JP2011217747A5 - - Google Patents

Download PDF

Info

Publication number
JP2011217747A5
JP2011217747A5 JP2011098737A JP2011098737A JP2011217747A5 JP 2011217747 A5 JP2011217747 A5 JP 2011217747A5 JP 2011098737 A JP2011098737 A JP 2011098737A JP 2011098737 A JP2011098737 A JP 2011098737A JP 2011217747 A5 JP2011217747 A5 JP 2011217747A5
Authority
JP
Japan
Prior art keywords
antibody
subject
sample
seq
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011098737A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011217747A (ja
JP5296138B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011217747A publication Critical patent/JP2011217747A/ja
Publication of JP2011217747A5 publication Critical patent/JP2011217747A5/ja
Application granted granted Critical
Publication of JP5296138B2 publication Critical patent/JP5296138B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

JP2011098737A 2003-02-01 2011-04-26 高親和性抗ヒトＩｇＥ抗体 Expired - Lifetime JP5296138B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44422903P 2003-02-01 2003-02-01
US60/444,229 2003-02-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006503245A Division JP4764334B2 (ja) 2003-02-01 2004-02-02 高親和性抗ヒトＩｇＥ抗体

Publications (3)

Publication Number Publication Date
JP2011217747A JP2011217747A (ja) 2011-11-04
JP2011217747A5 true JP2011217747A5 (enExample) 2012-09-13
JP5296138B2 JP5296138B2 (ja) 2013-09-25

Family

ID=32850839

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2006503243A Pending JP2006516408A (ja) 2003-02-01 2004-02-02 高親和性抗体の生成方法
JP2006503245A Expired - Lifetime JP4764334B2 (ja) 2003-02-01 2004-02-02 高親和性抗ヒトＩｇＥ抗体
JP2010202452A Pending JP2011042654A (ja) 2003-02-01 2010-09-09 新規のＩｇＥエピトープの同定
JP2011098737A Expired - Lifetime JP5296138B2 (ja) 2003-02-01 2011-04-26 高親和性抗ヒトＩｇＥ抗体

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2006503243A Pending JP2006516408A (ja) 2003-02-01 2004-02-02 高親和性抗体の生成方法
JP2006503245A Expired - Lifetime JP4764334B2 (ja) 2003-02-01 2004-02-02 高親和性抗ヒトＩｇＥ抗体
JP2010202452A Pending JP2011042654A (ja) 2003-02-01 2010-09-09 新規のＩｇＥエピトープの同定

Country Status (15)

Country Link
US (4) US7531169B2 (enExample)
EP (4) EP1592777A4 (enExample)
JP (4) JP2006516408A (enExample)
CN (3) CN1829806A (enExample)
AU (3) AU2004209638B2 (enExample)
CA (2) CA2514839A1 (enExample)
CY (2) CY1118063T1 (enExample)
DK (2) DK2407485T3 (enExample)
ES (2) ES2575547T3 (enExample)
HU (2) HUE028407T2 (enExample)
IL (1) IL176940A (enExample)
MX (1) MX338940B (enExample)
PT (1) PT2000481E (enExample)
SI (2) SI2000481T1 (enExample)
WO (2) WO2004070011A2 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
US20060234296A1 (en) * 2003-02-01 2006-10-19 Sanjaya Singh Method for generating high affinity antibodies
ES2575547T3 (es) * 2003-02-01 2016-06-29 Tanox, Inc. Anticuerpos anti-IgE de humano de alta afinidad
DK2805728T3 (da) 2003-12-23 2020-04-20 Genentech Inc Hidtil ukendte anti-IL13-antistoffer og anvendelser deraf
KR20070008578A (ko) * 2004-02-02 2007-01-17 타녹스 인코퍼레이티드 신규한 ＩｇＥ 에피토프의 확인
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
WO2006055704A2 (en) * 2004-11-17 2006-05-26 Curagen Corporation Antibodies directed to ten-m proteins and uses thereof
US8137670B2 (en) * 2005-09-29 2012-03-20 Medimmune, Llc Method of identifying membrane IgE specific antibodies and use thereof for targeting IgE producing precursor cells
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
AR065368A1 (es) 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
RU2500686C2 (ru) 2007-03-22 2013-12-10 Дженентек, Инк. АПОПТОТИЧЕСКИЕ АНТИТЕЛА ПРОТИВ IgE
DE102007052281A1 (de) * 2007-11-02 2009-05-07 Zenteris Gmbh Einschritt-Multiplex-Immuntest
US20100248971A1 (en) 2007-12-03 2010-09-30 Takashi Inagaki Process for antibody production
US20130338038A1 (en) 2007-12-21 2013-12-19 Pdl Biopharma, Inc. Method of screening complex protein libraries to identify altered properties
CN101230103B (zh) * 2008-03-25 2011-09-07 中国医药集团总公司四川抗菌素工业研究所 一全人源重组抗-IgE抗体
WO2010033736A1 (en) 2008-09-17 2010-03-25 Xencor, Inc. Novel compositons and methods for treating ige-mediated disorders
ES2615881T3 (es) 2009-05-07 2017-06-08 Stallergenes Uso de inmunoglobulinas igg1 y/o de ligandos del receptor cd32 para el tratamiento de enfermedades y manifestaciones inflamatorias por vía mucosa.
EP2494356B1 (en) 2009-10-26 2017-03-15 Genentech, Inc. Assays for detecting antibodies specific to therapeutic anti-ige antibodies and their use in anaphylaxis
CN102958537B (zh) * 2010-04-07 2015-09-16 Abbvie公司 TNF-α结合蛋白
WO2013096791A1 (en) 2011-12-23 2013-06-27 Genentech, Inc. Process for making high concentration protein formulations
AR091305A1 (es) 2012-01-31 2015-01-28 Genentech Inc ANTICUERPOS ANTI-IgE Y SUS METODOS DE USO
AU2013262611B2 (en) 2012-05-18 2018-03-01 Genentech, Inc. High-concentration monoclonal antibody formulations
WO2014031610A1 (en) 2012-08-21 2014-02-27 Sanofi Methods for treating or preventing asthma by administering an il-4r antagonist
HRP20181227T1 (hr) 2012-09-07 2018-10-05 Regeneron Pharmaceuticals, Inc. Metode za liječenje atopijskog dermatitisa primjenom antagonista il-4r
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法
WO2015013668A1 (en) * 2013-07-26 2015-01-29 Ke Zhang Anti-immunoglobulin e antibodies and methods of use thereof
CN106471372B (zh) 2014-01-29 2019-10-11 通用电气健康护理生物科学股份公司 用于相互作用分析的方法和系统
RU2704999C2 (ru) 2014-02-28 2019-11-01 Ридженерон Фармасьютикалз, Инк. Способ лечения кожной инфекции путем введения антагониста il-4r
PT3157951T (pt) * 2014-06-17 2020-08-24 Academia Sinica Anticorpos anti-ige humanizados que reticulam cd23 em linfócitos b, mas não sensibilizam mastócitos
WO2016062734A1 (en) * 2014-10-24 2016-04-28 F. Hoffmann-La Roche Ag Vh-vl-interdomain angle based antibody humanization
US10066017B2 (en) 2014-11-14 2018-09-04 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist
CN109789196B (zh) 2016-09-01 2024-03-19 瑞泽恩制药公司 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法
TWI857389B (zh) 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
AU2017382281B2 (en) 2016-12-22 2024-07-11 Genentech, Inc. Methods and formulations for reducing reconstitution time of lyophilized polypeptides
US11518818B2 (en) * 2017-01-06 2022-12-06 The Regents Of The University Of California Therapeutic anti-IgE antibodies and methods and compositions thereof
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
PT3515465T (pt) 2017-08-18 2024-03-04 Regeneron Pharma Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
PL3703818T3 (pl) 2017-10-30 2024-03-25 Sanofi Biotechnology Antagonista IL-4R do zastosowania w sposobie leczenia lub zapobiegania astmie
EP3749362A1 (en) 2018-02-09 2020-12-16 F. Hoffmann-La Roche AG Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
JP7589045B2 (ja) * 2018-03-26 2024-11-25 ノバルティス アーゲー リゲリズマブを使用して慢性特発性蕁麻疹を治療する方法
EP3793597A1 (en) 2018-05-13 2021-03-24 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r inhibitor
CN109651510B (zh) * 2018-12-04 2023-03-24 上海长征医院 抗Eno1抗体及其用途
MA55372A (fr) 2019-03-21 2022-01-26 Regeneron Pharma Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie
GB2589049C (en) 2019-04-11 2024-02-21 argenx BV Anti-IgE antibodies
JP7592064B2 (ja) 2019-07-16 2024-11-29 サノフィ・バイオテクノロジー Ｉｌ－４ｒアンタゴニストを投与することにより喘息を治療するまたは予防するための方法
AU2020326713A1 (en) 2019-08-05 2022-02-17 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
CN114173819A (zh) 2019-08-05 2022-03-11 瑞泽恩制药公司 通过施用il-4r拮抗剂治疗过敏和增强过敏原特异性免疫疗法的方法
JP2021141861A (ja) * 2020-03-13 2021-09-24 富士フイルム和光純薬株式会社 抗原に対する親和力が向上した抗体のスクリーニング方法および製造方法
WO2021255621A1 (en) 2020-06-15 2021-12-23 Novartis Ag Treatment of food allergy using anti-ige antibodies
JP2024509971A (ja) 2021-03-11 2024-03-05 アイジェニックス， インコーポレイテッド アレルギー応答を予測するための方法およびシステム
US20240269279A1 (en) 2021-06-14 2024-08-15 Novartis Ag PHARMACEUTICAL FORMULATION CONTAINING AN ANTI-IgE ANTIBODY
US20260035484A1 (en) * 2021-10-29 2026-02-05 Longbio Pharma (Suzhou) Co., Ltd. Isolated antigen binding protein and use thereof
CN118647401A (zh) 2021-12-14 2024-09-13 诺华股份有限公司 使用抗ige抗体治疗过敏反应
CN120271714A (zh) * 2022-12-07 2025-07-08 南开大学 一种针对IgE的抗体或其抗原结合片段以及Fc变体
CN116359516A (zh) * 2023-04-04 2023-06-30 郑州安图生物工程股份有限公司 检测血清总IgE含量的试剂盒及应用
CN119490594B (zh) * 2023-08-15 2025-09-16 东莞市朋志生物科技有限公司 一种抗免疫球蛋白e的抗体及其应用
CN119745868A (zh) * 2024-11-21 2025-04-04 广州创瑞健康科技有限公司 一种人免疫球蛋白e拮抗剂、筛选方法以及应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1268176A (en) * 1916-11-29 1918-06-04 Us Slicing Machine Co Power mechanism for slicing-machines.
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
WO1989006138A1 (en) 1987-12-31 1989-07-13 Tanox Biosystems, Inc. UNIQUE ANTIGENIC EPITOPES ON IgE-BEARING B LYMPHOCYTES
US5449760A (en) 1987-12-31 1995-09-12 Tanox Biosystems, Inc. Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils
US5428133A (en) 1987-12-31 1995-06-27 Tanox Biosystems, Inc. Chimeric anti-human IgE-monoclonal antibody which binds to secreted IgE and membrane-bound IgE expressed by IgE-expressing B cells but notto IgE bound to FC receptors on basophils
US5614611A (en) 1987-12-31 1997-03-25 Tanox Biosystems, Inc. Humanized monoclonal antibodies binding to IgE-bearing B cells but not basophils
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
IL94611A (en) 1989-06-05 1994-12-29 Organogenesis Inc Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
DE69129154T2 (de) * 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
WO1992017207A1 (en) * 1991-03-26 1992-10-15 Tanox Biosystems, Inc. MONOCLONAL ANTIBODIES WHICH BIND TO SECRETED AND MEMBRANE-BOUND IgE, BUT NOT TO IgE ON BASOPHILS
DE69333807T2 (de) 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
DK0656789T3 (da) 1992-08-21 1998-08-24 Genentech Inc Fremgangsmåde til behandling af en LFA-1-medieretforstyrrelse.
EP1452542A3 (en) * 1992-09-24 2007-05-02 Novartis AG Reshaped human monoclonal antibodies specific for IgE
US6066718A (en) * 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US5958708A (en) * 1992-09-25 1999-09-28 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
EP1005870B1 (en) 1992-11-13 2009-01-21 Biogen Idec Inc. Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5994511A (en) * 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US6172213B1 (en) * 1997-07-02 2001-01-09 Genentech, Inc. Anti-IgE antibodies and method of improving polypeptides
EP1056471A4 (en) * 1998-01-29 2001-05-30 Tanox Inc TREATMENT OF ATOPIC DERMATITIS USING IgE ANTAGONISTS
US6299875B1 (en) 1998-06-04 2001-10-09 Panacea Pharmaceuticals, Llc Methods to block IGE binding to cell surface receptors of mast cells
US20050169909A1 (en) 2004-02-02 2005-08-04 Sanjaya Singh Identification of novel IgE epitopes
US20060234296A1 (en) 2003-02-01 2006-10-19 Sanjaya Singh Method for generating high affinity antibodies
ES2575547T3 (es) * 2003-02-01 2016-06-29 Tanox, Inc. Anticuerpos anti-IgE de humano de alta afinidad

Similar Documents

Publication Publication Date Title
JP2011217747A5 (enExample)
JP2013060443A5 (enExample)
NZ716369A (en) Anti-ox40 antibodies and methods of using the same
JP2016029056A5 (enExample)
JP2012143232A5 (enExample)
JP2018536393A5 (enExample)
RU2015103228A (ru) Антитела против тау
JP2021501744A5 (enExample)
JP2021500916A5 (enExample)
JP2015530971A5 (enExample)
JP2015535828A5 (enExample)
FI2897981T3 (fi) Anti-CD3-vasta-aineita, bispesifisiä antigeeniä sitovia molekyylejä, jotka sitovat CD3:a ja CD20:ta, ja niiden käyttöjä
WO2013054331A8 (en) Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam)
HRP20250850T1 (hr) Antitijela protiv claudina 18.2 korisna u dijagnozi raka
NZ602621A (en) Antibodies against csf-1r
JP2015527367A5 (enExample)
RU2013107776A (ru) Антитело к противоопухолевому антигену и способы применения
JP2011530514A5 (enExample)
JP2013500940A5 (enExample)
RU2010117018A (ru) Антитела к gdf8 и их применения
RU2015129813A (ru) Антитела, которые связываются с лигандом запрограммированной клеточной смерти 1 (pd-l1)
IL273196B2 (en) Claudin6 antibodies and methods of treating cancer
JP2017505125A5 (enExample)
RU2014146707A (ru) Антитела против тофацитиниба и их применение для лекарственного мониторинга
JP2020537520A5 (enExample)