KR102271498B1 - 종양 치료를 위한 키누레닌 고갈 효소의 투여 - Google Patents
종양 치료를 위한 키누레닌 고갈 효소의 투여 Download PDFInfo
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- KR102271498B1 KR102271498B1 KR1020167008486A KR20167008486A KR102271498B1 KR 102271498 B1 KR102271498 B1 KR 102271498B1 KR 1020167008486 A KR1020167008486 A KR 1020167008486A KR 20167008486 A KR20167008486 A KR 20167008486A KR 102271498 B1 KR102271498 B1 KR 102271498B1
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| IL250833B (en) * | 2014-08-29 | 2022-09-01 | Univ Texas | Administration of kynurenine depleting enzymes for tumor therapy |
| KR102122463B1 (ko) | 2014-10-14 | 2020-06-15 | 할로자임, 아이엔씨 | 아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법 |
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| JP2020527025A (ja) * | 2017-07-12 | 2020-09-03 | シンロジック オペレーティング カンパニー インコーポレイテッド | 腫瘍細胞において免疫モジュレーターおよび抗がん治療剤を産生するようにプログラムされた微生物 |
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| CN112105382A (zh) | 2018-02-23 | 2020-12-18 | 恩多塞特公司 | 用于car t细胞疗法的顺序方法 |
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| CN1330774C (zh) * | 2002-03-01 | 2007-08-08 | 国家人类基因组南方研究中心 | 犬尿氨酸水解酶多态性及其用途 |
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| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR20120085209A (ko) * | 2011-01-21 | 2012-07-31 | 인제대학교 산학협력단 | 트립토판 대사효소 유전자를 발현하는 줄기세포를 함유하는 면역 반응 억제용 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2012099441A2 (ko) | 2011-01-21 | 2012-07-26 | 인제대학교산학협력단 | 트립토판 대사효소 유전자를 발현하는 줄기세포를 함유하는 면역 반응 억제용 조성물 |
Non-Patent Citations (1)
| Title |
|---|
| J Med Chem. 2009, Vol.52, No.2, pp.389-396 |
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