CA2922670C - Administration of kynurenine depleting enzymes for tumor therapy - Google Patents

Administration of kynurenine depleting enzymes for tumor therapy Download PDF

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Publication number
CA2922670C
CA2922670C CA2922670A CA2922670A CA2922670C CA 2922670 C CA2922670 C CA 2922670C CA 2922670 A CA2922670 A CA 2922670A CA 2922670 A CA2922670 A CA 2922670A CA 2922670 C CA2922670 C CA 2922670C
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Prior art keywords
kynureninase
composition
tumor
kynurenine
peg
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CA2922670A
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English (en)
French (fr)
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CA2922670A1 (en
Inventor
George Georgiou
Everett Stone
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University of Texas System
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University of Texas System
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Priority to CA3173052A priority Critical patent/CA3173052A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4244Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y307/00Hydrolases acting on carbon-carbon bonds (3.7)
    • C12Y307/01Hydrolases acting on carbon-carbon bonds (3.7) in ketonic substances (3.7.1)
    • C12Y307/01003Kynureninase (3.7.1.3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2922670A 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy Active CA2922670C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3173052A CA3173052A1 (en) 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361872132P 2013-08-30 2013-08-30
US61/872,132 2013-08-30
US201461986366P 2014-04-30 2014-04-30
US61/986,366 2014-04-30
PCT/US2014/053437 WO2015031771A2 (en) 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3173052A Division CA3173052A1 (en) 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy

Publications (2)

Publication Number Publication Date
CA2922670A1 CA2922670A1 (en) 2015-03-05
CA2922670C true CA2922670C (en) 2022-11-29

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CA2922670A Active CA2922670C (en) 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy
CA3173052A Pending CA3173052A1 (en) 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3173052A Pending CA3173052A1 (en) 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy

Country Status (12)

Country Link
US (5) US9808486B2 (enExample)
EP (2) EP3492094A1 (enExample)
JP (4) JP6307163B2 (enExample)
KR (2) KR102271498B1 (enExample)
CN (2) CN105722522B (enExample)
AU (1) AU2014312119B2 (enExample)
BR (1) BR112016004095A2 (enExample)
CA (2) CA2922670C (enExample)
ES (1) ES2707711T3 (enExample)
IL (2) IL244312B (enExample)
WO (1) WO2015031771A2 (enExample)
ZA (1) ZA201601443B (enExample)

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WO2017151860A1 (en) 2016-03-02 2017-09-08 Broard Of Regents, The University Of Texas System Human kynureninase enzyme variants having improved pharmacological properties
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WO2019165237A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
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US20220056407A1 (en) * 2018-12-14 2022-02-24 Autolus Limited Cell
WO2021076966A1 (en) * 2019-10-17 2021-04-22 Ikena Oncology, Inc. Pegylated kynureninase enzymes and uses thereof for the treatment of cancer
JPWO2023229024A1 (enExample) * 2022-05-27 2023-11-30
WO2024085280A1 (ko) * 2022-10-20 2024-04-25 서울대학교 산학협력단 신규한 키뉴레니나제 및 이의 용도

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EP3186371B1 (en) 2014-08-29 2024-08-14 Board of Regents, The University of Texas System Administration of kynurenine depleting enzymes for tumor therapy
WO2017151860A1 (en) 2016-03-02 2017-09-08 Broard Of Regents, The University Of Texas System Human kynureninase enzyme variants having improved pharmacological properties
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Also Published As

Publication number Publication date
US10772913B2 (en) 2020-09-15
CA2922670A1 (en) 2015-03-05
EP3038636A2 (en) 2016-07-06
ES2707711T3 (es) 2019-04-04
JP7029316B2 (ja) 2022-03-03
NZ717492A (en) 2021-10-29
JP2018127463A (ja) 2018-08-16
CN113957061A (zh) 2022-01-21
KR102442231B1 (ko) 2022-09-13
US20240091258A1 (en) 2024-03-21
JP2022159570A (ja) 2022-10-17
EP3038636B1 (en) 2018-11-07
CA3173052A1 (en) 2015-03-05
US9808486B2 (en) 2017-11-07
IL244312B (en) 2019-03-31
JP2020111611A (ja) 2020-07-27
EP3492094A1 (en) 2019-06-05
BR112016004095A2 (pt) 2017-10-17
AU2014312119A1 (en) 2016-03-17
CN105722522A (zh) 2016-06-29
WO2015031771A3 (en) 2015-05-14
KR20210082264A (ko) 2021-07-02
IL264901B (en) 2019-08-29
US20210213059A1 (en) 2021-07-15
KR20160048971A (ko) 2016-05-04
JP6307163B2 (ja) 2018-04-04
AU2014312119B2 (en) 2019-09-19
US11534463B2 (en) 2022-12-27
IL244312A0 (en) 2016-04-21
KR102271498B1 (ko) 2021-07-05
CN105722522B (zh) 2021-10-19
EP3038636A4 (en) 2017-04-26
US20200054674A1 (en) 2020-02-20
ZA201601443B (en) 2019-08-28
US20150064154A1 (en) 2015-03-05
WO2015031771A2 (en) 2015-03-05
US20170056449A1 (en) 2017-03-02
JP2016533753A (ja) 2016-11-04

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