper zur Reduktion des Nullwerts beim Nachweis von Antigen-spezifisch gebundenen Antikörpern einer bestimmten Immunglobulinklasse in Array-Testformaten |
| WO2006096697A2 (en) | 2005-03-08 | 2006-09-14 | Tanox, Inc. | Methods for determining the bivalency of protein and antibody therapeutics |
| SI2457929T1 (sl) * | 2006-10-04 | 2016-09-30 | Genentech, Inc. | ELISA za VEGF |
| EP1917854A1 (en) | 2006-11-06 | 2008-05-07 | F. Hoffmann-La Roche Ag | Method for producing anti idiotypic antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| US8242247B2 (en) | 2007-12-21 | 2012-08-14 | Hoffmann-La Roche Inc. | Bivalent, bispecific antibodies |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US8227577B2 (en) | 2007-12-21 | 2012-07-24 | Hoffman-La Roche Inc. | Bivalent, bispecific antibodies |
| CN102369215B (zh) | 2009-04-02 | 2015-01-21 | 罗切格利卡特公司 | 包含全长抗体和单链Fab片段的多特异性抗体 |
| DK2417156T3 (en) | 2009-04-07 | 2015-03-02 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| RU2570633C2 (ru) | 2009-05-27 | 2015-12-10 | Ф.Хоффманн-Ля Рош Аг | Три- или тетраспецифические антитела |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| US8703132B2 (en) | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| CN102207054B (zh) | 2010-03-31 | 2013-03-13 | 比亚迪股份有限公司 | 一种混合动力车的爆震控制系统及方法 |
| CN102207504A (zh) * | 2011-03-23 | 2011-10-05 | 北京华创远航科技有限公司 | 一种酶联检测试剂盒及其制备方法 |
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2012
- 2012-12-18 CN CN201280063032.5A patent/CN104040350B/zh active Active
- 2012-12-18 KR KR1020147016700A patent/KR20140099277A/ko not_active Ceased
- 2012-12-18 RU RU2014128510A patent/RU2633488C2/ru not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| US20150072359A1 (en) | 2015-03-12 |
| HK1201920A1 (zh) | 2015-09-11 |
| CN104040350B (zh) | 2016-05-18 |
| RU2014128510A (ru) | 2016-02-10 |
| BR112014011535A2 (pt) | 2017-05-09 |
| EP2795335B1 (en) | 2017-09-06 |
| MX2014007095A (es) | 2014-07-22 |
| WO2013092611A3 (en) | 2013-10-17 |
| RU2633488C2 (ru) | 2017-10-12 |
| US9671394B2 (en) | 2017-06-06 |
| JP2015502547A (ja) | 2015-01-22 |
| WO2013092611A2 (en) | 2013-06-27 |
| CN104040350A (zh) | 2014-09-10 |
| JP6203747B2 (ja) | 2017-09-27 |
| MX349003B (es) | 2017-07-06 |
| CA2853917A1 (en) | 2013-06-27 |
| EP2795335A2 (en) | 2014-10-29 |
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