JP2016533753A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016533753A5 JP2016533753A5 JP2016537898A JP2016537898A JP2016533753A5 JP 2016533753 A5 JP2016533753 A5 JP 2016533753A5 JP 2016537898 A JP2016537898 A JP 2016537898A JP 2016537898 A JP2016537898 A JP 2016537898A JP 2016533753 A5 JP2016533753 A5 JP 2016533753A5
- Authority
- JP
- Japan
- Prior art keywords
- kynureninase
- present
- therapy
- seq
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010031676 Kynureninase Proteins 0.000 claims description 45
- 102000005447 kynureninase Human genes 0.000 claims description 45
- 239000000203 mixture Substances 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 34
- 206010028980 Neoplasm Diseases 0.000 claims description 19
- YGPSJZOEDVAXAB-UHFFFAOYSA-N kynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-UHFFFAOYSA-N 0.000 claims description 16
- 238000009472 formulation Methods 0.000 claims description 15
- 238000011319 anticancer therapy Methods 0.000 claims description 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 11
- 229920001223 polyethylene glycol Polymers 0.000 claims description 11
- 238000006467 substitution reaction Methods 0.000 claims description 11
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 101001021858 Homo sapiens Kynureninase Proteins 0.000 claims description 6
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 102000004127 Cytokines Human genes 0.000 claims description 5
- 108090000695 Cytokines Proteins 0.000 claims description 5
- 241000288906 Primates Species 0.000 claims description 5
- 238000002512 chemotherapy Methods 0.000 claims description 5
- 238000001794 hormone therapy Methods 0.000 claims description 5
- 238000009169 immunotherapy Methods 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- 102000009027 Albumins Human genes 0.000 claims description 4
- 108010088751 Albumins Proteins 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 238000001959 radiotherapy Methods 0.000 claims description 4
- 229940045513 CTLA4 antagonist Drugs 0.000 claims description 3
- 102220487216 Cytochrome b-245 chaperone 1_F306L_mutation Human genes 0.000 claims description 3
- 238000000315 cryotherapy Methods 0.000 claims description 3
- 238000001361 intraarterial administration Methods 0.000 claims description 3
- 238000007917 intracranial administration Methods 0.000 claims description 3
- 238000007912 intraperitoneal administration Methods 0.000 claims description 3
- 230000002601 intratumoral effect Effects 0.000 claims description 3
- 238000001990 intravenous administration Methods 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 3
- NSTPXGARCQOSAU-VIFPVBQESA-N N-formyl-L-phenylalanine Chemical compound O=CN[C@H](C(=O)O)CC1=CC=CC=C1 NSTPXGARCQOSAU-VIFPVBQESA-N 0.000 claims description 2
- 230000003197 catalytic effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 230000010412 perfusion Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 210000004027 cell Anatomy 0.000 description 17
- 108020004707 nucleic acids Proteins 0.000 description 12
- 150000007523 nucleic acids Chemical class 0.000 description 12
- 102000039446 nucleic acids Human genes 0.000 description 12
- 230000009261 transgenic effect Effects 0.000 description 7
- 210000001744 T-lymphocyte Anatomy 0.000 description 5
- 241000238631 Hexapoda Species 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000013604 expression vector Substances 0.000 description 3
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 description 2
- 101001037261 Homo sapiens Indoleamine 2,3-dioxygenase 2 Proteins 0.000 description 2
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 description 2
- 102100040062 Indoleamine 2,3-dioxygenase 2 Human genes 0.000 description 2
- 102100040653 Tryptophan 2,3-dioxygenase Human genes 0.000 description 2
- 101710136122 Tryptophan 2,3-dioxygenase Proteins 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 208000019691 hematopoietic and lymphoid cell neoplasm Diseases 0.000 description 2
- 210000002751 lymph Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101001021851 Pseudomonas fluorescens Kynureninase Proteins 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361872132P | 2013-08-30 | 2013-08-30 | |
| US61/872,132 | 2013-08-30 | ||
| US201461986366P | 2014-04-30 | 2014-04-30 | |
| US61/986,366 | 2014-04-30 | ||
| PCT/US2014/053437 WO2015031771A2 (en) | 2013-08-30 | 2014-08-29 | Administration of kynurenine depleting enzymes for tumor therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018042760A Division JP7029316B2 (ja) | 2013-08-30 | 2018-03-09 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016533753A JP2016533753A (ja) | 2016-11-04 |
| JP2016533753A5 true JP2016533753A5 (enExample) | 2017-10-05 |
| JP6307163B2 JP6307163B2 (ja) | 2018-04-04 |
Family
ID=52583559
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016537898A Active JP6307163B2 (ja) | 2013-08-30 | 2014-08-29 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
| JP2018042760A Active JP7029316B2 (ja) | 2013-08-30 | 2018-03-09 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
| JP2020073212A Withdrawn JP2020111611A (ja) | 2013-08-30 | 2020-04-16 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
| JP2022132161A Pending JP2022159570A (ja) | 2013-08-30 | 2022-08-23 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018042760A Active JP7029316B2 (ja) | 2013-08-30 | 2018-03-09 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
| JP2020073212A Withdrawn JP2020111611A (ja) | 2013-08-30 | 2020-04-16 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
| JP2022132161A Pending JP2022159570A (ja) | 2013-08-30 | 2022-08-23 | 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US9808486B2 (enExample) |
| EP (2) | EP3492094A1 (enExample) |
| JP (4) | JP6307163B2 (enExample) |
| KR (2) | KR102271498B1 (enExample) |
| CN (2) | CN113957061A (enExample) |
| AU (1) | AU2014312119B2 (enExample) |
| BR (1) | BR112016004095A2 (enExample) |
| CA (2) | CA3173052A1 (enExample) |
| ES (1) | ES2707711T3 (enExample) |
| IL (2) | IL244312B (enExample) |
| WO (1) | WO2015031771A2 (enExample) |
| ZA (1) | ZA201601443B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| EP3492094A1 (en) * | 2013-08-30 | 2019-06-05 | Board of Regents, The University of Texas System | Administration of kynurenine depleting enzymes for tumor therapy |
| US9975959B2 (en) | 2014-08-29 | 2018-05-22 | Board Of Regents, The University Of Texas System | Administration of kynurenine depleting enzymes for tumor therapy |
| CA3126536C (en) | 2014-10-14 | 2023-07-25 | Halozyme, Inc. | Compositions of adenosine deaminase-2 (ada2), variants thereof and methods of using same |
| EP3271463A4 (en) * | 2015-03-18 | 2018-08-01 | Baylor College of Medicine | Her2/erbb2 chimeric antigen receptor |
| EP3402498A1 (en) | 2016-01-11 | 2018-11-21 | Synlogic, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
| WO2017151860A1 (en) | 2016-03-02 | 2017-09-08 | Broard Of Regents, The University Of Texas System | Human kynureninase enzyme variants having improved pharmacological properties |
| CA3019835A1 (en) | 2016-04-08 | 2017-10-12 | Purdue Research Foundation | Methods and compositions for car t cell therapy |
| AU2017343780B2 (en) | 2016-10-13 | 2023-08-31 | Juno Therapeutics, Inc. | Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators |
| AU2018219226B2 (en) | 2017-02-07 | 2024-12-19 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| ES3010559T3 (en) | 2017-02-28 | 2025-04-03 | Endocyte Inc | Compositions and methods for car t cell therapy |
| JP2020527025A (ja) * | 2017-07-12 | 2020-09-03 | シンロジック オペレーティング カンパニー インコーポレイテッド | 腫瘍細胞において免疫モジュレーターおよび抗がん治療剤を産生するようにプログラムされた微生物 |
| WO2019089740A1 (en) * | 2017-11-03 | 2019-05-09 | Dana-Farber Cancer Institute, Inc. | Biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy |
| AU2019209432B2 (en) | 2018-01-22 | 2026-01-08 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Methods of use for CAR T cells |
| AU2019218729B2 (en) | 2018-02-06 | 2025-12-04 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors |
| TW202000229A (zh) | 2018-02-23 | 2020-01-01 | 美商安德賽特公司 | Car t細胞療法之順序方法 |
| AU2019257340B2 (en) * | 2018-04-16 | 2025-07-24 | Board Of Regents, The University Of Texas System | Human kynureninase enzymes and uses thereof |
| CN110412179A (zh) * | 2018-04-26 | 2019-11-05 | 缪荣明 | 一种液相色谱检测颗粒酶a的方法 |
| EP3893923A2 (en) * | 2018-12-14 | 2021-10-20 | Autolus Limited | Cell |
| KR20220103944A (ko) * | 2019-10-17 | 2022-07-25 | 이케나 온콜로지, 인코포레이티드 | Peg화 키뉴레니나제 효소 및 암 치료를 위한 그의 용도 |
| EP4535004A4 (en) * | 2022-05-27 | 2025-09-17 | Fujifilm Corp | METHOD FOR AID IN THE DIAGNOSIS OF A BLOOD TUMOR, METHOD FOR OBTAINING DATA FOR THE DIAGNOSIS OF A BLOOD TUMOR AND KIT FOR SAID METHODS |
| WO2024085280A1 (ko) * | 2022-10-20 | 2024-04-25 | 서울대학교 산학협력단 | 신규한 키뉴레니나제 및 이의 용도 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4870287A (en) | 1988-03-03 | 1989-09-26 | Loma Linda University Medical Center | Multi-station proton beam therapy system |
| US5329028A (en) | 1992-08-05 | 1994-07-12 | Genentech, Inc. | Carbohydrate-directed cross-linking reagents |
| US5846945A (en) | 1993-02-16 | 1998-12-08 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| US20030194721A1 (en) | 2001-09-19 | 2003-10-16 | Incyte Genomics, Inc. | Genes expressed in treated foam cells |
| JP2005516605A (ja) | 2002-02-01 | 2005-06-09 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 心血管疾患を処置するための方法および組成物 |
| CN1330774C (zh) * | 2002-03-01 | 2007-08-08 | 国家人类基因组南方研究中心 | 犬尿氨酸水解酶多态性及其用途 |
| WO2004093871A1 (en) * | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Novel methods for the treatment of cancer |
| US20070207158A1 (en) | 2003-06-17 | 2007-09-06 | Harrison Roger G | Conjugate for the specific targeting of anticancer agents to tumor cells or tumor vasculature and production thereof |
| EP1648512A4 (en) | 2003-07-31 | 2009-01-21 | Immunomedics Inc | ANTI-CD19 ANTIBODIES |
| JP2008237022A (ja) | 2005-06-30 | 2008-10-09 | Osaka Prefecture | 非小細胞肺がんの予防・治療剤および診断薬 |
| WO2008036642A2 (en) * | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| GB0625310D0 (en) * | 2006-12-19 | 2007-01-24 | Bioalvo | Yeast platform construction and screening methods |
| US8465743B2 (en) | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| US9212229B2 (en) | 2010-09-08 | 2015-12-15 | Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus | Chimeric antigen receptors with an optimized hinge region |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| WO2012099441A2 (ko) * | 2011-01-21 | 2012-07-26 | 인제대학교산학협력단 | 트립토판 대사효소 유전자를 발현하는 줄기세포를 함유하는 면역 반응 억제용 조성물 |
| KR20120085209A (ko) * | 2011-01-21 | 2012-07-31 | 인제대학교 산학협력단 | 트립토판 대사효소 유전자를 발현하는 줄기세포를 함유하는 면역 반응 억제용 조성물 |
| RU2640913C2 (ru) * | 2011-09-07 | 2018-01-12 | Дойчес Кребсфоршунгсцентрум | Средства и способы лечения и/или предотвращения рака, зависимого от природного лиганда ahr |
| BR112014008849A2 (pt) | 2011-10-20 | 2017-09-12 | Us Health | receptores quiméricos de antígeno anti-cd22 |
| EP3492094A1 (en) | 2013-08-30 | 2019-06-05 | Board of Regents, The University of Texas System | Administration of kynurenine depleting enzymes for tumor therapy |
| US9975959B2 (en) | 2014-08-29 | 2018-05-22 | Board Of Regents, The University Of Texas System | Administration of kynurenine depleting enzymes for tumor therapy |
| WO2017151860A1 (en) | 2016-03-02 | 2017-09-08 | Broard Of Regents, The University Of Texas System | Human kynureninase enzyme variants having improved pharmacological properties |
| JP6912171B2 (ja) * | 2016-09-15 | 2021-07-28 | 株式会社トプコン | 眼科検査装置 |
| AU2019257340B2 (en) | 2018-04-16 | 2025-07-24 | Board Of Regents, The University Of Texas System | Human kynureninase enzymes and uses thereof |
-
2014
- 2014-08-29 EP EP18204264.8A patent/EP3492094A1/en active Pending
- 2014-08-29 CA CA3173052A patent/CA3173052A1/en active Pending
- 2014-08-29 AU AU2014312119A patent/AU2014312119B2/en active Active
- 2014-08-29 WO PCT/US2014/053437 patent/WO2015031771A2/en not_active Ceased
- 2014-08-29 JP JP2016537898A patent/JP6307163B2/ja active Active
- 2014-08-29 CA CA2922670A patent/CA2922670C/en active Active
- 2014-08-29 CN CN202111132607.1A patent/CN113957061A/zh active Pending
- 2014-08-29 CN CN201480053899.1A patent/CN105722522B/zh active Active
- 2014-08-29 US US14/473,040 patent/US9808486B2/en active Active
- 2014-08-29 ES ES14840339T patent/ES2707711T3/es active Active
- 2014-08-29 BR BR112016004095A patent/BR112016004095A2/pt not_active Application Discontinuation
- 2014-08-29 EP EP14840339.7A patent/EP3038636B1/en active Active
- 2014-08-29 KR KR1020167008486A patent/KR102271498B1/ko active Active
- 2014-08-29 KR KR1020217019661A patent/KR102442231B1/ko active Active
-
2016
- 2016-02-28 IL IL244312A patent/IL244312B/en active IP Right Grant
- 2016-03-02 ZA ZA2016/01443A patent/ZA201601443B/en unknown
- 2016-11-14 US US15/351,060 patent/US20170056449A1/en not_active Abandoned
-
2018
- 2018-03-09 JP JP2018042760A patent/JP7029316B2/ja active Active
-
2019
- 2019-02-19 IL IL264901A patent/IL264901B/en active IP Right Grant
- 2019-04-02 US US16/373,588 patent/US10772913B2/en active Active
-
2020
- 2020-04-16 JP JP2020073212A patent/JP2020111611A/ja not_active Withdrawn
- 2020-08-18 US US16/996,806 patent/US11534463B2/en active Active
-
2022
- 2022-08-23 JP JP2022132161A patent/JP2022159570A/ja active Pending
- 2022-12-13 US US18/065,451 patent/US20240091258A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016533753A5 (enExample) | ||
| TWI669311B (zh) | Ｉｌ－１５異源二聚體蛋白及其用途 | |
| Dasgupta et al. | Inhibition of NK cell activity through TGF-β1 by down-regulation of NKG2D in a murine model of head and neck cancer | |
| Gildener-Leapman et al. | Promising systemic immunotherapies in head and neck squamous cell carcinoma | |
| JP6731405B2 (ja) | ウイルス粒子を用いた癌免疫療法 | |
| CN116723851A (zh) | 白介素-18变体和使用方法 | |
| JP2018505893A5 (enExample) | ||
| CN110835371A (zh) | 抗ccr8单克隆抗体及其应用 | |
| JP2019507582A5 (enExample) | ||
| US8597647B1 (en) | Humanized anti-IL-20 antibody and uses thereof | |
| JP7099956B2 (ja) | がんの治療のためのｍｉｃａ／ｂアルファ３ドメインによるワクチン接種 | |
| JP2017526368A5 (enExample) | ||
| JP2021521777A (ja) | ヒトキヌレニナーゼ酵素及びその使用 | |
| CN112955168A (zh) | 与另一种药理活性剂组合的长效白介素-15受体激动剂 | |
| Liu et al. | Treatment of B-cell lymphoma with chimeric IgG and single-chain Fv antibody–interleukin-2 fusion proteins | |
| CN109929037B (zh) | 针对程序性死亡配体的结合物及其应用 | |
| Namkoong et al. | Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11 | |
| EP4471068A1 (en) | Bifunctional molecule formed by fusion of pd1 antibody and interleukin 2 | |
| WO2024078479A1 (zh) | 一种异源二聚体融合蛋白及其应用 | |
| JP2021506320A5 (enExample) | ||
| US20230406927A1 (en) | Masked single-domain antibodies and methods thereof | |
| EP4168431A1 (en) | Modified cxcl10 for immunotherapy of cancer diseases | |
| JP2023549112A (ja) | Ｉｌ－７タンパク質とヌクレオチドワクチンの組み合わせで腫瘍を治療する方法 | |
| WO2008037225A1 (es) | Composiciones terapéuticas para potenciar el efecto de la terapia con anticuerpos contra el receptor del factor de crecimiento epidérmico | |
| JP6853921B2 (ja) | ｃＦＬＩＰ ｓｉＲＮＡを含むインターフェロンベータ抵抗性がん疾患治療用又は感作用組成物 |