JP6307163B2 - 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 - Google Patents

腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 Download PDF

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JP6307163B2
JP6307163B2 JP2016537898A JP2016537898A JP6307163B2 JP 6307163 B2 JP6307163 B2 JP 6307163B2 JP 2016537898 A JP2016537898 A JP 2016537898A JP 2016537898 A JP2016537898 A JP 2016537898A JP 6307163 B2 JP6307163 B2 JP 6307163B2
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kynureninase
kynurenine
pharmaceutical composition
cell
tumor
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JP2016533753A5 (enExample
JP2016533753A (ja
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ジョージ ジョージウー
ジョージ ジョージウー
エバレット ストーン
エバレット ストーン
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University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4244—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y307/00—Hydrolases acting on carbon-carbon bonds (3.7)
    • C12Y307/01—Hydrolases acting on carbon-carbon bonds (3.7) in ketonic substances (3.7.1)
    • C12Y307/01003—Kynureninase (3.7.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016537898A 2013-08-30 2014-08-29 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与 Active JP6307163B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361872132P 2013-08-30 2013-08-30
US61/872,132 2013-08-30
US201461986366P 2014-04-30 2014-04-30
US61/986,366 2014-04-30
PCT/US2014/053437 WO2015031771A2 (en) 2013-08-30 2014-08-29 Administration of kynurenine depleting enzymes for tumor therapy

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JP2018042760A Division JP7029316B2 (ja) 2013-08-30 2018-03-09 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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JP2016533753A JP2016533753A (ja) 2016-11-04
JP2016533753A5 JP2016533753A5 (enExample) 2017-10-05
JP6307163B2 true JP6307163B2 (ja) 2018-04-04

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JP2016537898A Active JP6307163B2 (ja) 2013-08-30 2014-08-29 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与
JP2018042760A Active JP7029316B2 (ja) 2013-08-30 2018-03-09 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与
JP2020073212A Withdrawn JP2020111611A (ja) 2013-08-30 2020-04-16 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与
JP2022132161A Pending JP2022159570A (ja) 2013-08-30 2022-08-23 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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JP2018042760A Active JP7029316B2 (ja) 2013-08-30 2018-03-09 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与
JP2020073212A Withdrawn JP2020111611A (ja) 2013-08-30 2020-04-16 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与
JP2022132161A Pending JP2022159570A (ja) 2013-08-30 2022-08-23 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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US (5) US9808486B2 (enExample)
EP (2) EP3492094A1 (enExample)
JP (4) JP6307163B2 (enExample)
KR (2) KR102271498B1 (enExample)
CN (2) CN105722522B (enExample)
AU (1) AU2014312119B2 (enExample)
BR (1) BR112016004095A2 (enExample)
CA (2) CA2922670C (enExample)
ES (1) ES2707711T3 (enExample)
IL (2) IL244312B (enExample)
WO (1) WO2015031771A2 (enExample)
ZA (1) ZA201601443B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2017526368A (ja) * 2014-08-29 2017-09-14 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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WO2019165237A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
JP7432851B2 (ja) * 2018-04-16 2024-02-19 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ヒトキヌレニナーゼ酵素及びその使用
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017526368A (ja) * 2014-08-29 2017-09-14 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与
JP7080053B2 (ja) 2014-08-29 2022-06-03 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 腫瘍の治療のための、キヌレニンを枯渇させる酵素の投与

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US10772913B2 (en) 2020-09-15
CA2922670A1 (en) 2015-03-05
EP3038636A2 (en) 2016-07-06
ES2707711T3 (es) 2019-04-04
JP7029316B2 (ja) 2022-03-03
NZ717492A (en) 2021-10-29
JP2018127463A (ja) 2018-08-16
CN113957061A (zh) 2022-01-21
KR102442231B1 (ko) 2022-09-13
US20240091258A1 (en) 2024-03-21
JP2022159570A (ja) 2022-10-17
EP3038636B1 (en) 2018-11-07
CA3173052A1 (en) 2015-03-05
US9808486B2 (en) 2017-11-07
IL244312B (en) 2019-03-31
JP2020111611A (ja) 2020-07-27
EP3492094A1 (en) 2019-06-05
BR112016004095A2 (pt) 2017-10-17
AU2014312119A1 (en) 2016-03-17
CN105722522A (zh) 2016-06-29
WO2015031771A3 (en) 2015-05-14
KR20210082264A (ko) 2021-07-02
IL264901B (en) 2019-08-29
US20210213059A1 (en) 2021-07-15
KR20160048971A (ko) 2016-05-04
AU2014312119B2 (en) 2019-09-19
US11534463B2 (en) 2022-12-27
IL244312A0 (en) 2016-04-21
KR102271498B1 (ko) 2021-07-05
CN105722522B (zh) 2021-10-19
EP3038636A4 (en) 2017-04-26
US20200054674A1 (en) 2020-02-20
ZA201601443B (en) 2019-08-28
US20150064154A1 (en) 2015-03-05
WO2015031771A2 (en) 2015-03-05
CA2922670C (en) 2022-11-29
US20170056449A1 (en) 2017-03-02
JP2016533753A (ja) 2016-11-04

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