JP2021506320A5 - - Google Patents
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- Publication number
- JP2021506320A5 JP2021506320A5 JP2020534518A JP2020534518A JP2021506320A5 JP 2021506320 A5 JP2021506320 A5 JP 2021506320A5 JP 2020534518 A JP2020534518 A JP 2020534518A JP 2020534518 A JP2020534518 A JP 2020534518A JP 2021506320 A5 JP2021506320 A5 JP 2021506320A5
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- present
- administration
- composition
- mtase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022009836A JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび／またはメチルチオアデノシンの酵素媒介枯渇方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762609000P | 2017-12-21 | 2017-12-21 | |
| US62/609,000 | 2017-12-21 | ||
| PCT/US2018/066731 WO2019126455A1 (en) | 2017-12-21 | 2018-12-20 | Enzyme-mediated depletion of adenosine and/or methylthioadenosine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022009836A Division JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび／またはメチルチオアデノシンの酵素媒介枯渇方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021506320A JP2021506320A (ja) | 2021-02-22 |
| JP2021506320A5 true JP2021506320A5 (enExample) | 2022-01-06 |
| JP7016958B2 JP7016958B2 (ja) | 2022-02-07 |
Family
ID=66993826
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534518A Expired - Fee Related JP7016958B2 (ja) | 2017-12-21 | 2018-12-20 | アデノシンおよび／またはメチルチオアデノシンの酵素媒介枯渇方法 |
| JP2022009836A Active JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび／またはメチルチオアデノシンの酵素媒介枯渇方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022009836A Active JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび／またはメチルチオアデノシンの酵素媒介枯渇方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20210054350A1 (enExample) |
| EP (1) | EP3727420A4 (enExample) |
| JP (2) | JP7016958B2 (enExample) |
| AU (1) | AU2018393093A1 (enExample) |
| CA (1) | CA3122502A1 (enExample) |
| WO (1) | WO2019126455A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210054350A1 (en) * | 2017-12-21 | 2021-02-25 | Board Of Regents, The University Of Texas System | Enzyme-mediated depletion of adenosine and/or methylthioadenosine |
| US11396647B2 (en) | 2020-01-07 | 2022-07-26 | Board Of Regents, The University Of Texas System | Human methylthioadenosine/adenosine depleting enzyme variants for cancer therapy |
| WO2025085615A1 (en) * | 2023-10-17 | 2025-04-24 | Baylor College Of Medicine | Methods to rapidly detect methylthioadenosine and related metabolites directly from patient samples to identify 9p21 loss cancers and treatment strategies for patients |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ289155B6 (cs) * | 1993-12-29 | 2001-11-14 | The Regents Of The University Of California | Izolovaný polynukleotid, který kóduje methylthioadenosin fosforylázu, expresní vektor a protilátka |
| US5840505A (en) * | 1993-12-29 | 1998-11-24 | The Regents Of The University Of California | Method for inhibiting adenylosuccinate synthetase activity in methylthioadenosine phosphorylase deficient cells |
| US6870037B1 (en) | 1995-07-03 | 2005-03-22 | Arch Development Corporation | Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders |
| CN1321765A (zh) * | 2000-04-29 | 2001-11-14 | 上海博德基因开发有限公司 | 一种新的多肽——人甲硫基腺苷磷酸化酶37和编码这种多肽的多核苷酸 |
| TW200427463A (en) * | 2003-02-14 | 2004-12-16 | Salmedix | Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers |
| CA2643056A1 (en) * | 2006-02-24 | 2007-08-30 | Industrial Research Limited | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
| GB0620715D0 (en) * | 2006-10-18 | 2006-11-29 | Univ Durham | Ethanol production |
| EP2506015A1 (en) * | 2011-04-01 | 2012-10-03 | Universität Regensburg | A prognostic and therapeutic signature for malignant melanoma |
| US20180010132A1 (en) * | 2014-09-11 | 2018-01-11 | Novartis Ag | Inhibition of prmt5 to treat mtap-deficiency-related diseases |
| US20210054350A1 (en) * | 2017-12-21 | 2021-02-25 | Board Of Regents, The University Of Texas System | Enzyme-mediated depletion of adenosine and/or methylthioadenosine |
-
2018
- 2018-12-20 US US16/956,340 patent/US20210054350A1/en not_active Abandoned
- 2018-12-20 JP JP2020534518A patent/JP7016958B2/ja not_active Expired - Fee Related
- 2018-12-20 WO PCT/US2018/066731 patent/WO2019126455A1/en not_active Ceased
- 2018-12-20 EP EP18890088.0A patent/EP3727420A4/en not_active Withdrawn
- 2018-12-20 AU AU2018393093A patent/AU2018393093A1/en not_active Abandoned
- 2018-12-20 CA CA3122502A patent/CA3122502A1/en active Pending
-
2020
- 2020-11-17 US US16/950,622 patent/US11118167B2/en not_active Expired - Fee Related
-
2022
- 2022-01-26 JP JP2022009836A patent/JP7313497B2/ja active Active
- 2022-11-10 US US18/054,347 patent/US20230227796A1/en not_active Abandoned
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