JP2022159570A - 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 - Google Patents
腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y307/00—Hydrolases acting on carbon-carbon bonds (3.7)
- C12Y307/01—Hydrolases acting on carbon-carbon bonds (3.7) in ketonic substances (3.7.1)
- C12Y307/01003—Kynureninase (3.7.1.3)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
本発明は概して、L-キヌレニンまたはL-3-ヒドロキシキヌレニンを枯渇させる酵素による癌の治療のための組成物及び方法に関する。さらに詳しくは、本発明は、ヒトの治療法に好適なL-キヌレニン分解活性を持つ細菌及び哺乳類の酵素の操作、薬理学的最適化及び使用に関する。
癌細胞によるインドールアミン-2,3-ジオキシゲナーゼアイソフォーム(IDO1またはIDO2)の過剰発現は、またはこれらの酵素のいずれかを発現するように癌浸潤白血球を再プログラムすることは、癌に対する適応免疫応答を減衰させることに対して深刻な影響を有することが示されている。間質細胞によるその発現が一部の腫瘍によって誘導されるIDO1及びIDO2と同様に酵素トリプトファン2,3-ジオキシゲナーゼ(TDO)は、L-キヌレニン(KYN)へのトリプトファン(Trp)の異化における律速段階を触媒する(Godin-Ethierら,2011)。免疫細胞に対してKYNのレベルを局所的に上げる一方でTrpのレベルを局所的に枯渇させる二重効果を有するLAT1様アミノ酸交換体(Kaperら,2007)を用いて、腫瘍は細胞質のKYN分子を細胞外のTrp分子と交換する。近隣の免疫細胞がKYNを内部移行させ、その際、それは、免疫細胞の分化及び/またはアポトーシスの誘導を介して腫瘍の寛容をもたらす多数のサイトカイン及びケモカインの発現を生じるアリール炭化水素受容体(AHR)の活性化リガンドである(Della Chiesaら,2006;Opitzら,2011;Songら,2011)。さらに、キヌレニンから形成される他のKYN関連の化合物、最も顕著にはキヌレン酸もオーファンGPCR GPCR35のアゴニストとして作用することによって免疫抑制効果を発揮する。IDO1またはTDOの阻害を介したKYN形成の阻害(従って、キヌレン酸、3-ヒドロキシキヌレニン及びキノリン酸を含むKYN代謝副産物の形成の阻害)は、癌の標的として十分量の注目を浴びている(Chen及びGuillemin,2009;Rutellaら,2009;Prendergast,2011)。IDO1に対する、たとえば、1-DL-メチルトリプトファンのような基質類似体阻害剤が開発されており、癌が誘導する腫瘍寛容を克服するので癌と闘うネイティブな免疫系の能力を回復することにおいて最初の有望さを示している(Lobら,2009)。しかしながら、KYNは腫瘍で発現されることも多いトリプトファン2,3-ジオキシゲナーゼ(TDO)によっても作られ、この酵素は1-DL-メチルトリプトファンによって阻害されない(Pilotteら,2012)。現在フェーズ1及び2の臨床試験中である1-DL-メチルトリプトファンのD異性体(1-D-MT)に対する追加の関心もある。逆説的には、1-D-MTはIDO1の発現を上方調節することができ、現にKYNのレベルを上昇させ、特定の癌では免疫抑制を誘導する(Opitzら,2011)。
単離された、修飾されたヒトキヌレニナーゼ酵素であって、前記修飾された酵素が、ネイティブなヒトキヌレニナーゼ(配列番号8を参照)に比べて少なくとも1つの置換を有し、前記少なくとも1つの置換が、ネイティブなヒトキヌレニナーゼの306位に通常見いだされるPheに対するMetまたはLeuによる置換を含む、前記キヌレニナーゼ酵素。
[本発明1002]
前記少なくとも1つの置換がPhe306Metを含む、本発明1001の酵素。
[本発明1003]
前記少なくとも1つの置換がPhe306Leuを含む、本発明1001の酵素。
[本発明1004]
異種ペプチドセグメントをさらに含む、本発明1001の酵素。
[本発明1005]
前記異種ペプチドセグメントが、XTENペプチド、IgGのFc、アルブミン、またはアルブミン結合ペプチドである、本発明1004の酵素。
[本発明1006]
ポリエチレングリコール(PEG)に結合されている、本発明1001の酵素。
[本発明1007]
1つ以上のLysまたはCys残基を介してPEGに結合されている、本発明1006の酵素。
[本発明1008]
本発明1001の酵素をコードするヌクレオチド配列を含む、核酸。
[本発明1009]
細菌、真菌、昆虫、または哺乳類における発現についてコドン最適化されている、本発明1008の核酸。
[本発明1010]
本発明1008または1009の核酸を含む、発現ベクター。
[本発明1011]
本発明1008または1009の核酸を含む、宿主細胞。
[本発明1012]
細菌細胞、真菌細胞、昆虫細胞、または哺乳類細胞である、本発明1011の宿主細胞。
[本発明1013]
キヌレニナーゼまたはキヌレニナーゼをコードする核酸を、薬学上許容可能なキャリア中に含む、医薬製剤。
[本発明1014]
前記キヌレニナーゼが、3'-OHキヌレニンよりもキヌレニンに対してより高い触媒活性を有する、本発明1013の製剤。
[本発明1015]
前記キヌレニナーゼが、少なくとも0.5M-1/s-1の、キヌレニンに対するkcat/KMを有する、本発明1013の製剤。
[本発明1016]
前記キヌレニナーゼが細菌のキヌレニナーゼである、本発明1013の製剤。
[本発明1017]
前記細菌のキヌレニナーゼが、シュードモナス・フルオレッセンス(Pseudomonas fluorescens)のキヌレニナーゼ、ムチラギニバクター・パルジス(Mucilaginibacter paludis)のキヌレニナーゼ、またはクラミドフィラ・ペコルム(Chlamydophila pecorum)のキヌレニナーゼである、本発明1016の製剤。
[本発明1018]
前記細菌のキヌレニナーゼが、配列番号7、13~52、及び57のいずれかに対して少なくとも90%同一であるアミノ酸配列を含む、本発明1016の製剤。
[本発明1019]
前記キヌレニナーゼが、哺乳類のキヌレニナーゼである、本発明1013の製剤。
[本発明1020]
前記哺乳類のキヌレニナーゼがマウスまたは霊長類のキヌレニナーゼである、本発明1019の製剤。
[本発明1021]
前記霊長類のキヌレニナーゼがヒトのキヌレニナーゼである、本発明1020の製剤。
[本発明1022]
前記霊長類のキヌレニナーゼが、配列番号8及び10~12のいずれかに対して少なくとも90%同一であるアミノ酸配列を含む、本発明1020の製剤。
[本発明1023]
前記マウスのキヌレニナーゼが、配列番号9に対して少なくとも90%同一であるアミノ酸配列を含む、本発明1020の製剤。
[本発明1024]
前記キヌレニナーゼが、本発明1001のキヌレニナーゼ酵素である、本発明1013の製剤。
[本発明1025]
前記キヌレニナーゼが異種ペプチドセグメントをさらに含む、本発明1013~1024のいずれかの製剤。
[本発明1026]
前記キヌレニナーゼがポリエチレングリコール(PEG)に結合されている、本発明1013~1024のいずれかの製剤。
[本発明1027]
前記キヌレニナーゼが1つ以上のLysまたはCys残基を介してPEGに結合されている、本発明1026の製剤。
[本発明1028]
前記キヌレニナーゼをコードする前記核酸が、細菌、真菌、昆虫、または哺乳類における発現についてコドン最適化されている、本発明1013の製剤。
[本発明1029]
前記核酸が発現ベクターの中にある、本発明1013の製剤。
[本発明1030]
腫瘍を有する対象を治療する方法であって、有効量の本発明1013の製剤を前記対象に投与することを含む、前記方法。
[本発明1031]
前記対象が、IDO1、IDO2、またはTDOを発現する腫瘍を有すると特定されている、本発明1030の方法。
[本発明1032]
前記腫瘍が固形腫瘍である、本発明1030の方法。
[本発明1033]
前記腫瘍が血液腫瘍である、本発明1030の方法。
[本発明1034]
前記対象がヒト患者である、本発明1030の方法。
[本発明1035]
前記製剤が、腫瘍内に、静脈内に、皮内に、動脈内に、腹腔内に、病変内に、頭蓋内に、関節内に、前立腺内に、胸膜腔内に、気管内に、眼内に、鼻内に、硝子体内に、膣内に、直腸内に、筋肉内に、皮下に、結膜下に、小嚢内に(intravesicularlly)、粘膜に、心膜内に、臍内に、経口で、吸入によって、注射によって、点滴によって、持続点滴によって、標的細胞を直接浸す局所潅流によって、カテーテルを介して、または洗浄を介して投与される、本発明1030の方法。
[本発明1036]
前記製剤が前記腫瘍の栄養媒体に投与される、本発明1030の方法。
[本発明1037]
前記栄養媒体が、血液、リンパ液、または脊髄液である、本発明1036の方法。
[本発明1038]
少なくとも第2の抗癌療法を前記対象に施すことをさらに含む、本発明1030の方法。
[本発明1039]
前記第2の抗癌療法が、外科療法、化学療法、放射線療法、寒冷療法、ホルモン療法、免疫療法、またはサイトカイン療法である、本発明1038の方法。
[本発明1040]
前記第2の抗癌療法が、抗PD1抗体、抗CTLA-4抗体、または抗PD-L1抗体を含む、本発明1038の方法。
[本発明1041]
発現されたキメラ抗原T細胞受容体(CAR)と、発現されたキヌレニナーゼ酵素とを含む、トランスジェニックT細胞。
[本発明1042]
ヒトのT細胞である、本発明1041の細胞。
[本発明1043]
前記キヌレニナーゼが、配列番号8及び10~12のいずれかに対して少なくとも90%同一であるアミノ酸配列を含む、本発明1041の細胞。
[本発明1044]
前記CARと前記キヌレニナーゼとをコードするDNAが細胞のゲノムに組み込まれている、本発明1041の細胞。
[本発明1045]
前記CARが癌細胞抗原を標的とする、本発明1041の細胞。
[本発明1046]
前記癌細胞抗原がHER2、CD19、CD20、またはGD2である、本発明1045の細胞。
[本発明1047]
腫瘍を有するヒト対象においてT細胞応答を提供する方法であって、有効量の本発明1041のトランスジェニック細胞を前記対象に投与することを含む、前記方法。
[本発明1048]
前記トランスジェニック細胞が自己である、本発明1047の方法。
[本発明1049]
前記トランスジェニック細胞が異種である、本発明1047の方法。
[本発明1050]
少なくとも第2の抗癌療法を前記対象に施すことをさらに含む、本発明1047の方法。
[本発明1051]
前記第2の抗癌療法が、外科療法、化学療法、放射線療法、寒冷療法、ホルモン療法、免疫療法、またはサイトカイン療法である、本発明1050の方法。
[本発明1052]
対象における腫瘍の治療において使用するための、キヌレニナーゼまたはキヌレニナーゼをコードする核酸を含む組成物。
[本発明1053]
前記キヌレニナーゼが、配列番号7~52及び57のいずれかに対して少なくとも90%同一であるアミノ酸配列を含む、本発明1052の組成物。
[本発明1054]
前記キヌレニナーゼが、306位でのPhe306MetまたはPhe306Leuの置換を持つ配列番号8に対して少なくとも90%同一であるアミノ酸配列を含む、本発明1053の組成物。
[本発明1055]
前記キヌレニナーゼがポリエチレングリコール(PEG)に結合されている、本発明1052の組成物。
[本発明1056]
前記キヌレニナーゼ酵素をコードする前記核酸が、細菌、真菌、昆虫、または哺乳類における発現についてコドン最適化されている、本発明1052の組成物。
[本発明1057]
前記核酸が発現ベクターの中にある、本発明1052の組成物。
[本発明1058]
前記対象が、IDO1、IDO2、またはTDOを発現する腫瘍を有すると特定されている、本発明1052の組成物。
[本発明1059]
前記腫瘍が固形腫瘍である、本発明1052の組成物。
[本発明1060]
前記腫瘍が血液腫瘍である、本発明1052の組成物。
[本発明1061]
腫瘍内投与、静脈内投与、皮内投与、動脈内投与、腹腔内投与、病変内投与、頭蓋内投与、関節内投与、前立腺内投与、胸膜腔内投与、気管内投与、眼内投与、鼻内投与、硝子体内投与、膣内投与、直腸内投与、筋肉内投与、皮下投与、結膜下投与、小嚢内投与、粘膜投与、心膜内投与、臍内投与、または経口投与のために製剤化されている、本発明1052の組成物。
[本発明1062]
前記腫瘍の栄養媒体への投与のために製剤化されている、本発明1052の組成物。
[本発明1063]
前記栄養媒体が血液、リンパ液、または脊髄液である、本発明1062の組成物。
[本発明1064]
少なくとも第2の抗癌療法をさらに含む、本発明1052の組成物。
[本発明1065]
前記第2の抗癌療法が、化学療法、放射線療法、ホルモン療法、免疫療法、またはサイトカイン療法である、本発明1064の組成物。
[本発明1066]
前記第2の抗癌療法が抗PD1抗体を含む、本発明1064の組成物。
[本発明1067]
ヒト対象における腫瘍の治療において使用するための、本発明1041~1046のいずれかのトランスジェニックT細胞を含む組成物。
[本発明1068]
前記トランスジェニックT細胞が自己である、本発明1067の組成物。
[本発明1069]
前記トランスジェニックT細胞が異種である、本発明1067の組成物。
[本発明1070]
少なくとも第2の抗癌療法をさらに含む、本発明1067の組成物。
[本発明1071]
前記第2の抗癌療法が、化学療法、ホルモン療法、免疫療法、またはサイトカイン療法である、本発明1070の組成物。
[本発明1072]
前記第2の抗癌療法が、抗PD1抗体、抗CTLA-4抗体、または抗PD-L1抗体を含む、本発明1070の組成物。
[本発明1073]
腫瘍の治療のための薬物の製造における、キヌレニナーゼまたはキヌレニナーゼをコードする核酸の使用。
[本発明1074]
腫瘍の治療のための薬物の製造における、本発明1001~1007のいずれかのキヌレニナーゼまたは本発明1008または1009のいずれかの核酸の使用。
本発明の他の目的、特徴及び利点は以下の詳細な記載から明らかになるであろう。しかしながら、本発明の精神と範囲の中にある種々の変更及び改変がこの詳細な記載から当業者に明らかになるので、詳細な記載及び具体的な実施例は、本発明の好まれる実施形態を示しながら、説明目的のみで提供されることが理解されるべきである。
キヌレニンは、インドールアミン―2,3-ジオキシゲナーゼ(IDO)またはトリプトファン-2,3-ジオキシゲナーゼ(TDO)の作用を介して生成されるアミノ酸、トリプトファンの代謝産物である。キヌレニンは細胞生理学に対して複数の効果を発揮し、その最も重要なものの1つがT細胞応答の調節である。多数の腫瘍細胞はIDO及び/またはTDOの合成を調節してキヌレニンの局所濃度を高め、それにはトリプトファンの枯渇が伴う。高レベルのキヌレニンは、さもなければ腫瘍を攻撃することになる腫瘍浸潤T細胞の機能を阻害する強力な方法として働く。
本明細書で使用されるとき、用語「タンパク質」及び「ポリペプチド」はペプチド結合を介して連結されるアミノ酸を含む化合物を指し、相互交換可能に使用される。
一部の実施形態は修飾されたタンパク質及びポリペプチドに関する。特定の実施形態は、未修飾の型に匹敵する少なくとも1つの機能的活性、好ましくはキヌレニン分解活性または3'-ヒドロキシキヌレニン分解活性を示す修飾されたタンパク質及びポリペプチドに関する。さらなる態様では、タンパク質またはポリペプチドはさらに修飾されて血清での安定性を高めてもよい。従って、本出願が「修飾されたタンパク質」または「修飾されたポリペプチド」の機能または活性を指す場合、当業者は、これが、たとえば、キヌレニン分解活性または3'-ヒドロキシキヌレニン分解活性のような未修飾のタンパク質またはポリペプチドを超える追加の利点を保有するタンパク質またはポリペプチド含むことを理解することになる。特定の実施形態では、未修飾のタンパク質またはポリペプチドはネイティブなキヌレニナーゼ、好ましくはヒトのキヌレニナーゼまたはシュードモナス・フルオレッセンスのキヌレニナーゼである。「修飾されたタンパク質」に関する実施形態は「修飾されたポリペプチド」に関して実施されてもよく、逆もまた同様であることが特に企図される。
特定の態様では、ポリペプチドは、キヌレニンの枯渇に感受性である癌を含む疾患のキヌレニンを枯渇させる酵素による治療に使用されて腫瘍が介在する寛容原性の効果を妨げ、代わりに腫瘍除去型の炎症誘発性反応に介在する。特定の態様では、キヌレニナーゼは、IDO1、IDO2及び/またはTDOを発現している腫瘍を治療することにおける使用について企図される。
本発明の組成物及び方法には、たとえば、異種のペプチドセグメントまたはポリマー、たとえば、ポリエチレングリコールとのコンジュゲートを形成することによって修飾されたキヌレニナーゼが関与する。さらなる態様では、キヌレニナーゼをPEGに連結して酵素の流体力学半径を大きくするので血清での持続を高める。特定の態様では、開示されるポリペプチドは、任意のターゲティング剤、たとえば、外部受容体または腫瘍細胞上の結合部位に特異的に且つ安定的に結合する能力を有するリガンドにコンジュゲートされてもよい(US2009/0304666)。
本発明の特定の実施形態は融合タンパク質に関する。これらの分子は、異種ドメインにN末端またはC末端で連結されたネイティブなまたは修飾されたキヌレニナーゼを有してもよい。たとえば、融合は、他の種に由来するリーダー配列も採用して異種宿主にてタンパク質の組換え発現を可能にしてもよい。別の有用な融合には、融合タンパク質の精製を円滑にするための、好ましくは切断可能な、タンパク質親和性タグ、たとえば、血清アルブミン親和性タグ、または6ヒスチジン残基、または免疫的に活性のあるドメイン、たとえば、抗体エピトープの付加が含まれる。非限定の親和性タグには、ポリヒスチジン、キチン結合タンパク質(CBP)、マルトース結合タンパク質(MBP)、及びグルタチオン-S-トランスフェラーゼ(GST)が挙げられる。
特定の実施形態では、キヌレニナーゼは、二官能性架橋試薬を用いて化学的にコンジュゲートされてもよいし、またはタンパク質レベルでペプチドリンカーと融合されてもよい。
本発明の特定の態様では、キヌレニナーゼのペグ化に関する方法及び組成物が開示される。たとえば、キヌレニナーゼは本明細書で開示される方法に従ってペグ化されてもよい。
特定の実施形態では、本発明は、たとえば、キヌレニナーゼのような少なくとも1つのタンパク質またはペプチドを含む新規の組成物に関する。これらのペプチドは融合タンパク質に含まれてもよく、または上述のような作用剤にコンジュゲートされてもよい。
本発明の特定の態様では、キヌレニナーゼまたはキヌレニナーゼを含有する融合タンパク質をコードする核酸配列が開示され得る。どの発現系が使用されるかに応じて、従来の方法に基づいて核酸配列を選択することができる。たとえば、キヌレニナーゼがヒトのキヌレニナーゼに由来し、大腸菌では稀にしか利用されない複数のコドンを含有するのであれば、それは発現を妨害する。従って、各遺伝子またはその改変体は大腸菌での発現についてコドンを最適化され得る。種々のベクターも用いて当該タンパク質を発現させてもよい。例となるベクターにはプラスミドベクター、ウイルスベクター、トランスポゾンまたはリポソームに基づくベクターが挙げられるが、これらに限定されない。
宿主細胞は、形質転換されてキヌレニナーゼ及びそのコンジュゲートの発現及び分泌を可能にし得るいずれかであってもよい。宿主細胞は細菌、哺乳類細胞、酵母または糸状菌であってもよい。種々の細菌にはエシェリキア(Escherichia)及びバチルス(Bacillus)が挙げられる。サッカロミセス(Saccharomyces)属、クルイベロミセス(Kiuyveromyces)属、ハンゼヌラ(Hansenula)属またはピキア(Pichia)属に属する酵母は適当な宿主細胞として使用される。以下の属:アスペルギルス(Aspergillus)、トリコデルマ(Trichoderma)、ニューロスポラ(Neurospora)、ペニシリウム(Penicillium)、セファロスポリウム(Cephalosporium)、アクリャ(Achlya)、ポドスポラ(Podospora)、エンドチア(Endothia)、ムコール(Mucor)、コクリオボルス(Cochliobolus)、及びピリキュラリア(Pyricularia)を含む糸状菌の種々の種は発現宿主として使用されてもよい。
タンパク質の精製法は当業者に周知である。これらの技法には、1つのレベルでは、細胞、組織または臓器の均質化及びそれのポリペプチド画分及び非ポリペプチド画分への粗分画化が関与する。当該タンパク質またはポリペプチドはクロマトグラフィ法及び電気泳動法を用いてさらに精製されて、特定されない限り、部分精製または完全精製(または均質性への精製)を達成してもよい。純粋なペプチドの調製に特に適する分析法は、イオン交換クロマトグラフィ、ゲル排除クロマトグラフィ、ポリアクリルアミドゲル電気泳動、アフィニティクロマトグラフィ、免疫アフィニティクロマトグラフィ、及び等電点電気泳動である。ペプチドを精製する特に効率的な方法は高速液体クロマトグラフィ(FPLC)またはさらに高速の液体クロマトグラフィ(HPLC)である。
新規のキヌレニナーゼを全身性にまたは局所で投与して、腫瘍細胞の増殖を阻害する、最も好ましくは局所の進行癌または転移癌の癌患者にて癌細胞を殺傷することができることが企図される。それらは静脈内に、クモ膜下に、及び/または腹腔内に投与することができる。それらは単独でまたは抗増殖剤との併用で投与することができる。一実施形態では、それらを投与して手術または他の処置に先立って患者における癌の負荷を軽減する。或いは、術後にそれらを投与して残りの癌(たとえば、手術が取り除けなかった癌)を確実に生き残らないようにすることができる。
特定の実施形態では、本実施形態の組成物及び方法には、第2の治療法または追加の治療法と併用したキヌレニナーゼの投与が関与する。そのような治療法はキヌレニン依存性に関連する疾患の治療に適用することができる。たとえば、疾患は癌であってもよい。
本実施形態に従って多種多様な化学療法剤を使用してもよい。用語「化学療法」は癌を治療するための薬剤の使用を指す。「化学療法剤」は癌の治療で投与される化合物または組成物を含意するのに使用される。これらの作用剤または薬剤は、細胞内での活性のその様式によって、たとえば、どの段階でそれらが細胞周期に影響するかどうかによって分類される。或いは、作用剤は、DNAを直接架橋する、DNAに挿入する、または核酸合成に影響することによって染色体異常及び有糸分裂異常を誘導するその能力に基づいて特徴付けされてもよい。
DNAの損傷を引き起こし、広範に使用されている他の因子には、γ線、X線として一般に知られるもの及び/または腫瘍細胞への放射性同位元素の指示された送達が挙げられる。たとえば、マイクロ波、プロトンビーム照射(US5,760,395及び4,870,287)及びUV照射のような、DNAを損傷する因子の他の形態も企図される。これらの因子すべてが、DNA、DNAの前駆体、DNAの複製及び修復、並びに染色体の集合及び維持における広い範囲の損傷に影響を及ぼす可能性が最も高い。X線の投与量範囲は、長期(3~4週)にわたる50~200レントゲンの一日線量から2000~6000レントゲンの単回線量に及ぶ。放射性同位元素の投与量範囲は広く変化し、同位元素の半減期、放出される放射線の強度及び種類、並びに腫瘍細胞による取り込みに左右される。
当業者は本実施形態の方法を併用してまたは併せて免疫療法を使用してもよいことを理解するであろう。癌治療の文脈では、免疫療法は一般に癌細胞を標的とし、破壊する免疫エフェクター細胞と分子の使用に頼る。リツキシマブ(リツキサン(登録商標))はそのような例である。たとえば、イピリミマブのようなチェックポイント阻害剤は別のそのような例である。免疫エフェクターは、たとえば、腫瘍細胞の表面上のあるマーカーに特異的な抗体であってもよい。抗体は単独で治療法のエフェクターとして働いてもよいし、またはそれが細胞の殺傷に実際に影響を及ぼす他の細胞を動員してもよい。抗体はまた薬剤または毒素(化学療法剤、放射性核種、リシンA鎖、コレラ毒素、百日咳毒素)にコンジュゲートされてもよく、単にターゲティング剤として働いてもよい。或いは、エフェクターは、腫瘍細胞標的と直接または間接的に相互作用する表面分子を運ぶリンパ球であってもよい。種々のエフェクター細胞には細胞傷害性T細胞及びNK細胞が挙げられる。
癌を持つヒトのおよそ60%が何らかの種類の手術を受け、それには、予防上の、診断上の、または段階決定の、治癒的な、及び緩和のための手術が含まれる。治療的手術には、癌性組織の全部または一部を物理的に取り除く、切除する及び/または破壊する切除が含まれ、たとえば、本実施形態の治療、化学療法、放射線療法、ホルモン療法、遺伝子治療、免疫療法、及び/または代替療法のような他の治療法と併せて使用されてもよい。腫瘍の切除は、腫瘍の少なくとも一部の物理的除去を指す。腫瘍の切除に加えて、手術による治療には、レーザー手術、冷凍手術、電気手術、及び顕微鏡的に制御された手術(Mohsの手術)が挙げられる。
他の作用剤を本実施形態の特定の態様と併用して使用して治療上の治療有効性を改善してもよいことが企図される。これらの追加の作用剤には、細胞表面受容体及びギャップ結合の上方調節に影響する作用剤、細胞増殖抑制及び分化の作用剤、細胞接着の阻害剤、アポトーシス誘導体への過剰増殖性細胞の感受性を高める作用剤、または他の生物作用剤が挙げられる。ギャップ結合の数を増やすことによる細胞間シグナルの増大は近隣の過剰増殖性細胞の集団で過剰増殖抑制効果を高めることになる。他の実施形態では、細胞増殖抑制及び分化の作用剤を本実施形態の特定の態様と併用して使用して治療の過剰増殖抑制の有効性を改善することができる。細胞接着の阻害剤は本実施形態の有効性を改善するように企図される。細胞接着阻害剤の例は焦点接着キナーゼ(FAK)阻害剤及びロバスタチンである。アポトーシスへの過剰増殖性細胞の感受性を高める他の作用剤、たとえば、抗体c225は本実施形態の特定の態様と併用して使用されて治療有効性を高めてもよいことがさらに企図される。
本発明の特定の態様は、たとえば、治療用キットのようなキットを提供してもよい。たとえば、キットは、本明細書で記載されるような1つ以上の医薬組成物と、任意で使用のための指示書とを含んでもよい。キットはまた、そのような組成物の投与を達成するための1つ以上の用具を含んでもよい。たとえば、主題のキットは、医薬組成物と、癌性腫瘍への該組成物の直接的な静脈内注射を達成するためのカテーテルとを含んでもよい。他の実施形態では、主題のキットは、任意で医薬として製剤化された、または送達用具で使用するために凍結乾燥されたキヌレニナーゼの事前に充填されたアンプルを含んでもよい。
本発明の好まれる実施形態を実証するために以下の実施例が包含される。以下に続く実施例で開示される技法は、本発明の実践で上手く機能することが本発明者らによって見いだされた技法を表すので、その実践で好まれる様式を構成すると見なすことができることが当業者によって十分に理解されるべきである。しかしながら、当業者は、本開示の観点から、本発明の精神及び範囲から逸脱することなく多数の変更を開示された特定の実施形態で行うことができ、それは類似のまたは似た結果をさらに得ることを十分に理解すべきである。
シュードモナス・フルオレッセンス由来のキヌレニナーゼ酵素(Pf-KYNU)の発現のための遺伝子を、DNA-Worksソフトウエア(Hoover及びLubkowski,2002)を用いて設計した4つのコドンを最適化した遺伝子ブロックのオーバーラップ伸長ポリメラーゼ連鎖反応(PCR)によって構築した。完全長の遺伝子には、N末端XbaI制限酵素部位(ヌクレオチド1~6)、最適化されたリボゾーム結合部位(RBS;ヌクレオチド29~55)、開始コドン(ヌクレオチド56~58)、N末端His6タグ(ヌクレオチド59~91)、大腸菌コドンに最適化されたPf-KYNU遺伝子(ヌクレオチド92~1336)、停止コドン(ヌクレオチド1337~1342)及びC末端BamHI制限酵素部位(ヌクレオチド1342~1347)が含まれる(配列番号1を参照のこと)。前述の制限酵素部位を用いて集合させた遺伝子をpET-28a+ベクター(Novagen)にクローニングした。次いでこの構築物を使用して発現のために大腸菌BL21(DE3)を形質転換した。50mg/Lのカナマイシンを伴ったテリフィックブロス(TB)培地にて210rpmで振盪しながら37℃で細胞を増殖させた。OD600が約1.0に達したとき、37℃で連続して一晩振盪しながらIPTG(0.5mMの最終濃度)を添加することによって発現を誘導した。次いで遠心分離によって細胞を回収し、50mMのリン酸ナトリウム、pH7.4、300mMのNaCl、0.5mMのリン酸ピリドキシル(PLP)、1mMのフッ化フェニルメチルスルホニル及び1μg/mLのDNA分解酵素から成る溶解緩衝液に再浮遊させた。溶解はフレンチプレスによって達成し、溶解物は20,000×gで4℃にて1時間遠心分離することによって粒子状物質を除いた。次いで5μmの注射器フィルターを介して上清を濾過し、50mMのリン酸ナトリウム、300mMのNaCl及び0.1mMのPLP、pH7.4で構成された緩衝液で事前に平衡化したNi-NTA/アガロースカラム(Qiagen)にかけた。溶解物をカラムに負荷した後、5カラム容量(CV)の30mMのイミダゾールを伴った50mMのリン酸ナトリウム、pH7.4、300mMのNaCl及び0.1mMのPLPで樹脂を洗浄した。次に、100CVの0.1mMのPLPと1%v/vのTRITON(登録商標)X114を伴った内毒素を含まないPBS(Corning)緩衝液でカラムを一晩ゆっくり洗浄するように流速を設定した。この一晩の洗浄によって、細菌発現系の典型的な混入物であるリポ多糖類(LPSまたは内毒素)を取り除く。次いで、5CVの0.1mMのPLPと250mMのイミダゾールを伴った内毒素を含まないPBSで、洗浄された酵素を溶出し、樹脂を2回目の5CV部分の0.1mMのPLPを伴った内毒素を含まないPBSですすいだ。この時点で酵素の緩衝液を新しいPBSに変えてイミダゾールを取り除き、10%グリセロールを加え、アリコートを-80℃での保存のために液体窒素で瞬間凍結した。或いは、酵素の緩衝液を直ちに、新しく作製した無菌の100mMのリン酸ナトリウム、pH8.4に交換して、イミダゾールの除去とペグ化の準備の双方を行った(実施例4を参照)。酵素の純度は通常、SDS-PAGE解析に基づいて>95%であり、典型的な収量は、培養物の75mg/L前後で平均された。Abs280nmを測定し、63,745M-1cm-1の算出された酵素の吸光係数を用いてタンパク質の量を評価した。
DNA-Worksソフトウエア(Hoover及びLubkowski,2002)を用いて設計した4つのコドンを最適化した遺伝子ブロックのオーバーラップ伸長ポリメラーゼ連鎖反応(PCR)によって、ヒト由来のキヌレニナーゼ酵素(h-KYNU)の発現のための遺伝子を得た。完全長の遺伝子には、N末端XbaI制限酵素部位(ヌクレオチド1~6)、最適化されたRBS(ヌクレオチド28~60)、開始コドン(ヌクレオチド61~63)、N末端His6タグ(ヌクレオチド64~96)、大腸菌コドンに最適化されたh-KYNU遺伝子(ヌクレオチド97~1488)、停止コドン(ヌクレオチド1489~1491)及びC末端BamHI制限酵素部位(ヌクレオチド1492~1497)が含まれる(配列番号2を参照のこと)。前述の制限酵素部位を用いて集合させた遺伝子をpET-28a+ベクター(Novagen)にクローニングした。次いでこの構築物を使用して発現のために大腸菌BL21(DE3)を形質転換した。50mg/Lのカナマイシンを伴ったテリフィックブロス(TB)培地にて210rpmで振盪しながら37℃で細胞を増殖させた。OD600が約1.0に達したとき、37℃で連続して一晩振盪しながらIPTG(0.5mMの最終濃度)を添加することによって発現を誘導した。次いで遠心分離によって細胞を回収し、50mMのリン酸ナトリウム、pH7.4、300mMのNaCl、0.5mMのリン酸ピリドキシル(PLP)、1mMのフッ化フェニルメチルスルホニル及び1μg/mLのDNA分解酵素から成る溶解緩衝液に再浮遊させた。溶解はフレンチプレスによって達成し、溶解物は20,000×gで4℃にて1時間遠心分離することによって粒子状物質を除いた。次いで5μmの注射器フィルターを介して上清を濾過し、50mMのリン酸ナトリウム、300mMのNaCl及び0.1mMのPLP、pH7.4で構成された緩衝液で事前に平衡化したNi-NTA/アガロースカラム(Qiagen)にかけた。溶解物をカラムに負荷した後、5カラム容量(CV)の30mMのイミダゾールを伴った50mMのリン酸ナトリウム、pH7.4、300mMのNaCl及び0.1mMのPLPで樹脂を洗浄した。次に、100CVの0.1mMのPLPと1%v/vのTRITON(登録商標)X114を伴った内毒素を含まないPBS(Corning)緩衝液でカラムを一晩ゆっくり洗浄するように流速を設定した。この一晩の洗浄によって、酵素の細菌発現系の典型的な混入物であるリポ多糖類(LPSまたは内毒素)を取り除く。次いで、5CVの0.1mMのPLPと250mMのイミダゾールを伴った内毒素を含まないPBSで、洗浄された酵素を溶出し、樹脂を2回目の5CV部分の0.1mMのPLPを伴った内毒素を含まないPBSですすいだ。この時点で酵素の緩衝液を新しいPBSに変えてイミダゾールを取り除き、10%グリセロールを加え、アリコートを-80℃での保存のために液体窒素で瞬間凍結した。或いは、酵素の緩衝液を直ちに、新しく作製した無菌の100mMのリン酸ナトリウム、pH8.4に交換して、イミダゾールの除去とペグ化の準備の双方を行った(実施例4を参照)。酵素の純度は通常、SDS-PAGE解析に基づいて>95%であり、典型的な収量は、培養物の20mg/L前後で平均された。Abs280nmを測定し、76,040M-1cm-1の算出された酵素の吸光係数を用いてタンパク質の量を評価した。
DNA-Worksソフトウエア(Hooverら,2002)を用いて設計した3つのコドンを最適化した遺伝子ブロックのオーバーラップ伸長ポリメラーゼ連鎖反応(PCR)によって、ハツカネズミ由来のキヌレニナーゼ酵素(m-KYNU)の発現のための遺伝子を得た。完全長の遺伝子には、N末端XbaI制限酵素部位(ヌクレオチド1~6)、最適化されたRBS(ヌクレオチド29~58)、開始コドン(ヌクレオチド59~61)、N末端His6タグ(ヌクレオチド62~94)、大腸菌コドンに最適化されたm-KYNU遺伝子(ヌクレオチド95~1483)、停止コドン(ヌクレオチド1484~1486)及びC末端BamHI制限酵素部位(ヌクレオチド1487~1492)が含まれる(配列番号3を参照のこと)。前述の制限酵素部位を用いて集合させた遺伝子をpET-28a+ベクター(Novagen)にクローニングした。この構築物を次いで使用して発現のために大腸菌BL21(DE3)を形質転換した。50mg/Lのカナマイシンを伴ったテリフィックブロス(TB)培地にて210rpmで振盪しながら37℃で細胞を増殖させた。OD600が約1.0に達したとき、37℃で連続して一晩振盪しながら0.5mMのIPTGを添加することによって発現を誘導した。次いで遠心分離によって細胞を回収し、50mMのリン酸ナトリウム、pH7.4、300mMのNaCl、0.5mMのリン酸ピリドキシル(PLP)、1mMのフッ化フェニルメチルスルホニル及び1μg/mLのDNA分解酵素から成る溶解緩衝液に再浮遊させた。溶解はフレンチプレスによって達成し、溶解物は20,000×gで4℃にて1時間遠心分離することによって粒子状物質を除いた。5μmの注射器フィルターを介して上清を濾過し、50mMのリン酸ナトリウム、300mMのNaCl及び0.1mMのPLP、pH7.4で構成された緩衝液で事前に平衡化したNi-NTA/アガロースカラム(Qiagen)にかけた。溶解物をカラムに負荷した後、5カラム容量(CV)の30mMのイミダゾールを伴った50mMのリン酸ナトリウム、pH7.4、300mMのNaCl及び0.1mMのPLPで樹脂を洗浄した。次に、100CVの0.1mMのPLPと1%v/vのTRITON(登録商標)X114を伴った内毒素を含まないPBS(Corning)緩衝液で一晩ゆっくり洗浄するように流速を設定した。この一晩の洗浄によって、酵素の細菌発現系の典型的な混入物であるリポ多糖類(LPSまたは内毒素)を取り除く。5CVの0.1mMのPLPと250mMのイミダゾールを伴った内毒素を含まないPBSで、洗浄された酵素を溶出し、樹脂を2回目の5CV部分の0.1mMのPLPを伴った内毒素を含まないPBSですすいだ。この時点で酵素の緩衝液を新しいPBSに変えてイミダゾールを取り除き、10%グリセロールを加え、アリコートを-80℃での保存のために液体窒素で瞬間凍結した。
インビボでの酵素の循環時間を改善するために、PEGへのコンジュゲーションによりタンパク質における表面反応基を官能化することによってKYNU酵素の流体力学半径を大きくした。一実施形態では、Pf-KYNUは表面のリジン残基のメトキシルPEG炭酸スクシンイミジル5000MW(NANOCS)との反応によって官能化された。精製し、内毒素を含まない酵素の緩衝液を、新しく調製した100mMのリン酸ナトリウム、pH8.4に十分に交換して10mg/mLに濃縮した。得られた溶液を直接、100:1のモル過剰の固形PEG試薬に加え、室温で1時間反応させた(図1)。100kDaカットオフの遠心濾過装置(AMICON(登録商標))にて新しい内毒素を含まないPBSに十分に緩衝液交換することによって未反応のPEGを溶液から取り除いた。次いでPBSにおけるサイズ排除HPLCカラム(Phenomenex)にて酵素の見かけの分子質量を確認した。BioRadのMW標準溶液を用いて検量線を生成し、酵素の保持時間をタンパク質標準のそれと比較した。検量線に基づいて、ペグ化されなかった酵素は40kDaの見かけの質量を有し、それはPf-KYNUの単量体1つの質量に近い。酵素のペグ化された型は1,300kDa、すなわち、未修飾の酵素より実質的に大きい見かけの質量を有すると見なされた。Chromo-LAL動的発色内毒素試験キット(Associates of Cape Cod,Inc.)を用いて内毒素のレベルを定量した。上述のような方法で洗浄した酵素は精製したPf-KYNUの0.19±0.07EU/mgのレベルで内毒素を通常生じた。
インビボでのヒト酵素の循環滞留時間を改善するために、PEGへのコンジュゲーションによりタンパク質における表面反応基を官能化することによってh-KYNUの流体力学半径を大きくした。一実施形態では、h-KYNUは表面のリジン残基のメトキシルPEG炭酸スクシンイミジル5000MW(NANOCS)との反応によって官能化された。精製し、内毒素を含まない酵素の緩衝液を、新しく調製した100mMのリン酸ナトリウム、pH8.4に十分に交換して10mg/mLに濃縮した。得られた溶液を直接、100:1のモル過剰の固形PEG試薬に加え、室温で1時間反応させた。100kDaカットオフの遠心濾過装置(AMICON(登録商標))にて新しい内毒素を含まないPBSに十分に緩衝液交換することによって未反応のPEGを溶液から取り除いた。PBSで平衡化したサイズ排除HPLCカラム(Phenomenex)を用いて酵素の見かけの分子質量を測定し、保持時間をMW標準溶液(BioRad)と比較した。Chromo-LAL動的発色内毒素試験キット(Associates of Cape Cod,Inc.)を用いて内毒素のレベルを定量した。
実施例4及び5に記載したようなPf-KYNU及びh-KYNUと同様にそれらのペグ化した型の動態パラメータを、酵素基質、L-キヌレニンの最大吸光度における減衰を時間の関数としてモニターする分光光度アッセイによって定量した。L-キヌレニン溶液をPBS緩衝液、pH7.4にて調製し、8μM~250μMに及ぶ最終濃度を生じた。L-キヌレニンは365nmでλmaxを持ち、4,500M-1cm-1の吸光係数を有する一方で、キヌレニナーゼ反応の生成物であるL-アントラニル酸及びL-アラニンは365nmで感知できるほど吸収しない。酵素溶液(最終、約20nM)を加え、基質溶液と素早く混合し、経時的にAbs365nmを測定することにより25℃での基質KYNの喪失をモニターすることによって反応を開始した。得られたデータを処理し、動態定数を決定するためにミカエリス-メンテンの方程式に適合させた。ペグ化されたPf-KYNU酵素の動態を同一の方法で測定した。ペグ化されていない酵素については、kcat/KM=1.0×105M-1s-1であり、ペグ化された形態については、kcat/KM=1.3×105M-1s-1であった。3-ヒドロキシ-L-キヌレン酸の加水分解についての動態パラメータもここで記載されたように測定した。
Pf-KYNUのインビトロでの安定性を測定するために、10μMの最終濃度でPBS緩衝液またはプールしたヒト血清に酵素を加え、37℃でインキュベートした。各時点でそれぞれの10μL部分を取り出し、L-キヌレニン/PBSの250μM溶液990μLに加えた。実施例3で記載されたように経時的に365nmでの吸光度の減衰を測定することによって反応初速度をモニターした。各時点でのL-キヌレニン触媒反応初速度を比較し、時間=0での速度と比較することによって酵素の安定性を決定した。得られたデータを時間に対する%活性としてプロットし、指数方程式に適合させて半減期(T1/2)を決定した。Pf-KYNUはPBSにてT1/2=34.3時間、及びプールしたヒト血清にてT1/2=2.4時間を有することが見いだされた(図2)。
L-キヌレニン、トリプトファン、キヌレン酸、3-ヒドロキシ-L-キヌレニン及びL-アントラニル酸(キヌレニナーゼの触媒作用の生成物の1つ)のインビボレベルをHPLCによって定量し、モニターした。マウスの解剖の際、血液、腫瘍、脾臓及び肝臓の試料を取り出した。血液試料を遠心分離し、血清と全血を分離した。組織試料を先ずホモジネートし、次いで遠心分離して固形部分を取り除いた。100%トリクロロ酢酸の1:10v/v部分を各液体部分に加え、高分子を沈殿させた。遠心分離によって固形分を再び取り除き、0.45μmの注射器フィルターに上清を通した。処理した上清をHPLC(Shimadzu)に直接かけ、溶液AがH2O+0.1%トリフルオロ酢酸であり、溶液Bがアセトニトリル+0.1%トリフルオロ酢酸である、0%溶液Bから出発して100%溶液Bまでの勾配を用いて標準の分析用C-18カラムにて分離した。190nmから900nmまでの完全な吸光度範囲を絶えず収集して考えられる分子すべてをモニターし、蛍光分光光度(Ex=365nm、Em=480nm)を同時に収集してキヌレニンのレベルを特にモニターした。純粋な分子(Sigma)から作製した標準溶液を用いて濃度及び保持時間を決定した。
脇腹皮下の注射によってB6-WTマウス(n=20)に2.5×105個のB16マウス黒色腫細胞を接種した。10日間腫瘍を根付かせた(腫瘍平均=20mm2)後、マウスを各n=10の2群に分けた。次いで、対照群は、腫瘍が350mm2のサイズに達するまで、3日ごとに腫瘍内注射によって、熱不活性化PEG-Pf-KYNUの20mg/kgで処理した。実験群は、腫瘍が350mm2のサイズに達するまで、3日ごとに腫瘍内注射によって活性のあるPEG-Pf-KYNUの20mg/kgで処理したことを除いて、同様に処理した。B16黒色腫腫瘍の増殖速度は、熱不活性化PEG-Pf-KYNUで同様に処理した群(図3)に比べて、活性のあるPEG-Pf-KYNUを投与した処理群では有意に遅延したということは有意な寿命の延長を生じた(図4)。対照群及び実験処理群から単離されたリンパ球を抗体のパネル(すなわち、抗CD45、CD4、Nk1.1、CD25、FoxP3、CD8、グランザイムB、IFNγ、CTLA4、CD11c、CD11b、F4/80、GR-1、及びLy6-C)で評価したが、それは、循環CD4+CD25+FoxP3+調節性T細胞の集団が活性のあるPEG-Pf-KYNUで処理した群にて有意に低下することを示した(4.8±0.8%対8.6±0.8%)。加えて、グランザイムB及びインターフェロンγを発現している腫瘍浸潤CD8+T細胞の集団が活性のある酵素で処理されたマウスにて有意に高かった(26±19%対4±2%)(図5A~B)。
一部の態様では、本発明はまた、異種のアミノ酸配列に連結された、細菌または哺乳類の修飾されたキヌレニナーゼを含むポリペプチドを企図する。たとえば、特異的に細胞表面腫瘍抗原を結合する単鎖可変断片(scFv)抗体にネイティブなまたは修飾されたキヌレニナーゼを連結してもよい。この実施形態では、既知の腫瘍抗原、好ましくは遅い速度で内部移行する腫瘍特異抗原、たとえば、MUC-1に対して特異的な親和性を有するタンパク質のscFv部分を伴うscFv/キヌレニナーゼ融合タンパク質は、融合タンパク質のキヌレニナーゼ部分が腫瘍細胞に送達され、KYNを分解するのを可能にすることになる。一例は、scFv部分が特定の種類の乳癌で上方調節されるヒト上皮増殖因子受容体2(HER2)を標的とし、それに結合するscFv/キヌレニナーゼ融合タンパク質である。
一部の態様では、本発明はまた、異種のアミノ酸配列に連結された、細菌または哺乳類の修飾されたキヌレニナーゼを含むポリペプチドを企図する。たとえば、細胞傷害性Tリンパ球抗原4(CTLA-4)受容体、プログラム細胞死1(PD-1)またはプログラム細胞死リガンド1(PD-L1)を結合する単鎖可変断片(scFv)抗体にネイティブなまたは修飾されたキヌレニナーゼを連結してもよい。アンタゴニスト抗体または抗体断片によるCTLA-4、PD-1、またはPD-L1の遮断は、抑制性T細胞シグナルが反転されるのを可能にし、CD28がT細胞の活性化を刺激するのを可能にする。この実施形態では、ネイティブなまたは修飾されたキヌレニナーゼ/抗CTLA-4、抗PD-1、または抗PD-L1/scFv融合タンパク質は、抑制性のタンパク質:タンパク質相互作用のシグナル伝達及び抑制性のキヌレニンのシグナル伝達の双方を除くように作用する。ネイティブなまたは修飾されたキヌレニナーゼ/scFv融合タンパク質のこの実施形態は、T細胞の活性化を強力に上方調節し、強固な抗腫瘍応答を促進することが期待される。
一部の態様では、本発明はまた、細菌または哺乳類の修飾されたキヌレニナーゼがキメラ抗原受容体(CAR)構築物に加えて同時発現するように、CAR構築物をT細胞に形質移入するのに好適なレンチウイルスベクターも企図する。CAR構築物は、CD3-ζ鎖及び多くはCD28分子に由来する膜貫通及び細胞質のシグナル伝達ドメインに融合された細胞外の抗原結合ドメインを含有するタンパク質である(Ahmedら、2010)。抗原結合ドメインは、膠芽細胞腫または骨肉腫によって発現されるHER2、種々のB細胞悪性腫瘍によって発現されるCD19またはCD20、または神経芽細胞腫によって発現されるGD2(Lipowska-Bhallaら,2012)である例を伴った腫瘍細胞により発現される抗原を、または任意の他の関連する標的を結合するように設計されたscFvであってもよい。この実施形態では、T細胞に適当なCAR構築物を送達するレンチウイルスベクターは、細胞質にてネイティブなまたは修飾された、細菌または哺乳類のキヌレニナーゼをさらに同時発現する。このCAR/キヌレニナーゼ構築物を含有するT細胞は1)特異的な腫瘍細胞に結合する、且つ2)KYNを分解する二重能力を有して、調節性の表現型及び/またはアポトーシスのKYNによる誘導を妨げる。別の実施形態では、T細胞は、CD19+またはCD20+のびまん性大B細胞リンパ腫に結合する一方で、この種の腫瘍によって産生されることが多い高濃度のKYNを分解するキヌレニナーゼを同時発現するCAR構築物を発現する(Yoshikawaら,2010;de Jongら,2011;Yaoら,2011)。
アミノ酸L-トリプトファン(L-Trp)はtrp生合成遺伝子の発現によってペントース由来の前駆体、コリスミ酸から合成される。大腸菌のような細菌では、trp生合成遺伝子は5つの遺伝子trpE、trpD、trpC、trpB、及びtrpAで構成されるオペロンにて構造化される。TrpE及びTrpDのタンパク質はコリスミ酸とL-グルタミンのアントラニル酸とL-グルタミン酸への変換での第1工程を触媒するアントラニル酸シンターゼ複合体の成分である。次いでその後、TrpC、TrpA及びTrpBの作用によってアントラニル酸はL-Trpに変換される。機能的なアントラニル酸シンターゼ遺伝子を欠く細胞はL-Trpに対して栄養要求性であり、トリプトファンを含まない最少培地では増殖できない。本発明者らは、キヌレニンは多くの生物の細胞質ゾルに輸送され得るので、十分に高い触媒活性を示す組換えL-キヌレニナーゼ酵素を発現している細胞は細胞質ゾルのL-キヌレニンをアントラニル酸に変換することができるはずであり、後者はその後、L-Trpの合成を可能にすると仮定した。対照的に、酵素を発現しないまたは低い触媒活性を持つ改変体を発現する細胞は、L-キヌレニンを伴った最少培地では増殖を示さないまたは非常に遅い増殖を示すはずである。
他の真核生物のキヌレニナーゼと同様に、ヒトの酵素は3'-OHキヌレニンの加水分解に対して高度に選択性であり、キヌレニンに対しては約1,000分の1の触媒活性を有する。キヌレニンに対するその乏しい触媒活性のために、ヒト酵素は治療目的に好適ではない。ペグ化したPf-KYNU(実施例9)、Mu-KYNU(実施例22及び実施例23)またはCp-KYNU(実施例17)(そのすべてが3'-OHキヌレニンの代わりにキヌレニンに対して高い触媒活性を示す)の投与は実施例9(図3)で示すように腫瘍増殖の遅延を生じた。しかしながら、ペグ化したヒトキヌレニナーゼの投与は類似のまたは高い投与でB16黒色腫腫瘍の増殖に効果を有さなかった(n=4)。しかしながら、実施例20で示したように、h-KYNUの操作はヒト酵素のL-キヌレニン分解活性を改善することができる。そのような操作されたh-KYNU改変体はペグ化したPf-KYNU(実施例9)、Mu-KYNU(実施例22及び実施例23)またはCp-KYNU(実施例17)で見られたように腫瘍増殖の遅延を生じ得る。
Mu-KYNUの動態パラメータを、酵素基質、L-キヌレニンの最大吸光度における減衰を時間の関数としてモニターする分光光度アッセイによって定量した。L-キヌレニン溶液をPBS緩衝液、pH7.4にて調製し、16μM~500μMに及ぶ最終濃度を生じた。L-キヌレニンは365nmでλmaxを持ち、4,500M-1cm-1の吸光係数を有する一方で、キヌレニナーゼ反応の生成物であるL-アントラニル酸及びL-アラニンは365nmで感知できるほど吸収しない。酵素溶液(約20nMの最終濃度)を加え、基質溶液と素早く混合し、経時的にAbs365nmを測定することにより25℃での基質の喪失をモニターすることによって反応を開始した。得られたデータを処理し、動態定数を決定するためにミカエリス-メンテンの方程式に適合させた。Mu-KYNUはkcat/KM=1.2×105M-1s-1を有することが測定された。
Mu-KYNUのインビトロでの安定性を測定するために、10μMの最終濃度でPBS緩衝液またはプールしたヒト血清に酵素を加え、37℃でインキュベートした。各時点でそれぞれの10μL部分を取り出し、L-キヌレニン/PBSの250μM溶液990μLに加えた。実施例3で記載されたように経時的に365nmでの吸光度の減衰を測定することによって反応初速度をモニターした。各時点でのL-キヌレニン触媒反応初速度を比較し、時間=0での速度と比較することによって酵素の安定性を決定した。得られたデータを時間に対する%活性としてプロットし、二相減衰モデル(Stoneら,2010)に適合させて半減期(T1/2)を決定した。PBSにおけるMu-KYNU酵素の活性は74%の残りの活性の多さを伴って1T1/2=6時間、及びその後の2T1/2=150時間を有することが見いだされた(図7)。プールしたヒト血清におけるMu-KYNU酵素の安定性は、30%の残りの活性の多さを伴って1T1/2=5時間、及びその後の2T1/2=73時間を有することが測定された(図7)。
クラミドフィラ・ペコルム由来のキヌレニナーゼ酵素(Cp-KYNU)の発現のための遺伝子を、大腸菌のコドンを最適化した遺伝子ブロックを用いて合成した。完全長の遺伝子には、N末端NcoI制限酵素部位(ヌクレオチド1~6)、開始コドン(ヌクレオチド3~5)、N末端His6タグ(ヌクレオチド6~35)、大腸菌コドンに最適化されたCp-KYNU遺伝子(ヌクレオチド36~1295)、停止コドン(ヌクレオチド1296~1298)及びC末端EcoRI制限酵素部位(ヌクレオチド1299~1304)が含まれる(配列番号53)。前述の制限酵素部位を用いて集合させた遺伝子をpET-28a+ベクター(Novagen)にクローニングした。次いでこの構築物を使用して発現のために大腸菌BL21(DE3)を形質転換した。50mg/Lのカナマイシンを伴ったテリフィックブロス(TB)培地にて210rpmで振盪しながら37℃で細胞を増殖させた。OD600が約1.0に達したとき、16℃で連続して一晩振盪しながらIPTG(0.5mMの最終濃度)を添加することによって発現を誘導した。次いで遠心分離によって細胞を回収し、50mMのリン酸ナトリウム、pH7.4、300mMのNaCl、0.5mMのリン酸ピリドキシル(PLP)、1mMのフッ化フェニルメチルスルホニル及び1μg/mLのDNA分解酵素から成る溶解緩衝液に再浮遊させた。溶解はフレンチプレスによって達成し、溶解物は20,000×gで4℃にて1時間遠心分離することによって粒子状物質を除いた。次いで5μmの注射器フィルターを介して上清を濾過し、50mMのリン酸ナトリウム、pH7.4、300mMのNaCl及び0.1mMのPLP緩衝液で事前に平衡化したNi-NTA/アガロースカラム(Qiagen)にかけた。溶解物をカラムに負荷した後、10カラム容量(CV)の30mMのイミダゾールを伴った50mMのリン酸ナトリウム、pH7.4、300mMのNaCl及び0.1mMのPLPで樹脂を洗浄した。次いで、5CVの0.1mMのPLPと250mMのイミダゾールを含有するPBSで、洗浄された酵素を溶出した。溶出した酵素の緩衝液を新しいPBSに交換してイミダゾールを取り除き、10%グリセロールを加え、アリコートを-80℃での保存のために液体窒素で瞬間凍結した。
Cp-KYNU(配列番号57)の動態パラメータを、酵素基質、L-キヌレニンの最大吸光度における減衰を時間の関数としてモニターする分光光度アッセイによって定量した。L-キヌレニン溶液をPBS緩衝液、pH7.4にて調製し、16μM~500μMに及ぶ最終濃度を生じた。L-キヌレニンは365nmでλmaxを持ち、4,500M-1cm-1の吸光係数を有する一方で、キヌレニナーゼ反応の生成物であるアントラニル酸及びL-アラニンは365nmで感知できるほど吸収しない。酵素溶液(200nMの最終濃度)を加え、基質溶液と素早く混合し、経時的にAbs365nmを測定することにより25℃での基質の喪失をモニターすることによって反応を開始した。得られたデータを処理し、動態定数を決定するためにミカエリス-メンテンの方程式に適合させた。Cp-KYNUはkcat/KM=3×104M-1s-1を有することが測定された。
インビボでの酵素の循環時間を改善するために、PEGへのコンジュゲーションによりタンパク質における表面反応基を官能化することによってMu-KYNUの流体力学半径を大きくした。一実施形態では、Mu-KYNUは表面のリジン残基のメトキシルPEG炭酸スクシンイミジル5000MW(NANOCS)との反応によってペグ化された。精製されたMu-KYNUは以下で記載されるように非常に低い内毒素レベル(<20EU/mg)を含有することが測定された。その緩衝液を、新しく調製した100mMのリン酸ナトリウム、pH8.4に十分に交換して1mg/mLを超えるまで濃縮した。得られた溶液を直接、100:1のモル過剰の固形PEG試薬に加え、撹拌しながら室温で1時間反応させた。100kDaカットオフの遠心濾過装置(Amicon)にて新しい内毒素を含まないPBSに十分に緩衝液交換することによって溶液から未反応のPEGを取り除いた。次いで、検量線を生成するためのBioRadのMW標準溶液を用いて、PBSにおけるサイズ排除HPLCカラム(Phenomenex)にて酵素の見かけの分子質量を確認し、酵素の保持時間をタンパク質標準のそれと比較した。Chromo-LAL動的発色内毒素試験キット(Associates of Cape Cod,Inc.)を用いて内毒素のレベルを定量した。
h-KYNU酵素は3'-OHキヌレニンの加水分解に対して高度に選択性であり、L-キヌレニンに対しては約1,000分の1の触媒活性を有する。L-キヌレニンに対する乏しい触媒活性の故に、野生型のヒト酵素は治療目的に好適ではない。h-KYNUにて改善されたL-キヌレニン分解活性を操作するために、h-KYNU遺伝子とアミノ酸F306に相当するコドンの変異を導入するように設計された1対のオリゴヌクレオチドとを用いてオーバーラップ伸長ポリメラーゼ連鎖反応(PCR)によって飽和変異誘発ライブラリを構築した。F306はh-KYNUの活性部位の中に位置し、基質の結合で役割を担うと思われる。実施例6のマイクロタイタープレートキヌレニナーゼアッセイを用いて活性についてF306飽和ライブラリをスクリーニングした。数十のクローンが野生型h-KYNUよりも有意に高い活性を示し、さらなる分析にためにそれらを選択した。これらのクローンの配列決定は、F306位における2種類のアミノ酸置換、すなわち、h-KYNU-F306M(配列番号55)及びh-KYNU-F306L(配列番号56)がL-キヌレニン分解活性の上昇を生じることを明らかにした。次いでこれらの改変体を均質に精製し、詳細な動態解析は、野生型のh-KYNUに比べて、h-KYNU-F306M及びh-KYNU-F306Lについて、L-キヌレニンに対するkcat/KMでそれぞれ2倍及び5倍の上昇を明らかにした。
抗PD1(クローンRMP1-14、BioXCell #BE0146)または抗CTLA-4(クローンUC10-4F10-11、BioXCell #BE0032)免疫チェックポイント阻害剤抗体との対照比較にて、ペグ化したシュードモナス・フルオレッセンスのキヌレニナーゼ(PEG-Pf-KYNU)をB16マウス黒色腫モデルで評価した。50,000個のB16細胞をC57BL/6Jマウスの脇腹に移植した(0日目、各群n=8匹)。触診可能な腫瘍が発達する(10日目)とすぐに、示した時間(図8)に250μgの抗PD1、100μgの抗CTLA-4(Holmgaardら(2013)のように200μgの1回目の投与)、または500μgのPEG-Pf-KYNUのいずれかで動物を処理した。熱不活性化PEG-Pf-KYNUを対照として使用した。PEG-Pf-KYNUの投与は、不活性化酵素またはPBSのみに対するPEG-Pf-KYNUについて抗PD1または抗CTLA-4チェックポイント阻害剤抗体で見られるものとは区別できない形で有意な腫瘍増殖の遅延を示し、且つ生存を延長した(図8)。
抗PD1免疫チェックポイント阻害剤抗体(Curranら,2010)との併用でB16黒色腫同種移植にてペグ化した酵素(PEG-Mu-KYNU及びPEG-Pf-KYNU)を評価した。4群のC57BL/6Jマウス(群当たり10匹)に50,000個のB16細胞を移植し(0日目)、腫瘍を発達させた。触診可能な腫瘍が発達する(10日目)とすぐに、腫瘍部位の近傍の皮下での500μgのPEG-Mu-KYNUまたは500μgのPEG-Pf-KYNUと共にまたはそれを伴わずに、10、13及び16日目にIP注射により250μgの抗PD1(クローンRMP1-14、BioXCell #BE0146)で動物を処理した。マウスは10日目~25日目の間に合計6回のKYNUの投与を受けた。1つの群はPD-1についての対照としてPBSのi.p.注射を行った。PBS対照に比べてすべての治療群で腫瘍増殖は劇的に損なわれ、さらに反転した(図9A)。重要なことに、KYNUと併用した抗PD1で相加効果が認められ、PEG-Pf-KYNU/抗PD1処理によって腫瘍の60%及びPEG-Mu-KYNU/抗PD1処理によって腫瘍の20%の完全寛解を生じた(図9B)。相当するカプラン-マイヤープロットを図9Cにて提供する。
ムチラギニバクター・パルジスのペグ化したキヌレニナーゼ(PEG-Mu-KYNU)をB16マウス黒色腫モデルにて評価した。C57BL/6Jマウスの脇腹に50,000個のB16細胞を移植すること(0日目、群当たりn=9匹)によって同種移植を開始した。触診可能な腫瘍が発達する(10日目)とすぐに、3日ごとに合計6回、腫瘍の近傍への皮下注射によって500μgのPEG-Mu-KYNUで動物を処理した。熱不活性化PEG-Mu-KYNUによる同一の処理計画を対照として用いた。PEG-Mu-KYNUの投与は、熱不活性化PEG-Mu-KYNU対照についての22日に比べて25日の延長した中央値生存時間(図10B)と共に腫瘍増殖の遅延(図10A)を生じた。
SEQUENCE LISTING
<110> Board of Regents, The University of Texas System
<120> Administration of kynurenine depleting enzymes for tumor therapy
<150> US 61/872,132
<151> 2013-08-30
<150> US 61/986,366
<151> 2014-04-30
<160> 57
<170> PatentIn version 3.5
<210> 1
<211> 1347
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic polynucleotide
<400> 1
tctagaaata attttgttta actttaagga aaacattaaa ataaggaggt agcaaatggg 60
cggtcatcat caccaccatc atgggagcgg caccacccgc aacgattgcc tggcgctgga 120
tgcgcaggat agcctggcac cgctgcgtca gcagtttgcg ctgccggaag gtgttattta 180
tctggatggc aacagcctgg gtgcgcgtcc ggttgcggcg ctggcgcgtg cgcaggcggt 240
gattgcggaa gaatggggca acggcctgat tcgcagctgg aacagcgcgg gctggcgcga 300
tctgagcgaa cgcctgggca accgcctggc gaccctgatt ggcgcgcgcg atggcgaagt 360
ggtggtgacc gataccacca gcattaacct gtttaaagtg ctgagcgcgg cgctgcgcgt 420
gcaggcgacc cgcagcccgg aacgccgcgt gattgtgacc gaaaccagca actttccgac 480
cgatctgtat attgcggaag gcctggcgga tatgctgcag cagggctata ccctgcgcct 540
ggtggatagc ccggaagaac tgccgcaggc gattgatcag gataccgcgg tggtgatgct 600
gacccatgtg aactataaaa ccggctatat gcatgatatg caggcgctga ccgcgctgag 660
ccatgaatgc ggcgcgctgg cgatttggga tctggcgcat agcgcgggcg cggtgccggt 720
ggatctgcat caggcgggcg cggattatgc gattggctgc acctataaat atctgaacgg 780
cggcccgggc agccaggcgt ttgtgtgggt gagcccgcag ctgtgcgatc tggtgccgca 840
gccgctgtct ggttggtttg gccatagccg ccagtttgcg atggaaccgc gctatgaacc 900
gagcaacggc attgcgcgct atctgtgcgg cacccagccg attaccagcc tggcgatggt 960
ggaatgcggc ctggatgtgt ttgcgcagac cgatatggcg agcctgcgcc gcaaaagcct 1020
ggcgctgacc gatctgttta ttgaactggt ggaacagcgc tgcgcggcgc atgaactgac 1080
cctggtgacc ccgcgcgaac atgcgaaacg cggcagccat gtgagctttg aacatccgga 1140
aggctatgcg gtgattcagg cgctgattga tcgcggcgtg attggcgatt atcgcgaacc 1200
gcgcattatg cgctttggct ttaccccgct gtataccacc tttaccgaag tgtgggatgc 1260
ggtgcagatt ctgggcgaaa ttctggatcg caaaacctgg gcgcaggcgc agtttcaggt 1320
gcgccatagc gtgacctagt aggatcc 1347
<210> 2
<211> 1497
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic polynucleotide
<400> 2
tctagaaata attttgttta actttaagga caaatcagga cacagttaag gaggtaaaat 60
atgggcggtc atcatcacca ccatcatggg agcggcgaac cgagctccct tgaacttccg 120
gccgataccg tgcaacggat agcggcggaa ttgaaatgtc acccgaccga cgaacgcgtc 180
gcgttacatc tggatgagga agacaagctg cgtcacttcc gcgagtgctt ttacattccg 240
aaaattcagg atctgccgcc agtggacttg agcctggtca acaaagacga gaacgccatc 300
tacttcctgg gcaatagcct gggcctgcaa ccaaagatgg tgaaaaccta tcttgaggag 360
gagcttgaca aatgggcgaa gatcgcggcc tacggccatg aagtcggcaa gcgtccctgg 420
attaccggcg atgagtcaat cgttggcttg atgaaggata tcgtcggcgc gaacgagaaa 480
gaaattgcgc tgatgaacgc gctgaccgtg aatctgcatc tgctgatgct gtcattcttt 540
aagcccaccc cgaagcgcta caaaatcctg ctggaagcga aagcgtttcc cagcgatcat 600
tatgcgatag aaagccagct gcaactgcac ggcctgaata tcgaggagag catgcgtatg 660
ataaaaccgc gcgaaggtga ggagaccctg cggattgagg acatcctgga ggtgatcgag 720
aaggagggcg acagtatcgc ggtgatactt ttcagcggcg tgcatttcta cacgggccaa 780
cacttcaata tcccggccat taccaaagcc ggccaggcga aagggtgcta tgtaggcttt 840
gatctggcgc atgcagtggg caacgtcgaa ctgtatcttc atgattgggg cgttgatttt 900
gcgtgctggt gcagctataa gtatctgaat gccggggccg gtgggattgc gggagccttt 960
attcatgaga aacacgcgca taccattaaa ccggcgctgg ttggctggtt tgggcacgaa 1020
ctgagcaccc gcttcaagat ggataacaaa ctgcaattga ttccgggcgt gtgcggcttt 1080
cgtattagca accccccgat tctgctggtc tgcagcctgc acgcgtctct ggagattttc 1140
aagcaggcga ccatgaaagc gctgcgtaag aaaagtgtgc ttctgacggg ctacctggag 1200
tacctgataa agcacaacta cggcaaggat aaggcggcca cgaagaagcc ggttgtgaac 1260
attatcaccc cgtctcatgt ggaagaacgt ggctgccaac tgacgataac gttcagcgtg 1320
ccaaacaagg acgtgttcca agagctggag aagcgtggcg tggtgtgtga taaacgtaat 1380
ccgaatggca ttcgtgtggc gcctgtgccg ctgtacaaca gcttccacga cgtgtataag 1440
ttcaccaacc tgctgacgag cattctggac agtgcggaaa ccaaaaacta gggatcc 1497
<210> 3
<211> 1492
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic polynucleotide
<400> 3
tctagaaata attttgttta actttaagaa cacggtcggg aatataagga ggtaaaatat 60
gggcggtcat catcaccacc atcatgggag cggcgagccg agcccgctgg aactgccggt 120
tgacgcggta cgtcgtattg cggcagaact gaactgtgac ccgaccgatg aacgtgtggc 180
gctgcgtctc gacgaagagg acaagctctc tcacttccgt aactgcttct atatccctaa 240
aatgcgtgac ctgccgagca tcgatctgtc tctggtttct gaagacgacg acgcgattta 300
cttcctgggt aactctctgg gtctgcagcc aaaaatggtt cgtacctacc tggaggaaga 360
gctggacaaa tgggcgaaaa tgggtgccta cggccatgat gtgggcaaac gcccgtggat 420
cgtcggcgac gaaagcattg tgtctctcat gaaggacatt gttggtgcac acgagaaaga 480
aattgcgctg atgaatgctc tgaccatcaa cctgcacctg ctgctcctgt ctttcttcaa 540
gccgaccccg aagcgtcata aaatcctgct cgaggctaaa gcgttcccgt ctgatcacta 600
cgcgatcgaa tctcaaatcc aactgcacgg tctggacgtt gagaagtcta tgcgtatggt 660
taagccgcgt gaaggcgagg agaccctccg tatggaagac atcctcgaag ttatcgaaga 720
agaaggtgac tctatcgcag ttattctgtt ctctggcctg cacttttaca ccggtcaact 780
gttcaatatc ccggcaatca ccaaagcggg ccacgcgaaa ggttgcttcg ttggtttcga 840
cctggcccat gcggttggta acgtggagct gcgcctccac gactggggtg ttgactttgc 900
gtgctggtgc tcttacaaat acctgaactc tggtgcgggt ggtctcgcgg gtgcgttcgt 960
ccacgaaaaa cacgcgcaca ccgttaaacc ggcgctggtt ggctggttcg gccacgacct 1020
ctctacgcgt ttcaacatgg acaacaaact ccagctgatc ccaggcgcca acggtttccg 1080
tatctctaac ccgccgatcc tcctggtttg ctctctgcac gcgtctctcg aggttttcca 1140
gcaggcgacc atgaccgccc tgcgccgtaa atctattctc ctgacgggtt atctggaata 1200
catgctgaag cactaccact ctaaagacaa cacggaaaac aaaggtccga tcgttaacat 1260
catcaccccg tctcgtgcgg aagaacgtgg ctgccaactg accctgacct tctctattcc 1320
gaaaaaatct gttttcaaag aactggagaa acgtggtgtt gtttgcgaca aacgtgaacc 1380
ggacggtatc cgcgttgctc cggtcccgct gtacaactct ttccatgacg tttataagtt 1440
cattcgtctg ctcacctcca tcctggactc tagcgaacgc tcctaaggat cc 1492
<210> 4
<211> 1251
<212> DNA
<213> Pseudomonas fluorescens
<400> 4
atgaccaccc gcaacgattg cctggcgctg gatgcgcagg atagcctggc accgctgcgt 60
cagcagtttg cgctgccgga aggtgttatt tatctggatg gcaacagcct gggtgcgcgt 120
ccggttgcgg cgctggcgcg tgcgcaggcg gtgattgcgg aagaatgggg caacggcctg 180
attcgcagct ggaacagcgc gggctggcgc gatctgagcg aacgcctggg caaccgcctg 240
gcgaccctga ttggcgcgcg cgatggcgaa gtggtggtga ccgataccac cagcattaac 300
ctgtttaaag tgctgagcgc ggcgctgcgc gtgcaggcga cccgcagccc ggaacgccgc 360
gtgattgtga ccgaaaccag caactttccg accgatctgt atattgcgga aggcctggcg 420
gatatgctgc agcagggcta taccctgcgc ctggtggata gcccggaaga actgccgcag 480
gcgattgatc aggataccgc ggtggtgatg ctgacccatg tgaactataa aaccggctat 540
atgcatgata tgcaggcgct gaccgcgctg agccatgaat gcggcgcgct ggcgatttgg 600
gatctggcgc atagcgcggg cgcggtgccg gtggatctgc atcaggcggg cgcggattat 660
gcgattggct gcacctataa atatctgaac ggcggcccgg gcagccaggc gtttgtgtgg 720
gtgagcccgc agctgtgcga tctggtgccg cagccgctgt ctggttggtt tggccatagc 780
cgccagtttg cgatggaacc gcgctatgaa ccgagcaacg gcattgcgcg ctatctgtgc 840
ggcacccagc cgattaccag cctggcgatg gtggaatgcg gcctggatgt gtttgcgcag 900
accgatatgg cgagcctgcg ccgcaaaagc ctggcgctga ccgatctgtt tattgaactg 960
gtggaacagc gctgcgcggc gcatgaactg accctggtga ccccgcgcga acatgcgaaa 1020
cgcggcagcc atgtgagctt tgaacatccg gaaggctatg cggtgattca ggcgctgatt 1080
gatcgcggcg tgattggcga ttatcgcgaa ccgcgcatta tgcgctttgg ctttaccccg 1140
ctgtatacca cctttaccga agtgtgggat gcggtgcaga ttctgggcga aattctggat 1200
cgcaaaacct gggcgcaggc gcagtttcag gtgcgccata gcgtgaccta g 1251
<210> 5
<211> 1398
<212> DNA
<213> Homo sapiens
<400> 5
atggaaccga gctcccttga acttccggcc gataccgtgc aacggatagc ggcggaattg 60
aaatgtcacc cgaccgacga acgcgtcgcg ttacatctgg atgaggaaga caagctgcgt 120
cacttccgcg agtgctttta cattccgaaa attcaggatc tgccgccagt ggacttgagc 180
ctggtcaaca aagacgagaa cgccatctac ttcctgggca atagcctggg cctgcaacca 240
aagatggtga aaacctatct tgaggaggag cttgacaaat gggcgaagat cgcggcctac 300
ggccatgaag tcggcaagcg tccctggatt accggcgatg agtcaatcgt tggcttgatg 360
aaggatatcg tcggcgcgaa cgagaaagaa attgcgctga tgaacgcgct gaccgtgaat 420
ctgcatctgc tgatgctgtc attctttaag cccaccccga agcgctacaa aatcctgctg 480
gaagcgaaag cgtttcccag cgatcattat gcgatagaaa gccagctgca actgcacggc 540
ctgaatatcg aggagagcat gcgtatgata aaaccgcgcg aaggtgagga gaccctgcgg 600
attgaggaca tcctggaggt gatcgagaag gagggcgaca gtatcgcggt gatacttttc 660
agcggcgtgc atttctacac gggccaacac ttcaatatcc cggccattac caaagccggc 720
caggcgaaag ggtgctatgt aggctttgat ctggcgcatg cagtgggcaa cgtcgaactg 780
tatcttcatg attggggcgt tgattttgcg tgctggtgca gctataagta tctgaatgcc 840
ggggccggtg ggattgcggg agcctttatt catgagaaac acgcgcatac cattaaaccg 900
gcgctggttg gctggtttgg gcacgaactg agcacccgct tcaagatgga taacaaactg 960
caattgattc cgggcgtgtg cggctttcgt attagcaacc ccccgattct gctggtctgc 1020
agcctgcacg cgtctctgga gattttcaag caggcgacca tgaaagcgct gcgtaagaaa 1080
agtgtgcttc tgacgggcta cctggagtac ctgataaagc acaactacgg caaggataag 1140
gcggccacga agaagccggt tgtgaacatt atcaccccgt ctcatgtgga agaacgtggc 1200
tgccaactga cgataacgtt cagcgtgcca aacaaggacg tgttccaaga gctggagaag 1260
cgtggcgtgg tgtgtgataa acgtaatccg aatggcattc gtgtggcgcc tgtgccgctg 1320
tacaacagct tccacgacgt gtataagttc accaacctgc tgacgagcat tctggacagt 1380
gcggaaacca aaaactag 1398
<210> 6
<211> 1395
<212> DNA
<213> Mus musculus
<400> 6
atggagccga gcccgctgga actgccggtt gacgcggtac gtcgtattgc ggcagaactg 60
aactgtgacc cgaccgatga acgtgtggcg ctgcgtctcg acgaagagga caagctctct 120
cacttccgta actgcttcta tatccctaaa atgcgtgacc tgccgagcat cgatctgtct 180
ctggtttctg aagacgacga cgcgatttac ttcctgggta actctctggg tctgcagcca 240
aaaatggttc gtacctacct ggaggaagag ctggacaaat gggcgaaaat gggtgcctac 300
ggccatgatg tgggcaaacg cccgtggatc gtcggcgacg aaagcattgt gtctctcatg 360
aaggacattg ttggtgcaca cgagaaagaa attgcgctga tgaatgctct gaccatcaac 420
ctgcacctgc tgctcctgtc tttcttcaag ccgaccccga agcgtcataa aatcctgctc 480
gaggctaaag cgttcccgtc tgatcactac gcgatcgaat ctcaaatcca actgcacggt 540
ctggacgttg agaagtctat gcgtatggtt aagccgcgtg aaggcgagga gaccctccgt 600
atggaagaca tcctcgaagt tatcgaagaa gaaggtgact ctatcgcagt tattctgttc 660
tctggcctgc acttttacac cggtcaactg ttcaatatcc cggcaatcac caaagcgggc 720
cacgcgaaag gttgcttcgt tggtttcgac ctggcccatg cggttggtaa cgtggagctg 780
cgcctccacg actggggtgt tgactttgcg tgctggtgct cttacaaata cctgaactct 840
ggtgcgggtg gtctcgcggg tgcgttcgtc cacgaaaaac acgcgcacac cgttaaaccg 900
gcgctggttg gctggttcgg ccacgacctc tctacgcgtt tcaacatgga caacaaactc 960
cagctgatcc caggcgccaa cggtttccgt atctctaacc cgccgatcct cctggtttgc 1020
tctctgcacg cgtctctcga ggttttccag caggcgacca tgaccgccct gcgccgtaaa 1080
tctattctcc tgacgggtta tctggaatac atgctgaagc actaccactc taaagacaac 1140
acggaaaaca aaggtccgat cgttaacatc atcaccccgt ctcgtgcgga agaacgtggc 1200
tgccaactga ccctgacctt ctctattccg aaaaaatctg ttttcaaaga actggagaaa 1260
cgtggtgttg tttgcgacaa acgtgaaccg gacggtatcc gcgttgctcc ggtcccgctg 1320
tacaactctt tccatgacgt ttataagttc attcgtctgc tcacctccat cctggactct 1380
agcgaacgct cctaa 1395
<210> 7
<211> 416
<212> PRT
<213> Pseudomonas fluorescens
<400> 7
Met Thr Thr Arg Asn Asp Cys Leu Ala Leu Asp Ala Gln Asp Ser Leu
1 5 10 15
Ala Pro Leu Arg Gln Gln Phe Ala Leu Pro Glu Gly Val Ile Tyr Leu
20 25 30
Asp Gly Asn Ser Leu Gly Ala Arg Pro Val Ala Ala Leu Ala Arg Ala
35 40 45
Gln Ala Val Ile Ala Glu Glu Trp Gly Asn Gly Leu Ile Arg Ser Trp
50 55 60
Asn Ser Ala Gly Trp Arg Asp Leu Ser Glu Arg Leu Gly Asn Arg Leu
65 70 75 80
Ala Thr Leu Ile Gly Ala Arg Asp Gly Glu Val Val Val Thr Asp Thr
85 90 95
Thr Ser Ile Asn Leu Phe Lys Val Leu Ser Ala Ala Leu Arg Val Gln
100 105 110
Ala Thr Arg Ser Pro Glu Arg Arg Val Ile Val Thr Glu Thr Ser Asn
115 120 125
Phe Pro Thr Asp Leu Tyr Ile Ala Glu Gly Leu Ala Asp Met Leu Gln
130 135 140
Gln Gly Tyr Thr Leu Arg Leu Val Asp Ser Pro Glu Glu Leu Pro Gln
145 150 155 160
Ala Ile Asp Gln Asp Thr Ala Val Val Met Leu Thr His Val Asn Tyr
165 170 175
Lys Thr Gly Tyr Met His Asp Met Gln Ala Leu Thr Ala Leu Ser His
180 185 190
Glu Cys Gly Ala Leu Ala Ile Trp Asp Leu Ala His Ser Ala Gly Ala
195 200 205
Val Pro Val Asp Leu His Gln Ala Gly Ala Asp Tyr Ala Ile Gly Cys
210 215 220
Thr Tyr Lys Tyr Leu Asn Gly Gly Pro Gly Ser Gln Ala Phe Val Trp
225 230 235 240
Val Ser Pro Gln Leu Cys Asp Leu Val Pro Gln Pro Leu Ser Gly Trp
245 250 255
Phe Gly His Ser Arg Gln Phe Ala Met Glu Pro Arg Tyr Glu Pro Ser
260 265 270
Asn Gly Ile Ala Arg Tyr Leu Cys Gly Thr Gln Pro Ile Thr Ser Leu
275 280 285
Ala Met Val Glu Cys Gly Leu Asp Val Phe Ala Gln Thr Asp Met Ala
290 295 300
Ser Leu Arg Arg Lys Ser Leu Ala Leu Thr Asp Leu Phe Ile Glu Leu
305 310 315 320
Val Glu Gln Arg Cys Ala Ala His Glu Leu Thr Leu Val Thr Pro Arg
325 330 335
Glu His Ala Lys Arg Gly Ser His Val Ser Phe Glu His Pro Glu Gly
340 345 350
Tyr Ala Val Ile Gln Ala Leu Ile Asp Arg Gly Val Ile Gly Asp Tyr
355 360 365
Arg Glu Pro Arg Ile Met Arg Phe Gly Phe Thr Pro Leu Tyr Thr Thr
370 375 380
Phe Thr Glu Val Trp Asp Ala Val Gln Ile Leu Gly Glu Ile Leu Asp
385 390 395 400
Arg Lys Thr Trp Ala Gln Ala Gln Phe Gln Val Arg His Ser Val Thr
405 410 415
<210> 8
<211> 464
<212> PRT
<213> Homo sapiens
<400> 8
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile
1 5 10 15
Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His
20 25 30
Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile
35 40 45
Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys
50 55 60
Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro
65 70 75 80
Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys
85 90 95
Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly
100 105 110
Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu
115 120 125
Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu
130 135 140
Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu
145 150 155 160
Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu
165 170 175
Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro
180 185 190
Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile
195 200 205
Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His
210 215 220
Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly
225 230 235 240
Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly
245 250 255
Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp
260 265 270
Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala
275 280 285
Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly
290 295 300
Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu
305 310 315 320
Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile
325 330 335
Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Thr
340 345 350
Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu Glu
355 360 365
Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys Lys
370 375 380
Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly Cys
385 390 395 400
Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln Glu
405 410 415
Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly Ile
420 425 430
Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr Lys
435 440 445
Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys Asn
450 455 460
<210> 9
<211> 464
<212> PRT
<213> Mus musculus
<400> 9
Met Glu Pro Ser Pro Leu Glu Leu Pro Val Asp Ala Val Arg Arg Ile
1 5 10 15
Ala Ala Glu Leu Asn Cys Asp Pro Thr Asp Glu Arg Val Ala Leu Arg
20 25 30
Leu Asp Glu Glu Asp Lys Leu Ser His Phe Arg Asn Cys Phe Tyr Ile
35 40 45
Pro Lys Met Arg Asp Leu Pro Ser Ile Asp Leu Ser Leu Val Ser Glu
50 55 60
Asp Asp Asp Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro
65 70 75 80
Lys Met Val Arg Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys
85 90 95
Met Gly Ala Tyr Gly His Asp Val Gly Lys Arg Pro Trp Ile Val Gly
100 105 110
Asp Glu Ser Ile Val Ser Leu Met Lys Asp Ile Val Gly Ala His Glu
115 120 125
Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Ile Asn Leu His Leu Leu
130 135 140
Leu Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg His Lys Ile Leu Leu
145 150 155 160
Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Ile
165 170 175
Gln Leu His Gly Leu Asp Val Glu Lys Ser Met Arg Met Val Lys Pro
180 185 190
Arg Glu Gly Glu Glu Thr Leu Arg Met Glu Asp Ile Leu Glu Val Ile
195 200 205
Glu Glu Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Leu His
210 215 220
Phe Tyr Thr Gly Gln Leu Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly
225 230 235 240
His Ala Lys Gly Cys Phe Val Gly Phe Asp Leu Ala His Ala Val Gly
245 250 255
Asn Val Glu Leu Arg Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp
260 265 270
Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Ala Gly Gly Leu Ala Gly Ala
275 280 285
Phe Val His Glu Lys His Ala His Thr Val Lys Pro Ala Leu Val Gly
290 295 300
Trp Phe Gly His Asp Leu Ser Thr Arg Phe Asn Met Asp Asn Lys Leu
305 310 315 320
Gln Leu Ile Pro Gly Ala Asn Gly Phe Arg Ile Ser Asn Pro Pro Ile
325 330 335
Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Val Phe Gln Gln Ala
340 345 350
Thr Met Thr Ala Leu Arg Arg Lys Ser Ile Leu Leu Thr Gly Tyr Leu
355 360 365
Glu Tyr Met Leu Lys His Tyr His Ser Lys Asp Asn Thr Glu Asn Lys
370 375 380
Gly Pro Ile Val Asn Ile Ile Thr Pro Ser Arg Ala Glu Glu Arg Gly
385 390 395 400
Cys Gln Leu Thr Leu Thr Phe Ser Ile Pro Lys Lys Ser Val Phe Lys
405 410 415
Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Glu Pro Asp Gly
420 425 430
Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr
435 440 445
Lys Phe Ile Arg Leu Leu Thr Ser Ile Leu Asp Ser Ser Glu Arg Ser
450 455 460
<210> 10
<211> 466
<212> PRT
<213> Pongo abelii
<400> 10
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile
1 5 10 15
Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His
20 25 30
Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Tyr Phe Tyr Ile
35 40 45
Pro Lys Ile Arg Asp Leu Pro Pro Val Asp Phe Ile Ile Ser Glu Ser
50 55 60
Lys Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln
65 70 75 80
Pro Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala
85 90 95
Lys Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr
100 105 110
Gly Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn
115 120 125
Glu Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu
130 135 140
Leu Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu
145 150 155 160
Leu Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln
165 170 175
Leu Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Val Lys
180 185 190
Pro Arg Glu Gly Glu Glu Thr Leu Arg Thr Glu Asp Ile Leu Glu Val
195 200 205
Ile Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val
210 215 220
His Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala
225 230 235 240
Gly Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val
245 250 255
Gly Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys
260 265 270
Trp Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly
275 280 285
Ala Phe Val His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val
290 295 300
Gly Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys
305 310 315 320
Leu Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro
325 330 335
Ile Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln
340 345 350
Ala Thr Met Lys Ala Leu Arg Lys Lys Ser Ile Leu Leu Thr Gly Tyr
355 360 365
Leu Glu Tyr Leu Ile Lys His Ser Tyr Gly Lys Asp Lys Ala Ala Thr
370 375 380
Lys Lys Pro Val Val Asn Ile Ile Thr Pro Ser His Ile Glu Glu Arg
385 390 395 400
Gly Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe
405 410 415
Gln Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn
420 425 430
Gly Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val
435 440 445
Tyr Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr
450 455 460
Thr Asn
465
<210> 11
<211> 465
<212> PRT
<213> Macaca fascicularis
<400> 11
Met Glu Pro Ser Pro Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile
1 5 10 15
Ala Thr Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His
20 25 30
Leu Asp Glu Val Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile
35 40 45
Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys
50 55 60
Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro
65 70 75 80
Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys
85 90 95
Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly
100 105 110
Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu
115 120 125
Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu
130 135 140
Leu Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu
145 150 155 160
Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu
165 170 175
Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro
180 185 190
Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile
195 200 205
Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His
210 215 220
Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly
225 230 235 240
Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly
245 250 255
Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp
260 265 270
Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala
275 280 285
Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly
290 295 300
Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu
305 310 315 320
Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile
325 330 335
Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Ala
340 345 350
Thr Met Lys Ala Leu Arg Lys Lys Ser Ile Leu Leu Thr Gly Tyr Leu
355 360 365
Glu Tyr Leu Ile Lys His Lys Tyr Gly Lys Asp Lys Ala Ala Thr Glu
370 375 380
Lys Pro Ile Val Asn Ile Ile Thr Pro Ser His Ile Glu Glu Arg Gly
385 390 395 400
Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln
405 410 415
Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly
420 425 430
Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr
435 440 445
Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Thr
450 455 460
Asn
465
<210> 12
<211> 465
<212> PRT
<213> Pan troglodytes
<400> 12
Met Glu Pro Ser Ser Val Glu Leu Pro Ala Asp Thr Val Gln Arg Ile
1 5 10 15
Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His
20 25 30
Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile
35 40 45
Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys
50 55 60
Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro
65 70 75 80
Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys
85 90 95
Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly
100 105 110
Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu
115 120 125
Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu
130 135 140
Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu
145 150 155 160
Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu
165 170 175
Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro
180 185 190
Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile
195 200 205
Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His
210 215 220
Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly
225 230 235 240
Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly
245 250 255
Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp
260 265 270
Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala
275 280 285
Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly
290 295 300
Trp Phe Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu
305 310 315 320
Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile
325 330 335
Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Ala
340 345 350
Thr Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu
355 360 365
Glu Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys
370 375 380
Lys Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly
385 390 395 400
Cys Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln
405 410 415
Glu Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly
420 425 430
Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr
435 440 445
Lys Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Thr
450 455 460
Asn
465
<210> 13
<211> 431
<212> PRT
<213> Arenitalea lutea
<400> 13
Met Leu Glu Thr Glu Asn Ile Arg Thr Leu Ser Asp Tyr Lys Leu Gly
1 5 10 15
Leu Asp Tyr Ala Leu Asp Gln Asp Arg Lys Asp Glu Leu Lys Ser Tyr
20 25 30
Arg Asn Gln Phe His Ile Pro Lys Asp Lys Gln Gly Asp Ala Trp Ile
35 40 45
Tyr Met Thr Gly Asn Ser Leu Gly Leu Gln Pro Lys Gln Thr Lys Ala
50 55 60
Tyr Val Asn Gln Glu Leu Asn Asp Trp Ala Asn Leu Gly Val Glu Gly
65 70 75 80
His Phe Glu Ala Lys Asn Pro Trp Leu Ala Tyr His Glu Phe Leu Thr
85 90 95
Glu Ser Met Ala Lys Val Val Gly Ala Lys Pro Ile Glu Val Val Val
100 105 110
Met Asn Thr Leu Thr Ala Asn Leu His Phe Met Met Val Ser Phe Tyr
115 120 125
Lys Pro Thr Lys Thr Arg Tyr Lys Ile Leu Ile Glu Ser Asp Ala Phe
130 135 140
Pro Ser Asp Lys Tyr Ala Val Glu Ser Gln Leu Arg His His Gly Phe
145 150 155 160
Asp Asp Lys Glu Gly Val Val Leu Trp Lys Pro Arg Pro Gly Glu Glu
165 170 175
Leu Leu Asn Tyr Asp Asp Leu Glu Thr Ile Leu Glu Thr Gln Gly Asp
180 185 190
Glu Ile Ala Leu Ile Met Ile Gly Gly Val Asn Tyr Tyr Thr Gly Gln
195 200 205
Tyr Phe Asp Leu Lys Arg Ile Thr Gln Leu Gly His Lys Gln Gly Cys
210 215 220
Asn Val Gly Phe Asp Cys Ala His Gly Ala Gly Asn Val Ala Leu Asn
225 230 235 240
Leu His Asp Ser Gly Ala Asp Phe Ala Val Trp Cys Thr Tyr Lys Tyr
245 250 255
Leu Asn Ser Gly Pro Gly Ser Leu Ala Gly Cys Phe Val His Glu Arg
260 265 270
His Ala Tyr Arg Lys Asp Leu Asn Arg Phe Thr Gly Trp Trp Ser His
275 280 285
Asn Lys Gln Thr Arg Phe Asn Met Arg Gly Glu Phe Asp Gln Leu Pro
290 295 300
Gly Ala Glu Gly Trp Gln Leu Ser Asn Pro Pro Ile Leu Ser Met Ala
305 310 315 320
Ala Ile Lys Ala Ser Leu Asp Leu Phe Asn Glu Val Gly Met Asp Lys
325 330 335
Leu Ile Asn Lys Ser Lys Lys Leu Thr Gly Tyr Phe Glu Tyr Leu Leu
340 345 350
Lys Gln Leu Gly Glu Asp Thr Ile Arg Ile Ile Thr Pro Lys Arg Ser
355 360 365
Glu Glu Arg Gly Cys Gln Leu Ser Ile Gln Val Lys Asn Ala Asp Lys
370 375 380
Ser Leu His Asn Lys Leu Thr Glu Val Gly Ile Ile Ser Asp Trp Arg
385 390 395 400
Glu Pro Asp Val Ile Arg Cys Ala Pro Val Pro Leu Tyr Asn Ser Phe
405 410 415
Glu Asp Val Tyr Arg Leu Val Glu Lys Leu Lys Gly Ile Leu Lys
420 425 430
<210> 14
<211> 429
<212> PRT
<213> Belliella Baltica DSM 15883
<400> 14
Met Ser Asn Gln Ile Asn Phe Glu Tyr Ser Leu Asp Phe Ala Gln Lys
1 5 10 15
Met Asp Glu Lys Asp Pro Leu Lys Ser Phe Arg Ser Lys Phe Phe Phe
20 25 30
Pro Lys Val Glu Asp Lys Glu Ala Ile Tyr Phe Cys Gly Asn Ser Leu
35 40 45
Gly Leu Gln Pro Lys Thr Thr Gln Asn Tyr Ile Gln Lys Glu Leu Ser
50 55 60
Asn Trp Ala Glu Met Ala Val Asp Gly His Phe His Gly Glu Asp Ala
65 70 75 80
Trp Tyr His Ile Arg Lys Lys Ser Lys Pro Ala Leu Ala Glu Ile Val
85 90 95
Gly Ala His Glu His Glu Val Val Ala Met Asn Asn Leu Thr Ser Asn
100 105 110
Leu His Phe Leu Met Val Ser Phe Tyr Arg Pro Asn Ala Lys Arg Phe
115 120 125
Lys Ile Ile Thr Glu Ala Gly Ala Phe Pro Ser Asp Met Tyr Met Leu
130 135 140
Glu Thr Gln Val Lys Phe His Gly Leu Asp Pro Asn Lys Ala Ile Val
145 150 155 160
Glu Leu Ala Pro Arg Asp Gly Glu His Thr Leu Arg Thr Glu Asp Ile
165 170 175
Leu Gln Ser Ile Lys Glu Gln Gly Glu Glu Leu Ala Leu Val Met Met
180 185 190
Ala Gly Leu Gln Tyr Tyr Thr Gly Gln Val Phe Asp Met Lys Ala Ile
195 200 205
Ala Gln Ala Val Lys Asp Glu Gly Ala Phe Val Gly Phe Asp Leu Ala
210 215 220
His Ala Ala Gly Asn Val Pro Leu Ala Leu His Asp Trp Gly Val Asp
225 230 235 240
Phe Ala Thr Trp Cys Ser Tyr Lys Tyr Met Asn Ser Gly Pro Gly Asn
245 250 255
Val Ser Gly Ile Phe Val His Glu Asn His Ala Glu Lys Pro Asp Met
260 265 270
Ile Arg Phe Ala Gly Trp Trp Gly His Asp Glu Gly Glu Arg Phe Lys
275 280 285
Met Glu Lys Gly Phe Lys Pro Met Phe Gly Ala Asp Gly Trp Gln Leu
290 295 300
Ala Asn Ser Asn Val Leu Ala Leu Ala Ala His Gln Ala Ser Leu Asp
305 310 315 320
Ile Phe Gln Gln Ala Gly Ile Lys Thr Leu Arg Glu Lys Ser Glu Thr
325 330 335
Leu Thr Ser Tyr Leu Glu Phe Leu Ile Gln Lys Ile Ser Gly Asn Ser
340 345 350
Gly Val Leu Glu Ile Ile Thr Pro Lys Asn Ile Asn Glu Arg Gly Cys
355 360 365
Gln Leu Ser Leu Leu Val His Lys Gly Gly Lys Ala Val Phe Asp Glu
370 375 380
Phe Tyr Lys Asn Gly Ile Val Gly Asp Trp Arg Asn Pro Asn Val Ile
385 390 395 400
Arg Ile Ala Pro Thr Pro Leu Tyr Asn Ser Tyr Glu Asp Val Phe Arg
405 410 415
Phe Ala Lys Ile Leu Glu Gln Ser Leu Gln Lys Phe Ala
420 425
<210> 15
<211> 422
<212> PRT
<213> Bizionia argentinensis
<400> 15
Met Ser Asn Phe Lys Thr Gly Ile Asp Phe Ala Lys Glu Gln Asp Glu
1 5 10 15
Asn Asp Thr Leu Ser Cys Tyr Arg Asn Gln Phe His Ile Pro Lys Asp
20 25 30
Lys Gln Gly Asn Asp Met Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu
35 40 45
Gln Pro Lys Ala Thr Lys Asp Tyr Ile Asn Gln Glu Leu Glu Asp Trp
50 55 60
Ala Asn Leu Gly Val Glu Gly His Thr His Ala Lys Asn Pro Trp Leu
65 70 75 80
Gly Tyr His Glu Phe Leu Thr Asp Ser Met Ala Lys Val Val Gly Ala
85 90 95
Lys Pro Ile Glu Val Val Val Met Asn Thr Leu Thr Ala Asn Leu His
100 105 110
Phe Met Met Val Ser Phe Tyr Lys Pro Thr Ile Glu Arg Tyr Lys Ile
115 120 125
Ile Ile Glu Ala Asp Ala Phe Pro Ser Asp Lys Tyr Ala Val Glu Ser
130 135 140
Gln Leu Arg His His Gly Tyr Asp Asp Lys Glu Gly Leu Leu Leu Trp
145 150 155 160
Lys Ala Arg Glu Gly Glu Glu Leu Leu Arg Tyr Glu Asp Leu Glu Ala
165 170 175
Ile Leu Lys Glu His Gly Asp Asp Val Ala Leu Val Met Ile Gly Gly
180 185 190
Val Asn Tyr Tyr Thr Gly Gln Phe Phe Asp Leu Lys Arg Ile Thr Glu
195 200 205
Leu Gly His Lys His Gly Cys Met Val Gly Phe Asp Cys Ala His Gly
210 215 220
Ala Gly Asn Val Glu Leu Asn Leu His Asp Ser Gly Ala Asp Phe Ala
225 230 235 240
Val Trp Cys Thr Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Ser Leu Gly
245 250 255
Gly Cys Phe Val His Glu Arg His Ala His Asn Lys Arg Leu Asn Arg
260 265 270
Phe Thr Gly Trp Trp Ser His Asn Lys Glu Thr Arg Phe Lys Met Arg
275 280 285
Asp Glu Phe Asp Ala Ile Pro Gly Ala Glu Gly Trp Gln Leu Ser Asn
290 295 300
Pro Pro Ile Leu Ser Met Ala Ala Ile Lys Ala Ser Leu Asp Ile Phe
305 310 315 320
Glu Glu Ile Gly Met Lys Lys Leu Asn Glu Lys Ser Arg Ala Leu Thr
325 330 335
Ala Tyr Phe Glu Phe Leu Leu Lys Gln Val Gly Asp Asp Ser Ile Arg
340 345 350
Ile Ile Thr Pro Glu Asn Pro Asp Glu Arg Gly Cys Gln Leu Ser Ile
355 360 365
Gln Val Lys Asn Ala Asp Arg Ser Leu His Asp Lys Leu Thr Asp Ala
370 375 380
Gly Val Ile Ser Asp Trp Arg Glu Pro Asp Val Ile Arg Cys Ala Pro
385 390 395 400
Ile Pro Leu Tyr Asn Ser Tyr Gln Asp Val Tyr His Met Val Glu Arg
405 410 415
Leu Lys Asn Ile Leu Glu
420
<210> 16
<211> 431
<212> PRT
<213> Candidatus Entotheonella sp. TSY2
<400> 16
Met Thr Ala Phe His Ala His Phe Gln Pro Thr Arg Glu Ala Ala Leu
1 5 10 15
Ala Leu Asp Ala Ser Asp Glu Leu Ala Pro Tyr Arg Asp Gln Phe Cys
20 25 30
Leu Pro Gln Thr Gln Gly Gln Pro Val Val Tyr Leu Cys Gly His Ser
35 40 45
Leu Gly Leu Gln Pro Lys Thr Val Arg Glu Tyr Ile Asp Glu Glu Leu
50 55 60
Gln Asp Trp Ala Ala Leu Gly Val Glu Gly His Phe His Ala Arg Arg
65 70 75 80
Pro Trp Leu Ser Tyr His Glu Ile Leu Thr Ala Gln Thr Ala Arg Leu
85 90 95
Ala Gly Ala Lys Pro Ala Glu Val Val Val Met Asn Ser Leu Thr Val
100 105 110
Asn Met His Leu Met Leu Val Ser Phe Tyr Arg Pro Thr Pro Glu Arg
115 120 125
Phe Lys Ile Leu Ile Glu Ala Asp Ala Phe Pro Ser Asp Arg Tyr Ala
130 135 140
Ala Glu Ser His Leu Arg Trp His Gly Tyr Asp Pro Gln Asp Ala Leu
145 150 155 160
Leu Thr Leu Gln Pro Arg Pro Gly Glu Ala Ala Val Arg Gln Glu Asp
165 170 175
Ile Ala Ala Phe Leu His Arg Glu Gly Glu Thr Ile Ala Leu Val Trp
180 185 190
Leu Gly Gly Val Asn Tyr Tyr Thr Gly Gln Val Phe Asp Met Ala Glu
195 200 205
Ile Thr Ala Ile Gly His Ala Gln Gly Cys Val Val Gly Phe Asp Leu
210 215 220
Ala His Ala Ala Gly Asn Ile Ile Leu Gln Leu His Asp Trp Asp Val
225 230 235 240
Asp Cys Ala Val Trp Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Pro Gly
245 250 255
Ala Ala Ala Gly Cys Phe Val His Glu Arg Tyr Ala Gln Arg Pro Asp
260 265 270
Leu Pro Arg Leu Ala Gly Trp Trp Gly His Asn Lys Asp Thr Arg Phe
275 280 285
Gln Met Pro Ala Gly Phe Asp Pro Ile Pro Gly Ala Glu Gly Trp Gln
290 295 300
Ile Ser Asn Pro Pro Ile Phe Gln Leu Ala Ala Leu Lys Ala Ser Met
305 310 315 320
Asp Ile Phe Asp Arg Ala Gly Met Met Arg Leu Arg Ala Lys Ser Glu
325 330 335
Arg Leu Thr Gly Tyr Leu Glu Tyr Leu Leu Arg Asp Arg Ala Leu Pro
340 345 350
Gly Val Ser Leu Ile Thr Pro Asp Asp Pro Ala Gln Arg Gly Ala Gln
355 360 365
Leu Ser Leu Gln Ile Lys Gln His Gly Cys Ala Leu His Gln Arg Leu
370 375 380
Ala Glu Ala His Ile Ile Cys Asp Trp Arg Glu Pro Asp Val Ile Arg
385 390 395 400
Val Ala Pro Val Pro Leu Tyr Asn Thr Phe Leu Asp Val Leu Thr Phe
405 410 415
Val Asn Ala Leu Asp Thr Ala His Arg Glu Val Leu Val Ser Ser
420 425 430
<210> 17
<211> 424
<212> PRT
<213> Candidatus Koribacter versatilis Ellin345
<400> 17
Met Ala Ala Ala Ala Phe Asp Thr Thr Glu Asn Phe Ala Ile Glu Met
1 5 10 15
Asp Ala Arg Asp Pro Met Ser Arg Phe Arg Gly Arg Phe His Ile Pro
20 25 30
Pro Ala Pro Asp Gly Ser Ala Ser Val Tyr Leu Val Gly His Ser Leu
35 40 45
Gly Leu Gln Pro Lys Thr Val Arg Ala Tyr Leu Glu Gln Glu Leu Lys
50 55 60
Asp Trp Glu Thr Leu Gly Val Glu Gly His Phe Arg Gly Lys His Pro
65 70 75 80
Trp Met Pro Tyr His Arg Leu Leu Thr Glu Gln Thr Ala Arg Leu Val
85 90 95
Cys Ala Gln Pro Ser Glu Val Val Val Met Asn Ser Leu Thr Val Asn
100 105 110
Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Arg Glu Arg His
115 120 125
Asn Ile Leu Ile Glu Gly Ser Ala Phe Pro Ser Asp Gln Tyr Ala Val
130 135 140
Gln Ser Gln Ile Lys Phe His Gly Phe Asp Pro Ala Ser Ser Leu Leu
145 150 155 160
Glu Leu Cys Pro Arg Val Gly Glu Ala Thr Met Arg Asp Glu Asp Ile
165 170 175
Leu Glu Leu Ile Glu Arg Glu Gly Gln Ser Ile Ala Leu Ile Leu Leu
180 185 190
Gly Gly Val Asn Tyr Ala Thr Gly Gln Ala Phe Asp Met Ala Glu Ile
195 200 205
Thr Lys Ala Gly His Ala Gln Gly Cys Val Val Ala Phe Asp Cys Ala
210 215 220
His Ala Ala Gly Asn Leu Glu Leu Lys Leu His Glu Trp Asp Val Asp
225 230 235 240
Trp Ala Ala Trp Cys Ser Tyr Lys Tyr Leu Asn Gly Gly Pro Gly Cys
245 250 255
Ile Gly Gly Cys Phe Val His Glu Arg Tyr Ala Arg Asp Phe Glu Leu
260 265 270
Pro Arg Phe Ala Gly Trp Trp Gly His Asp Gln Glu Thr Arg Phe Lys
275 280 285
Met Gly Pro Glu Phe His Pro Met Ala Gly Ala Glu Gly Trp Gln Leu
290 295 300
Ser Asn Pro Ser Ile Leu Thr Met Ala Ala Leu Arg Ala Ser Met Glu
305 310 315 320
Ile Phe Asp Glu Ala Gly Ile Gly Lys Leu Arg Gln Arg Ser Ile Ala
325 330 335
Leu Thr Gly Tyr Leu Glu Phe Leu Leu Asp Gln Gln Lys Ser Ala Arg
340 345 350
Phe Glu Ile Ile Thr Pro Arg Glu Pro Glu Arg Arg Gly Ala Gln Leu
355 360 365
Ser Ile Arg Val Ala Ala Gly Asn Arg Ser Val Cys Asp Arg Leu Val
370 375 380
Glu Glu Gly Ala Leu Cys Asp Trp Arg Glu Pro Asp Ile Leu Arg Val
385 390 395 400
Ala Pro Val Pro Leu Tyr Cys Ser Tyr Arg Asp Cys Tyr Arg Phe Val
405 410 415
Gln Arg Phe Val Ala Asn Leu Asn
420
<210> 18
<211> 428
<212> PRT
<213> Cecembia lonarensis
<400> 18
Met Ser Asn Asn Gln Tyr Glu Phe Ser Glu Ser Phe Ala Arg Gln Met
1 5 10 15
Asp Val Gln Asp Thr Leu Ser Gly Phe Arg Asp Arg Phe Tyr Phe Pro
20 25 30
Gln Ile Asn Gly Lys Glu Ala Ile Tyr Phe Cys Gly Asn Ser Leu Gly
35 40 45
Leu Gln Pro Lys Thr Val Ala Thr Tyr Ile Asn Lys Glu Leu Asp Asn
50 55 60
Trp Ala Lys Leu Gly Val Asp Gly His Phe Tyr Gly Glu Asp Ala Trp
65 70 75 80
Tyr His Val Arg Lys Lys Ser Lys Pro Ala Leu Ser Ala Ile Val Gly
85 90 95
Ala His Glu His Glu Val Val Ala Met Asn Asn Leu Thr Ser Asn Leu
100 105 110
His Phe Leu Met Val Ser Phe Tyr Cys Pro Asp Gln Thr Arg Tyr Lys
115 120 125
Ile Ile Thr Glu Ala Gly Ala Phe Pro Ser Asp Met Tyr Met Leu Glu
130 135 140
Thr Gln Val Lys Phe His Gly Leu Asp Pro Glu Lys Cys Ile Val Glu
145 150 155 160
Leu Ser Pro Arg Ala Gly Glu Tyr Thr Leu Arg Thr Glu Asp Ile Leu
165 170 175
Met Ala Ile Glu Ala Asn Lys Glu Asn Leu Ala Leu Val Met Met Ala
180 185 190
Gly Leu Gln Tyr Tyr Thr Gly Gln Val Phe Asp Met Lys Ala Ile Thr
195 200 205
Ala Ala Ala His Gln Val Gly Ala Arg Ala Gly Phe Asp Leu Ala His
210 215 220
Ala Val Gly Asn Ala Lys Leu Glu Leu His Asp Trp Gly Val Asp Phe
225 230 235 240
Ala Thr Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Asn Ile
245 250 255
Ser Gly Ile Phe Val His Glu Arg His Ala Glu Asn Gln Glu Leu Pro
260 265 270
Arg Phe Ala Gly Trp Trp Gly His Asp Glu Gly Glu Arg Phe Arg Met
275 280 285
Glu Lys Gly Phe Lys Pro Met Tyr Gly Ala Asp Gly Trp Gln Leu Ala
290 295 300
Asn Ser Asn Val Leu Ala Leu Ala Ala His Gln Ala Ser Leu Asp Ile
305 310 315 320
Phe Glu Glu Ala Gly Met Asp Arg Leu Arg Ala Lys Ser Glu Leu Leu
325 330 335
Thr Gly Tyr Leu Glu Phe Leu Ile Glu Lys Ile Ser Gly Asp Ser Gly
340 345 350
Val Leu Glu Ile Ile Thr Pro Lys Ile Pro Asn Glu Arg Gly Cys Gln
355 360 365
Leu Ser Leu Leu Ile His Lys Gly Gly Lys Ser Val Phe Asp Glu Phe
370 375 380
Tyr Lys His Gly Val Val Gly Asp Trp Arg Asn Pro Asn Val Ile Arg
385 390 395 400
Leu Ala Pro Thr Pro Leu Tyr Asn Ser Phe Ile Asp Ile Tyr Gln Phe
405 410 415
Ala Lys Ile Leu Glu Gln Ser Leu Gln Lys Phe Ala
420 425
<210> 19
<211> 421
<212> PRT
<213> Chlamydia pecorum PV3056/3
<400> 19
Met Ile Glu Lys Leu Lys Gln Tyr His Asp Glu Ala Ile Ser Leu Asp
1 5 10 15
Ser Leu Asp Pro Leu Gln Lys Phe Lys Glu Cys Phe Thr Leu Pro Lys
20 25 30
Glu Pro Gly Ala Leu Tyr Phe Cys Ser Asn Ser Leu Gly Leu Pro Ala
35 40 45
Lys Ala Ala Ser Gln Lys Leu Glu Glu Gln Leu Gln Arg Trp Ser Glu
50 55 60
Leu Gly Ala Arg Gly Trp Phe Glu Gly Glu Gly Asn Trp Tyr Asn Ser
65 70 75 80
Leu Glu Glu Ser Ile Val Arg Pro Leu Ser Lys Ile Leu Gly Ala Glu
85 90 95
Ser Asn Glu Val Thr Leu Met Asn Ser Leu Thr Val Asn Leu His Met
100 105 110
Leu Leu Ile Ser Phe Tyr Arg Pro Thr Lys Thr Arg Tyr Lys Ile Leu
115 120 125
Ile Asp Gly Pro Ala Phe Pro Ser Asp Leu Tyr Ala Ile Lys Ser His
130 135 140
Leu Arg Phe His Lys Lys Glu Glu Gly Leu Ile Leu Ile Glu Pro Arg
145 150 155 160
Pro Gly Glu His Leu Val Gln Glu Glu Asp Phe Leu Arg Val Ile Lys
165 170 175
Ile Gln Gly Glu Glu Ile Ala Leu Val Phe Leu Asn Cys Val Asn Phe
180 185 190
Leu Ser Gly Gln Val Leu Lys Val Asp Glu Ile Thr Arg Tyr Ala Lys
195 200 205
Glu Ala Gly Cys Cys Val Gly Tyr Asp Leu Ala His Ala Ala Gly Asn
210 215 220
Ile Pro Leu Ser Leu His Asp Leu Gly Gly Asp Phe Ala Val Gly Cys
225 230 235 240
Ser Tyr Lys Tyr Leu Cys Gly Gly Pro Gly Gly Pro Gly Ile Ala Tyr
245 250 255
Val His Ala Ser His His His Gln Gln Phe Val Arg Phe Ser Gly Trp
260 265 270
Trp Gly Asn Asp Pro Asn Thr Arg Phe Tyr Phe Pro Lys Glu Phe Val
275 280 285
Pro Tyr Gly Gly Ala Ser Ser Trp Gln Val Ser Thr Pro Ser Ile Leu
290 295 300
Ala Lys Leu Pro Leu Ile Ala Ala Leu Glu Val Phe Glu Glu Ala Gly
305 310 315 320
Met Glu Asn Ile Arg Glu Lys Ser Lys Lys Gln Thr Ala Phe Leu Tyr
325 330 335
Thr Leu Leu Glu Asn Ala Arg Gly Thr His Phe Asp Met Ile Thr Pro
340 345 350
Lys Glu Pro Glu Leu Arg Gly Cys Gln Leu Ser Leu Arg Ile Lys Cys
355 360 365
Ser Arg Ser Glu Glu Ile Leu Arg Lys Leu Glu Arg Leu Gly Ile Thr
370 375 380
Cys Asp Phe Arg Ser Pro Asn Ile Leu Arg Val Thr Pro Ser Pro Leu
385 390 395 400
Tyr Thr Ser Phe Tyr Glu Ile Tyr Arg Phe Ala Tyr Thr Phe Leu Glu
405 410 415
Val Leu Lys Thr Ile
420
<210> 20
<211> 425
<212> PRT
<213> Chlamydophila caviae GPIC
<400> 20
Met Asn Glu Ile Leu Lys His Tyr Gln Lys Lys Ala Ala Gln Leu Asp
1 5 10 15
Glu Gln Asp Ser Leu Lys His Leu Arg Ala Arg Phe Ala Leu Pro Lys
20 25 30
Asp Pro Asn Ala Ile Tyr Phe Cys Asn Asn Ser Leu Gly Leu Pro Ala
35 40 45
Val Gly Ala Phe Thr Lys Ile Glu Glu Leu Leu Gln Arg Trp Ser Asp
50 55 60
Val Gly Val Asn Gly Trp Phe Glu Gly Val Gly Asn Trp Tyr Arg Ser
65 70 75 80
Phe Asp Asn Pro Leu Arg Gln Pro Leu Ser Lys Ile Leu Gly Ala Glu
85 90 95
Tyr Glu Glu Val Val Val Met Asn Ser Leu Thr Met Asn Leu His Leu
100 105 110
Leu Leu Val Ser Phe Tyr Arg Pro Thr Asp Thr Arg Tyr Lys Ile Leu
115 120 125
Ile Glu Gly Pro Thr Phe Pro Ser Asp Leu Tyr Ala Ile Lys Ser Gln
130 135 140
Leu Ser Phe His Gly Lys Asn Pro Asp Asp Ala Leu Ile Ile Leu Glu
145 150 155 160
Pro Arg Ala Gly Glu Asp Leu Leu Arg Tyr Glu Asp Phe Gln Gln Thr
165 170 175
Leu Glu Glu Gln Gly Glu Ser Ile Ala Leu Val Phe Met Asn Cys Val
180 185 190
Asn Phe Leu Thr Gly Gln Val Leu Glu Val Glu Ala Ile Thr Asn Leu
195 200 205
Ala Lys Glu Lys Gly Cys Val Val Gly Cys Asp Leu Ala His Ala Ala
210 215 220
Gly Asn Ile Pro Leu Lys Leu His Glu Trp Gly Val Asp Phe Ala Leu
225 230 235 240
Gly Cys Ser Tyr Lys Tyr Leu Cys Gly Gly Pro Gly Gly Pro Gly Ile
245 250 255
Ala Phe Val His Lys Ser His His Asn Glu Gln Leu Pro Arg Phe Ser
260 265 270
Gly Trp Trp Gly Asn Asp Pro Glu Thr Arg Phe Gln Met Gln Leu Gln
275 280 285
Pro Glu Phe Ile Pro Tyr Ser Gly Ala Tyr Ser Trp Gln Val Ser Thr
290 295 300
Pro Ser Ile Val Ser Leu Met Pro Leu Leu Ala Thr Leu Glu Val Phe
305 310 315 320
Glu Glu Ala Gly Met Glu Arg Val Arg His Lys Ser Lys Gln Met Thr
325 330 335
Ala Phe Leu Leu Glu Leu Leu Glu Leu Ala Pro Pro Ser Cys Phe Glu
340 345 350
Ile Ile Thr Pro Arg Asp Pro Glu Leu Arg Gly Ser Gln Leu Ser Ile
355 360 365
Arg Ile Gln Gln His Ser Glu Glu Val Leu Gln Lys Leu Glu Ala Gln
370 375 380
Arg Ile Thr Cys Asp Ser Arg Pro Pro Asp Ile Ile Arg Val Thr Ala
385 390 395 400
Thr Pro Leu Tyr Asn Thr Phe Ser Glu Ile Tyr Lys Phe Thr Cys Lys
405 410 415
Leu Phe Glu Val Leu Glu Ile Lys Ser
420 425
<210> 21
<211> 425
<212> PRT
<213> Corallococcus coralloides DSM 2259
<400> 21
Met Thr Ala Pro Val Tyr Glu Asn Thr Asp Val Phe Ala Tyr Gly Leu
1 5 10 15
Asp Ala Ala Asp Pro Leu Arg Pro Leu Arg Asp Glu Phe Leu Phe Pro
20 25 30
Pro Ala Pro Ser Gly Ala Pro Ala Ile Tyr Leu Ala Gly Asn Ser Leu
35 40 45
Gly Leu Gln Pro Arg Lys Ala Arg Lys Tyr Val Gln Met Glu Met Glu
50 55 60
Asp Trp Glu Arg Leu Gly Val Glu Gly His Val His Gly Arg His Pro
65 70 75 80
Trp Leu Pro Tyr His Glu Gln Leu Thr Asp Met Val Ala Arg Val Val
85 90 95
Gly Ala Gln Pro Ile Glu Val Val Val Met Asn Thr Leu Ser Val Asn
100 105 110
Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Arg Glu Arg Phe
115 120 125
Lys Ile Leu Ile Glu Gly Gly Ala Phe Pro Ser Asp Gln Tyr Ala Val
130 135 140
Ala Ser Gln Ala Arg Phe His Gly Tyr Asp Pro Lys Glu Ala Ile Val
145 150 155 160
Arg Leu Met Pro Arg Glu Gly Glu Asp Thr Leu Arg Ser Glu Asp Ile
165 170 175
Leu Glu Ala Ile Glu Arg His Gly Lys Glu Leu Ala Leu Val Met Leu
180 185 190
Gly Ser Val Asn Tyr Leu Thr Gly Gln Ala Phe Asp Leu Arg Glu Ile
195 200 205
Thr Arg Val Ala His Ala Gln Gly Cys Lys Val Gly Phe Asp Leu Ala
210 215 220
His Ala Ala Gly Asn Leu Lys Leu Ser Leu His Asp Asp Gly Pro Asp
225 230 235 240
Phe Ala Val Trp Cys Ser Tyr Lys Tyr Leu Asn Gly Gly Pro Gly Ser
245 250 255
Leu Gly Gly Val Phe Val His Glu Arg His Ala His Ser Pro Gln Leu
260 265 270
Pro Arg Phe Glu Gly Trp Trp Gly His Asn Lys Ala Thr Arg Phe Glu
275 280 285
Met Gly Pro Thr Phe Asp Pro Leu Pro Gly Ala Glu Gly Trp Gln Leu
290 295 300
Ser Asn Pro Pro Ile Phe Gln Leu Ala Ala Leu Arg Ser Ser Leu Glu
305 310 315 320
Leu Phe Asp Lys Ala Thr Met Ala Ala Leu Arg Thr Lys Ser Asp Gln
325 330 335
Leu Thr Gly Tyr Leu Glu Phe Leu Leu Asp Arg Leu Pro Ala Gly Tyr
340 345 350
Val Ser Ile Thr Thr Pro Arg Asp Leu Lys Gln Arg Gly Ala Gln Leu
355 360 365
Ser Leu Arg Phe Lys Gly Glu Pro Lys Arg Leu Leu Gln Arg Leu Ser
370 375 380
Ala Ala Gly Ile Ile Cys Asp Phe Arg Glu Pro Asp Ile Ile Arg Ala
385 390 395 400
Ala Pro Thr Pro Leu Tyr Asn Thr Tyr Leu Asp Val Phe Arg Phe Val
405 410 415
Lys Ala Leu Glu Ala His Ala Leu Glu
420 425
<210> 22
<211> 426
<212> PRT
<213> Cyclobacterium marinum DSM 745
<400> 22
Met Asp Gln Ile Ala Phe Glu Leu Thr Pro Glu Phe Ala Arg Lys Met
1 5 10 15
Asp Leu Ala Asp Pro Leu Ser Thr Tyr Arg Glu Lys Phe Tyr Ile Pro
20 25 30
Glu Lys Asn Gly Gln Pro Leu Ile Tyr Phe Cys Gly Asn Ser Leu Gly
35 40 45
Leu Gln Pro Arg Ser Val Asn Ala Tyr Leu Lys Gln Glu Leu Glu Lys
50 55 60
Trp Ala Asp Lys Gly Val Asp Gly His Phe Glu Gly Lys Val Pro Trp
65 70 75 80
Ile Asp Ala Arg Lys Pro Ser Lys Arg Leu Ile Ala Pro Leu Val Gly
85 90 95
Ala Asn Glu Gln Glu Val Val Ala Met Asn Ser Leu Ser Val Asn Leu
100 105 110
His Leu Leu Met Val Ser Phe Tyr Gln Pro Lys Gly Lys Lys Phe Lys
115 120 125
Ile Leu Thr Glu Ala Gly Ala Phe Pro Ser Asp Gln Tyr Ile Leu Glu
130 135 140
Ser Gln Val Lys Phe His Gly Leu Leu Pro Asp Glu Ala Ile Leu Glu
145 150 155 160
Met Ala Pro Arg Pro Asn Glu His Leu Leu Arg Thr Glu Asp Ile Leu
165 170 175
Gln Lys Ile Glu Asp His Lys Asp Glu Leu Ala Leu Ile Met Leu Ser
180 185 190
Gly Leu Gln Tyr Tyr Thr Gly Gln Leu Phe Asp Leu Glu Ala Ile Ser
195 200 205
Ser Ala Ala Asn Lys Gln Gly Ile Thr Ile Gly Phe Asp Leu Ala His
210 215 220
Ala Ile Gly Asn Val Pro Leu Arg Leu His Asp Trp Gly Val Asp Phe
225 230 235 240
Ala Thr Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Asn Val
245 250 255
Ser Gly Ile Phe Val His Glu Lys His Ser Asp Asn Ala Leu Leu Pro
260 265 270
Arg Phe Ala Gly Trp Trp Gly His Asp Glu Lys Glu Arg Phe Lys Met
275 280 285
Lys Lys Gly Phe Lys His Met Pro Gly Ala Asp Gly Trp Leu Leu Ser
290 295 300
Asn Asp Asn Val Leu Gly Leu Ala Ala His Gln Ala Ser Leu Glu Leu
305 310 315 320
Phe Ala Glu Ala Gly Leu Asp Lys Leu Arg Lys Lys Ser Ile Gln Leu
325 330 335
Thr Asn Tyr Leu Glu Phe Ala Ile His Glu Thr Ile Lys Asp Ser Glu
340 345 350
Leu Leu Glu Ile Ile Thr Pro Leu Lys Pro Thr Glu Arg Gly Cys Gln
355 360 365
Leu Ser Leu Leu Ile His Lys Lys Gly Lys Glu Val Phe Asp Tyr Trp
370 375 380
Ile Asp Asn Gly Val Val Ala Asp Trp Arg Asn Pro Asn Val Ile Arg
385 390 395 400
Leu Ala Pro Thr Pro Met Tyr Asn Thr Phe Gln Asp Val Phe Glu Phe
405 410 415
Ser Arg Ile Leu Lys Asn Ser Leu Glu Ala
420 425
<210> 23
<211> 426
<212> PRT
<213> Cystobacter fuscus
<400> 23
Met Ser Gly Glu Ala Val Arg Phe Glu Pro Gly Glu Ala Phe Ala Arg
1 5 10 15
Arg Met Asp Ala Glu Asp Pro Leu Arg Ser Phe Arg Glu Glu Phe Leu
20 25 30
Phe Pro Val His Gly Asp Gly His Glu Leu Tyr Leu Leu Gly Asn Ser
35 40 45
Leu Gly Leu Gln Pro Arg Lys Ala Lys Glu Tyr Val Leu Ala Ala Met
50 55 60
Glu Asp Trp Ala Arg Leu Gly Val Asp Gly His Phe Lys Gly Ser Pro
65 70 75 80
Pro Trp Met Glu Phe His Val Gly Leu Gly Glu Gln Met Ala Arg Val
85 90 95
Val Gly Ala Arg Pro Glu Glu Val Val Val Met Asn Thr Leu Thr Val
100 105 110
Asn Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Pro Glu Arg
115 120 125
Ser Lys Ile Leu Met Glu Ala Ser Ala Phe Pro Ser Asp Gln Tyr Ala
130 135 140
Val Ala Ala Gln Val Arg His His Gly Tyr Ser Pro Glu Gln Thr Val
145 150 155 160
Ile Pro Leu Ala Pro Arg Pro Gly Glu His Thr Leu Arg His Glu Asp
165 170 175
Ile Leu Asp Thr Leu Glu Arg His Gly Lys Glu Ile Ala Leu Val Leu
180 185 190
Leu Gly Asn Val Asn Tyr Leu Thr Gly Gln Ala Phe Asp Met Ala Ala
195 200 205
Ile Thr Arg Ala Ala His Gln Arg Gly Cys Arg Val Gly Phe Asp Leu
210 215 220
Ala His Ala Ala Gly Asn Leu Arg Leu Ser Leu His Glu Asp Gly Pro
225 230 235 240
Asp Phe Ala Val Trp Cys Thr Tyr Lys Tyr Leu Asn Gly Gly Pro Gly
245 250 255
Ala Leu Gly Gly Val Phe Ile His Glu Arg His Leu Arg Asp Ala Ser
260 265 270
Leu His Arg Leu Pro Gly Trp Trp Gly Asn Asp Arg Gly Thr Arg Phe
275 280 285
Gln Met Lys Pro Asp Phe Glu Pro Ala Pro Gly Ala Glu Gly Trp Val
290 295 300
Leu Ser Asn Pro Pro Ile Ile Gln Met Ala Ala Leu Arg Ala Ser Leu
305 310 315 320
Glu Leu Phe Asp Arg Ala Thr Met Pro Ala Leu Arg Ala Lys Ser Glu
325 330 335
Lys Leu Thr Gly Tyr Leu Glu Phe Leu Ile Asp Arg Leu Pro Glu Gly
340 345 350
Phe Val His Ser Leu Thr Pro Arg Asp Pro Gly Gln Arg Gly Ala His
355 360 365
Leu Ser Leu Arg Phe Thr Lys Asp Pro Gln Arg Met Leu Glu Thr Leu
370 375 380
Arg Ala Glu Gly Ile His Cys Asp Phe Arg Tyr Pro Asp Ile Ile Arg
385 390 395 400
Ala Ala Pro Val Pro Leu Tyr Asn Ser Phe Leu Asp Val His Arg Phe
405 410 415
Val Ser Val Leu Glu Arg Tyr Ala Arg Gly
420 425
<210> 24
<211> 426
<212> PRT
<213> Echinicola vietnamensis DSM 17526
<400> 24
Met Ser Ser Tyr Arg Tyr Ser Leu Ala Phe Ala Gln Glu Arg Asp Arg
1 5 10 15
Glu Asp Pro Leu Arg Lys Phe Gln Ser Arg Phe His Phe Pro Lys Val
20 25 30
Asn Gly Glu Ala Ala Ile Tyr Phe Cys Gly Asn Ser Leu Gly Leu Gln
35 40 45
Pro Lys Ala Val Arg Glu His Leu Asp Arg Asp Leu Glu Ser Trp Ala
50 55 60
Ser Lys Ala Val Asp Gly His Phe Glu Gly Asp Ala Pro Trp Phe Ser
65 70 75 80
Val His Glu Arg Ser Lys Ala Ala Leu Ala Glu Ile Val Gly Ala Lys
85 90 95
Lys His Glu Val Val Ala Met Gly Ser Leu Thr Thr Asn Leu His Ala
100 105 110
Leu Leu Val Ser Phe Tyr Gln Pro Asn Gly Lys Arg Asn Lys Ile Leu
115 120 125
Thr Glu Ala Gly Ala Phe Pro Ser Asp Met Tyr Ala Leu Glu Ser Gln
130 135 140
Val Lys Tyr His Gly Leu Asp Pro Asp Glu Ala Ile Val Glu Val Gly
145 150 155 160
Pro Arg Pro Gly Glu His Thr Ile Arg Thr Glu Asp Ile Leu Gln Ala
165 170 175
Ile Ser Lys His Gln Asp Glu Leu Ala Cys Val Met Met Ala Gly Leu
180 185 190
Gln Tyr Tyr Thr Gly Gln Val Phe Asp Met Lys Ala Ile Ala Ser Ala
195 200 205
Ala His Ala Val Gly Ala Thr Val Gly Phe Asp Leu Ala His Ala Ala
210 215 220
Gly Asn Ala Pro Leu His Leu His Asp Trp Gly Val Asp Phe Ala Ala
225 230 235 240
Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Asn Val Ala Gly
245 250 255
Ile Phe Val His Glu Arg His Gly Asn Asn Pro Ala Leu Asn Arg Phe
260 265 270
Ala Gly Trp Trp Gly His Asp Glu Lys Val Arg Phe Lys Met Glu Lys
275 280 285
Gly Phe Val Pro Met Tyr Gly Ala Asp Gly Trp Gln Asn Ser Asn Gly
290 295 300
Asn Val Leu Gly Met Ala Ala His Gln Ala Ser Leu Asp Ile Phe Gln
305 310 315 320
Glu Ala Gly Met Val His Leu Arg Lys Lys Ser Val Gln Leu Thr Gly
325 330 335
Phe Leu Ala Phe Leu Ile Arg Glu Ile Ser Gly Glu Ser Gly Val Leu
340 345 350
Glu Val Ile Thr Pro Asn Ala Glu Ala Glu Arg Gly Cys Gln Leu Ser
355 360 365
Leu Leu Ile His Lys Gly Gly Lys Ala Val Phe Asp Glu Phe Tyr Gln
370 375 380
Asn Gly Ile Val Gly Asp Trp Arg Asn Pro Asn Val Ile Arg Ile Ala
385 390 395 400
Pro Thr Pro Leu Tyr Asn Ser Phe Glu Asp Val Phe Arg Phe Ala Lys
405 410 415
Ile Leu Glu Gln Ser Leu Ser Lys Phe Ala
420 425
<210> 25
<211> 420
<212> PRT
<213> Flavobacteria bacterium BBFL7
<400> 25
Met Glu Phe Asn Thr Thr Arg Asp Tyr Ala Leu Gln Leu Asp Gln Glu
1 5 10 15
Asp Ser Leu Ser Arg Phe Arg Glu Ser Phe His Ile Pro Lys His Thr
20 25 30
Asp Gly Thr Asp Ser Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln
35 40 45
Pro Arg Gln Thr Lys Thr Phe Leu Asn Gln Glu Leu Asp Asp Trp Ala
50 55 60
Lys Leu Gly Val Glu Gly His Phe His Ala Glu Asn Pro Trp Met Pro
65 70 75 80
Tyr His Glu Phe Leu Thr Glu Thr Thr Ala Gln Val Val Gly Ala Lys
85 90 95
Pro His Glu Val Val Ile Met Asn Thr Leu Thr Thr Asn Leu His Leu
100 105 110
Met Met Val Ser Phe Tyr Gln Pro Lys Gly Lys Arg Thr Lys Ile Ile
115 120 125
Ile Glu Ala Asp Ala Phe Pro Ser Asp Arg Tyr Ala Val Ala Ser Gln
130 135 140
Val Gln Phe His Gly His Asp Asp Lys Glu Asn Ile Ile Glu Trp Ala
145 150 155 160
Pro Arg Thr Gly Glu His Thr Pro Arg Leu Glu Asp Leu Glu Thr Ile
165 170 175
Leu Lys Glu Gln Gly Asp Glu Ile Ala Leu Ile Met Val Gly Ala Val
180 185 190
Asn Tyr Tyr Thr Gly Gln Phe Phe Asp Leu Lys Lys Ile Thr Glu Leu
195 200 205
Gly His Ala Ala Gly Ala Met Val Gly Phe Asp Cys Ala His Gly Ala
210 215 220
Gly Asn Val Asp Leu Gln Leu His Asp Ser Gly Ala Asp Phe Ala Val
225 230 235 240
Trp Cys Thr Tyr Lys Tyr Met Asn Ser Gly Pro Gly Ser Leu Gly Gly
245 250 255
Cys Phe Val His Glu Arg His Ala Asn Asn Ser Glu Leu Pro Arg Phe
260 265 270
Thr Gly Trp Trp Gly His Asn Lys Asp Thr Arg Phe Lys Met Arg Asp
275 280 285
Asp Phe Glu Pro Met His Gly Ala Glu Gly Trp Gln Leu Ser Asn Pro
290 295 300
Pro Ile Leu Ser Met Val Ala Ile Arg Ala Ser Leu Asp Leu Phe Ala
305 310 315 320
Gln Ala Gly Phe Glu Asn Leu Arg Lys Lys Ser Ile Gln Leu Thr Asn
325 330 335
Tyr Leu Glu Tyr Leu Val Gly Glu Leu Asp Gly Asp Arg Ile Ser Ile
340 345 350
Ile Thr Pro Arg Asp Pro Lys Asp Arg Gly Cys Gln Leu Ser Leu Ala
355 360 365
Val Lys Asn Ala Asp Lys Ser Leu Phe Asp Ala Ile Thr Ala Lys Gly
370 375 380
Val Ile Ala Asp Trp Arg Glu Pro Asp Val Ile Arg Ile Ala Pro Val
385 390 395 400
Pro Leu Tyr Asn Asn Tyr Glu Asp Cys Trp Arg Phe Val Asp Val Leu
405 410 415
Lys Ser Glu Leu
420
<210> 26
<211> 442
<212> PRT
<213> Flexibacter litoralis DSM 6794
<400> 26
Met Asn Phe Glu Thr Thr Lys Asn Phe Ala Ser Gln Leu Asp Asn Asn
1 5 10 15
Asp Ser Leu Ala His Phe Arg Asp Lys Phe Trp Ile Pro Thr Leu Asn
20 25 30
Ser Ile Ser Lys Asn Thr Asn Ser Ser Asn Glu Lys Gly Lys Glu Lys
35 40 45
Val Val Tyr Phe Cys Gly Asn Ser Leu Gly Leu Gln Pro Lys Thr Thr
50 55 60
Lys Ala Tyr Ile Glu Gln Glu Leu Glu Asp Trp Lys Asn Leu Gly Val
65 70 75 80
Glu Gly His Phe His Gly Lys Asn Pro Trp Leu Ser Tyr His Lys Leu
85 90 95
Leu Thr Asn Gln Thr Ala Lys Ile Val Gly Ala Lys Pro Ile Glu Val
100 105 110
Val Val Met Asn Asn Leu Thr Val Asn Leu His Leu Leu Met Val Ser
115 120 125
Phe Tyr Arg Pro Asn Gln Lys Arg Phe Lys Ile Leu Met Glu Gly Gly
130 135 140
Ala Phe Pro Ser Asp Gln Tyr Ala Ile Glu Ser Gln Val Lys Phe His
145 150 155 160
Gly Phe Ser Pro Asp Asp Ala Ile Val Glu Met Met Pro Arg Lys Asn
165 170 175
Glu Asn Ser Glu Gly Glu Glu Thr Leu Arg Thr Glu Asp Ile Leu Lys
180 185 190
Lys Ile Glu Glu Leu Gly Asp Glu Leu Ala Leu Val Met Phe Gly Gly
195 200 205
Val Asn Tyr Tyr Thr Gly Gln Phe Phe Asp Leu Glu Lys Ile Thr Gln
210 215 220
Ala Ala His Lys Val Gly Ala Thr Ala Gly Phe Asp Leu Ala His Ala
225 230 235 240
Ala Gly Asn Val Pro Leu Lys Leu His Asp Trp Lys Val Asp Phe Ala
245 250 255
Thr Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Ala Gly Gly Thr Ser
260 265 270
Gly Val Phe Ile Asn Glu Lys Tyr Ala Asp Asp Asp Ser Leu Pro Arg
275 280 285
Phe Ala Gly Trp Trp Gly His Asp Glu Lys Asp Arg Phe Lys Met Lys
290 295 300
Lys Gly Phe Ile Pro Met Arg Gly Ala Glu Gly Trp Gln Leu Ser Asn
305 310 315 320
Ala Gln Ile Leu Pro Met Ala Val His Lys Ala Ser Leu Asp Ile Phe
325 330 335
Glu Glu Ala Gly Phe Glu Asn Leu Arg Gln Lys Ser Glu Gln Leu Thr
340 345 350
Val Tyr Met Glu Phe Leu Ile Glu Asn Phe Asn Lys Glu Gln Ser Lys
355 360 365
Ile Lys Ile Lys Ile Ile Thr Pro Lys Asn Lys Leu Glu Arg Gly Cys
370 375 380
Gln Leu Ser Leu Val Phe Asp Lys Glu Gly Lys Lys Tyr His Glu Thr
385 390 395 400
Leu Thr Lys Arg Gly Val Ile Ser Asp Trp Arg Glu Pro Asn Val Ile
405 410 415
Arg Ile Ala Pro Ile Pro Leu Tyr Asn Ser Phe Met Asp Cys Tyr Arg
420 425 430
Phe Tyr Glu Ile Leu Lys Glu Ile Ala Val
435 440
<210> 27
<211> 423
<212> PRT
<213> Formosa sp. AK20
<400> 27
Met Ser Asn Tyr Lys Pro Gly Leu Asp Tyr Ala Lys Glu Gln Asp Gln
1 5 10 15
Asn Asp Ala Leu Ser His Tyr Arg Ser Gln Phe His Ile Pro Lys Asp
20 25 30
Asn Gln Gly Asn Asn Trp Leu Tyr Phe Thr Gly Asn Ser Leu Gly Leu
35 40 45
Gln Pro Lys Ser Thr Gln Lys Tyr Ile Gln Gln Glu Leu Asp Asp Trp
50 55 60
Ala Asn Leu Gly Val Glu Gly His Phe Glu Ala Lys Asn Pro Trp Met
65 70 75 80
Pro Tyr His Glu Phe Leu Thr Asp Ser Met Ala Lys Ile Val Gly Ala
85 90 95
Lys Pro Ile Glu Val Val Thr Met Asn Thr Leu Thr Thr Asn Leu His
100 105 110
Leu Leu Met Val Ser Phe Tyr Gln Pro Thr Lys Thr Lys Tyr Lys Ile
115 120 125
Val Ile Glu Ser Asp Ala Phe Pro Ser Asp Arg Tyr Ala Val Gln Thr
130 135 140
Gln Leu Glu Phe His Gly Phe Asp Ala Asn Glu Gly Leu Ile Glu Trp
145 150 155 160
Lys Pro Arg Gln Gly Glu Glu Leu Leu Asn Leu Asp Asp Leu Glu Thr
165 170 175
Ile Leu Glu Glu Gln Gly Asp Glu Ile Ala Leu Leu Leu Ile Gly Gly
180 185 190
Val Asn Tyr Tyr Thr Gly Gln Tyr Leu Asp Leu Lys Lys Ile Ala Glu
195 200 205
Leu Gly His Ala Lys Asn Cys Met Val Gly Ile Asp Leu Ala His Gly
210 215 220
Ala Gly Asn Ile Lys Pro Glu Leu His Asp Ser Gly Val Asp Phe Ala
225 230 235 240
Ala Trp Cys Thr Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Ser Leu Gly
245 250 255
Gly Leu Phe Val His Glu Lys His Ala His Asn Lys Lys Leu Lys Arg
260 265 270
Phe Ala Gly Trp Trp Ser His Asn Lys Ala Thr Arg Phe Asn Met Arg
275 280 285
Gln Pro Leu Asp Val Ile Pro Gly Ala Glu Gly Trp Gln Leu Ser Asn
290 295 300
Pro Pro Ile Leu Ser Met Ala Ala Ile Lys Ala Ser Leu Asp Met Phe
305 310 315 320
Asn Glu Val Gly Met Asp Ala Leu Arg Glu Lys Ser Glu Lys Leu Thr
325 330 335
Gly Tyr Phe Glu Phe Leu Leu Asn Glu Leu Asn Asn Asp Lys Val Lys
340 345 350
Ile Ile Thr Pro Ser Asn Pro Lys Glu Arg Gly Cys Gln Leu Ser Ile
355 360 365
Gln Val Arg Asp Ala Asp Lys Ser Leu His Lys Lys Leu Thr Lys Ala
370 375 380
His Ile Ile Thr Asp Trp Arg Glu Pro Asp Val Ile Arg Cys Ala Pro
385 390 395 400
Val Pro Leu Tyr Asn Ser Phe Glu Asp Val Tyr Arg Met Val Asp Lys
405 410 415
Leu Lys Gln Ile Leu Asn Thr
420
<210> 28
<211> 429
<212> PRT
<213> Fulvivirga imtechensis
<400> 28
Met Ala Lys Asp Ile Leu His Met Thr Tyr Glu Asn Ser Leu Thr Phe
1 5 10 15
Ala Gln Asp Leu Asp Arg Asp Asp Pro Leu Arg His Phe Arg Asn Lys
20 25 30
Phe His Ile Pro Gln Leu Asn Asp Lys Asp Val Ile Tyr Phe Thr Gly
35 40 45
Asn Ser Leu Gly Leu Gln Pro Lys Asn Thr Arg Val Tyr Ile Glu Glu
50 55 60
Glu Leu Glu Gly Trp Ala Thr Leu Gly Val Asp Gly His Phe His Ser
65 70 75 80
Gln Lys Arg Pro Trp Phe Tyr Tyr His Lys Phe Ser Lys Glu Ala Leu
85 90 95
Ala Lys Ile Val Gly Ala Lys Pro Ser Glu Val Val Ser Met Asn Asn
100 105 110
Leu Thr Val Asn Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr
115 120 125
Ser Ser Arg Phe Lys Ile Met Ile Glu Ala Gly Ala Phe Pro Ser Asp
130 135 140
Gln Tyr Ala Val Glu Ser Gln Ile Lys Phe His Gly Tyr Asn Tyr Glu
145 150 155 160
Asp Ala Leu Ile Glu Ile Ser Pro Arg Glu Gly Glu Tyr His Leu Arg
165 170 175
Thr Glu Asp Ile Leu Ser Lys Ile Glu Glu Asn Lys Asp Ser Leu Ala
180 185 190
Leu Val Leu Phe Gly Gly Val Gln Tyr Tyr Thr Gly Gln Leu Phe Asp
195 200 205
Ile Gly Ser Ile Thr Ala Ala Gly His Trp Ala Gly Ala Ile Val Gly
210 215 220
Phe Asp Leu Ala His Ala Ala Gly Asn Val Pro Leu Asn Leu His Asn
225 230 235 240
Asp Gln Val Asp Phe Ala Ala Trp Cys Ser Tyr Lys Tyr Leu Asn Ser
245 250 255
Gly Pro Gly Gly Val Ser Gly Ile Phe Val His Glu Lys His Gly Asp
260 265 270
Ala Glu Leu Pro Arg Phe Ala Gly Trp Trp Gly His Asn Glu Ser Glu
275 280 285
Arg Phe Lys Met Lys Lys Gly Phe Ile Pro Met Ser Gly Ala Asp Gly
290 295 300
Trp Gln Leu Ser Asn Val Asn Ile Leu Ser Ser Ala Ala His Leu Ala
305 310 315 320
Ala Leu Glu Ile Tyr Asp Glu Ala Gly Met Glu Ala Leu Arg Gln Lys
325 330 335
Ser Ile Arg Leu Thr Gly Phe Met Glu Tyr Leu Leu Asn Gly Phe Asn
340 345 350
Leu Gly Asp Asp Val Leu Lys Ile Ile Thr Pro Thr Asp Pro Ala Ala
355 360 365
Arg Gly Cys Gln Leu Ser Leu Leu Val Ser Lys Asn Gly Lys Ala Ile
370 375 380
Phe Glu His Leu Thr Arg Ser Gly Val Val Ala Asp Trp Arg Glu Pro
385 390 395 400
Asp Val Ile Arg Val Ala Pro Val Pro Leu Tyr Asn Thr Phe Glu Asp
405 410 415
Val Tyr Asn Phe Cys Glu Ile Leu Lys Lys Val Ile Phe
420 425
<210> 29
<211> 425
<212> PRT
<213> Kangiella aquimarina
<400> 29
Met Thr Asp Ile Phe Ser Ile Asp Tyr Ala Arg Gln Leu Asp Gln Gln
1 5 10 15
Asp Pro Ile Ser Arg Met Arg Glu Gln Phe His Ile Pro Lys Gln Asp
20 25 30
Asn Gly Asp Asp Glu Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln
35 40 45
Pro Lys Arg Thr Gln Glu Tyr Leu Asn Tyr Glu Leu Ser Gln Trp Gln
50 55 60
Lys Leu Gly Val Lys Gly His Phe Ser Gly Asp Phe Pro Trp Met Pro
65 70 75 80
Tyr His Glu Phe Leu Thr Glu Glu Ser Ala Lys Leu Val Gly Ala Lys
85 90 95
Asn Ser Glu Val Val Cys Met Asn Ser Leu Thr Ala Asn Leu His Phe
100 105 110
Met Met Val Ser Phe Tyr Arg Pro Thr Ala Thr Arg Asn Lys Ile Leu
115 120 125
Ile Glu Asp His Ala Phe Pro Ser Asp His Tyr Ala Val Glu Ser Gln
130 135 140
Val Arg Tyr His Gly Phe Asp Pro Asp Gln Ala Met Leu Leu Ala Lys
145 150 155 160
Pro Arg Glu Gly Glu Glu Thr Leu Arg Thr Glu Asp Leu Leu Asn Leu
165 170 175
Ile Glu Leu His Gly Glu Glu Ile Ala Leu Ile Met Leu Pro Gly Val
180 185 190
Gln Tyr Tyr Thr Gly Gln Val Leu Asp Met Lys Ala Ile Thr Gln Ala
195 200 205
Gly His Ala Lys Gly Cys Lys Val Gly Phe Asp Leu Ala His Ala Thr
210 215 220
Gly Asn Ile Pro Met His Leu His Asp Trp Asp Val Asp Phe Ala Ala
225 230 235 240
Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Ser Val Ala Gly
245 250 255
Cys Phe Val His Glu Lys His His Thr Asn Met Glu Leu Pro Arg Phe
260 265 270
Ala Gly Trp Trp Gly His Asp Lys Asp Ser Arg Phe Lys Met Glu Asn
275 280 285
His Phe Ile Pro Met Lys Ser Ala Glu Ala Trp Gln Leu Ser Asn Pro
290 295 300
Pro Ile Leu Ser Leu Ala Ala Ile Arg Ala Ser Leu Asp Thr Ile Lys
305 310 315 320
Asp Ala Gly Gly Ile Gln Ala Leu Arg Asp Lys Ser Leu Lys Leu Ser
325 330 335
Arg Tyr Leu Arg Asp Leu Leu Glu Gln Glu Leu Ala Asp Glu Ile Asn
340 345 350
Ile Leu Thr Pro Ala Asp Glu Lys Ala Ser Gly Cys Gln Leu Ser Leu
355 360 365
Thr Val Asn Leu His Gly Leu Asp Gly Lys Thr Val Phe Asp Arg Ile
370 375 380
Glu Ala Ala Gly Val Thr Cys Asp Phe Arg His Pro Asn Val Ile Arg
385 390 395 400
Val Ala Pro Val Pro Leu Tyr Asn Ser Phe Glu Asp Ala Tyr Arg Phe
405 410 415
Val Thr Ile Leu Lys Asp Ser Leu Lys
420 425
<210> 30
<211> 425
<212> PRT
<213> Kangiella koreensis DSM 16069
<400> 30
Met Asn Asn Leu Phe Ser Leu Glu His Ala Gln Gln Leu Asp Gln Gln
1 5 10 15
Asp Pro Leu His His Met Arg Asp Gln Phe His Ile Pro Lys Gln Asp
20 25 30
Asn Gly Asp Asp Glu Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln
35 40 45
Pro Lys Arg Thr Gln Glu Tyr Leu Asn Tyr Glu Leu Asn Gln Trp Gln
50 55 60
Lys Leu Gly Val Lys Gly His Phe Ser Gly Asp Phe Pro Trp Met Pro
65 70 75 80
Tyr His Glu Phe Leu Thr Glu Glu Ser Ala Lys Leu Val Gly Ala Lys
85 90 95
Asn Thr Glu Val Val Cys Met Asn Ser Leu Thr Ala Asn Leu His Phe
100 105 110
Met Met Val Ser Phe Tyr Arg Pro Ser Lys Thr Arg Asn Lys Ile Leu
115 120 125
Ile Glu Asp His Ala Phe Pro Ser Asp His Tyr Ala Val Glu Ser Gln
130 135 140
Ile Arg Phe His Gly Phe Asp Pro Asp Gln Ala Met Leu Leu Ala Lys
145 150 155 160
Pro Arg Glu Gly Glu Glu Thr Leu Arg Thr Glu Asp Leu Leu Asn Leu
165 170 175
Ile Glu Met His Gly Asp Glu Ile Ala Leu Ile Met Leu Pro Gly Val
180 185 190
Gln Tyr Tyr Thr Gly Gln Val Leu Asp Met Lys Thr Ile Thr Glu Ala
195 200 205
Gly His Ala Lys Gly Cys Met Val Gly Phe Asp Leu Ala His Ala Thr
210 215 220
Gly Asn Ile Pro Met Asn Leu His Asp Trp Asn Val Asp Phe Ala Ala
225 230 235 240
Trp Cys Thr Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Ser Val Ala Gly
245 250 255
Cys Phe Val His Glu Lys His His Ser Asn Leu Glu Leu Pro Arg Phe
260 265 270
Ala Gly Trp Trp Gly His Asp Lys Glu Ser Arg Phe Arg Met Glu Asn
275 280 285
Arg Phe Val Pro Met Gln Ser Ala Glu Ala Trp Gln Val Ser Asn Pro
290 295 300
Pro Ile Leu Ser Leu Ala Ala Ile Arg Ala Ser Leu Asp Thr Val Lys
305 310 315 320
Glu Ala Gly Gly Ile Asp Ala Leu Arg Glu Lys Ser Leu Lys Leu Thr
325 330 335
Arg Tyr Leu Arg Asp Leu Leu Glu Gln Glu Leu Ser Glu Glu Ile Asn
340 345 350
Ile Leu Thr Pro Ala Asp Asn Ser Ala Ser Gly Cys Gln Leu Ser Leu
355 360 365
Thr Val Asn Leu His Val Leu Asp Gly Lys Thr Val Phe Asp Arg Ile
370 375 380
Glu Ala Ala Gly Val Thr Cys Asp Phe Arg His Pro Asn Val Ile Arg
385 390 395 400
Val Ala Pro Val Pro Leu Tyr Asn Ser Phe Glu Asp Ala Tyr Arg Phe
405 410 415
Val Ser Ile Leu Lys Asp Ser Leu Gln
420 425
<210> 31
<211> 421
<212> PRT
<213> Lacinutrix sp. 5H-3-7-4
<400> 31
Met Ser Asn Tyr Thr Leu Gly Arg Asp Phe Ala Gln Gln Leu Asp Lys
1 5 10 15
Glu Asp Gln Leu Ala His Tyr Arg Asn Gln Phe His Ile Pro Lys Asp
20 25 30
Lys Asn Gly Asp Asp Leu Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu
35 40 45
Gln Pro Lys Val Thr Lys Asp Tyr Ile Asn Gln Glu Leu Glu Asp Trp
50 55 60
Ala Asn Leu Gly Val Glu Gly His Thr Glu Gly Lys Asn Pro Trp Leu
65 70 75 80
Pro Tyr His Glu Phe Leu Thr Glu Ser Met Ala Lys Val Val Gly Ala
85 90 95
Lys Pro Ile Glu Val Val Val Met Asn Thr Leu Thr Ala Asn Leu His
100 105 110
Phe Met Met Val Ser Phe Tyr Lys Pro Thr Lys Lys Arg Tyr Lys Ile
115 120 125
Leu Ile Glu Ala Asp Ala Phe Pro Ser Asp Lys Tyr Ala Val Glu Ser
130 135 140
Gln Leu Arg His His Gly Phe Asp Asp Lys Glu Gly Leu Val Leu Trp
145 150 155 160
Lys Ala Arg Glu Gly Glu Glu Leu Ala Asn Tyr Glu Asp Leu Glu Ala
165 170 175
Ile Leu Glu Ala Gln Gly Asp Glu Ile Ala Leu Ile Met Ile Gly Gly
180 185 190
Val Asn Tyr Tyr Thr Gly Gln Phe Phe Asp Phe Lys Arg Ile Ala Ala
195 200 205
Leu Gly His Lys Asn Gly Cys Met Val Gly Phe Asp Cys Ala His Gly
210 215 220
Ala Gly Asn Val Asn Leu Asp Leu His Asn Ser Gly Ala Asp Phe Ala
225 230 235 240
Val Trp Cys Thr Tyr Lys Tyr Met Asn Ala Gly Pro Gly Ser Leu Ser
245 250 255
Gly Cys Phe Val His Glu Arg His Ala His Asn Lys Asp Leu Asn Arg
260 265 270
Phe Thr Gly Trp Trp Ser His Asn Lys Glu Thr Arg Phe Asn Met Arg
275 280 285
Gly Glu Phe Asp Gln Leu Pro Gly Ala Glu Gly Trp Gln Leu Ser Asn
290 295 300
Pro Pro Ile Leu Ser Met Ala Ala Ile Lys Ala Ser Ala Asp Ile Phe
305 310 315 320
Ala Glu Val Gly Met Glu Lys Leu Thr Gln Lys Ser Lys Lys Leu Thr
325 330 335
Gly Tyr Phe Glu Phe Leu Leu Asn Glu Leu Asn Asn Ser Asp Ile Lys
340 345 350
Ile Ile Thr Pro Ser Asn Pro Asn Glu Arg Gly Cys Gln Leu Ser Ile
355 360 365
Gln Val Lys Asn Ala Asp Lys Ala Leu His His Lys Leu Thr Glu Ser
370 375 380
Gly Val Ile Ser Asp Trp Arg Glu Pro Asp Val Ile Arg Cys Ala Pro
385 390 395 400
Val Pro Leu Tyr Asn Ser Phe Glu Asp Val Tyr Asn Met Val Glu Arg
405 410 415
Leu Lys Ala Cys Leu
420
<210> 32
<211> 428
<212> PRT
<213> Cecembia lonarensis
<400> 32
Met Thr Thr Thr Asp Phe Glu Tyr Thr Glu Asp Phe Ala Lys Arg Met
1 5 10 15
Asp Asp Leu Asp Pro Phe Arg His Phe Arg Ser Met Phe His Phe Pro
20 25 30
Tyr Val Asn Gly Lys Glu Ala Ile Tyr Phe Cys Gly Asn Ser Leu Gly
35 40 45
Leu Gln Pro Lys Ser Val Arg Glu Tyr Leu Asp Arg Glu Leu Lys Asn
50 55 60
Trp Glu Leu Met Ala Val Asp Gly His Phe His Gly Glu Asp Ala Trp
65 70 75 80
Tyr His Val Arg Lys Lys Ser Lys Pro Ala Leu Ala Glu Ile Val Gly
85 90 95
Ala His Glu His Glu Val Val Ala Met Asn Asn Leu Ser Ser Asn Leu
100 105 110
His Phe Leu Met Val Ser Phe Tyr Arg Pro Thr Lys Glu Arg Tyr Lys
115 120 125
Ile Ile Thr Glu Ala Gly Ala Phe Pro Ser Asp Met Tyr Met Leu Glu
130 135 140
Thr Gln Val Lys Phe His Gly Phe Asp Pro Ala Asp Ala Ile Ile Glu
145 150 155 160
Val Ala Pro Arg Pro Gly Glu Tyr Thr Ile Arg Thr Glu Asp Ile Leu
165 170 175
Ala Ala Ile Glu Asp Asn Gln Asp Glu Leu Ala Leu Val Met Met Ala
180 185 190
Gly Leu Gln Tyr Tyr Thr Gly Gln Val Phe Asp Met Glu Ala Ile Thr
195 200 205
Lys Ala Gly His Gly Ile Gly Val Pro Val Gly Phe Asp Leu Ala His
210 215 220
Ala Ala Gly Asn Ile Pro Leu Arg Leu His Asp Trp Gly Val Asp Phe
225 230 235 240
Ala Ala Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Asn Ile
245 250 255
Ser Gly Ile Phe Val His Glu Arg His Ala Asp Asn Thr Glu Leu Pro
260 265 270
Arg Phe Gly Gly Trp Trp Gly His Asp Glu Ala Ile Arg Phe Lys Met
275 280 285
Glu Lys Gly Phe Glu Pro Met Tyr Gly Ala Asp Gly Trp Gln Leu Ala
290 295 300
Asn Ser Asn Val Leu Ala Leu Ala Val His Gln Ala Ser Leu Asp Ile
305 310 315 320
Phe Gln Glu Ala Gly Met Glu Arg Leu Arg Thr Lys Ser Glu Leu Leu
325 330 335
Thr Gly Tyr Leu Glu Phe Leu Ile Arg Lys Val Gly Phe Ala Asn Gly
340 345 350
Val Leu Glu Ile Ile Thr Pro Asn Asn Pro Lys Glu Arg Gly Cys Gln
355 360 365
Leu Ser Leu Leu Val His Lys Gly Gly Lys Leu Val Phe Asp His Leu
370 375 380
Tyr Ala Asn Gly Val Val Gly Asp Trp Arg His Pro Asn Val Ile Arg
385 390 395 400
Val Ala Pro Thr Pro Leu Tyr Asn Ser Phe Thr Asp Val Phe Arg Phe
405 410 415
Ala Lys Ile Leu Glu His Ser Leu Gln Lys Phe Ala
420 425
<210> 33
<211> 429
<212> PRT
<213> Mucilaginibacter paludis
<400> 33
Met Asn Tyr Gln Asn Thr Leu Ala Phe Ala Arg Glu Leu Asp Glu Gln
1 5 10 15
Asp Asn Leu Ala Gly Phe Arg Asn Glu Phe Ile Ile Pro Gln His His
20 25 30
Gly Arg Asp Met Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln Pro
35 40 45
Lys Ala Thr Ala Gly Val Ile Ala Glu Gln Leu Ser Asn Trp Gly Ser
50 55 60
Leu Ala Val Glu Gly Trp Phe Glu Gly Asp Ser Pro Trp Met His Tyr
65 70 75 80
His Lys Lys Leu Thr Glu Pro Leu Ala Ala Ile Val Gly Ala Leu Asn
85 90 95
Thr Glu Val Val Ala Met Asn Thr Leu Thr Val Asn Leu His Phe Leu
100 105 110
Leu Val Ser Phe Tyr Arg Pro Thr Ala Lys Lys Tyr Lys Ile Leu Met
115 120 125
Glu Gly Gly Ala Phe Pro Ser Asp Gln Tyr Ala Ile Glu Ser Gln Val
130 135 140
His Phe His Gly Tyr Gln Pro Asp Asp Ala Ile Ile Glu Val Phe Pro
145 150 155 160
Arg Ala Gly Glu Asp Thr Leu Arg Thr Glu Asp Ile Ile Arg Thr Ile
165 170 175
His Asp His Ala Asp Asp Leu Ala Leu Val Leu Phe Gly Gly Ile Asn
180 185 190
Tyr Tyr Thr Gly Gln Phe Tyr Asp Leu Glu Gln Ile Thr Gln Ala Ala
195 200 205
His Gln Val Gly Ala Tyr Ala Gly Phe Asp Leu Ala His Ala Ala Gly
210 215 220
Asn Val Pro Leu Gln Leu His His Trp Gln Val Asp Phe Ala Cys Trp
225 230 235 240
Cys Ser Tyr Lys Tyr Met Asn Ser Ser Pro Gly Gly Ile Ser Gly Ala
245 250 255
Phe Ile His Glu Lys His Phe Gly Asn Lys Glu Leu Asn Arg Phe Ala
260 265 270
Gly Trp Trp Gly Tyr Arg Glu Asp Lys Arg Phe Glu Met Lys Pro Gly
275 280 285
Phe Lys Pro Gln Glu Gly Ala Glu Gly Trp Gln Val Ser Cys Ser Pro
290 295 300
Leu Leu Leu Met Ala Ala His Lys Ala Ser Leu Asn Val Phe Glu Lys
305 310 315 320
Ala Gly Tyr Ile Glu Pro Leu Arg Lys Lys Ser Lys Leu Leu Thr Gly
325 330 335
Tyr Leu Glu Tyr Leu Ile Glu Gly Ile Asn Thr Ala His Gln Lys Gln
340 345 350
Leu Phe Lys Ile Ile Thr Pro Lys Asn Glu Asn Glu Arg Gly Cys Gln
355 360 365
Leu Ser Ile Val Cys Asp Asn Gly Lys Ala Ile Phe Asp Gln Leu Val
370 375 380
Glu Gly Gly Val Leu Gly Asp Trp Arg Glu Pro Asp Val Ile Arg Leu
385 390 395 400
Ser Pro Ile Pro Leu Tyr Asn Ser Phe Glu Asp Val Tyr Leu Ala Gly
405 410 415
Lys Leu Leu Ala Gly Ser Val Thr Gln Phe Phe Ala Glu
420 425
<210> 34
<211> 425
<212> PRT
<213> Myroides odoratimimus
<400> 34
Met Ser Phe Glu Asn Thr Leu Ala Tyr Ala Lys Ser Leu Asp Glu Lys
1 5 10 15
Asp Pro Leu Ala Lys Tyr Arg Asp Glu Phe Asn Phe Pro Glu Val Asn
20 25 30
Gly Lys Gln Val Ile Tyr Phe Thr Gly Asn Ser Leu Gly Leu Gln Pro
35 40 45
Lys Arg Ala Val Glu Tyr Val Asn Glu Val Met Asn Asp Trp Gly Ala
50 55 60
Leu Ala Val Glu Gly His Phe Tyr Ala Glu Lys Pro Trp Trp Asp Tyr
65 70 75 80
His Glu Arg Leu Ser Glu Pro Leu Ser Arg Ile Val Gly Ala Lys Ser
85 90 95
Ser Glu Ile Thr Val Met Asn Thr Leu Thr Val Asn Leu His Leu Leu
100 105 110
Met Thr Thr Phe Tyr Arg Pro Thr Ala Ser Lys Tyr Lys Ile Ile Cys
115 120 125
Glu Glu Lys Ala Phe Pro Ser Asp Gln Tyr Leu Ile Gln Ser Gln Val
130 135 140
Arg Leu His Gly Leu Asp Pro Lys Glu Ala Ile Ile Glu Leu Lys Lys
145 150 155 160
Arg Pro Gly Glu His Asn Phe Arg Leu Glu Asp Ile Leu Glu Lys Ile
165 170 175
Asp Glu Val Gly Glu Glu Val Ala Leu Val Leu Ile Gly Gly Leu Asn
180 185 190
Tyr Tyr Thr Gly Gln Val Phe Asp Ile Gln Thr Ile Thr Ala His Ala
195 200 205
His Gln Tyr Gly Ala Lys Val Gly Trp Asp Leu Ala His Ala Ala Gly
210 215 220
Asn Ile Glu Leu Lys Leu His Glu Trp Asn Val Asp Phe Ala Ala Trp
225 230 235 240
Cys Ser Tyr Lys Tyr Met Asn Ala Gly Pro Gly Ser Ala Ser Gly Cys
245 250 255
Phe Ile His Glu Arg Tyr His Thr Asp Lys Asp Leu Val Arg Leu Ala
260 265 270
Gly Trp Trp Gly His Asn Lys Glu Arg Arg Phe Leu Met Glu Lys Lys
275 280 285
Phe Asp Ala Val Glu Ser Ala His Gly Trp Gln Ile Ser Asn Pro Ser
290 295 300
Ile Leu Ser Leu Ala Pro Tyr Leu Ala Ser Ile Glu Met Phe Asp Glu
305 310 315 320
Val Gly Met Glu Ala Leu Ile Thr Lys Gln Arg Lys Ile Thr Ala Tyr
325 330 335
Leu Glu Phe Val Met Glu Asp Val Ala Lys Ala Val Asn Ala Asn Tyr
340 345 350
Glu Leu Ile Thr Pro Lys Glu Glu Ser Glu Arg Gly Ser Gln Leu Ser
355 360 365
Val Phe Leu His Gly Lys Gly Lys Asp Leu Phe Ser Tyr Leu Met Asn
370 375 380
Glu Gly Val Ile Val Asp Trp Arg Glu Pro Asn Val Val Arg Leu Ala
385 390 395 400
Pro Val Pro Phe Tyr Thr Ser Tyr Glu Asp Ile Tyr Arg Phe Gly Glu
405 410 415
Ile Leu Lys Lys Ala Asp Ser Leu Phe
420 425
<210> 35
<211> 426
<212> PRT
<213> Myxococcus fulvus HW-1
<400> 35
Met Thr Thr Pro His Ala Phe Glu Asp Thr Glu Ala Phe Ala His Thr
1 5 10 15
Leu Asp Ala Glu Asp Ala Leu Arg Gly Tyr Arg Asp Ala Phe His Phe
20 25 30
Pro Pro Gly Pro Asp Gly Lys Pro Val Val Tyr Leu Ala Gly Asn Ser
35 40 45
Leu Gly Leu Gln Pro Arg Asn Ala Ala Arg Tyr Ile Gln Glu Glu Leu
50 55 60
Glu Asp Trp Ala Arg Leu Gly Val Glu Gly His His His Gly Arg His
65 70 75 80
Pro Trp Leu His Tyr His Glu Leu Val Thr Glu Gln Ala Ala Arg Leu
85 90 95
Val Gly Ala Lys Pro Leu Glu Val Val Val Met Asn Thr Leu Ser Val
100 105 110
Asn Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Lys Gln Arg
115 120 125
Phe Lys Ile Leu Val Glu Ala Gly Ala Phe Pro Ser Asp Gln Tyr Ala
130 135 140
Val Ala Ser Gln Val Arg Phe His Gly His Asp Ala Arg Glu Ala Val
145 150 155 160
Leu Glu Leu Lys Pro Arg Glu Gly Glu Glu Thr Leu Arg Thr Glu Asp
165 170 175
Ile Leu Asp Thr Leu Glu Arg His Gly His Glu Val Ala Leu Val Met
180 185 190
Leu Gly Ser Val Asn Tyr Leu Thr Gly Gln Ala Phe Asp Leu Ala Ala
195 200 205
Ile Thr Lys Ala Ala His Ala Lys Gly Cys Leu Val Gly Phe Asp Leu
210 215 220
Ala His Gly Ala Gly Asn Leu Lys Leu Ser Leu His Asp Asp Gly Pro
225 230 235 240
Asp Phe Ala Val Trp Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Pro Gly
245 250 255
Ala Leu Gly Gly Val Phe Val His Glu Arg His Ala His Thr Lys Asp
260 265 270
Leu Pro Arg Phe Glu Gly Trp Trp Gly His Asp Lys Gln Thr Arg Phe
275 280 285
Gln Met Gly Pro Thr Phe His Ala Leu Pro Gly Ala Glu Gly Trp Gln
290 295 300
Leu Ser Asn Pro Pro Ile Phe Gln Leu Ala Ala Leu Arg Ala Ser Leu
305 310 315 320
Glu Leu Phe Asp Gln Ala Gly Met Ala Ala Leu Arg Ala Lys Ser Glu
325 330 335
Arg Leu Thr Gly Tyr Leu Glu Phe Leu Leu Asp Lys Leu Pro Gln Gly
340 345 350
Phe Val Arg Ile Thr Thr Pro Arg Asp Val Lys Gln Arg Gly Ala Gln
355 360 365
Leu Ser Leu Arg Phe Arg Gly Glu Pro Gln Gly Leu Leu Lys Arg Met
370 375 380
Gly Asp Ala Gly Ile Val Cys Asp Phe Arg Lys Pro Asp Ile Ile Arg
385 390 395 400
Ala Ala Pro Ala Pro Leu Tyr Asn Ser Phe Thr Asp Val Tyr Arg Phe
405 410 415
Val Lys Ala Leu Glu Gly Tyr Ala Arg Glu
420 425
<210> 36
<211> 425
<212> PRT
<213> Myxococcus stipitatus DSM 14675
<400> 36
Met Thr Thr His Ser Phe Glu Asp Thr Glu Asp Phe Ala Arg Arg Ala
1 5 10 15
Asp Glu Ala Asp Ala Leu Arg Ser Phe Arg Asp Ala Phe His Phe Pro
20 25 30
Pro Gly Thr Asp Gly Lys Pro Leu Val Tyr Leu Ala Gly Asn Ser Leu
35 40 45
Gly Leu Gln Pro Lys Asn Ala Ala Arg Tyr Val Gln Glu Glu Leu Glu
50 55 60
Asp Trp Ala Arg Phe Gly Val Glu Gly His His His Gly Arg His Pro
65 70 75 80
Trp Leu His Tyr His Glu Leu Val Thr Glu Gln Ala Ala Arg Leu Val
85 90 95
Gly Ala Lys Pro Gln Glu Val Val Val Met Asn Thr Leu Thr Val Asn
100 105 110
Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Lys Thr Arg Phe
115 120 125
Lys Ile Leu Val Glu Gly Gly Ala Phe Pro Ser Asp Gln Tyr Ala Val
130 135 140
Ala Ser Gln Ala Arg Phe His Gly Tyr Asp Pro Arg Glu Ala Ile Leu
145 150 155 160
Glu Leu Lys Pro Arg Pro Gly Glu Glu Thr Leu Arg Thr Glu Asp Ile
165 170 175
Leu Ala Thr Leu Asp Gln His Gly His Glu Val Ala Leu Val Met Leu
180 185 190
Gly Ser Val Asn Tyr Leu Thr Gly Gln Ala Phe Asp Ile Pro Ala Ile
195 200 205
Thr Lys Thr Ala His Ala Lys Gly Cys Phe Val Gly Phe Asp Leu Ala
210 215 220
His Gly Ala Gly Asn Leu Lys Leu Ala Leu His Asp Asp Gly Pro Asp
225 230 235 240
Phe Ala Val Trp Cys Ser Tyr Lys Tyr Leu Asn Gly Gly Pro Gly Ala
245 250 255
Leu Ala Gly Val Phe Val His Glu Arg His Ala Arg Ser Lys Asp Ile
260 265 270
Pro Arg Phe Glu Gly Trp Trp Gly His Asp Lys Ala Thr Arg Phe Gln
275 280 285
Met Gly Pro Thr Phe Asp Pro Leu Pro Gly Ala Glu Gly Trp Gln Leu
290 295 300
Ser Asn Pro Pro Ile Leu Gln Leu Ala Ala Leu Arg Ala Ser Phe Glu
305 310 315 320
Leu Phe Asp Gln Ala Gly Met Glu Ala Leu Arg Ala Lys Ser Glu Lys
325 330 335
Leu Thr Gly Tyr Leu Glu Phe Leu Leu Glu Lys Leu Pro Pro Gly Phe
340 345 350
Val Arg Ile Ile Thr Pro Arg Asp Val Lys Gln Arg Gly Ala Gln Leu
355 360 365
Ser Leu Arg Phe Lys Gly Glu Ala Gln Gly Met Leu Lys Arg Leu Ser
370 375 380
Asp Ala Gly Ile Ile Cys Asp Phe Arg Lys Pro Asp Ile Ile Arg Ala
385 390 395 400
Ala Pro Ala Pro Leu Tyr Cys Ser Phe Thr Asp Val Tyr Arg Phe Val
405 410 415
Arg Thr Leu Glu Ala His Ala Arg Asp
420 425
<210> 37
<211> 426
<212> PRT
<213> Myxococcus xanthus DK 1622
<400> 37
Met Thr Thr Pro Tyr Leu Phe Glu Asp Ser Glu Ser Phe Ala Arg Lys
1 5 10 15
Leu Asp Ala Glu Asp Ala Leu Arg Gly Tyr Arg Asp Ala Phe His Phe
20 25 30
Pro Pro Gly Pro Asp Gly Lys Pro Val Val Tyr Leu Ala Gly Asn Ser
35 40 45
Leu Gly Leu Gln Pro Arg Asn Ala Ala Arg Tyr Ile Gln Glu Glu Leu
50 55 60
Glu Asp Trp Ala Arg Leu Gly Val Glu Gly His His His Gly Arg His
65 70 75 80
Pro Trp Leu His Tyr His Glu Leu Val Thr Glu His Ala Ala Arg Leu
85 90 95
Val Gly Ala Lys Pro Leu Glu Val Val Val Met Asn Thr Leu Ser Val
100 105 110
Asn Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Lys Gln Arg
115 120 125
Phe Lys Ile Leu Val Glu Ala Gly Ala Phe Pro Ser Asp Gln Tyr Ala
130 135 140
Val Ala Ser Gln Val Arg Phe His Gly Tyr Asp Ala Arg Glu Ala Val
145 150 155 160
Leu Glu Leu Lys Pro Arg Glu Gly Glu Glu Thr Leu Arg Thr Glu Asp
165 170 175
Ile Leu Glu Thr Ile Glu Arg His Gly His Glu Val Ala Leu Val Met
180 185 190
Leu Gly Ser Val Asn Tyr Leu Thr Gly Gln Ala Phe Asp Leu Ala Ala
195 200 205
Ile Thr Lys Ala Ala His Ala Lys Gly Cys Phe Val Gly Phe Asp Leu
210 215 220
Ala His Gly Ala Gly Asn Leu Arg Leu Ser Leu His Asp Asp Gly Pro
225 230 235 240
Asp Phe Ala Val Trp Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Pro Gly
245 250 255
Ala Leu Gly Gly Val Phe Val His Glu Arg His Ala His Thr Lys Asp
260 265 270
Leu Pro Arg Phe Glu Gly Trp Trp Gly His Asp Lys Gln Thr Arg Phe
275 280 285
Gln Met Gly Pro Thr Phe Ser Ala Leu Pro Gly Ala Glu Gly Trp Gln
290 295 300
Leu Ser Asn Pro Pro Ile Phe Gln Leu Ala Ala Leu Arg Ala Ser Leu
305 310 315 320
Glu Leu Phe Asp Gln Ala Gly Met Ala Ala Leu Arg Ala Lys Ser Glu
325 330 335
Arg Leu Thr Gly Tyr Leu Glu Phe Leu Leu Asp Arg Leu Pro Glu Gly
340 345 350
Phe Val Arg Ile Thr Thr Pro Arg Asp Val Lys Gln Arg Gly Ala Gln
355 360 365
Leu Ser Leu Arg Phe Arg Gly Glu Pro Gln Gly Leu Leu Lys Arg Leu
370 375 380
Gly Asp Ala Gly Ile Ile Cys Asp Phe Arg Lys Pro Asp Ile Ile Arg
385 390 395 400
Ala Ala Pro Ala Pro Leu Tyr Asn Ser Phe Thr Asp Val Tyr Arg Phe
405 410 415
Val Lys Thr Leu Glu Gly His Ala Arg Glu
420 425
<210> 38
<211> 428
<212> PRT
<213> Nafulsella turpanensis
<400> 38
Met Ile Asn Gln Tyr Gln Ser Asn Gln Ala Tyr Ala Arg Glu Gln Asp
1 5 10 15
Ala Arg Asp Pro Leu Arg Gln Phe Arg Glu Gln Phe Ile Ile Pro Pro
20 25 30
Ala Lys Ser Gly Gly Glu Ala Ile Tyr Phe Cys Gly Asn Ser Leu Gly
35 40 45
Leu Gln Pro Lys Asn Thr Arg Ser Tyr Leu Asp Arg Glu Leu Glu Lys
50 55 60
Trp Ala Thr Tyr Ala Val Asp Gly His Phe His Ala Pro Glu Pro Trp
65 70 75 80
Leu His Tyr His Arg Leu Leu Lys Glu Pro Leu Ala Arg Ile Val Gly
85 90 95
Ala Lys Pro Glu Glu Val Val Val Met Asn Asn Leu Ser Ser Asn Leu
100 105 110
His Phe Leu Met Val Ser Phe Tyr Gln Pro Thr Thr Lys Arg Tyr Lys
115 120 125
Val Leu Met Glu Gly Gly Ala Phe Pro Ser Asp Gln Tyr Ala Val Glu
130 135 140
Ser Gln Val Lys Phe Arg Gly Tyr Thr Pro Glu Glu Ala Ile Val Glu
145 150 155 160
Val Phe Pro Arg Glu Gly Glu Gln Thr Leu Arg Thr Glu Asp Ile Leu
165 170 175
Ala Ala Ile Glu Gln His Gln Asp Glu Leu Ala Leu Val Leu Phe Ala
180 185 190
Gly Leu Gln Tyr Tyr Thr Gly Gln Val Phe Asp Met Ala Ala Ile Thr
195 200 205
Lys Ala Gly Gln Ala Ala Gly Ala Lys Val Gly Phe Asp Leu Ala His
210 215 220
Ala Ala Gly Asn Val Pro Leu Gln Leu His Asp Trp Gly Val Asp Phe
225 230 235 240
Ala Ala Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Ser Asn
245 250 255
Ser Gly Ile Phe Val His Glu Arg Tyr Ala Asn Gln Ala Glu Leu Pro
260 265 270
Arg Phe Ala Gly Trp Trp Gly His Asp Glu Lys Glu Arg Phe Leu Met
275 280 285
Gln Lys Gly Phe Lys Pro Met Tyr Gly Ala Asp Gly Trp Gln Leu Ser
290 295 300
Asn Gly Asn Ile Leu Pro Leu Ala Ala Gln Arg Ala Ser Leu Glu Ile
305 310 315 320
Phe Glu Gln Ala Gly Met Asp Asn Leu Arg Gln Lys Ser Ile Gln Leu
325 330 335
Thr Gly Tyr Leu Glu Tyr Leu Ile Arg Glu Glu Val Ser Ser Lys Ala
340 345 350
Asn Arg Leu Gln Ile Ile Thr Pro Ser Gln Pro Glu Glu Arg Gly Cys
355 360 365
Gln Leu Ser Leu Phe Val Glu Lys Asn Gly Lys Gln Leu Phe Glu Gln
370 375 380
Ile Ser Gln Ala Gly Val Val Gly Asp Trp Arg Glu Pro Asn Val Ile
385 390 395 400
Arg Val Ala Pro Thr Pro Leu Tyr Asn Thr Phe Thr Asp Val Phe Gln
405 410 415
Phe Ala Gln Leu Leu Lys Lys Ala Ile Lys Glu Gln
420 425
<210> 39
<211> 428
<212> PRT
<213> Niastella koreensis GR20-10
<400> 39
Met Ile Phe Glu Asn Ser His Ser Phe Ala Tyr Val Leu Asp Glu Gln
1 5 10 15
Asp Glu Leu Arg Ser Phe Arg Glu Gln Phe Ile Met Pro Val Ile Asp
20 25 30
Gly Lys Gln Gln Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro
35 40 45
Lys Arg Thr Asn Asp Tyr Leu Gln Gln Val Leu Asn Lys Trp Ala Asn
50 55 60
Tyr Gly Val Glu Gly Phe Phe Met Gly Glu Gln Pro Trp Leu Gln Tyr
65 70 75 80
His Asp His Leu Thr Lys Pro Leu Ser Thr Ile Val Gly Ala Leu Pro
85 90 95
His Glu Val Val Ala Met Asn Gln Leu Thr Val Asn Leu His Leu Leu
100 105 110
Leu Val Ser Phe Tyr Asn Pro His Gly Lys Arg Asn Lys Ile Ile Cys
115 120 125
Glu Ala Lys Ala Phe Pro Ser Asp Gln Tyr Met Leu Glu Thr His Val
130 135 140
Lys Tyr Cys Gly Phe Asn Pro Asp Asp Val Ile Val Glu Val Gly Pro
145 150 155 160
Arg Lys Gly Glu His Thr Ile Arg His Glu Asp Ile Leu Gln Ala Ile
165 170 175
Gln Gln His Lys Asp Glu Leu Ala Leu Val Leu Trp Gly Gly Met Asn
180 185 190
Tyr Tyr Thr Gly Gln Leu Phe Asp Met Ala Ala Ile Thr Lys Ala Ala
195 200 205
Gln Ala Val Gly Ala Lys Val Gly Phe Asp Leu Ala His Ala Ala Gly
210 215 220
Asn Val Pro Leu Gln Leu His Asn Trp Asn Val Asp Phe Ala Ala Trp
225 230 235 240
Cys Ser Tyr Lys Tyr Met Asn Ser Gly Pro Gly Gly Ile Gly Gly Ala
245 250 255
Tyr Ile His Glu Arg Tyr His Asn Asp Thr Ser Leu Pro Arg Phe Ala
260 265 270
Gly Trp Trp Gly Tyr Asp Lys Ala Thr Arg Phe Leu Met Gln Lys Gly
275 280 285
Phe Asn Ala Thr Arg Ser Ala Glu Gly Trp Gln Leu Ser Thr Pro Ser
290 295 300
Pro Leu Leu Tyr Ala Ala His Arg Ala Ala Leu Asp Leu Phe Met Glu
305 310 315 320
Ala Gly Phe Asn Arg Leu Gln Asn Lys Arg Gln Leu Leu Asn Lys Trp
325 330 335
Leu Trp Phe Leu Leu Asp Asp Leu Asn Asn Ala Gln Thr Glu Pro Val
340 345 350
Val Glu Phe Ile Thr Pro Arg Asn Glu Ala Glu Arg Gly Cys Gln Val
355 360 365
Ser Met Leu Met Leu Gln Gln Gly Lys Gln Val Phe Asp Glu Leu Ala
370 375 380
Arg Ala Gly Val Ile Val Asp Trp Arg Glu Pro Asn Val Ile Arg Leu
385 390 395 400
Ala Pro Val Pro Leu Tyr Asn Ser Phe Glu Glu Val Trp Gln Phe Thr
405 410 415
Asn Ile Leu Arg Gln Ile Leu Gln Leu Gln His Ala
420 425
<210> 40
<211> 420
<212> PRT
<213> Nonlabens dokdonensis DSW-6
<400> 40
Met Asn Phe Lys Thr Asp His Asn Phe Ala Ile Glu Leu Asn Lys Ser
1 5 10 15
Asp Ser Leu Ser Arg Phe Arg Glu Ser Phe His Ile Pro Lys His Thr
20 25 30
Asp Gly Thr Asp Ser Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln
35 40 45
Pro Arg Gln Thr Lys Thr Phe Leu Asn Gln Glu Leu Asp Asp Trp Ala
50 55 60
Arg Leu Gly Val Glu Gly His Phe His Ala Ala His Pro Trp Met Pro
65 70 75 80
Tyr His Glu Phe Leu Thr Glu Thr Thr Ala Gln Ile Val Gly Ala Lys
85 90 95
Pro His Glu Val Val Ile Met Asn Thr Leu Thr Thr Asn Leu His Leu
100 105 110
Met Met Val Ser Phe Tyr Gln Pro Lys Gly Lys Arg Thr Lys Ile Ile
115 120 125
Ile Glu Ala Asp Ala Phe Pro Ser Asp Arg Tyr Ala Val Ala Ser Gln
130 135 140
Val Lys Phe His Gly His Asp Asp Lys Glu Asn Ile Ile Glu Trp Ser
145 150 155 160
Pro Arg Ala Gly Glu His Thr Pro Arg Ile Glu Asp Leu Glu Asn Leu
165 170 175
Leu Lys Glu Gln Gly Asp Glu Ile Ala Leu Ile Met Val Gly Ala Val
180 185 190
Asn Tyr Tyr Thr Gly Gln Phe Phe Asp Leu Lys Lys Ile Thr Glu Leu
195 200 205
Gly His Ala Ala Gly Ala Met Val Gly Phe Asp Cys Ala His Gly Ala
210 215 220
Gly Asn Val Asp Leu Gln Leu His Asn Ser Gly Ala Asp Phe Ala Val
225 230 235 240
Trp Cys Thr Tyr Lys Tyr Met Asn Ser Gly Pro Gly Ser Leu Gly Gly
245 250 255
Cys Phe Val His Glu Arg His Ala Ser Asn Ser Asp Leu Pro Arg Phe
260 265 270
Thr Gly Trp Trp Gly His Asn Lys Asp Thr Arg Phe Lys Met Arg Asp
275 280 285
Asp Phe Glu Pro Met His Gly Ala Glu Gly Trp Gln Leu Ser Asn Pro
290 295 300
Pro Ile Leu Ser Met Val Ala Ile Arg Ala Ser Leu Asp Leu Phe Ala
305 310 315 320
Gln Ala Gly Phe Glu Asn Leu Arg Gln Lys Ser Ile Gln Leu Thr Asn
325 330 335
Tyr Leu Glu Tyr Leu Leu Ser Asn Leu Glu Gly Asp Arg Ile Ser Ile
340 345 350
Ile Thr Pro Glu Asn Pro Lys Asp Arg Gly Cys Gln Leu Ser Leu Ala
355 360 365
Val Lys Asn Ala Asp Lys Ser Leu Phe Asp Ala Ile Thr Glu Lys Gly
370 375 380
Val Ile Ala Asp Trp Arg Glu Pro Asp Val Ile Arg Ile Ala Pro Val
385 390 395 400
Pro Leu Tyr Asn Asn Tyr Glu Asp Cys Trp Arg Phe Val Asp Val Leu
405 410 415
Lys Ser Glu Leu
420
<210> 41
<211> 431
<212> PRT
<213> Pedobacter agri
<400> 41
Met Lys Leu Glu Asn Thr Leu Ala Phe Ala Lys Glu Gln Asp Glu Lys
1 5 10 15
Asp Glu Leu Lys His Phe Arg Asp Gln Phe Leu Phe Pro Lys Tyr Gln
20 25 30
Asp Lys Phe Phe Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln Pro
35 40 45
Lys Val Ala Lys Glu Val Ile Asn Ser Gln Leu Asp Asn Trp Ala Asn
50 55 60
Leu Ala Val Glu Gly Trp Phe Asp Gly Glu Glu Pro Trp Met Tyr Tyr
65 70 75 80
His Lys Glu Leu Lys Lys Leu Met Ala Pro Ile Val Gly Ala Leu Pro
85 90 95
Ser Glu Val Cys Pro Met Asn Thr Leu Thr Val Asn Leu His Leu Leu
100 105 110
Met Ile Ser Phe Tyr Gln Pro Gln Gly Lys Arg Phe Lys Ile Ile Met
115 120 125
Glu Gly Gly Ala Phe Pro Ser Asp Gln Tyr Ala Ile Glu Ser Gln Val
130 135 140
Arg Phe His Gly Phe Asp Pro Ser Asp Ala Ile Ile Glu Val Phe Pro
145 150 155 160
Arg Glu Gly Glu Glu Ile Leu Arg Thr Glu Asp Ile Val Ala Lys Ile
165 170 175
Lys Glu His Gly Asp Glu Ile Ala Leu Leu Leu Phe Gly Gly Ile Asn
180 185 190
Tyr Tyr Thr Gly Gln Trp Tyr Asp Met Glu Asn Ile Thr Lys Ala Gly
195 200 205
His Ser Ile Gly Ala Met Val Gly Trp Asp Leu Ala His Ala Ala Gly
210 215 220
Asn Val Pro Val Lys Leu His Asp Trp Asn Val Asp Phe Ala Cys Trp
225 230 235 240
Cys Ser Tyr Lys Tyr Gln Asn Ala Gly Pro Gly Gly Ile Ser Gly Ile
245 250 255
Phe Val His Glu Lys His Phe Glu Asn Lys Ala Leu Asn Arg Phe Ala
260 265 270
Gly Trp Trp Gly Tyr Gln Glu Asn Lys Arg Phe Lys Met Glu Lys Gly
275 280 285
Phe Val Pro Glu Ala Gly Ala Asp Gly Trp Gln Val Ser Cys Thr Gln
290 295 300
Val Met Pro Met Ala Leu Tyr His Ala Ser Leu Gln Ile Phe Lys Glu
305 310 315 320
Ala Gly Phe Leu Asn Thr Leu Arg Asn Lys Ser Ile Ser Leu Thr Ser
325 330 335
Tyr Leu Glu Phe Val Val Asn Glu Leu Asn Ile Glu Leu Glu Lys Glu
340 345 350
Gln Tyr Lys Ile Ile Thr Pro Lys Asn Ser Ala Glu Arg Gly Ala Gln
355 360 365
Leu Ser Ile Ile Ala Ala Arg Asn Gly Lys Glu Ile Phe Asp Gly Leu
370 375 380
Leu Ala His Gly Ile Leu Gly Asp Trp Arg Glu Pro Asn Val Ile Arg
385 390 395 400
Leu Ser Pro Val Pro Leu Tyr Asn Ser Phe Glu Asp Ile Tyr Gln Thr
405 410 415
Gly Lys Ala Leu Ser Glu Val Thr Arg Lys Ile Leu Thr Thr Ala
420 425 430
<210> 42
<211> 449
<212> PRT
<213> Pedobacter sp. BAL39
<400> 42
Met Lys Val Val Asp Asn Lys Lys Thr Gly Leu Phe Asn Tyr Ile Pro
1 5 10 15
Phe Leu Trp Ile Phe Gly Thr Met Asn Phe Glu Asn Thr Leu Ala Phe
20 25 30
Ala Gln Gly Leu Asp Gln Ala Asp Pro Leu Arg Asp Leu Arg Asn Glu
35 40 45
Phe Leu Phe Pro Gln Gln Asn Gly Lys Pro Phe Ile Tyr Leu Cys Gly
50 55 60
Asn Ser Leu Gly Leu Gln Pro Lys Val Ala Arg Glu Val Leu Asp Arg
65 70 75 80
Gln Leu Asn Asn Trp Gln Asn Leu Ala Val Glu Gly Trp Phe Glu Gly
85 90 95
Glu Thr Pro Trp Met Tyr Tyr His Lys Ala Leu Lys Glu Leu Met Ala
100 105 110
Pro Ile Val Gly Ala Arg Pro Ala Glu Val Cys Pro Met Asn Thr Leu
115 120 125
Thr Val Asn Leu His Leu Leu Met Val Ser Phe Tyr Lys Pro Lys Ala
130 135 140
Lys Arg Phe Lys Ile Met Met Glu Ala Gly Ala Phe Pro Ser Asp Gln
145 150 155 160
Tyr Ala Ile Glu Ser Gln Val Arg Phe His Gly Tyr Asp Pro Lys Asp
165 170 175
Ala Ile Ile Glu Val Ser Pro Arg Pro Gly Glu Tyr Thr Leu Arg Thr
180 185 190
Glu Asp Ile Leu Glu Gln Ile Ser Leu Gln Gly Asp Gln Ile Ala Leu
195 200 205
Val Leu Phe Gly Gly Ile Asn Tyr Phe Thr Gly Gln Trp Phe Asp Met
210 215 220
Glu Ala Ile Thr Arg Ala Gly His Gln Ala Gly Ala Val Val Gly Phe
225 230 235 240
Asp Leu Ala His Ala Ala Gly Asn Val Pro Val Gln Leu His Asp Trp
245 250 255
Asp Val Asp Phe Ala Cys Trp Cys Ser Tyr Lys Tyr Gln Asn Ser Gly
260 265 270
Pro Gly Gly Ile Ser Gly Ile Phe Val His Glu Arg His Phe Gly Asp
275 280 285
Gln Thr Leu Ser Arg Phe Ala Gly Trp Trp Gly Tyr Gln Glu Ser Gln
290 295 300
Arg Phe Lys Met Glu Lys Gly Phe Val Pro Glu Ala Gly Ala Asp Gly
305 310 315 320
Trp Gln Val Ser Cys Thr Gln Val Met Pro Met Ala Leu Tyr His Ala
325 330 335
Ala Leu Gln Ile Phe Glu Lys Ala Gly Phe Ile Gly Pro Leu Arg Lys
340 345 350
Lys Ser Lys Ala Leu Thr Ala Tyr Leu Phe Tyr Leu Ile Asn Glu Val
355 360 365
Asn Asn Glu Leu Cys Glu Met Gln Tyr Gln Val Ile Thr Pro Ser Ser
370 375 380
Ala Glu Asp Arg Gly Ala Gln Val Ser Ile Ile Ala Lys Ala Asn Gly
385 390 395 400
Lys Tyr Ile Phe Glu Gln Leu Val Ala Asn Asn Val Leu Gly Asp Trp
405 410 415
Arg Glu Pro Asn Val Ile Arg Leu Ser Pro Val Pro Ser Tyr Asn Ser
420 425 430
Phe Glu Asp Val Phe Arg Thr Ala Glu Leu Leu Leu Gln Ile Gly Arg
435 440 445
Lys
<210> 43
<211> 428
<212> PRT
<213> Pedobacter sp. V48
<400> 43
Met Asn Phe Glu Asn Asn Leu Ala Phe Ala Gln Ser Leu Asp Gln Ala
1 5 10 15
Asp Pro Leu Ser Ser Phe Arg His Asp Phe Leu Phe Pro Gln Gln Asn
20 25 30
Gly Asn Pro Phe Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln Pro
35 40 45
Lys Ala Val Arg Lys Val Val Asp Glu Gln Leu Asn Asn Trp Arg Asn
50 55 60
Leu Ala Val Glu Gly Trp Phe Glu Gly Asp Asn Pro Trp Met Phe Tyr
65 70 75 80
His Lys Glu Leu Lys Lys Leu Met Gly Pro Leu Val Gly Ala Ser Thr
85 90 95
Asp Glu Val Cys Pro Met Asn Thr Leu Thr Val Asn Leu His Leu Leu
100 105 110
Met Val Ser Phe Tyr Lys Pro Val Arg Gly Arg Phe Lys Ile Ile Met
115 120 125
Glu Ala Gly Ala Phe Pro Ser Asp Gln Tyr Ala Val Glu Ser Gln Val
130 135 140
Arg Phe His Gly Tyr Asp Ala Lys Glu Ala Ile Val Glu Val Ala Pro
145 150 155 160
Arg Ile Gly Glu Tyr Ile Leu Arg Thr Glu Asp Ile Leu Ala Gln Ile
165 170 175
Ala Lys His Gly Asp Glu Val Ala Leu Val Leu Phe Ser Gly Val Asn
180 185 190
Tyr Phe Thr Gly Gln Trp Phe Asp Met Glu Ala Ile Thr Met Ala Gly
195 200 205
His Ala Glu Gly Ala Val Val Gly Phe Asp Leu Ala His Ala Ala Gly
210 215 220
Asn Val Pro Leu Lys Leu His Asp Trp Asp Ile Asp Phe Ala Cys Trp
225 230 235 240
Cys Ser Tyr Lys Tyr Gln Asn Ser Gly Pro Gly Gly Ile Ser Gly Ile
245 250 255
Phe Val His Glu Lys His Phe Thr Asp Thr Thr Leu Asn Arg Phe Ala
260 265 270
Gly Trp Trp Gly Tyr Gln Gln Ala His Arg Phe Lys Met Glu Lys Gly
275 280 285
Phe Leu Pro Glu Pro Gly Ala Asp Gly Trp Gln Val Ser Cys Thr Gln
290 295 300
Val Met Pro Met Ala Leu Tyr Phe Ala Ser Leu Gln Ile Phe Glu Lys
305 310 315 320
Ala Gly Phe Ile Glu Pro Leu Arg Leu Lys Ser Lys Thr Leu Thr Ser
325 330 335
Tyr Leu Phe His Ile Val Asn Gln Val Asn Lys Leu Leu Ser Cys Glu
340 345 350
Gln Phe Glu Ile Ile Thr Pro Asp Asn Glu Asn Glu Arg Gly Ala Gln
355 360 365
Val Ser Ile Ile Ala Lys Gln Lys Gly Lys Glu Ile Phe Glu Lys Leu
370 375 380
Ile Ala Asn Asn Val Leu Gly Asp Trp Arg Glu Pro Asn Val Ile Arg
385 390 395 400
Leu Ser Pro Val Pro Leu Tyr Asn Ser Phe Glu Asp Val Phe Arg Thr
405 410 415
Gly Glu Leu Leu Leu Gln Ile Thr Lys Gly Val Ile
420 425
<210> 44
<211> 428
<212> PRT
<213> Rhodonellum psychrophilum
<400> 44
Met Lys Asp Ile Lys Tyr Glu Tyr Ser Glu Phe Phe Ala Arg Gln Leu
1 5 10 15
Asp Asn Glu Asp Pro Leu Lys Asp Phe Arg Asn Glu Phe Tyr Phe Pro
20 25 30
Lys Ile Glu Gly Lys Glu Ala Ile Tyr Phe Cys Gly Asn Ser Leu Gly
35 40 45
Leu Gln Pro Arg Ser Thr Lys Glu Tyr Ile Gln Arg Glu Leu Asp Asn
50 55 60
Trp Ala Glu Leu Ala Val Asp Gly His Phe Lys Gly Glu Asp Ala Trp
65 70 75 80
Tyr His Val Arg Lys Lys Ser Lys Pro Ala Leu Ser Glu Ile Val Gly
85 90 95
Ala His Glu His Glu Val Val Ala Met Asn Asn Leu Ser Ser Asn Leu
100 105 110
His Phe Leu Met Val Ser Phe Tyr Arg Pro Ser Lys Thr Arg Phe Lys
115 120 125
Ile Ile Thr Glu Ala Gly Ala Phe Pro Ser Asp Met Tyr Met Leu Glu
130 135 140
Thr Gln Val Lys Phe His Gly Leu Asp Pro Glu Lys Thr Ile Ile Glu
145 150 155 160
Val Ala Pro Arg Pro Gly Glu His Thr Leu Arg Thr Glu Asp Ile Leu
165 170 175
Leu Ala Ile Glu Glu Gln Gly Glu Glu Leu Ala Leu Val Met Met Ala
180 185 190
Gly Leu Gln Tyr Tyr Thr Gly Gln Val Phe Asp Met Glu Ser Ile Thr
195 200 205
Arg Ala Gly His Ser Val Gly Ala Asn Val Gly Phe Asp Leu Ala His
210 215 220
Ala Ala Gly Asn Val Pro Met Ser Leu His Asp Trp Gly Val Asp Phe
225 230 235 240
Ala Thr Trp Cys Ser Tyr Lys Tyr Met Asn Ser Gly Pro Gly Asn Val
245 250 255
Ser Gly Val Phe Val His Glu Arg His Ala Gln Asn Pro Asp Leu Pro
260 265 270
Arg Phe Ala Gly Trp Trp Gly His Asp Glu Glu Glu Arg Phe Lys Met
275 280 285
Glu Lys Gly Phe Lys Pro Met Tyr Gly Ala Asp Gly Trp Gln Val Ala
290 295 300
Asn Ser Asn Val Leu Ala Leu Ala Ala His Gln Ser Ser Leu Asp Ile
305 310 315 320
Phe Glu Arg Ala Gly Ile Lys Asn Leu Arg Glu Lys Ser Glu Leu Leu
325 330 335
Thr Gly Tyr Leu Glu Phe Leu Ile Gln Gln Ile Ser Gly Asp Ser Gly
340 345 350
Val Ile Glu Ile Ile Thr Pro Lys Asn Pro Gln Glu Arg Gly Cys Gln
355 360 365
Leu Ser Leu Leu Val His Lys Gly Gly Lys Ala Val Phe Asp Glu Leu
370 375 380
Tyr Leu Asn Gly Ile Ile Gly Asp Trp Arg His Pro Lys Val Met Arg
385 390 395 400
Ile Ala Pro Thr Pro Leu His Asn Ser Phe Leu Asp Val Phe Arg Phe
405 410 415
Ala Gln Ile Leu Glu Lys Ser Ile Leu Lys Phe Ala
420 425
<210> 45
<211> 430
<212> PRT
<213> Salinispora arenicola
<400> 45
Met Asn Lys Glu Glu Leu Asp Gln Glu Glu Lys Ala Ala Asn Arg Leu
1 5 10 15
Asp Thr Ala Asp Pro Gly His Arg His Leu Phe His Leu Pro Pro Ser
20 25 30
Asp Gly Gly Arg Tyr Gln Gln Ala Ala Tyr Leu Ala Gly Asn Ser Leu
35 40 45
Gly Leu Gln Pro Leu Ala Thr Arg Asp Glu Leu Leu Ala Asp Leu Asp
50 55 60
Ala Trp Arg Arg Leu Gly Val Glu Gly His Leu Glu Ala Asp Arg Pro
65 70 75 80
Trp Leu Pro Tyr His Glu Leu Leu Thr Ala Pro Thr Ala Arg Leu Val
85 90 95
Gly Ala Arg Pro Ala Glu Val Val Val Met Asn Ser Leu Thr Val Asn
100 105 110
Leu His Leu Leu Met Val Ser Phe Tyr Arg Pro Val Gly Ala Arg Thr
115 120 125
Arg Ile Val Ile Glu Asp Asn Ala Phe Pro Ser Asp Ser Tyr Ala Val
130 135 140
Arg Ser Gln Ala Arg Phe His Gly Leu Asp Pro Asp Thr Thr Val Val
145 150 155 160
Arg Leu Ala Pro Arg Pro Gly Glu Asp Thr Leu Arg Thr Val Asp Val
165 170 175
Leu Asp Leu Leu Ala Ala Glu Gly Asp Thr Ile Ala Leu Val Leu Leu
180 185 190
Gly Gly Val Asn Tyr Leu Thr Gly Glu Leu Leu Asp Ile Pro Ala Ile
195 200 205
Thr Ala Ala Gly Arg Ala Ala Gly Ala Ala Val Gly Trp Asp Leu Ala
210 215 220
His Ala Ala Gly Asn Val Pro Leu Ser Leu His Asp Trp Asp Val Asp
225 230 235 240
Phe Ala Ala Trp Cys Ser Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Gly
245 250 255
Leu Ser Ser Val Phe Val His Glu Arg His Leu Ala Asp Pro Thr Leu
260 265 270
Pro Arg Phe Glu Gly Trp Trp Ser Thr Asp Ala Ala Val Arg Phe Glu
275 280 285
Met Ser Pro Val Ala Arg Pro Pro Ala Thr Ala Glu Ala Trp Gln Val
290 295 300
Ser Asn Pro Pro Ile Phe Ala Met Gly Pro Val Arg Thr Ser Leu Glu
305 310 315 320
Leu Phe Asp Ser Val Gly Met Thr Ala Leu Arg Glu Arg Ser Val Arg
325 330 335
Leu Thr Gly Tyr Leu Glu Trp Leu Leu Asp Gln Ile Thr Pro Gly Arg
340 345 350
Gln Leu Ala Val Val Thr Pro Arg Asp Pro Asp Arg Arg Gly Ala Gln
355 360 365
Leu Ser Val Arg Val Gly Ser Gly Ser Ala Ala Glu Leu Thr Lys Arg
370 375 380
Leu Arg Cys Glu Tyr Gly Val Ile Ala Asp Ala Arg Glu Pro Asp Ile
385 390 395 400
Val Arg Phe Ala Pro Val Pro Leu Tyr Ser Thr Tyr His Asp Cys Trp
405 410 415
Arg Val Ala Asp Ala Leu Ala Ala Thr Val Glu Val Arg Gly
420 425 430
<210> 46
<211> 425
<212> PRT
<213> Saprospira grandis str. Lewin
<400> 46
Met Gln Glu Val Gln Phe Glu Asp Ala Leu Asp Tyr Ala Lys Ala Gln
1 5 10 15
Asp Val Ser Asp Pro Leu Ala His Phe Arg Pro Gln Phe His Phe Pro
20 25 30
Lys Gln Ala Asp Gly Ser Pro Ile Ile Tyr Leu Cys Gly Asn Ser Leu
35 40 45
Gly Leu Gln Pro Arg Leu Ala Gln Gln Leu Met Gln Asp Glu Met Asp
50 55 60
Val Trp Lys Glu Leu Ala Val Glu Gly His Phe Lys Ala Glu Arg Pro
65 70 75 80
Trp Met Thr Tyr His Glu Glu Phe Ser Arg Gln Leu Ser Pro Ile Val
85 90 95
Gly Ala Leu Pro Lys Glu Ile Thr Val Met Asn Thr Leu Ser Val Asn
100 105 110
Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Lys Ser Arg Tyr
115 120 125
Lys Ile Val Ile Glu Gly Gly Ala Phe Pro Ser Asp Lys Tyr Ala Val
130 135 140
Asp Ser Gln Leu Arg Phe His Gly Ile Asp Pro Gln Asp Gly Leu Ile
145 150 155 160
Gln Leu Arg Pro Arg Met Gly Glu Asp His Leu Arg Thr Glu Asp Ile
165 170 175
Leu Gln Ala Leu Glu Arg Glu Lys Asp Ser Ile Ala Leu Val Met Leu
180 185 190
Ser Gly Ile Asn Tyr Tyr Thr Gly Gln Cys Phe Asp Met Lys Ser Ile
195 200 205
Thr Lys Lys Gly His Glu Ile Gly Ala Met Val Gly Phe Asp Leu Ala
210 215 220
His Ala Ala Gly Asn Val Arg Leu Gln Leu His Asp Trp Gly Met Asp
225 230 235 240
Phe Ala Val Trp Cys His Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Cys
245 250 255
Ile Ala Gly Ala Phe Val His Glu Arg His Leu Asn Arg Lys Asp Leu
260 265 270
Pro Arg Phe Glu Gly Trp Trp Gly His His Lys Glu Ser Arg Phe Lys
275 280 285
Met Pro Ala Thr Phe Glu Pro Ala Pro Asn Ala Asp Ala Trp Gln Ile
290 295 300
Ser Asn Ala Pro Ile Leu Ala Met Val Pro Met Arg Ala Ser Leu Ala
305 310 315 320
Leu Phe Asn Glu Ala Gly Met Asp Arg Leu Leu Ala Lys Ser Lys Lys
325 330 335
Leu Thr Ala Tyr Leu Glu Phe Leu Leu Asn Gln Leu Pro Thr Asp Arg
340 345 350
Ile Arg Ile Leu Thr Pro Lys Asp Pro Lys Asp Arg Gly Ala Gln Leu
355 360 365
Ser Ile Gln Val Lys Gly Ala Asp Arg Ser Leu Phe Asp Asp Leu Val
370 375 380
Lys Asn Gly Val Ile Gly Asp Trp Arg Glu Pro Asp Val Ile Arg Ile
385 390 395 400
Ser Pro Ala Pro Ile Tyr Asn Ser Phe Glu Asp Val Tyr Arg Met Val
405 410 415
Gln Ile Leu Lys Lys Cys Leu Gln Leu
420 425
<210> 47
<211> 427
<212> PRT
<213> Stigmatella aurantiaca DW4/3-1
<400> 47
Met Thr Glu Ala Ser Met Arg Phe Glu Glu Gly Glu Gly Phe Ala Arg
1 5 10 15
Arg Met Asp Ala Glu Asp Pro Leu Arg Ser Phe Arg Glu Glu Phe Leu
20 25 30
Phe Pro Gln Ser Pro Gln Gly Glu Pro Leu Val Tyr Leu Ala Gly Asn
35 40 45
Ser Leu Gly Leu Gln Pro Arg Arg Ala Gln Gln Tyr Val Gln Glu Glu
50 55 60
Met Glu Asp Trp Ala Arg Leu Gly Val Glu Gly His Phe His Ala Arg
65 70 75 80
Arg Pro Trp Leu Pro Tyr His Glu Asn Leu Thr Gly Gln Thr Ala Arg
85 90 95
Leu Val Gly Ala Leu Pro Leu Glu Val Val Val Met Asn Thr Leu Ser
100 105 110
Val Asn Leu His Leu Met Met Val Ser Phe Tyr Arg Pro Thr Arg Glu
115 120 125
Arg Phe Lys Ile Leu Ile Glu Gly Gly Ala Phe Pro Ser Asp Gln Tyr
130 135 140
Ala Val Ala Ser Gln Ala Arg Phe His Gly Phe Asp Pro Lys Asp Ala
145 150 155 160
Val Leu Lys Leu Glu Pro Arg Ala Gly Glu Asp Thr Leu Arg Thr Glu
165 170 175
Asp Ile Leu Glu Thr Leu Glu Arg His Gly Ser Glu Ile Ala Leu Val
180 185 190
Leu Leu Gly Asn Val Asn Tyr Leu Thr Gly Gln Ala Phe Asp Met Lys
195 200 205
Ala Leu Thr Gln Ala Ala His Ala Arg Gly Cys Arg Val Gly Phe Asp
210 215 220
Leu Ala His Gly Ala Gly Asn Leu Arg Leu Ser Leu His Asp Asp Gly
225 230 235 240
Pro Asp Phe Ala Val Trp Cys Ser Tyr Lys Tyr Leu Asn Gly Gly Pro
245 250 255
Gly Ala Leu Gly Gly Val Phe Ile His Glu Arg His Ala Arg Ala Glu
260 265 270
Gly Leu Pro Arg Phe Glu Gly Trp Trp Gly Asn Asp Lys Ala Ile Arg
275 280 285
Phe Gln Met Gly Pro Asp Phe Val Pro Leu Pro Gly Ala Glu Gly Trp
290 295 300
Gln Leu Ser Asn Pro Pro Ile Phe Gln Leu Ala Ala Leu Arg Ala Ser
305 310 315 320
Met Glu Leu Phe Asp Arg Ala Thr Met Pro Ser Leu Arg Gly Lys Gly
325 330 335
Asp Arg Leu Thr Gly Tyr Leu Glu Phe Leu Leu Asp Arg Leu Pro Ser
340 345 350
Gly Phe Val Arg Ile Thr Thr Pro Arg Asp Val Lys Ala Arg Gly Ser
355 360 365
Gln Leu Ser Leu Arg Phe Ser Lys Asp Pro Arg Arg Leu Leu Thr Arg
370 375 380
Leu Ser Glu Ala Gly Val Cys Cys Asp Phe Arg Ser Pro Asp Ile Ile
385 390 395 400
Arg Ala Ala Pro Ala Pro Leu Tyr Asn Ser Phe Gln Asp Val Tyr Arg
405 410 415
Phe Val Lys Val Leu Glu Ser His Ala Arg Asp
420 425
<210> 48
<211> 423
<212> PRT
<213> Xanthomonas axonopodis
<400> 48
Met Thr Asp Pro Leu Ser Arg Ala His Ala Ala Ala Leu Asp Ala Ala
1 5 10 15
Asp Pro Leu Arg Asn Leu Arg Asp Ala Phe Val Phe Pro Gln His Gly
20 25 30
Asp Asp Asp Gln Thr Tyr Phe Val Gly Asn Ser Leu Gly Leu Gln Pro
35 40 45
Arg Ala Ala Arg Ala Met Val Asp Glu Val Leu Asp Gln Trp Gly Ala
50 55 60
Leu Ala Val Glu Gly His Phe Thr Gly Pro Thr Gln Trp Leu Thr Tyr
65 70 75 80
His Gln Leu Val Arg Asp Ala Leu Ala Arg Val Val Gly Ala Gln Pro
85 90 95
Gly Glu Val Val Ala Met Asn Thr Leu Ser Val Asn Leu His Leu Met
100 105 110
Met Ala Ser Phe Tyr Arg Pro Thr Ala Glu Arg Gly Ala Ile Leu Ile
115 120 125
Glu Ala Gly Ala Phe Pro Ser Asp Arg His Ala Val Glu Ser Gln Leu
130 135 140
Arg Leu His Gly Leu Asp Pro Ala Thr His Leu Ile Glu Val Glu Ala
145 150 155 160
Asp Glu Pro Asn Gly Thr Val Ser Met Ser Ala Ile Ala Glu Ala Ile
165 170 175
Ala Gln His Gly Pro His Leu Ala Leu Val Leu Trp Pro Gly Ile Gln
180 185 190
Tyr Arg Thr Gly Gln Ala Phe Asp Leu Ala Glu Ile Val Arg Leu Ala
195 200 205
Arg Ala Gln Gly Ala Ala Val Gly Phe Asp Leu Ala His Ala Val Gly
210 215 220
Asn Leu Pro Leu Thr Leu His Asp Asp Gly Val Asp Phe Ala Val Trp
225 230 235 240
Cys His Tyr Lys Tyr Leu Asn Ala Gly Pro Gly Ala Val Gly Gly Cys
245 250 255
Phe Val His Ala Arg His Ala Thr Ser Asp Leu Pro Arg Met Ala Gly
260 265 270
Trp Trp Gly His Glu Gln Gln Thr Arg Phe Arg Met Asp Pro Gln Phe
275 280 285
Val Pro Ser Pro Gly Ala Glu Gly Trp Gln Leu Ser Asn Pro Pro Val
290 295 300
Leu Ala Leu Ala Pro Leu Arg Ala Ser Leu Ala Leu Phe Asp Gln Ala
305 310 315 320
Gly Met Ala Ala Leu Arg Ala Lys Ser Glu Gln Leu Thr Gly His Leu
325 330 335
Glu Gln Leu Ile His Ala Arg Ala Pro Gln Val Leu Gln Ile Val Thr
340 345 350
Pro Val Glu Pro Ala Arg Arg Gly Cys Gln Leu Ser Leu Arg Val Ala
355 360 365
Gly Gly Arg Ala Arg Gly Arg Ala Leu Phe Glu His Leu His Ala Ala
370 375 380
Gly Val Leu Gly Asp Trp Arg Glu Pro Asp Val Ile Arg Ile Ala Pro
385 390 395 400
Val Pro Leu Tyr Asn Arg Phe Ser Asp Leu His Thr Phe Val Glu Gln
405 410 415
Val Glu Ala Trp Ala Ala Ala
420
<210> 49
<211> 422
<212> PRT
<213> Psychroflexus gondwanensis
<400> 49
Met Lys Tyr Gln Asn Thr Lys Ser Phe Ala Glu Gln Leu Asp Glu Ala
1 5 10 15
Asp Pro Leu Lys Ala Tyr Arg Ser Glu Phe Leu Phe Pro Lys Ala Lys
20 25 30
Asp Gly Ser Pro Lys Val Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln
35 40 45
Pro Lys Gln Thr Ser Ala Phe Ile Gln Gln Glu Leu Gln Asp Trp Ala
50 55 60
Asp Leu Gly Val Glu Gly His Ser His Ala Thr His Pro Trp Met Thr
65 70 75 80
Ser Asn Glu Asp Leu Ala Asp Ser Met Ala Lys Ile Val Gly Ala Gln
85 90 95
Pro Gln Glu Val Val Ile Met Asn Thr Leu Thr Val Asn Leu His Leu
100 105 110
Met Met Val Ser Phe Tyr Lys Pro Thr Pro Lys Lys Phe Lys Ile Leu
115 120 125
Ile Glu Ser Asp Ala Phe Pro Ser Asp Lys Tyr Ala Val Glu Ser Gln
130 135 140
Leu Lys Phe His Asn Ile Asp Pro Lys Glu Gly Leu Leu Leu Trp Lys
145 150 155 160
Pro Arg Pro Gly Glu His Leu Cys Arg Thr Glu Asp Phe Glu Gln Ile
165 170 175
Ile Glu Glu His Gly Asp Glu Ile Ala Leu Val Met Ile Gly Ser Thr
180 185 190
Asn Tyr Tyr Ser Gly Gln Ala Tyr Asp Leu Lys Arg Ile Thr Glu Val
195 200 205
Ser Lys Thr Lys Asp Ile Thr Val Gly Phe Asp Leu Ala His Gly Ala
210 215 220
Gly Asn Ile Gln Pro Asn Leu His Asp Ile Gly Ala Asp Phe Ala Val
225 230 235 240
Trp Cys Thr Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Ser Leu Gly Gly
245 250 255
Cys Phe Ile His Glu Lys His Ile Ala Asp Glu His Ile Asn Arg Phe
260 265 270
Val Gly Trp Trp Gly His Asn Lys Asp Ser Arg Phe Asn Met Arg Val
275 280 285
Asp Phe Asp Pro Ile Pro Thr Ala Asp Gly Trp Gln Leu Ser Asn Pro
290 295 300
Pro Ile Leu Ser Leu Ala Gly Thr Arg Ser Ser Leu Asp Leu Phe Asp
305 310 315 320
Lys Ala Gly Phe Asp Asn Ile Arg Lys Lys Ser Val Leu Leu Thr Gly
325 330 335
Phe Leu Glu Phe Leu Ile Asp Asp Leu Asp Met Glu Glu Ile Ser Ile
340 345 350
Leu Thr Pro Arg Ser Pro Glu Glu Arg Gly Cys Gln Leu Ser Ile Gln
355 360 365
Val Lys Asn Ala Asn Lys Ser Leu Phe His Gln Leu Met Asp Lys Gly
370 375 380
Val Val Ala Asp Trp Arg Glu Pro Asp Val Ile Arg Ile Ala Pro Ala
385 390 395 400
Pro Leu Tyr Asn Ser Tyr Thr Asp Val Phe Thr Phe Val Glu Ile Leu
405 410 415
Lys His Cys Leu Asn Ala
420
<210> 50
<211> 422
<212> PRT
<213> Lewinella cohaerens
<400> 50
Met Thr Tyr Gln Ala Thr Arg Glu Tyr Ala Gln Ser Gln Asp Asp Lys
1 5 10 15
Asp Pro Met Arg Gly Phe Arg Glu Arg Phe His Leu Pro Arg Gln Ala
20 25 30
Asn Gly Glu Pro Phe Ile Tyr Leu Cys Gly Asn Ser Leu Gly Leu Gln
35 40 45
Pro Lys Ser Thr Lys Ala Ala Ile Asp Gln Glu Leu Leu Asp Trp Gln
50 55 60
Asn Leu Gly Val Glu Gly His Leu His Ala Lys Asn Pro Trp Leu Pro
65 70 75 80
Tyr His Glu Phe Leu Thr Glu Lys Met Ala Glu Ile Val Gly Ala Lys
85 90 95
Pro Ile Glu Val Val Met Met Asn Thr Leu Thr Val Asn Leu His Leu
100 105 110
Met Met Val Ser Phe Tyr Arg Pro Glu Gly Lys Arg Thr Lys Ile Leu
115 120 125
Met Glu Ala Asp Ala Phe Pro Ser Asp Arg Tyr Ala Ile Ser Ser Gln
130 135 140
Leu Lys Phe His Gly Tyr Asp Pro Ala Glu His Leu Val Glu Leu Lys
145 150 155 160
Ala Arg Asp Gly Glu Val Leu Ile Arg Glu Glu Asp Ile Ala His Ile
165 170 175
Leu Glu Glu Gln Gly Ala Glu Ile Ala Leu Val Leu Leu Gly Asn Thr
180 185 190
Asn Tyr Tyr Thr Gly Gln Phe Phe Asn Met Pro Glu Ile Thr Lys Leu
195 200 205
Ala His Ala Gln Gly Cys Met Val Gly Phe Asp Cys Ala His Gly Ala
210 215 220
Gly Asn Val Pro Leu Asp Leu His Asp Ser Gly Ala Asp Phe Ala Val
225 230 235 240
Trp Cys Ser Tyr Lys Tyr Ile Asn Ser Gly Pro Gly Ser Val Ser Gly
245 250 255
Cys Phe Val His Glu Arg His Ala His Asp Lys Glu Leu Pro Arg Phe
260 265 270
Thr Gly Trp Trp Gly His Asn Lys Val Thr Arg Phe Gly Met Arg Asp
275 280 285
Asp Phe Asp Pro Ile Pro Gly Val Glu Ala Trp Gln Leu Ser Asn Pro
290 295 300
Pro Ile Leu Ser Leu Ala Ala Ile Lys Ala Ser Leu Glu Val Phe Ala
305 310 315 320
Glu Ala Gly Met Asn Asn Leu Arg Gln Lys Ser Leu Ala Leu Thr Gly
325 330 335
Tyr Leu Glu Tyr Leu Val Asp Gln Leu Pro Gly Gly Lys Ile Ser Ile
340 345 350
Ile Thr Pro Arg Asp Pro Glu Arg Arg Gly Cys Gln Leu Ser Ile Gln
355 360 365
Val Gln Asp Ala Asp Lys Ser Leu Tyr Glu Ala Ile Ser Ala Ala Gly
370 375 380
Val Ile Ala Asp Trp Arg Glu Pro Asp Val Ile Arg Val Ala Pro Val
385 390 395 400
Pro Leu Tyr Asn Thr Phe Thr Glu Val Tyr Asp Phe Val Lys Ile Leu
405 410 415
Gly Glu Lys Met Glu Ala
420
<210> 51
<211> 425
<212> PRT
<213> Lewinella persica
<400> 51
Met Val Glu Glu Phe Gln Asn Asp Leu Ala Phe Ala Arg Lys Met Asp
1 5 10 15
Glu Arg Asp Glu Leu Arg Ala Tyr Arg Ser Gln Tyr His Met Pro Val
20 25 30
Gln Ala Asn Gly Gln Pro Tyr Val Tyr Leu Cys Gly Asn Ser Leu Gly
35 40 45
Leu Gln Pro Lys Ala Thr Glu Gly Tyr Leu Leu Gln Glu Leu Glu Asp
50 55 60
Trp Lys Asn Leu Gly Val Glu Gly His Phe His Ala Lys Asn Pro Trp
65 70 75 80
Met Pro Tyr His Glu Phe Leu Thr Glu Ala Met Ala Arg Val Val Gly
85 90 95
Ala Lys Pro Ser Glu Val Val Val Met Asn Thr Leu Thr Val Asn Leu
100 105 110
His Leu Met Met Val Ser Phe Tyr Arg Pro Val Gly Arg Arg Lys Lys
115 120 125
Ile Ile Ile Glu Ala Asp Ala Phe Pro Ser Asp Lys Tyr Ala Val Glu
130 135 140
Ser Gln Ile Arg Phe His Gly Leu Ser Pro Glu Asp Cys Leu Ile Glu
145 150 155 160
Leu Lys Ala Arg Asp Gly Glu Val Cys Leu Arg Gln Glu Asp Ile Leu
165 170 175
Gly Val Ile Asp Ala His Ser Glu Asp Ile Ala Leu Ile Leu Leu Gly
180 185 190
Asn Thr Asn Tyr Tyr Thr Gly Gln Phe Phe Asp Met Lys Thr Ile Ser
195 200 205
Glu His Gly His Ala Lys Gly Cys Met Val Gly Phe Asp Cys Ala His
210 215 220
Gly Ala Gly Asn Val Pro Leu Asn Leu His Asp Ser Gly Cys Asp Phe
225 230 235 240
Ala Val Trp Cys Asn Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Gly Met
245 250 255
Gly Gly Ala Phe Ile His Glu Arg His Ala Asp Ser Lys Asp Ile Pro
260 265 270
Arg Phe Glu Gly Trp Trp Gly His Asn Lys Glu Thr Arg Phe Lys Met
275 280 285
Arg Asp Ala Phe Asp Pro Thr Pro Gly Thr Glu Ala Trp Gln Leu Ser
290 295 300
Asn Pro Pro Ile Leu Ala Met Val Ala Val Trp Ser Ala Leu Lys Leu
305 310 315 320
Phe Asp Glu Val Gly Met Thr Arg Leu Arg Lys Lys Ala Ile Ser Leu
325 330 335
Thr Gly Tyr Leu Glu Tyr Leu Val Asn Thr Leu Gly Asp Asp Val Val
340 345 350
Asn Ile Val Thr Pro Ala Asp Pro Ala Gln Arg Gly Ser Gln Leu Ser
355 360 365
Ile Gln Val Lys Thr Ala Asp Lys Lys Leu Phe Asn Lys Ile Thr Glu
370 375 380
Ala Gly Val Ile Ala Asp Trp Arg Glu Pro Asp Val Ile Arg Val Ala
385 390 395 400
Pro Val Pro Met Tyr Asn Ser Tyr Glu Asp Val Tyr Asn Phe Tyr Thr
405 410 415
Ile Leu Lys Ser Ala Ile Ala Gly Asn
420 425
<210> 52
<211> 424
<212> PRT
<213> Pontibacter roseus
<400> 52
Met Asn Tyr Gln Asn Thr Leu Ala Phe Ala Gln Glu Gln Asp Asn Leu
1 5 10 15
Asp Pro Leu Lys His Phe Lys Asp Arg Phe Tyr Phe Pro Gln Val Asn
20 25 30
Gly Arg Asp Ala Ile Tyr Phe Cys Gly Asn Ser Leu Gly Leu Gln Pro
35 40 45
Lys Ser Ala Gln Met Tyr Ile Asp Asn Glu Met Tyr Lys Trp Ala Asn
50 55 60
Tyr Ala Val Glu Gly His Phe Lys Val Glu Glu Pro Trp Phe Asn Tyr
65 70 75 80
His Arg Leu Leu Thr Asp Gly Ala Ala Arg Val Val Gly Ala Arg Pro
85 90 95
Gln Glu Val Val Ile Met Asn Gln Leu Thr Val Asn Leu His Leu Met
100 105 110
Leu Val Ser Phe Tyr Arg Pro Glu Gly Arg Arg Ile Lys Ile Ile Met
115 120 125
Glu Gly Gly Ala Phe Pro Ser Asp Gln Tyr Ala Leu Glu Thr Gln Val
130 135 140
Lys Phe His Gly Tyr Thr Pro Glu Glu Ala Ile Ile Glu Leu Phe Pro
145 150 155 160
Arg Glu Gly Glu His Thr Leu Arg Thr Glu Asp Ile Leu Lys Ser Ile
165 170 175
Glu Ala Ala Gly Asp Glu Leu Ala Leu Val Leu Met Gly Gly Ile Asn
180 185 190
Tyr Tyr Thr Gly Gln Val Tyr Asp Met Ala Ala Ile Thr Gln Ala Gly
195 200 205
His Gly Val Gly Ala Val Val Gly Phe Asp Leu Ala His Ala Ala Gly
210 215 220
Asn Val Pro Leu Gln Leu His Asp Trp Gly Val Asp Phe Ala Val Trp
225 230 235 240
Cys Thr Tyr Lys Tyr Leu Asn Ser Gly Pro Gly Gly Thr Ala Gly Val
245 250 255
Phe Val His Glu Arg His Ala Asn Asn Pro Asp Leu Pro Arg Phe Ala
260 265 270
Gly Trp Trp Gly His Asp Ala Ser Val Arg Phe Gln Met Lys Lys Gly
275 280 285
Phe Ile Pro Met Thr Gly Ala Glu Gly Trp Gln Leu Ser Asn Ala Gln
290 295 300
Ile Leu Pro Met Ala Val His Arg Ala Ala Leu Glu Leu Phe Asp Glu
305 310 315 320
Ala Gly Met Asp Asn Leu Arg Ala Lys Ser Glu Lys Leu Thr Gly Tyr
325 330 335
Leu Glu Tyr Leu Ile Asp Asp Val His Val Gly Lys Glu Leu Leu Glu
340 345 350
Met Ile Thr Pro Arg Asp Pro Gln Ala Arg Gly Cys Gln Ile Ser Leu
355 360 365
Leu Val Lys Gln Asn Ala Arg Glu Leu Phe Asn Arg Leu Met Glu Ala
370 375 380
Gly Ile Ile Val Asp Phe Arg Glu Pro Ser Val Ile Arg Val Ala Pro
385 390 395 400
Thr Pro Leu Tyr Asn Ser Phe Glu Glu Val Tyr Arg Phe Ser Glu Ile
405 410 415
Leu His Asp Cys Leu Gln Ser His
420
<210> 53
<211> 1304
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic polynucleotide
<400> 53
ccatgggcgg acaccatcat caccaccacg gcggcattga aaaactgaaa cagtatcacg 60
atgaagcgat cagcctggat agccttgatc ccttacagaa attcaaagaa tgctttacat 120
taccgaagga acctggagca ctgtatttct gcagcaatag tctgggcttg cccgcgaaag 180
cggcttccca gaaactggaa gaacagttac agcggtggag cgaattaggc gctcgtggat 240
ggtttgaagg cgagggtaat tggtataaca gcttggaaga gcctattgtg cgtccattga 300
gcaaaatctt aggagcggaa agcaatgaag tgaccctgat gaatagcttg accgtgaatc 360
tgcacatgtt gttgattagt ttctatcgtc cgaccaaaat gcgttataag atactgattg 420
atggcccagc ctttccgtcc gatctgtatg ccattaagtc gcatctgcgt tttcataaga 480
aagaagaagg tcttattctg atagaaccgc gtccgggcga acatctggtg caggaagaag 540
actttctgcg cgtgataaag aagcaaggag aggaaattgc gttggtgttt ctgaactgcg 600
tgaattttct gagcggccag gtgctgaaag tggatgaaat cacccgttat gccaaggagg 660
ctggctgctg cgtcggttat gatctggcgc atgcagcagg caatattccc ttaagcttgc 720
atgatcttgg cggcgacttt gcggtgggct gctcctacaa atatctgtgc ggaggcccag 780
gaggtccagg catagcctac gttcacgcgt cacatcacca ccaacagttc gtgcgtttca 840
gcgggtggtg gggcaatgat ccgaataccc ggttttactt ccccaaagag tttgtgccgt 900
atggcggtgc gagctcctgg caggtgagca ccccgtcgat tctggcgaaa ctgccgttaa 960
ttgcggcact ggaggtgttt gaggaagcgg gcatggagaa tatacgtgaa aagagcaaga 1020
aacaaacagc gttcctgtat accctgttag aaaatgctcg cggcacccat tttgatatga 1080
taaccccgaa agaaccggag ctgcgtggct gtcagcttag cctgcgtatc aaatgcagcc 1140
gtagcgaaga gatcttacgg aagctggaac gtttaggcat tacatgcgat ttccgttcgc 1200
cgaacattct gcgtgtggcg ccgagcccgt tgtacaccag cttttacgaa atctatcgtt 1260
ttgcgtacac ctttctggaa gtcctgaaaa ccatttgaga attc 1304
<210> 54
<211> 431
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetic polypeptide
<400> 54
Met Gly Gly His His His His His His Gly Gly Ile Glu Lys Leu Lys
1 5 10 15
Gln Tyr His Asp Glu Ala Ile Ser Leu Asp Ser Leu Asp Pro Leu Gln
20 25 30
Lys Phe Lys Glu Cys Phe Thr Leu Pro Lys Glu Pro Gly Ala Leu Tyr
35 40 45
Phe Cys Ser Asn Ser Leu Gly Leu Pro Ala Lys Ala Ala Ser Gln Lys
50 55 60
Leu Glu Glu Gln Leu Gln Arg Trp Ser Glu Leu Gly Ala Arg Gly Trp
65 70 75 80
Phe Glu Gly Glu Gly Asn Trp Tyr Asn Ser Leu Glu Glu Pro Ile Val
85 90 95
Arg Pro Leu Ser Lys Ile Leu Gly Ala Glu Ser Asn Glu Val Thr Leu
100 105 110
Met Asn Ser Leu Thr Val Asn Leu His Met Leu Leu Ile Ser Phe Tyr
115 120 125
Arg Pro Thr Lys Met Arg Tyr Lys Ile Leu Ile Asp Gly Pro Ala Phe
130 135 140
Pro Ser Asp Leu Tyr Ala Ile Lys Ser His Leu Arg Phe His Lys Lys
145 150 155 160
Glu Glu Gly Leu Ile Leu Ile Glu Pro Arg Pro Gly Glu His Leu Val
165 170 175
Gln Glu Glu Asp Phe Leu Arg Val Ile Lys Lys Gln Gly Glu Glu Ile
180 185 190
Ala Leu Val Phe Leu Asn Cys Val Asn Phe Leu Ser Gly Gln Val Leu
195 200 205
Lys Val Asp Glu Ile Thr Arg Tyr Ala Lys Glu Ala Gly Cys Cys Val
210 215 220
Gly Tyr Asp Leu Ala His Ala Ala Gly Asn Ile Pro Leu Ser Leu His
225 230 235 240
Asp Leu Gly Gly Asp Phe Ala Val Gly Cys Ser Tyr Lys Tyr Leu Cys
245 250 255
Gly Gly Pro Gly Gly Pro Gly Ile Ala Tyr Val His Ala Ser His His
260 265 270
His Gln Gln Phe Val Arg Phe Ser Gly Trp Trp Gly Asn Asp Pro Asn
275 280 285
Thr Arg Phe Tyr Phe Pro Lys Glu Phe Val Pro Tyr Gly Gly Ala Ser
290 295 300
Ser Trp Gln Val Ser Thr Pro Ser Ile Leu Ala Lys Leu Pro Leu Ile
305 310 315 320
Ala Ala Leu Glu Val Phe Glu Glu Ala Gly Met Glu Asn Ile Arg Glu
325 330 335
Lys Ser Lys Lys Gln Thr Ala Phe Leu Tyr Thr Leu Leu Glu Asn Ala
340 345 350
Arg Gly Thr His Phe Asp Met Ile Thr Pro Lys Glu Pro Glu Leu Arg
355 360 365
Gly Cys Gln Leu Ser Leu Arg Ile Lys Cys Ser Arg Ser Glu Glu Ile
370 375 380
Leu Arg Lys Leu Glu Arg Leu Gly Ile Thr Cys Asp Phe Arg Ser Pro
385 390 395 400
Asn Ile Leu Arg Val Ala Pro Ser Pro Leu Tyr Thr Ser Phe Tyr Glu
405 410 415
Ile Tyr Arg Phe Ala Tyr Thr Phe Leu Glu Val Leu Lys Thr Ile
420 425 430
<210> 55
<211> 464
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetic polypeptide
<400> 55
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile
1 5 10 15
Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His
20 25 30
Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile
35 40 45
Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys
50 55 60
Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro
65 70 75 80
Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys
85 90 95
Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly
100 105 110
Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu
115 120 125
Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu
130 135 140
Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu
145 150 155 160
Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu
165 170 175
Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro
180 185 190
Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile
195 200 205
Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His
210 215 220
Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly
225 230 235 240
Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly
245 250 255
Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp
260 265 270
Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala
275 280 285
Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly
290 295 300
Trp Met Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu
305 310 315 320
Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile
325 330 335
Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Thr
340 345 350
Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu Glu
355 360 365
Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys Lys
370 375 380
Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly Cys
385 390 395 400
Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln Glu
405 410 415
Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly Ile
420 425 430
Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr Lys
435 440 445
Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys Asn
450 455 460
<210> 56
<211> 464
<212> PRT
<213> Artificial Sequence
<220>
<223> Synthetic polypeptide
<400> 56
Met Glu Pro Ser Ser Leu Glu Leu Pro Ala Asp Thr Val Gln Arg Ile
1 5 10 15
Ala Ala Glu Leu Lys Cys His Pro Thr Asp Glu Arg Val Ala Leu His
20 25 30
Leu Asp Glu Glu Asp Lys Leu Arg His Phe Arg Glu Cys Phe Tyr Ile
35 40 45
Pro Lys Ile Gln Asp Leu Pro Pro Val Asp Leu Ser Leu Val Asn Lys
50 55 60
Asp Glu Asn Ala Ile Tyr Phe Leu Gly Asn Ser Leu Gly Leu Gln Pro
65 70 75 80
Lys Met Val Lys Thr Tyr Leu Glu Glu Glu Leu Asp Lys Trp Ala Lys
85 90 95
Ile Ala Ala Tyr Gly His Glu Val Gly Lys Arg Pro Trp Ile Thr Gly
100 105 110
Asp Glu Ser Ile Val Gly Leu Met Lys Asp Ile Val Gly Ala Asn Glu
115 120 125
Lys Glu Ile Ala Leu Met Asn Ala Leu Thr Val Asn Leu His Leu Leu
130 135 140
Met Leu Ser Phe Phe Lys Pro Thr Pro Lys Arg Tyr Lys Ile Leu Leu
145 150 155 160
Glu Ala Lys Ala Phe Pro Ser Asp His Tyr Ala Ile Glu Ser Gln Leu
165 170 175
Gln Leu His Gly Leu Asn Ile Glu Glu Ser Met Arg Met Ile Lys Pro
180 185 190
Arg Glu Gly Glu Glu Thr Leu Arg Ile Glu Asp Ile Leu Glu Val Ile
195 200 205
Glu Lys Glu Gly Asp Ser Ile Ala Val Ile Leu Phe Ser Gly Val His
210 215 220
Phe Tyr Thr Gly Gln His Phe Asn Ile Pro Ala Ile Thr Lys Ala Gly
225 230 235 240
Gln Ala Lys Gly Cys Tyr Val Gly Phe Asp Leu Ala His Ala Val Gly
245 250 255
Asn Val Glu Leu Tyr Leu His Asp Trp Gly Val Asp Phe Ala Cys Trp
260 265 270
Cys Ser Tyr Lys Tyr Leu Asn Ala Gly Ala Gly Gly Ile Ala Gly Ala
275 280 285
Phe Ile His Glu Lys His Ala His Thr Ile Lys Pro Ala Leu Val Gly
290 295 300
Trp Leu Gly His Glu Leu Ser Thr Arg Phe Lys Met Asp Asn Lys Leu
305 310 315 320
Gln Leu Ile Pro Gly Val Cys Gly Phe Arg Ile Ser Asn Pro Pro Ile
325 330 335
Leu Leu Val Cys Ser Leu His Ala Ser Leu Glu Ile Phe Lys Gln Thr
340 345 350
Met Lys Ala Leu Arg Lys Lys Ser Val Leu Leu Thr Gly Tyr Leu Glu
355 360 365
Tyr Leu Ile Lys His Asn Tyr Gly Lys Asp Lys Ala Ala Thr Lys Lys
370 375 380
Pro Val Val Asn Ile Ile Thr Pro Ser His Val Glu Glu Arg Gly Cys
385 390 395 400
Gln Leu Thr Ile Thr Phe Ser Val Pro Asn Lys Asp Val Phe Gln Glu
405 410 415
Leu Glu Lys Arg Gly Val Val Cys Asp Lys Arg Asn Pro Asn Gly Ile
420 425 430
Arg Val Ala Pro Val Pro Leu Tyr Asn Ser Phe His Asp Val Tyr Lys
435 440 445
Phe Thr Asn Leu Leu Thr Ser Ile Leu Asp Ser Ala Glu Thr Lys Asn
450 455 460
<210> 57
<211> 420
<212> PRT
<213> Chlamydophila pecorum
<400> 57
Ile Glu Lys Leu Lys Gln Tyr His Asp Glu Ala Ile Ser Leu Asp Ser
1 5 10 15
Leu Asp Pro Leu Gln Lys Phe Lys Glu Cys Phe Thr Leu Pro Lys Glu
20 25 30
Pro Gly Ala Leu Tyr Phe Cys Ser Asn Ser Leu Gly Leu Pro Ala Lys
35 40 45
Ala Ala Ser Gln Lys Leu Glu Glu Gln Leu Gln Arg Trp Ser Glu Leu
50 55 60
Gly Ala Arg Gly Trp Phe Glu Gly Glu Gly Asn Trp Tyr Asn Ser Leu
65 70 75 80
Glu Glu Pro Ile Val Arg Pro Leu Ser Lys Ile Leu Gly Ala Glu Ser
85 90 95
Asn Glu Val Thr Leu Met Asn Ser Leu Thr Val Asn Leu His Met Leu
100 105 110
Leu Ile Ser Phe Tyr Arg Pro Thr Lys Met Arg Tyr Lys Ile Leu Ile
115 120 125
Asp Gly Pro Ala Phe Pro Ser Asp Leu Tyr Ala Ile Lys Ser His Leu
130 135 140
Arg Phe His Lys Lys Glu Glu Gly Leu Ile Leu Ile Glu Pro Arg Pro
145 150 155 160
Gly Glu His Leu Val Gln Glu Glu Asp Phe Leu Arg Val Ile Lys Lys
165 170 175
Gln Gly Glu Glu Ile Ala Leu Val Phe Leu Asn Cys Val Asn Phe Leu
180 185 190
Ser Gly Gln Val Leu Lys Val Asp Glu Ile Thr Arg Tyr Ala Lys Glu
195 200 205
Ala Gly Cys Cys Val Gly Tyr Asp Leu Ala His Ala Ala Gly Asn Ile
210 215 220
Pro Leu Ser Leu His Asp Leu Gly Gly Asp Phe Ala Val Gly Cys Ser
225 230 235 240
Tyr Lys Tyr Leu Cys Gly Gly Pro Gly Gly Pro Gly Ile Ala Tyr Val
245 250 255
His Ala Ser His His His Gln Gln Phe Val Arg Phe Ser Gly Trp Trp
260 265 270
Gly Asn Asp Pro Asn Thr Arg Phe Tyr Phe Pro Lys Glu Phe Val Pro
275 280 285
Tyr Gly Gly Ala Ser Ser Trp Gln Val Ser Thr Pro Ser Ile Leu Ala
290 295 300
Lys Leu Pro Leu Ile Ala Ala Leu Glu Val Phe Glu Glu Ala Gly Met
305 310 315 320
Glu Asn Ile Arg Glu Lys Ser Lys Lys Gln Thr Ala Phe Leu Tyr Thr
325 330 335
Leu Leu Glu Asn Ala Arg Gly Thr His Phe Asp Met Ile Thr Pro Lys
340 345 350
Glu Pro Glu Leu Arg Gly Cys Gln Leu Ser Leu Arg Ile Lys Cys Ser
355 360 365
Arg Ser Glu Glu Ile Leu Arg Lys Leu Glu Arg Leu Gly Ile Thr Cys
370 375 380
Asp Phe Arg Ser Pro Asn Ile Leu Arg Val Ala Pro Ser Pro Leu Tyr
385 390 395 400
Thr Ser Phe Tyr Glu Ile Tyr Arg Phe Ala Tyr Thr Phe Leu Glu Val
405 410 415
Leu Lys Thr Ile
420
Claims (16)
- (i)配列番号7、8、10-52または57に記載の配列を含むキヌレニナーゼポリペプチド;または
(ii)配列番号7、8、10-52または57に対して少なくとも95%同一である配列を含むキヌレニナーゼポリペプチドであって、キヌレニナーゼ活性を有するポリペプチド、
および薬学上許容可能なキャリアを含む有効量の医薬製剤を含む、腫瘍を有する対象を治療するための医薬組成物。 - キヌレニナーゼが霊長類またはヒトのキヌレニナーゼであり、霊長類のキヌレニナーゼが、配列番号8及び10~12のいずれかに対して少なくとも95%同一であるアミノ酸配列を含み、キヌレニナーゼ活性を有する、請求項1に記載の医薬組成物。
- キヌレニナーゼが、単離された、修飾されたヒトキヌレニナーゼ酵素であって、前記修飾された酵素が、ネイティブなヒトキヌレニナーゼ(配列番号8を参照)に比べて少なくとも1つの置換を有し、前記少なくとも1つの置換が、ネイティブなヒトキヌレニナーゼの306位に通常見いだされるPheに対するMetまたはLeuによる置換を含む、請求項1に記載の医薬組成物。
- 前記対象がヒト患者である、請求項1に記載の医薬組成物。
- 前記製剤が、腫瘍内に、静脈内に、皮内に、動脈内に、腹腔内に、病変内に、頭蓋内に、関節内に、前立腺内に、胸膜腔内に、気管内に、眼内に、鼻内に、硝子体内に、膣内に、直腸内に、筋肉内に、皮下に、結膜下に、小嚢内に(intravesicularlly)、粘膜に、心膜内に、臍内に、経口で、吸入によって、注射によって、点滴によって、持続点滴によって、標的細胞を直接浸す局所潅流によって、カテーテルを介して、または洗浄を介して投与される、請求項1に記載の医薬組成物。
- 前記対象が少なくとも第2の抗癌療法を施される、請求項1に記載の医薬組成物。
- 前記第2の抗癌療法が、外科療法、化学療法、放射線療法、寒冷療法、ホルモン療法、免疫療法、またはサイトカイン療法である、請求項6に記載の医薬組成物。
- 前記第2の抗癌療法が、抗PD1抗体、抗CTLA-4抗体、または抗PD-L1抗体による療法を含む、請求項6に記載の医薬組成物。
- 前記少なくとも1つの置換がPhe306Metを含む、請求項3に記載の医薬組成物。
- 前記少なくとも1つの置換がPhe306Leuを含む、請求項3に記載の医薬組成物。
- 前記キヌレニナーゼが異種ペプチドセグメントをさらに含む、請求項1に記載の医薬組成物。
- 前記異種ペプチドセグメントが、XTENペプチド、IgGのFc、アルブミン、またはアルブミン結合ペプチドである、請求項11に記載の医薬組成物。
- 前記キヌレニナーゼがポリエチレングリコール(PEG)に結合されている、請求項1に記載の医薬組成物。
- 前記キヌレニナーゼが1つ以上のLysまたはCys残基を介してPEGに結合されている、請求項13に記載の医薬組成物。
- 前記キヌレニナーゼが、3'-OHキヌレニンよりもキヌレニンに対してより高い触媒活性を有する、請求項1に記載の医薬組成物。
- 前記キヌレニナーゼが細菌のキヌレニナーゼであり、前記細菌のキヌレニナーゼが、配列番号7、13~52、及び57のいずれかに対して少なくとも95%同一であるアミノ酸配列を含み、キヌレニナーゼ活性を有する、請求項1に記載の医薬組成物。
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AR115051A1 (es) * | 2018-04-16 | 2020-11-25 | Univ Texas | Enzimas quinureninasa humanas y sus usos |
CN110412179A (zh) * | 2018-04-26 | 2019-11-05 | 缪荣明 | 一种液相色谱检测颗粒酶a的方法 |
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