JP7016958B2 - アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 - Google Patents

アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 Download PDF

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JP7016958B2
JP7016958B2 JP2020534518A JP2020534518A JP7016958B2 JP 7016958 B2 JP7016958 B2 JP 7016958B2 JP 2020534518 A JP2020534518 A JP 2020534518A JP 2020534518 A JP2020534518 A JP 2020534518A JP 7016958 B2 JP7016958 B2 JP 7016958B2
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mtase
enzyme
tumor
antibody
mtap
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JP2021506320A (ja
JP2021506320A5 (enExample
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エヴェレット ストーン
ドンジェタ ジュカ
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University of Texas System
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1077Pentosyltransferases (2.4.2)
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JP2020534518A 2017-12-21 2018-12-20 アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法 Expired - Fee Related JP7016958B2 (ja)

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KR20220124718A (ko) * 2020-01-07 2022-09-14 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 암 치료를 위한 개선된 인간 메틸 티오아데노신/아데노신 고갈 효소 변이체
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000509247A (ja) 1996-03-08 2000-07-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 悪性メチルチオアデノシンホスホリラーゼ欠損細胞でアデニロコハク酸シンセターゼ活性を抑制する方法
WO2004074325A2 (en) 2003-02-14 2004-09-02 Salmedix, Inc Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers
JP2009528996A (ja) 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
WO2012131052A1 (en) 2011-04-01 2012-10-04 Universität Regensburg A prognostic and therapeutic signature for malignant melanoma
WO2016038550A1 (en) 2014-09-11 2016-03-17 Novartis Ag Inhibition of prmt5 to treat mtap-deficiency-related diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL181667B1 (pl) * 1993-12-29 2001-08-31 Univ California Sposób wykrywania obecnosci katalitycznie aktywneji katalitycznie nieaktywnej fosforylazy metylotioadenozynowej (MTAzy), wyizolowany polinukleotyd oraz zrekombinowany wektor ekspresyjny PL
US6870037B1 (en) 1995-07-03 2005-03-22 Arch Development Corporation Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders
CN1321765A (zh) * 2000-04-29 2001-11-14 上海博德基因开发有限公司 一种新的多肽——人甲硫基腺苷磷酸化酶37和编码这种多肽的多核苷酸
GB0620715D0 (en) * 2006-10-18 2006-11-29 Univ Durham Ethanol production
JP7016958B2 (ja) * 2017-12-21 2022-02-07 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム アデノシンおよび/またはメチルチオアデノシンの酵素媒介枯渇方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000509247A (ja) 1996-03-08 2000-07-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 悪性メチルチオアデノシンホスホリラーゼ欠損細胞でアデニロコハク酸シンセターゼ活性を抑制する方法
WO2004074325A2 (en) 2003-02-14 2004-09-02 Salmedix, Inc Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers
JP2009528996A (ja) 2006-02-24 2009-08-13 インダストリアル リサーチ リミテッド ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
WO2012131052A1 (en) 2011-04-01 2012-10-04 Universität Regensburg A prognostic and therapeutic signature for malignant melanoma
WO2016038550A1 (en) 2014-09-11 2016-03-17 Novartis Ag Inhibition of prmt5 to treat mtap-deficiency-related diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PNAS (1996) Vol.93, pp.6203-6208

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WO2019126455A1 (en) 2019-06-27
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