JP2011217747A5 - - Google Patents
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- Publication number
- JP2011217747A5 JP2011217747A5 JP2011098737A JP2011098737A JP2011217747A5 JP 2011217747 A5 JP2011217747 A5 JP 2011217747A5 JP 2011098737 A JP2011098737 A JP 2011098737A JP 2011098737 A JP2011098737 A JP 2011098737A JP 2011217747 A5 JP2011217747 A5 JP 2011217747A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- subject
- sample
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 7
- 239000013068 control sample Substances 0.000 claims 4
- 230000014759 maintenance of location Effects 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010012434 Dermatitis allergic Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 201000010435 allergic urticaria Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44422903P | 2003-02-01 | 2003-02-01 | |
| US60/444,229 | 2003-02-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503245A Division JP4764334B2 (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗ヒトＩｇＥ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011217747A JP2011217747A (ja) | 2011-11-04 |
| JP2011217747A5 true JP2011217747A5 (enExample) | 2012-09-13 |
| JP5296138B2 JP5296138B2 (ja) | 2013-09-25 |
Family
ID=32850839
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503243A Pending JP2006516408A (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗体の生成方法 |
| JP2006503245A Expired - Lifetime JP4764334B2 (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗ヒトＩｇＥ抗体 |
| JP2010202452A Pending JP2011042654A (ja) | 2003-02-01 | 2010-09-09 | 新規のＩｇＥエピトープの同定 |
| JP2011098737A Expired - Lifetime JP5296138B2 (ja) | 2003-02-01 | 2011-04-26 | 高親和性抗ヒトＩｇＥ抗体 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503243A Pending JP2006516408A (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗体の生成方法 |
| JP2006503245A Expired - Lifetime JP4764334B2 (ja) | 2003-02-01 | 2004-02-02 | 高親和性抗ヒトＩｇＥ抗体 |
| JP2010202452A Pending JP2011042654A (ja) | 2003-02-01 | 2010-09-09 | 新規のＩｇＥエピトープの同定 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7531169B2 (enExample) |
| EP (4) | EP1592777A4 (enExample) |
| JP (4) | JP2006516408A (enExample) |
| CN (3) | CN1771338B (enExample) |
| AU (3) | AU2004209638B2 (enExample) |
| CA (2) | CA2514839A1 (enExample) |
| CY (2) | CY1118063T1 (enExample) |
| DK (2) | DK2000481T3 (enExample) |
| ES (2) | ES2575547T3 (enExample) |
| HU (2) | HUE028458T2 (enExample) |
| IL (1) | IL176940A (enExample) |
| MX (1) | MX338940B (enExample) |
| PT (1) | PT2000481E (enExample) |
| SI (2) | SI2000481T1 (enExample) |
| WO (2) | WO2004070010A2 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| EP1592777A4 (en) * | 2003-02-01 | 2008-06-04 | Tanox Inc | METHOD OF GENERATING HIGH-ANTIBODY ANTIBODIES |
| US20060234296A1 (en) * | 2003-02-01 | 2006-10-19 | Sanjaya Singh | Method for generating high affinity antibodies |
| DK3718564T3 (da) | 2003-12-23 | 2023-11-06 | Genentech Inc | Nye anti-IL-13-antistoffer og anvendelser |
| KR101581659B1 (ko) * | 2004-02-02 | 2015-12-31 | 타녹스 인코퍼레이티드 | 신규한 ＩｇＥ 에피토프의 확인 |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| WO2006055704A2 (en) * | 2004-11-17 | 2006-05-26 | Curagen Corporation | Antibodies directed to ten-m proteins and uses thereof |
| EP1941275B1 (en) * | 2005-09-29 | 2013-07-24 | Medimmune, Inc. | Method of identifying membrane lg specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| AR065368A1 (es) | 2007-02-15 | 2009-06-03 | Astrazeneca Ab | Anticuerpos para moleculas de ige |
| RS53402B (sr) * | 2007-03-22 | 2014-10-31 | Genentech, Inc. | Vezivanje apoptotskih anti-ige antitela za membranski ige |
| DE102007052281A1 (de) * | 2007-11-02 | 2009-05-07 | Zenteris Gmbh | Einschritt-Multiplex-Immuntest |
| JP5414535B2 (ja) | 2007-12-03 | 2014-02-12 | 株式会社アドバンス | １本鎖抗体ｓｃＦｖの製造方法 |
| US20130338038A1 (en) | 2007-12-21 | 2013-12-19 | Pdl Biopharma, Inc. | Method of screening complex protein libraries to identify altered properties |
| CN101230103B (zh) * | 2008-03-25 | 2011-09-07 | 中国医药集团总公司四川抗菌素工业研究所 | 一全人源重组抗-IgE抗体 |
| EP3190128B1 (en) | 2008-09-17 | 2018-11-14 | Xencor, Inc. | Compositions and methods for treating ige-mediated disorders |
| WO2010128265A2 (fr) | 2009-05-07 | 2010-11-11 | Stallergenes S.A. | Utilisation d'immunoglobulines igg1 et/ou de ligands du récepteur cd32 pour le traitement de maladies et manifestations inflammatoires par voie mucosale |
| HUE033492T2 (en) | 2009-10-26 | 2017-12-28 | Genentech Inc | Tests for the detection of antibodies specific for therapeutic anti-verb antibodies and their use in anaphylaxis |
| KR20130010123A (ko) * | 2010-04-07 | 2013-01-25 | 아비에 인코포레이티드 | ＴＮＦ-α 결합 단백질 |
| WO2013096791A1 (en) | 2011-12-23 | 2013-06-27 | Genentech, Inc. | Process for making high concentration protein formulations |
| TW201334789A (zh) | 2012-01-31 | 2013-09-01 | Genentech Inc | 抗ｉｇｅ抗體及其使用方法 |
| CA2873646C (en) | 2012-05-18 | 2022-04-26 | Genentech, Inc. | High-concentration monoclonal antibody formulations |
| JP6306588B2 (ja) | 2012-08-21 | 2018-04-04 | サノフィ・バイオテクノロジー | Ｉｌ−４ｒアンタゴニストを投与することにより喘息を処置又は予防するための方法 |
| TWI755763B (zh) | 2013-06-04 | 2022-02-21 | 美商再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
| TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| US10196458B2 (en) | 2013-07-26 | 2019-02-05 | The Regents Of The University Of California | Anti-immunoglobulin E antibodies and methods of using thereof |
| WO2015114056A1 (en) | 2014-01-29 | 2015-08-06 | Ge Healthcare Bio-Sciences Ab | Method and system for interaction analysis |
| EP3110848B1 (en) | 2014-02-28 | 2024-02-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
| US10047166B2 (en) * | 2014-06-17 | 2018-08-14 | Academia Sinica | Humanized anti-IgE antibodies that crosslink CD23 on B lymphocytes but do not sensitize mast cells |
| DK3209684T3 (da) * | 2014-10-24 | 2021-02-22 | Hoffmann La Roche | VH-VL-interdomænevinkelbaseret antistofhumanisering |
| JP6861630B2 (ja) | 2014-11-14 | 2021-04-21 | サノフィ・バイオテクノロジー | Ｉｌ−４ｒアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法 |
| CN118141914A (zh) | 2016-09-01 | 2024-06-07 | 瑞泽恩制药公司 | 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法 |
| US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
| TWI857389B (zh) | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
| CA3044686A1 (en) | 2016-12-22 | 2018-06-28 | Genentech, Inc. | Methods and formulations for reducing reconstitution time of lyophilized polypeptides |
| US11518818B2 (en) | 2017-01-06 | 2022-12-06 | The Regents Of The University Of California | Therapeutic anti-IgE antibodies and methods and compositions thereof |
| US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
| EP4344706A3 (en) | 2017-10-30 | 2024-05-22 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| WO2019157358A1 (en) | 2018-02-09 | 2019-08-15 | Genentech, Inc. | Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases |
| US20210115155A1 (en) | 2018-03-26 | 2021-04-22 | Novartis Ag | Methods of treating chronic spontaneous urticaria using ligelizumab |
| MA52624A (fr) | 2018-05-13 | 2021-03-24 | Regeneron Pharma | Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r |
| CN109651510B (zh) * | 2018-12-04 | 2023-03-24 | 上海长征医院 | 抗Eno1抗体及其用途 |
| WO2020191346A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
| GB2589049C (en) | 2019-04-11 | 2024-02-21 | argenx BV | Anti-IgE antibodies |
| EP3999114A1 (en) | 2019-07-16 | 2022-05-25 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4r antagonist |
| SG11202113310UA (en) | 2019-08-05 | 2021-12-30 | Regeneron Pharma | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| EP4010001A1 (en) | 2019-08-05 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist |
| JP2021141861A (ja) * | 2020-03-13 | 2021-09-24 | 富士フイルム和光純薬株式会社 | 抗原に対する親和力が向上した抗体のスクリーニング方法および製造方法 |
| WO2021255621A1 (en) | 2020-06-15 | 2021-12-23 | Novartis Ag | Treatment of food allergy using anti-ige antibodies |
| CA3213283A1 (en) | 2021-03-11 | 2022-09-15 | IgGenix, Inc. | Methods and systems for predicting allergic response |
| IL308278A (en) | 2021-06-14 | 2024-01-01 | Novartis Ag | A medicinal formulation containing an anti-Ig antibody |
| WO2023070502A1 (zh) * | 2021-10-29 | 2023-05-04 | 天辰生物医药(苏州)有限公司 | 分离的抗原结合蛋白及其用途 |
| JP2024544380A (ja) | 2021-12-14 | 2024-11-29 | ノバルティス アーゲー | 抗ＩｇＥ抗体を使用したアレルギー反応の治療 |
| CN116143932B (zh) * | 2022-12-07 | 2025-02-11 | 南开大学 | 一种针对IgE的抗体或其抗原结合片段以及Fc变体 |
| CN119490594B (zh) * | 2023-08-15 | 2025-09-16 | 东莞市朋志生物科技有限公司 | 一种抗免疫球蛋白e的抗体及其应用 |
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| US1268176A (en) * | 1916-11-29 | 1918-06-04 | Us Slicing Machine Co | Power mechanism for slicing-machines. |
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
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| US5428133A (en) * | 1987-12-31 | 1995-06-27 | Tanox Biosystems, Inc. | Chimeric anti-human IgE-monoclonal antibody which binds to secreted IgE and membrane-bound IgE expressed by IgE-expressing B cells but notto IgE bound to FC receptors on basophils |
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| US20050169909A1 (en) * | 2004-02-02 | 2005-08-04 | Sanjaya Singh | Identification of novel IgE epitopes |
-
2004
- 2004-02-02 EP EP04707380A patent/EP1592777A4/en not_active Withdrawn
- 2004-02-02 AU AU2004209638A patent/AU2004209638B2/en not_active Expired
- 2004-02-02 EP EP11170255.1A patent/EP2407485B1/en not_active Expired - Lifetime
- 2004-02-02 JP JP2006503243A patent/JP2006516408A/ja active Pending
- 2004-02-02 HU HUE11170255A patent/HUE028458T2/en unknown
- 2004-02-02 WO PCT/US2004/002892 patent/WO2004070010A2/en not_active Ceased
- 2004-02-02 SI SI200432324A patent/SI2000481T1/sl unknown
- 2004-02-02 EP EP04707368A patent/EP1592776A4/en not_active Withdrawn
- 2004-02-02 HU HUE08104978A patent/HUE028407T2/hu unknown
- 2004-02-02 CA CA002514839A patent/CA2514839A1/en not_active Abandoned
- 2004-02-02 EP EP08104978.5A patent/EP2000481B1/en not_active Expired - Lifetime
- 2004-02-02 PT PT08104978T patent/PT2000481E/pt unknown
- 2004-02-02 DK DK08104978.5T patent/DK2000481T3/en active
- 2004-02-02 CN CN2004800070117A patent/CN1771338B/zh not_active Expired - Lifetime
- 2004-02-02 ES ES08104978.5T patent/ES2575547T3/es not_active Expired - Lifetime
- 2004-02-02 ES ES11170255.1T patent/ES2566778T3/es not_active Expired - Lifetime
- 2004-02-02 US US10/544,056 patent/US7531169B2/en not_active Expired - Lifetime
- 2004-02-02 AU AU2004209637A patent/AU2004209637A1/en not_active Abandoned
- 2004-02-02 JP JP2006503245A patent/JP4764334B2/ja not_active Expired - Lifetime
- 2004-02-02 DK DK11170255.1T patent/DK2407485T3/en active
- 2004-02-02 WO PCT/US2004/002894 patent/WO2004070011A2/en not_active Ceased
- 2004-02-02 SI SI200432311A patent/SI2407485T1/sl unknown
- 2004-02-02 CA CA2514840A patent/CA2514840C/en not_active Expired - Lifetime
- 2004-02-02 CN CNA2004800082701A patent/CN1829806A/zh active Pending
- 2004-02-02 CN CN201210316908.4A patent/CN102993306B/zh not_active Expired - Lifetime
- 2004-07-29 MX MX2011007343A patent/MX338940B/es unknown
-
2006
- 2006-07-18 IL IL176940A patent/IL176940A/en active IP Right Grant
-
2009
- 2009-03-27 US US12/413,014 patent/US8252284B2/en not_active Expired - Fee Related
-
2010
- 2010-09-09 JP JP2010202452A patent/JP2011042654A/ja active Pending
-
2011
- 2011-04-26 JP JP2011098737A patent/JP5296138B2/ja not_active Expired - Lifetime
- 2011-05-03 AU AU2011202021A patent/AU2011202021B2/en not_active Expired
-
2012
- 2012-07-27 US US13/559,938 patent/US8604171B2/en not_active Expired - Lifetime
-
2013
- 2013-11-07 US US14/074,309 patent/US9156908B2/en not_active Expired - Lifetime
-
2016
- 2016-04-04 CY CY20161100269T patent/CY1118063T1/el unknown
- 2016-06-09 CY CY20161100504T patent/CY1117617T1/el unknown
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