JP7016958B2 - アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 - Google Patents
アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 Download PDFInfo
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- JP7016958B2 JP7016958B2 JP2020534518A JP2020534518A JP7016958B2 JP 7016958 B2 JP7016958 B2 JP 7016958B2 JP 2020534518 A JP2020534518 A JP 2020534518A JP 2020534518 A JP2020534518 A JP 2020534518A JP 7016958 B2 JP7016958 B2 JP 7016958B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12Y—ENZYMES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022009836A JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762609000P | 2017-12-21 | 2017-12-21 | |
| US62/609,000 | 2017-12-21 | ||
| PCT/US2018/066731 WO2019126455A1 (en) | 2017-12-21 | 2018-12-20 | Enzyme-mediated depletion of adenosine and/or methylthioadenosine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022009836A Division JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021506320A JP2021506320A (ja) | 2021-02-22 |
| JP2021506320A5 JP2021506320A5 (enExample) | 2022-01-06 |
| JP7016958B2 true JP7016958B2 (ja) | 2022-02-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534518A Expired - Fee Related JP7016958B2 (ja) | 2017-12-21 | 2018-12-20 | アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 |
| JP2022009836A Active JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2022009836A Active JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20210054350A1 (enExample) |
| EP (1) | EP3727420A4 (enExample) |
| JP (2) | JP7016958B2 (enExample) |
| AU (1) | AU2018393093A1 (enExample) |
| CA (1) | CA3122502A1 (enExample) |
| WO (1) | WO2019126455A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7016958B2 (ja) * | 2017-12-21 | 2022-02-07 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 |
| KR20220124718A (ko) * | 2020-01-07 | 2022-09-14 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 암 치료를 위한 개선된 인간 메틸 티오아데노신/아데노신 고갈 효소 변이체 |
| WO2025085615A1 (en) * | 2023-10-17 | 2025-04-24 | Baylor College Of Medicine | Methods to rapidly detect methylthioadenosine and related metabolites directly from patient samples to identify 9p21 loss cancers and treatment strategies for patients |
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| JP2000509247A (ja) | 1996-03-08 | 2000-07-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 悪性メチルチオアデノシンホスホリラーゼ欠損細胞でアデニロコハク酸シンセターゼ活性を抑制する方法 |
| WO2004074325A2 (en) | 2003-02-14 | 2004-09-02 | Salmedix, Inc | Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers |
| JP2009528996A (ja) | 2006-02-24 | 2009-08-13 | インダストリアル リサーチ リミテッド | ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法 |
| WO2012131052A1 (en) | 2011-04-01 | 2012-10-04 | Universität Regensburg | A prognostic and therapeutic signature for malignant melanoma |
| WO2016038550A1 (en) | 2014-09-11 | 2016-03-17 | Novartis Ag | Inhibition of prmt5 to treat mtap-deficiency-related diseases |
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| PL181667B1 (pl) * | 1993-12-29 | 2001-08-31 | Univ California | Sposób wykrywania obecnosci katalitycznie aktywneji katalitycznie nieaktywnej fosforylazy metylotioadenozynowej (MTAzy), wyizolowany polinukleotyd oraz zrekombinowany wektor ekspresyjny PL |
| US6870037B1 (en) | 1995-07-03 | 2005-03-22 | Arch Development Corporation | Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders |
| CN1321765A (zh) * | 2000-04-29 | 2001-11-14 | 上海博德基因开发有限公司 | 一种新的多肽——人甲硫基腺苷磷酸化酶37和编码这种多肽的多核苷酸 |
| GB0620715D0 (en) * | 2006-10-18 | 2006-11-29 | Univ Durham | Ethanol production |
| JP7016958B2 (ja) * | 2017-12-21 | 2022-02-07 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 |
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2018
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- 2018-12-20 WO PCT/US2018/066731 patent/WO2019126455A1/en not_active Ceased
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- 2018-12-20 AU AU2018393093A patent/AU2018393093A1/en not_active Abandoned
- 2018-12-20 CA CA3122502A patent/CA3122502A1/en active Pending
- 2018-12-20 EP EP18890088.0A patent/EP3727420A4/en not_active Withdrawn
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2022
- 2022-01-26 JP JP2022009836A patent/JP7313497B2/ja active Active
- 2022-11-10 US US18/054,347 patent/US20230227796A1/en not_active Abandoned
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| JP2000509247A (ja) | 1996-03-08 | 2000-07-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 悪性メチルチオアデノシンホスホリラーゼ欠損細胞でアデニロコハク酸シンセターゼ活性を抑制する方法 |
| WO2004074325A2 (en) | 2003-02-14 | 2004-09-02 | Salmedix, Inc | Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers |
| JP2009528996A (ja) | 2006-02-24 | 2009-08-13 | インダストリアル リサーチ リミテッド | ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法 |
| WO2012131052A1 (en) | 2011-04-01 | 2012-10-04 | Universität Regensburg | A prognostic and therapeutic signature for malignant melanoma |
| WO2016038550A1 (en) | 2014-09-11 | 2016-03-17 | Novartis Ag | Inhibition of prmt5 to treat mtap-deficiency-related diseases |
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| Publication number | Publication date |
|---|---|
| JP2022069441A (ja) | 2022-05-11 |
| EP3727420A4 (en) | 2022-04-06 |
| AU2018393093A1 (en) | 2020-08-06 |
| US20230227796A1 (en) | 2023-07-20 |
| EP3727420A1 (en) | 2020-10-28 |
| CA3122502A1 (en) | 2019-06-27 |
| JP2021506320A (ja) | 2021-02-22 |
| WO2019126455A1 (en) | 2019-06-27 |
| US11118167B2 (en) | 2021-09-14 |
| JP7313497B2 (ja) | 2023-07-24 |
| US20210054350A1 (en) | 2021-02-25 |
| US20210095264A1 (en) | 2021-04-01 |
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