JP6203747B2 - 多特異性結合体の遊離結合パートナーの検出方法 - Google Patents

多特異性結合体の遊離結合パートナーの検出方法 Download PDF

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JP6203747B2
JP6203747B2 JP2014547933A JP2014547933A JP6203747B2 JP 6203747 B2 JP6203747 B2 JP 6203747B2 JP 2014547933 A JP2014547933 A JP 2014547933A JP 2014547933 A JP2014547933 A JP 2014547933A JP 6203747 B2 JP6203747 B2 JP 6203747B2
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antibody
antigen
multispecific
sample
binding specificity
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JP2015502547A5 (enExample
JP2015502547A (ja
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カイ−グンナー スチュベンラウチ
カイ−グンナー スチュベンラウチ
ウベ ウェセルス
ウベ ウェセルス
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
JP2014547933A 2011-12-19 2012-12-18 多特異性結合体の遊離結合パートナーの検出方法 Active JP6203747B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11194350 2011-12-19
EP11194350.2 2011-12-19
PCT/EP2012/075991 WO2013092611A2 (en) 2011-12-19 2012-12-18 Method for the detection of free binding partner of a multispecific binder

Publications (3)

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JP2015502547A JP2015502547A (ja) 2015-01-22
JP2015502547A5 JP2015502547A5 (enExample) 2016-02-04
JP6203747B2 true JP6203747B2 (ja) 2017-09-27

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US (1) US9671394B2 (enExample)
EP (1) EP2795335B1 (enExample)
JP (1) JP6203747B2 (enExample)
KR (1) KR20140099277A (enExample)
CN (1) CN104040350B (enExample)
BR (1) BR112014011535A2 (enExample)
CA (1) CA2853917A1 (enExample)
MX (1) MX349003B (enExample)
RU (1) RU2633488C2 (enExample)
WO (1) WO2013092611A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2017223710A (ja) * 2012-02-01 2017-12-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性結合物の結合パートナーを検出するための方法

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US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
BR112015000665A2 (pt) 2012-07-13 2017-06-27 Hoffmann La Roche método para a determinação da quantidade de um anticorpo
WO2015067547A1 (en) * 2013-11-05 2015-05-14 Roche Diagnostics Gmbh A method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto
US10401368B2 (en) * 2014-03-20 2019-09-03 Pdl Biopharma, Inc. Antibodies and methods for the detection of cell death
WO2016097116A1 (en) 2014-12-18 2016-06-23 Roche Diagnostics Gmbh Methods for reducing interferences
WO2019018828A1 (en) 2017-07-20 2019-01-24 Cytomx Therapeutics, Inc. METHODS OF QUALITATIVE AND / OR QUANTITATIVE ANALYSIS OF ACTIVATABLE ANTIBODY PROPERTIES AND USES THEREOF
CN109358192B (zh) * 2018-02-08 2020-05-12 中国科学院上海药物研究所 一种去除抗药抗体检测样品中游离药物的装置和方法、该装置的制备方法及应用
JP7370322B2 (ja) 2018-06-04 2023-10-27 中外製薬株式会社 複合体を検出する方法
MX2021013519A (es) * 2019-05-13 2021-12-10 Regeneron Pharma Ensayos de union de ligandos competitivos mejorados.
CN119470884A (zh) * 2019-05-13 2025-02-18 豪夫迈·罗氏有限公司 抑制干扰的药代动力学免疫测定
CN117805397A (zh) * 2024-02-29 2024-04-02 军科正源（北京）药物研究有限责任公司 检测游离vegf的方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017223710A (ja) * 2012-02-01 2017-12-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 多重特異性結合物の結合パートナーを検出するための方法
US10761097B2 (en) 2012-02-01 2020-09-01 Hoffmann-La Roche Inc. Method for the detection of a binding partner of a multispecific binder

Also Published As

Publication number Publication date
WO2013092611A2 (en) 2013-06-27
CN104040350A (zh) 2014-09-10
HK1201920A1 (zh) 2015-09-11
CN104040350B (zh) 2016-05-18
US20150072359A1 (en) 2015-03-12
WO2013092611A3 (en) 2013-10-17
EP2795335B1 (en) 2017-09-06
JP2015502547A (ja) 2015-01-22
RU2014128510A (ru) 2016-02-10
EP2795335A2 (en) 2014-10-29
CA2853917A1 (en) 2013-06-27
RU2633488C2 (ru) 2017-10-12
MX2014007095A (es) 2014-07-22
BR112014011535A2 (pt) 2017-05-09
MX349003B (es) 2017-07-06
KR20140099277A (ko) 2014-08-11
US9671394B2 (en) 2017-06-06

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