JP2021506320A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2021506320A5 JP2021506320A5 JP2020534518A JP2020534518A JP2021506320A5 JP 2021506320 A5 JP2021506320 A5 JP 2021506320A5 JP 2020534518 A JP2020534518 A JP 2020534518A JP 2020534518 A JP2020534518 A JP 2020534518A JP 2021506320 A5 JP2021506320 A5 JP 2021506320A5
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- present
- administration
- composition
- mtase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090001123 antibodies Proteins 0.000 claims description 42
- 102000004965 antibodies Human genes 0.000 claims description 42
- 102100002025 MTAP Human genes 0.000 claims description 33
- 108090000790 Enzymes Proteins 0.000 claims description 32
- 102000004190 Enzymes Human genes 0.000 claims description 32
- 206010028980 Neoplasm Diseases 0.000 claims description 31
- 239000002202 Polyethylene glycol Substances 0.000 claims description 19
- 229920001223 polyethylene glycol Polymers 0.000 claims description 19
- 230000001093 anti-cancer Effects 0.000 claims description 9
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 7
- 229940121650 immune-checkpoint protein inhibitors Drugs 0.000 claims description 7
- 210000001519 tissues Anatomy 0.000 claims description 3
- 108010034457 5'-methylthioadenosine phosphorylase Proteins 0.000 claims 9
- 230000036499 Half live Effects 0.000 claims 4
- 210000002966 Serum Anatomy 0.000 claims 4
- 150000001875 compounds Chemical group 0.000 claims 4
- WUUGFSXJNOTRMR-IOSLPCCCSA-N 5'-S-methyl-5'-thioadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WUUGFSXJNOTRMR-IOSLPCCCSA-N 0.000 claims 3
- 229960000643 Adenine Drugs 0.000 claims 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Natural products NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 2
- GFSGWJLGPQTRMG-KJESCUSBSA-N OP(O)(O)=O.CC(=S)[C@H](O)[C@H](O)[C@H](O)CO Chemical compound OP(O)(O)=O.CC(=S)[C@H](O)[C@H](O)[C@H](O)CO GFSGWJLGPQTRMG-KJESCUSBSA-N 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 210000000349 Chromosomes Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000002759 chromosomal Effects 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 230000000593 degrading Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 108060003250 treS Proteins 0.000 description 75
- 229920001184 polypeptide Polymers 0.000 description 35
- 108060006326 MTAP Proteins 0.000 description 24
- 230000000694 effects Effects 0.000 description 16
- 108060006328 mtnN Proteins 0.000 description 16
- 125000003275 alpha amino acid group Chemical group 0.000 description 14
- 210000004027 cells Anatomy 0.000 description 11
- 101710027066 ALB Proteins 0.000 description 10
- 102100001249 ALB Human genes 0.000 description 10
- 229940050528 albumin Drugs 0.000 description 10
- 238000001802 infusion Methods 0.000 description 8
- 125000000415 L-cysteinyl group Chemical group O=C([*])[C@@](N([H])[H])([H])C([H])([H])S[H] 0.000 description 5
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 5
- 108010072668 atezolizumab Proteins 0.000 description 5
- 102100017286 ADO Human genes 0.000 description 4
- 102100009509 ENTPD1 Human genes 0.000 description 4
- 101710011427 ENTPD1 Proteins 0.000 description 4
- 102100017063 NT5E Human genes 0.000 description 4
- 101710039712 NT5E Proteins 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- 238000009169 immunotherapy Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000001361 intraarterial administration Methods 0.000 description 4
- 238000007917 intracranial administration Methods 0.000 description 4
- 238000007912 intraperitoneal administration Methods 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 238000007920 subcutaneous administration Methods 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 102000009914 Adenosine deaminases Human genes 0.000 description 3
- 108091022188 Adenosine deaminases Proteins 0.000 description 3
- 210000003205 Muscles Anatomy 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229950002916 Avelumab Drugs 0.000 description 2
- 210000004369 Blood Anatomy 0.000 description 2
- 229950009791 Durvalumab Drugs 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 108010089187 Ipilimumab Proteins 0.000 description 2
- 206010027476 Metastasis Diseases 0.000 description 2
- 108010019706 Nivolumab Proteins 0.000 description 2
- 229950007217 Tremelimumab Drugs 0.000 description 2
- 229960003852 atezolizumab Drugs 0.000 description 2
- 108010010826 avelumab Proteins 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000002659 cell therapy Methods 0.000 description 2
- 108010054779 cemiplimab Proteins 0.000 description 2
- 229940121420 cemiplimab Drugs 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 238000000315 cryotherapy Methods 0.000 description 2
- 108010016436 durvalumab Proteins 0.000 description 2
- 238000001794 hormone therapy Methods 0.000 description 2
- 229960005386 ipilimumab Drugs 0.000 description 2
- 229960003301 nivolumab Drugs 0.000 description 2
- 108010026276 pembrolizumab Proteins 0.000 description 2
- 229960002621 pembrolizumab Drugs 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 108010072993 tremelimumab Proteins 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 206010010099 Combined immunodeficiency Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010017758 Gastric cancer Diseases 0.000 description 1
- 206010018338 Glioma Diseases 0.000 description 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 description 1
- 206010025650 Malignant melanoma Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 229920001850 Nucleic acid sequence Polymers 0.000 description 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 description 1
- 208000006265 Renal Cell Carcinoma Diseases 0.000 description 1
- 208000002491 Severe Combined Immunodeficiency Diseases 0.000 description 1
- 206010041823 Squamous cell carcinoma Diseases 0.000 description 1
- 230000001580 bacterial Effects 0.000 description 1
- 201000009047 chordoma Diseases 0.000 description 1
- 230000002538 fungal Effects 0.000 description 1
- 201000010175 gallbladder cancer Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000004962 mammalian cells Anatomy 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
Description
[æ¬çºæ1001]
æäœã«ã³ã³ãžã¥ã²ãŒããããŠãããåé¢ãããæ¹å€ïŒïŒŽïœïœïœ é µçŽ ã
[æ¬çºæ1002]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1001ã®é µçŽ ã
[æ¬çºæ1003]
åèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã90ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1002ã®é µçŽ ã
[æ¬çºæ1004]
åèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1003ã®é µçŽ ã
[æ¬çºæ1005]
åèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã®ã¢ããé žé åãå«ããæ¬çºæ1004ã®é µçŽ ã
[æ¬çºæ1006]
åèšïŒïŒŽïœïœïœ ãåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1001ã®é µçŽ ã
[æ¬çºæ1007]
åèšåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã90ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1006ã®é µçŽ ã
[æ¬çºæ1008]
åèšåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1007ã®é µçŽ ã
[æ¬çºæ1009]
åèšåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã®ã¢ããé žé åãå«ããæ¬çºæ1008ã®é µçŽ ã
[æ¬çºæ1010]
åèšæäœãïœïœïŒŠïœæäœã§ãããæ¬çºæ1001ã1009ã®ããããã®é µçŽ ã
[æ¬çºæ1011]
åèšæäœãŸãã¯ïœïœïŒŠïœæäœãæïŒïŒµïŒ£1æäœãæ2æäœãæ4æäœãæ1æäœããŸãã¯æ1æäœã§ãããæ¬çºæ1001ãŸãã¯1010ã®é µçŽ ã
[æ¬çºæ1012]
ç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1001ã1011ã®ããããã®é µçŽ ã
[æ¬çºæ1013]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1012ã®é µçŽ ã
[æ¬çºæ1014]
ããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1001ã1013ã®ããããã®é µçŽ ã
[æ¬çºæ1015]
1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ã«çµåããŠãããæ¬çºæ1014ã®é µçŽ ã
[æ¬çºæ1016]
æ¬çºæ1001ã1015ã®ããããã®é µçŽ ãã³ãŒããããã¯ã¬ãªããé åãå«ããæ žé žã
[æ¬çºæ1017]
现èãçèãæè«ããŸãã¯åºä¹³é¡ã§ã®çºçŸã«æé©åãããã³ãã³ã§ãããæ¬çºæ1016ã®æ žé žã
[æ¬çºæ1018]
æ¬çºæ1016ãŸãã¯1017ã®æ žé žãå«ããçºçŸãã¯ã¿ãŒã
[æ¬çºæ1019]
æ¬çºæ1016ãŸãã¯1017ã®æ žé žãå«ãã宿䞻现èã
[æ¬çºæ1020]
åèšå®¿äž»çŽ°èã现è现èãçè现èãæè«çŽ°èããŸãã¯åºä¹³é¡çŽ°èã§ãããæ¬çºæ1019ã®å®¿äž»çŽ°èã
[æ¬çºæ1021]
æ¬çºæ1001ã1015ã®ããããã®ïŒïŒŽïœïœïœ âæäœã³ã³ãžã¥ã²ãŒããå«ããå»è¬è£œå€ã
[æ¬çºæ1022]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã«ïŒïŒŽïœïœïœ ããªãããããå«ãæå¹éã®å»è¬è£œå€ãæ£è ã«æäžããããšãå«ããè «çãæããæ£è ã®æ²»çæ¹æ³ã§ãã£ãŠãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1023]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1022ã®æ¹æ³ã
[æ¬çºæ1024]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1023ã®æ¹æ³ã
[æ¬çºæ1025]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1023ã®æ¹æ³ã
[æ¬çºæ1026]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1023ã®æ¹æ³ã
[æ¬çºæ1027]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1024ã®æ¹æ³ã
[æ¬çºæ1028]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1024ã®æ¹æ³ã
[æ¬çºæ1029]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1022ã1028ã®ããããã®æ¹æ³ã
[æ¬çºæ1030]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1029ã®æ¹æ³ã
[æ¬çºæ1031]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1022ã1030ã®ããããã®æ¹æ³ã
[æ¬çºæ1032]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1031ã®æ¹æ³ã
[æ¬çºæ1033]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1022ã1032ã®ããããã®æ¹æ³ã
[æ¬çºæ1034]
åèšæäœãïœïœïŒŠïœæäœã§ãããæ¬çºæ1033ã®é µçŽ ã
[æ¬çºæ1035]
åèšæäœãŸãã¯ïœïœïŒŠïœæäœãæïŒïŒµïŒ£1æäœãæ2æäœãæ4æäœãæ1æäœããŸãã¯æ1æäœã§ãããæ¬çºæ1033ãŸãã¯1034ã®é µçŽ ã
[æ¬çºæ1036]
åèšè «çãå å®æ§è «çã§ãããæ¬çºæ1022ã1035ã®ããããã®æ¹æ³ã
[æ¬çºæ1037]
åèšè «çãè¡æ¶²è «çã§ãããæ¬çºæ1022ã1035ã®ããããã®æ¹æ³ã
[æ¬çºæ1038]
åèšè «çã骚èè «ãèµçãèçŽ¢è «ãäžç®è «ã现èãè è «ãè 现èçãé»è²è «ãæå¹³äžç®çŽ°èçãèå¢çãèçããŸãã¯è现èçã§ãããæ¬çºæ1022ã1035ã®ããããã®æ¹æ³ã
[æ¬çºæ1039]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1040]
åèšè «çãïŒïŒŽïŒ¡ïŒ°æ¬ æãæãããæ¬çºæ1039ã®æ¹æ³ã
[æ¬çºæ1041]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1042]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1041ã®æ¹æ³ã
[æ¬çºæ1043]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1044]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1045]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1046]
åèšåç §ã¬ãã«ããåèšæ£è ã®å¥å šãªçµç¹ã«ãããã¬ãã«ã§ãããæ¬çºæ1039ããã³1041ã1045ã®ããããã®æ¹æ³ã
[æ¬çºæ1047]
åèšåç §ã¬ãã«ãå¥å šãªå¯Ÿè±¡ã«ãããã¬ãã«ã§ãããæ¬çºæ1039ããã³1041ã1045ã®ããããã®æ¹æ³ã
[æ¬çºæ1048]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1022ã1047ã®ããããã®æ¹æ³ã
[æ¬çºæ1049]
åèšè£œå€ããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1022ã1048ã®ããããã®æ¹æ³ã
[æ¬çºæ1050]
å ç«çæ³ã«å¯Ÿããæ床ãå¢å ãããããã®æ¹æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1022ã1049ã®ããããã®æ¹æ³ã
[æ¬çºæ1051]
åèšæ£è ãã以åã«å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ã®æäžã«å¯ŸããŠå¿çããªãã£ããæ¬çºæ1049ã®æ¹æ³ã
[æ¬çºæ1052]
åèšå¯Ÿè±¡ã«ãå°ãªããšã第2ã®æçæ²»çæ³ãæœãããšãæŽã«å«ããæ¬çºæ1022ã1051ã®ããããã®æ¹æ³ã
[æ¬çºæ1053]
åèšç¬¬2ã®æçæ²»çæ³ãå€ç§çæ³ãååŠçæ³ãæŸå°ç·çæ³ãåçµæ²»çããã«ã¢ã³çæ³ãå ç«çæ³ãŸãã¯ãµã€ãã«ã€ã³çæ³ã§ãããæ¬çºæ1052ã®æ¹æ³ã
[æ¬çºæ1054]
åèšç¬¬2ã®æçæ²»çæ³ããé€å现èçæ³ãæ1æäœãæâ4æäœãããã³ïŒãŸãã¯æâ1æäœãå«ããæ¬çºæ1052ã®æ¹æ³ã
[æ¬çºæ1055]
åèšæâ1æäœããã¢ããŸãªãºãããã¢ãã«ããããã¥ã«ãã«ãããïŒïŒ³â036559ããŸãã¯ïŒ£ïŒ«â301ãå«ããæ¬çºæ1054ã®æ¹æ³ã
[æ¬çºæ1056]
åèšæ1æäœããããã«ããããã ãããªãºãããããã£ãªãºãããïŒïŒ°â223ãïŒïŒ°â514ãã»ãããªããããŸãã¯ïŒ°ïŒ€ïŒ²â001ãå«ããæ¬çºæ1054ã®æ¹æ³ã
[æ¬çºæ1057]
åèšæâ4æ²»çæ³ããã€ããªã ãããŸãã¯ãã¬ã¡ãªã ãããå«ããæ¬çºæ1054ã®æ¹æ³ã
[æ¬çºæ1058]
転移ã®äºé²æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1022ã1057ã®ããããã®æ¹æ³ã
[æ¬çºæ1059]
è€åæå¹éã®ïŒïŒŽïœïœïœ ããªãããããšå ç«ãã§ãã¯ãã€ã³ãé»å®³å€ãçšããŠæ²»çããããã®è «çãæããæ£è ãéžæããããã®æ¹æ³ã§ãã£ãŠã
ïŒïœïŒåèšæ£è ã®è «çããåç §ã¬ãã«ã«å¯ŸããŠãäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ããŸãã¯ãå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæãããåŠããå€å®ããããšãšã
ïŒïœïŒåèšæ£è ã®è «çããåç §ã¬ãã«ã«å¯ŸããŠãäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ããŸãã¯ãå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæããå Žåãæ²»çã®ããã«åèšæ£è ãéžæããããšãš
ãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1060]
è€åæå¹éã®ïŒïŒŽïœïœïœ ããªããããããã³å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ããåèšéžæããæ£è ã«æäžããããšãæŽã«å«ããæ¬çºæ1059ã®æ¹æ³ã
[æ¬çºæ1061]
åèšæ£è ãã以åã«å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ã®æäžã«å¯ŸããŠå¿çããªãã£ãå Žåãæ²»çã®ããã«åèšæ£è ãéžæããããšãæŽã«å«ããæ¬çºæ1059ã®æ¹æ³ã
[æ¬çºæ1062]
åèšæ£è ãã以åã«å°ãªããšãäžåã®æçæ²»çãåããŠãããæ¬çºæ1059ã®æ¹æ³ã
[æ¬çºæ1063]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1059ã1062ã®ããããã®æ¹æ³ã
[æ¬çºæ1064]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1063ã®æ¹æ³ã
[æ¬çºæ1065]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1063ã®æ¹æ³ã
[æ¬çºæ1066]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1063ã®æ¹æ³ã
[æ¬çºæ1067]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1064ã®æ¹æ³ã
[æ¬çºæ1068]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1064ã®æ¹æ³ã
[æ¬çºæ1069]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1059ã1068ã®ããããã®æ¹æ³ã
[æ¬çºæ1070]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1069ã®æ¹æ³ã
[æ¬çºæ1071]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1059ã1070ã®ããããã®æ¹æ³ã
[æ¬çºæ1072]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1071ã®æ¹æ³ã
[æ¬çºæ1073]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1059ã1072ã®ããããã®æ¹æ³ã
[æ¬çºæ1074]
åèšæäœãïœïœïŒŠïœæäœã§ãããæ¬çºæ1073ã®é µçŽ ã
[æ¬çºæ1075]
åèšæäœãŸãã¯ïœïœïŒŠïœæäœãæïŒïŒµïŒ£1æäœãæ2æäœãæ4æäœãæ1æäœããŸãã¯æ1æäœã§ãããæ¬çºæ1073ãŸãã¯1074ã®é µçŽ ã
[æ¬çºæ1076]
åèšè «çãå å®æ§è «çã§ãããæ¬çºæ1059ã1075ã®ããããã®æ¹æ³ã
[æ¬çºæ1077]
åèšè «çãè¡æ¶²è «çã§ãããæ¬çºæ1059ã1075ã®ããããã®æ¹æ³ã
[æ¬çºæ1078]
åèšè «çã骚èè «ãèµçãèçŽ¢è «ãäžç®è «ã现èãè è «ãè 现èçãé»è²è «ãæå¹³äžç®çŽ°èçãèå¢çãèçããŸãã¯è现èçã§ãããæ¬çºæ1059ã1075ã®ããããã®æ¹æ³ã
[æ¬çºæ1079]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1080]
åèšè «çãïŒïŒŽïŒ¡ïŒ°æ¬ æãæãããæ¬çºæ1079ã®æ¹æ³ã
[æ¬çºæ1081]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1082]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1081ã®æ¹æ³ã
[æ¬çºæ1083]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1084]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1085]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1086]
åèšåç §ã¬ãã«ããåèšæ£è ã®å¥å šãªçµç¹ã«ãããã¬ãã«ã§ãããæ¬çºæ1079ããã³1081ã1085ã®ããããã®æ¹æ³ã
[æ¬çºæ1087]
åèšåç §ã¬ãã«ãå¥å šãªå¯Ÿè±¡ã«ãããã¬ãã«ã§ãããæ¬çºæ1079ããã³1081ã1085ã®ããããã®æ¹æ³ã
[æ¬çºæ1088]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1059ã1087ã®ããããã®æ¹æ³ã
[æ¬çºæ1089]
åèšïŒïŒŽïœïœïœ ããªããããããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1060ã1088ã®ããããã®æ¹æ³ã
[æ¬çºæ1090]
å ç«çæ³ã«å¯Ÿããæ床ãå¢å ãããããã®æ¹æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1060ã1088ã®ããããã®æ¹æ³ã
[æ¬çºæ1091]
åèšæ£è ãã以åã«å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ã®æäžã«å¯ŸããŠå¿çããªãã£ããæ¬çºæ1090ã®æ¹æ³ã
[æ¬çºæ1092]
åèšå¯Ÿè±¡ã«ãå°ãªããšã第2ã®æçæ²»çæ³ãæœãããšãæŽã«å«ããæ¬çºæ1059ã1091ã®ããããã®æ¹æ³ã
[æ¬çºæ1093]
åèšç¬¬2ã®æçæ²»çæ³ãå€ç§çæ³ãååŠçæ³ãæŸå°ç·çæ³ãåçµæ²»çããã«ã¢ã³çæ³ãå ç«çæ³ãŸãã¯ãµã€ãã«ã€ã³çæ³ã§ãããæ¬çºæ1092ã®æ¹æ³ã
[æ¬çºæ1094]
åèšç¬¬2ã®æçæ²»çæ³ããé€å现èçæ³ãæ1æäœãæâ4æäœãããã³ïŒãŸãã¯æâ1æäœãå«ããæ¬çºæ1092ã®æ¹æ³ã
[æ¬çºæ1095]
åèšæâ1æäœããã¢ããŸãªãºãããã¢ãã«ããããã¥ã«ãã«ãããïŒïŒ³â036559ããŸãã¯ïŒ£ïŒ«â301ãå«ããæ¬çºæ1094ã®æ¹æ³ã
[æ¬çºæ1096]
åèšæ1æäœããããã«ããããã ãããªãºãããããã£ãªãºãããïŒïŒ°â223ãïŒïŒ°â514ãã»ãããªããããŸãã¯ïŒ°ïŒ€ïŒ²â001ãå«ããæ¬çºæ1094ã®æ¹æ³ã
[æ¬çºæ1097]
åèšæâ4æ²»çæ³ããã€ããªã ãããŸãã¯ãã¬ã¡ãªã ãããå«ããæ¬çºæ1094ã®æ¹æ³ã
[æ¬çºæ1098]
転移ã®äºé²æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1059ã1097ã®ããããã®æ¹æ³ã
[æ¬çºæ1099]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã«ïŒïŒŽïœïœïœ ããªãããããå«ãæå¹éã®å»è¬è£œå€ã察象ã«æäžããããšãå«ããéçè€ååå ç«äžå šïŒïŒ³ïŒ£ïŒ©ïŒ€ïŒãæããæ£è ã®æ²»çæ¹æ³ã§ãã£ãŠãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1100]
åèšæ£è ãã¢ããã·ã³ãã¢ãããŒãŒéºäŒåã«å°ãªããšã1ã€ã®å€ç°ãæãããæ¬çºæ1099ã®æ¹æ³ã
[æ¬çºæ1101]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1099ãŸãã¯1100ã®æ¹æ³ã
[æ¬çºæ1102]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1101ã®æ¹æ³ã
[æ¬çºæ1103]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1101ã®æ¹æ³ã
[æ¬çºæ1104]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1101ã®æ¹æ³ã
[æ¬çºæ1105]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1102ã®æ¹æ³ã
[æ¬çºæ1106]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1102ã®æ¹æ³ã
[æ¬çºæ1107]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1099ã1106ã®ããããã®æ¹æ³ã
[æ¬çºæ1108]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1107ã®æ¹æ³ã
[æ¬çºæ1109]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1099ã1108ã®ããããã®æ¹æ³ã
[æ¬çºæ1110]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1109ã®æ¹æ³ã
[æ¬çºæ1111]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1099ã1110ã®ããããã®æ¹æ³ã
[æ¬çºæ1112]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1099ã1111ã®ããããã®æ¹æ³ã
[æ¬çºæ1113]
åèšè£œå€ããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1099ã1112ã®ããããã®æ¹æ³ã
[æ¬çºæ1114]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã«ïŒïŒŽïœïœïœ ããªãããããå«ãæå¹éã®å»è¬è£œå€ã§æ²»çããããã®ïŒ³ïŒ£ïŒ©ïŒ€ãæããæ£è ãéžæããããã®æ¹æ³ã§ãã£ãŠã
ïŒïœïŒåèšæ£è ããã¢ããã·ã³ãã¢ãããŒãŒéºäŒåã«å°ãªããšã1ã€ã®å€ç°ãæãããåŠããå€å®ããããšãšã
ïŒïœïŒåèšæ£è ãã¢ããã·ã³ãã¢ãããŒãŒéºäŒåã«å°ãªããšã1ã€ã®å€ç°ãæããå Žåãæ²»çã®ããã«åèšæ£è ãéžæããããšãš
ãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1115]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã®æå¹éã®ïŒïŒŽïœïœïœ ããªããããããåèšéžæããæ£è ã«æäžããããšãæŽã«å«ããæ¬çºæ1114ã®æ¹æ³ã
[æ¬çºæ1116]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1114ãŸãã¯1115ã®æ¹æ³ã
[æ¬çºæ1117]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1116ã®æ¹æ³ã
[æ¬çºæ1118]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1116ã®æ¹æ³ã
[æ¬çºæ1119]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1116ã®æ¹æ³ã
[æ¬çºæ1120]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1117ã®æ¹æ³ã
[æ¬çºæ1121]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1117ã®æ¹æ³ã
[æ¬çºæ1122]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1114ã1121ã®ããããã®æ¹æ³ã
[æ¬çºæ1123]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1122ã®æ¹æ³ã
[æ¬çºæ1124]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1099ã1123ã®ããããã®æ¹æ³ã
[æ¬çºæ1125]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1124ã®æ¹æ³ã
[æ¬çºæ1126]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1099ã1125ã®ããããã®æ¹æ³ã
[æ¬çºæ1127]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1099ã1126ã®ããããã®æ¹æ³ã
[æ¬çºæ1128]
åèšè£œå€ããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1099ã1127ã®ããããã®æ¹æ³ã
æ¬çºæã®ä»ã®ç®çãç¹åŸŽããã³å©ç¹ã¯ã以äžã®è©³çŽ°ãªèª¬æããæããã«ãªãã ãããããããæ¬çºæã®è¶£æšããã³ç¯å²å ã§ã®çš®ã ã®å€åããã³å€æŽãããã®è©³çŽ°ã®èª¬æããåœæ¥è ã«ã¯æãããšãªãããã詳现ã®èª¬æããã³ç¹å®ã®å®æœäŸã¯ãæ¬çºæã®å¥œãŸããå®æœåœ¢æ ã瀺ããŠãããã®ã®ãå®äŸãšããŠã®ã¿äžããããããšãç解ãããªããã°ãªããªãã
æäœã«ã³ã³ãžã¥ã²ãŒããããŠãããåé¢ãããæ¹å€ïŒïŒŽïœïœïœ é µçŽ ã
[æ¬çºæ1002]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1001ã®é µçŽ ã
[æ¬çºæ1003]
åèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã90ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1002ã®é µçŽ ã
[æ¬çºæ1004]
åèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1003ã®é µçŽ ã
[æ¬çºæ1005]
åèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã®ã¢ããé žé åãå«ããæ¬çºæ1004ã®é µçŽ ã
[æ¬çºæ1006]
åèšïŒïŒŽïœïœïœ ãåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1001ã®é µçŽ ã
[æ¬çºæ1007]
åèšåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã90ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1006ã®é µçŽ ã
[æ¬çºæ1008]
åèšåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ããæ¬çºæ1007ã®é µçŽ ã
[æ¬çºæ1009]
åèšåºä¹³é¡ã®ïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã®ã¢ããé žé åãå«ããæ¬çºæ1008ã®é µçŽ ã
[æ¬çºæ1010]
åèšæäœãïœïœïŒŠïœæäœã§ãããæ¬çºæ1001ã1009ã®ããããã®é µçŽ ã
[æ¬çºæ1011]
åèšæäœãŸãã¯ïœïœïŒŠïœæäœãæïŒïŒµïŒ£1æäœãæ2æäœãæ4æäœãæ1æäœããŸãã¯æ1æäœã§ãããæ¬çºæ1001ãŸãã¯1010ã®é µçŽ ã
[æ¬çºæ1012]
ç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1001ã1011ã®ããããã®é µçŽ ã
[æ¬çºæ1013]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1012ã®é µçŽ ã
[æ¬çºæ1014]
ããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1001ã1013ã®ããããã®é µçŽ ã
[æ¬çºæ1015]
1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ã«çµåããŠãããæ¬çºæ1014ã®é µçŽ ã
[æ¬çºæ1016]
æ¬çºæ1001ã1015ã®ããããã®é µçŽ ãã³ãŒããããã¯ã¬ãªããé åãå«ããæ žé žã
[æ¬çºæ1017]
现èãçèãæè«ããŸãã¯åºä¹³é¡ã§ã®çºçŸã«æé©åãããã³ãã³ã§ãããæ¬çºæ1016ã®æ žé žã
[æ¬çºæ1018]
æ¬çºæ1016ãŸãã¯1017ã®æ žé žãå«ããçºçŸãã¯ã¿ãŒã
[æ¬çºæ1019]
æ¬çºæ1016ãŸãã¯1017ã®æ žé žãå«ãã宿䞻现èã
[æ¬çºæ1020]
åèšå®¿äž»çŽ°èã现è现èãçè现èãæè«çŽ°èããŸãã¯åºä¹³é¡çŽ°èã§ãããæ¬çºæ1019ã®å®¿äž»çŽ°èã
[æ¬çºæ1021]
æ¬çºæ1001ã1015ã®ããããã®ïŒïŒŽïœïœïœ âæäœã³ã³ãžã¥ã²ãŒããå«ããå»è¬è£œå€ã
[æ¬çºæ1022]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã«ïŒïŒŽïœïœïœ ããªãããããå«ãæå¹éã®å»è¬è£œå€ãæ£è ã«æäžããããšãå«ããè «çãæããæ£è ã®æ²»çæ¹æ³ã§ãã£ãŠãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1023]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1022ã®æ¹æ³ã
[æ¬çºæ1024]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1023ã®æ¹æ³ã
[æ¬çºæ1025]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1023ã®æ¹æ³ã
[æ¬çºæ1026]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1023ã®æ¹æ³ã
[æ¬çºæ1027]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1024ã®æ¹æ³ã
[æ¬çºæ1028]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1024ã®æ¹æ³ã
[æ¬çºæ1029]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1022ã1028ã®ããããã®æ¹æ³ã
[æ¬çºæ1030]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1029ã®æ¹æ³ã
[æ¬çºæ1031]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1022ã1030ã®ããããã®æ¹æ³ã
[æ¬çºæ1032]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1031ã®æ¹æ³ã
[æ¬çºæ1033]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1022ã1032ã®ããããã®æ¹æ³ã
[æ¬çºæ1034]
åèšæäœãïœïœïŒŠïœæäœã§ãããæ¬çºæ1033ã®é µçŽ ã
[æ¬çºæ1035]
åèšæäœãŸãã¯ïœïœïŒŠïœæäœãæïŒïŒµïŒ£1æäœãæ2æäœãæ4æäœãæ1æäœããŸãã¯æ1æäœã§ãããæ¬çºæ1033ãŸãã¯1034ã®é µçŽ ã
[æ¬çºæ1036]
åèšè «çãå å®æ§è «çã§ãããæ¬çºæ1022ã1035ã®ããããã®æ¹æ³ã
[æ¬çºæ1037]
åèšè «çãè¡æ¶²è «çã§ãããæ¬çºæ1022ã1035ã®ããããã®æ¹æ³ã
[æ¬çºæ1038]
åèšè «çã骚èè «ãèµçãèçŽ¢è «ãäžç®è «ã现èãè è «ãè 现èçãé»è²è «ãæå¹³äžç®çŽ°èçãèå¢çãèçããŸãã¯è现èçã§ãããæ¬çºæ1022ã1035ã®ããããã®æ¹æ³ã
[æ¬çºæ1039]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1040]
åèšè «çãïŒïŒŽïŒ¡ïŒ°æ¬ æãæãããæ¬çºæ1039ã®æ¹æ³ã
[æ¬çºæ1041]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1042]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1041ã®æ¹æ³ã
[æ¬çºæ1043]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1044]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1045]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæãããæ¬çºæ1022ã1038ã®ããããã®æ¹æ³ã
[æ¬çºæ1046]
åèšåç §ã¬ãã«ããåèšæ£è ã®å¥å šãªçµç¹ã«ãããã¬ãã«ã§ãããæ¬çºæ1039ããã³1041ã1045ã®ããããã®æ¹æ³ã
[æ¬çºæ1047]
åèšåç §ã¬ãã«ãå¥å šãªå¯Ÿè±¡ã«ãããã¬ãã«ã§ãããæ¬çºæ1039ããã³1041ã1045ã®ããããã®æ¹æ³ã
[æ¬çºæ1048]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1022ã1047ã®ããããã®æ¹æ³ã
[æ¬çºæ1049]
åèšè£œå€ããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1022ã1048ã®ããããã®æ¹æ³ã
[æ¬çºæ1050]
å ç«çæ³ã«å¯Ÿããæ床ãå¢å ãããããã®æ¹æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1022ã1049ã®ããããã®æ¹æ³ã
[æ¬çºæ1051]
åèšæ£è ãã以åã«å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ã®æäžã«å¯ŸããŠå¿çããªãã£ããæ¬çºæ1049ã®æ¹æ³ã
[æ¬çºæ1052]
åèšå¯Ÿè±¡ã«ãå°ãªããšã第2ã®æçæ²»çæ³ãæœãããšãæŽã«å«ããæ¬çºæ1022ã1051ã®ããããã®æ¹æ³ã
[æ¬çºæ1053]
åèšç¬¬2ã®æçæ²»çæ³ãå€ç§çæ³ãååŠçæ³ãæŸå°ç·çæ³ãåçµæ²»çããã«ã¢ã³çæ³ãå ç«çæ³ãŸãã¯ãµã€ãã«ã€ã³çæ³ã§ãããæ¬çºæ1052ã®æ¹æ³ã
[æ¬çºæ1054]
åèšç¬¬2ã®æçæ²»çæ³ããé€å现èçæ³ãæ1æäœãæâ4æäœãããã³ïŒãŸãã¯æâ1æäœãå«ããæ¬çºæ1052ã®æ¹æ³ã
[æ¬çºæ1055]
åèšæâ1æäœããã¢ããŸãªãºãããã¢ãã«ããããã¥ã«ãã«ãããïŒïŒ³â036559ããŸãã¯ïŒ£ïŒ«â301ãå«ããæ¬çºæ1054ã®æ¹æ³ã
[æ¬çºæ1056]
åèšæ1æäœããããã«ããããã ãããªãºãããããã£ãªãºãããïŒïŒ°â223ãïŒïŒ°â514ãã»ãããªããããŸãã¯ïŒ°ïŒ€ïŒ²â001ãå«ããæ¬çºæ1054ã®æ¹æ³ã
[æ¬çºæ1057]
åèšæâ4æ²»çæ³ããã€ããªã ãããŸãã¯ãã¬ã¡ãªã ãããå«ããæ¬çºæ1054ã®æ¹æ³ã
[æ¬çºæ1058]
転移ã®äºé²æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1022ã1057ã®ããããã®æ¹æ³ã
[æ¬çºæ1059]
è€åæå¹éã®ïŒïŒŽïœïœïœ ããªãããããšå ç«ãã§ãã¯ãã€ã³ãé»å®³å€ãçšããŠæ²»çããããã®è «çãæããæ£è ãéžæããããã®æ¹æ³ã§ãã£ãŠã
ïŒïœïŒåèšæ£è ã®è «çããåç §ã¬ãã«ã«å¯ŸããŠãäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ããŸãã¯ãå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæãããåŠããå€å®ããããšãšã
ïŒïœïŒåèšæ£è ã®è «çããåç §ã¬ãã«ã«å¯ŸããŠãäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ããŸãã¯ãå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæããå Žåãæ²»çã®ããã«åèšæ£è ãéžæããããšãš
ãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1060]
è€åæå¹éã®ïŒïŒŽïœïœïœ ããªããããããã³å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ããåèšéžæããæ£è ã«æäžããããšãæŽã«å«ããæ¬çºæ1059ã®æ¹æ³ã
[æ¬çºæ1061]
åèšæ£è ãã以åã«å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ã®æäžã«å¯ŸããŠå¿çããªãã£ãå Žåãæ²»çã®ããã«åèšæ£è ãéžæããããšãæŽã«å«ããæ¬çºæ1059ã®æ¹æ³ã
[æ¬çºæ1062]
åèšæ£è ãã以åã«å°ãªããšãäžåã®æçæ²»çãåããŠãããæ¬çºæ1059ã®æ¹æ³ã
[æ¬çºæ1063]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1059ã1062ã®ããããã®æ¹æ³ã
[æ¬çºæ1064]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1063ã®æ¹æ³ã
[æ¬çºæ1065]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1063ã®æ¹æ³ã
[æ¬çºæ1066]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1063ã®æ¹æ³ã
[æ¬çºæ1067]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1064ã®æ¹æ³ã
[æ¬çºæ1068]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1064ã®æ¹æ³ã
[æ¬çºæ1069]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1059ã1068ã®ããããã®æ¹æ³ã
[æ¬çºæ1070]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1069ã®æ¹æ³ã
[æ¬çºæ1071]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1059ã1070ã®ããããã®æ¹æ³ã
[æ¬çºæ1072]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1071ã®æ¹æ³ã
[æ¬çºæ1073]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1059ã1072ã®ããããã®æ¹æ³ã
[æ¬çºæ1074]
åèšæäœãïœïœïŒŠïœæäœã§ãããæ¬çºæ1073ã®é µçŽ ã
[æ¬çºæ1075]
åèšæäœãŸãã¯ïœïœïŒŠïœæäœãæïŒïŒµïŒ£1æäœãæ2æäœãæ4æäœãæ1æäœããŸãã¯æ1æäœã§ãããæ¬çºæ1073ãŸãã¯1074ã®é µçŽ ã
[æ¬çºæ1076]
åèšè «çãå å®æ§è «çã§ãããæ¬çºæ1059ã1075ã®ããããã®æ¹æ³ã
[æ¬çºæ1077]
åèšè «çãè¡æ¶²è «çã§ãããæ¬çºæ1059ã1075ã®ããããã®æ¹æ³ã
[æ¬çºæ1078]
åèšè «çã骚èè «ãèµçãèçŽ¢è «ãäžç®è «ã现èãè è «ãè 现èçãé»è²è «ãæå¹³äžç®çŽ°èçãèå¢çãèçããŸãã¯è现èçã§ãããæ¬çºæ1059ã1075ã®ããããã®æ¹æ³ã
[æ¬çºæ1079]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1080]
åèšè «çãïŒïŒŽïŒ¡ïŒ°æ¬ æãæãããæ¬çºæ1079ã®æ¹æ³ã
[æ¬çºæ1081]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€73ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1082]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ïŒïŒŽïŒ¡ïŒ°ãæãããæ¬çºæ1081ã®æ¹æ³ã
[æ¬çºæ1083]
åèšè «çããåç §ãµã³ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ£ïŒ€39ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1084]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒïŒŽïŒ¡ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1085]
åèšè «çããåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ïŒ¡ïŒ€ïŒ¯ãæãããæ¬çºæ1059ã1078ã®ããããã®æ¹æ³ã
[æ¬çºæ1086]
åèšåç §ã¬ãã«ããåèšæ£è ã®å¥å šãªçµç¹ã«ãããã¬ãã«ã§ãããæ¬çºæ1079ããã³1081ã1085ã®ããããã®æ¹æ³ã
[æ¬çºæ1087]
åèšåç §ã¬ãã«ãå¥å šãªå¯Ÿè±¡ã«ãããã¬ãã«ã§ãããæ¬çºæ1079ããã³1081ã1085ã®ããããã®æ¹æ³ã
[æ¬çºæ1088]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1059ã1087ã®ããããã®æ¹æ³ã
[æ¬çºæ1089]
åèšïŒïŒŽïœïœïœ ããªããããããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1060ã1088ã®ããããã®æ¹æ³ã
[æ¬çºæ1090]
å ç«çæ³ã«å¯Ÿããæ床ãå¢å ãããããã®æ¹æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1060ã1088ã®ããããã®æ¹æ³ã
[æ¬çºæ1091]
åèšæ£è ãã以åã«å ç«ãã§ãã¯ãã€ã³ãé»å®³å€ã®æäžã«å¯ŸããŠå¿çããªãã£ããæ¬çºæ1090ã®æ¹æ³ã
[æ¬çºæ1092]
åèšå¯Ÿè±¡ã«ãå°ãªããšã第2ã®æçæ²»çæ³ãæœãããšãæŽã«å«ããæ¬çºæ1059ã1091ã®ããããã®æ¹æ³ã
[æ¬çºæ1093]
åèšç¬¬2ã®æçæ²»çæ³ãå€ç§çæ³ãååŠçæ³ãæŸå°ç·çæ³ãåçµæ²»çããã«ã¢ã³çæ³ãå ç«çæ³ãŸãã¯ãµã€ãã«ã€ã³çæ³ã§ãããæ¬çºæ1092ã®æ¹æ³ã
[æ¬çºæ1094]
åèšç¬¬2ã®æçæ²»çæ³ããé€å现èçæ³ãæ1æäœãæâ4æäœãããã³ïŒãŸãã¯æâ1æäœãå«ããæ¬çºæ1092ã®æ¹æ³ã
[æ¬çºæ1095]
åèšæâ1æäœããã¢ããŸãªãºãããã¢ãã«ããããã¥ã«ãã«ãããïŒïŒ³â036559ããŸãã¯ïŒ£ïŒ«â301ãå«ããæ¬çºæ1094ã®æ¹æ³ã
[æ¬çºæ1096]
åèšæ1æäœããããã«ããããã ãããªãºãããããã£ãªãºãããïŒïŒ°â223ãïŒïŒ°â514ãã»ãããªããããŸãã¯ïŒ°ïŒ€ïŒ²â001ãå«ããæ¬çºæ1094ã®æ¹æ³ã
[æ¬çºæ1097]
åèšæâ4æ²»çæ³ããã€ããªã ãããŸãã¯ãã¬ã¡ãªã ãããå«ããæ¬çºæ1094ã®æ¹æ³ã
[æ¬çºæ1098]
転移ã®äºé²æ³ãšããŠæŽã«å®çŸ©ããããæ¬çºæ1059ã1097ã®ããããã®æ¹æ³ã
[æ¬çºæ1099]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã«ïŒïŒŽïœïœïœ ããªãããããå«ãæå¹éã®å»è¬è£œå€ã察象ã«æäžããããšãå«ããéçè€ååå ç«äžå šïŒïŒ³ïŒ£ïŒ©ïŒ€ïŒãæããæ£è ã®æ²»çæ¹æ³ã§ãã£ãŠãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1100]
åèšæ£è ãã¢ããã·ã³ãã¢ãããŒãŒéºäŒåã«å°ãªããšã1ã€ã®å€ç°ãæãããæ¬çºæ1099ã®æ¹æ³ã
[æ¬çºæ1101]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1099ãŸãã¯1100ã®æ¹æ³ã
[æ¬çºæ1102]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1101ã®æ¹æ³ã
[æ¬çºæ1103]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1101ã®æ¹æ³ã
[æ¬çºæ1104]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1101ã®æ¹æ³ã
[æ¬çºæ1105]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1102ã®æ¹æ³ã
[æ¬çºæ1106]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1102ã®æ¹æ³ã
[æ¬çºæ1107]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1099ã1106ã®ããããã®æ¹æ³ã
[æ¬çºæ1108]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1107ã®æ¹æ³ã
[æ¬çºæ1109]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1099ã1108ã®ããããã®æ¹æ³ã
[æ¬çºæ1110]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1109ã®æ¹æ³ã
[æ¬çºæ1111]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1099ã1110ã®ããããã®æ¹æ³ã
[æ¬çºæ1112]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1099ã1111ã®ããããã®æ¹æ³ã
[æ¬çºæ1113]
åèšè£œå€ããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1099ã1112ã®ããããã®æ¹æ³ã
[æ¬çºæ1114]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã«ïŒïŒŽïœïœïœ ããªãããããå«ãæå¹éã®å»è¬è£œå€ã§æ²»çããããã®ïŒ³ïŒ£ïŒ©ïŒ€ãæããæ£è ãéžæããããã®æ¹æ³ã§ãã£ãŠã
ïŒïœïŒåèšæ£è ããã¢ããã·ã³ãã¢ãããŒãŒéºäŒåã«å°ãªããšã1ã€ã®å€ç°ãæãããåŠããå€å®ããããšãšã
ïŒïœïŒåèšæ£è ãã¢ããã·ã³ãã¢ãããŒãŒéºäŒåã«å°ãªããšã1ã€ã®å€ç°ãæããå Žåãæ²»çã®ããã«åèšæ£è ãéžæããããšãš
ãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã90ïŒ ã®åäžæ§ãæããé åãå«ã¿ãåèšïŒïŒŽïœïœïœ ããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããåèšæ¹æ³ã
[æ¬çºæ1115]
è¬åŠçã«èš±å®¹ã§ããæ äœäžã®æå¹éã®ïŒïŒŽïœïœïœ ããªããããããåèšéžæããæ£è ã«æäžããããšãæŽã«å«ããæ¬çºæ1114ã®æ¹æ³ã
[æ¬çºæ1116]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã«å¯ŸããŠå°ãªããšã95ïŒ ã®åäžæ§ãæããåèšããªãããããïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1114ãŸãã¯1115ã®æ¹æ³ã
[æ¬çºæ1117]
åèšïŒïŒŽïœïœïœ ããªãããããé åçªå·1ãŸãã¯3ã®é åãæãããæ¬çºæ1116ã®æ¹æ³ã
[æ¬çºæ1118]
åèšïŒïŒŽïœïœïœ ãåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããåèšåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ããé åçªå·3ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1116ã®æ¹æ³ã
[æ¬çºæ1119]
åèšïŒïŒŽïœïœïœ ãããïŒïŒŽïŒ¡ïŒ°ã§ãããåèšããïŒïŒŽïŒ¡ïŒ°ããé åçªå·1ã«å¯ŸããŠå°ãªããšã95ïŒ åäžã®ã¢ããé žé åãå«ã¿ããã€ïŒïŒŽïœïœïœ 掻æ§ãæãããæ¬çºæ1116ã®æ¹æ³ã
[æ¬çºæ1120]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·3ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ®ã§ãããæ¬çºæ1117ã®æ¹æ³ã
[æ¬çºæ1121]
åèšïŒïŒŽïœïœïœ ããªããããããé åçªå·1ã®é åãæããåæ žçç©ã®ïŒïŒŽïŒ¡ïŒ°ã§ãããæ¬çºæ1117ã®æ¹æ³ã
[æ¬çºæ1122]
åèšïŒïŒŽïœïœïœ ãããªãšãã¬ã³ã°ãªã³ãŒã«ïŒïŒ°ïŒ¥ïŒ§ïŒãšçµåããŠãããæ¬çºæ1114ã1121ã®ããããã®æ¹æ³ã
[æ¬çºæ1123]
åèšïŒïŒŽïœïœïœ ãã1ã€ä»¥äžã®ïŒ¬ïœïœãŸãã¯ïŒ£ïœïœæ®åºãä»ããŠïŒ°ïŒ¥ïŒ§ãšçµåããŠãããæ¬çºæ1122ã®æ¹æ³ã
[æ¬çºæ1124]
åèšïŒïŒŽïœïœïœ ãç°çš®ããããã»ã°ã¡ã³ããæŽã«å«ããæ¬çºæ1099ã1123ã®ããããã®æ¹æ³ã
[æ¬çºæ1125]
åèšç°çš®ããããã»ã°ã¡ã³ãããããããïœïŒ§ ïœãã¢ã«ããã³ããŸãã¯ã¢ã«ããã³çµåããããã§ãããæ¬çºæ1124ã®æ¹æ³ã
[æ¬çºæ1126]
åèšïŒïŒŽïœïœïœ ãæäœã«ã³ã³ãžã¥ã²ãŒããããŠãããæ¬çºæ1099ã1125ã®ããããã®æ¹æ³ã
[æ¬çºæ1127]
åèšæ£è ãããæ£è ã§ãããæ¬çºæ1099ã1126ã®ããããã®æ¹æ³ã
[æ¬çºæ1128]
åèšè£œå€ããåžå ¥ã«ããã泚å°ã«ãããæ³šå ¥ã«ãããé£ç¶æ³šå ¥ã«ãããæšç现èãçŽæ¥æµžãå±ææœ æµã«ãããã«ããŒãã«ãä»ããŠããŸãã¯æŽæµã«ãããè «çå æäžãéèå æäžãç®å æäžãåèå æäžãè ¹è å æäžãç å·£å æäžãé èå æäžãé¢ç¯å æäžãåç«è ºå æäžãèžèå æäžãæ°ç®¡å æäžãçŒå æäžã錻åå æäžãç¡åäœå æäžãè å æäžãçŽè žå æäžãçèå æäžãç®äžæäžãçµèäžæäžãèè±å æäžãç²èæäžãå¿èå æäžãè垯å æäžãçµå£æäžããããæ¬çºæ1099ã1127ã®ããããã®æ¹æ³ã
æ¬çºæã®ä»ã®ç®çãç¹åŸŽããã³å©ç¹ã¯ã以äžã®è©³çŽ°ãªèª¬æããæããã«ãªãã ãããããããæ¬çºæã®è¶£æšããã³ç¯å²å ã§ã®çš®ã ã®å€åããã³å€æŽãããã®è©³çŽ°ã®èª¬æããåœæ¥è ã«ã¯æãããšãªãããã詳现ã®èª¬æããã³ç¹å®ã®å®æœäŸã¯ãæ¬çºæã®å¥œãŸããå®æœåœ¢æ ã瀺ããŠãããã®ã®ãå®äŸãšããŠã®ã¿äžããããããšãç解ãããªããã°ãªããªãã
Claims (15)
- é µçŽ ã®è¡æž åæžæãå¢å ãããããšãã§ããååç©ã«çµåããŠãããã¡ãã«ããªã¢ããã·ã³ãã¡ãã«ããªãªããŒã¹âãã¹ãã§ãŒãããã³ã¢ããã³ã«å ãªã³é žå解ããããšãã§ããè©²é µçŽ ãå«ããã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒæ¬ æçãæ²»çããããã®çµæç©ã§ãã£ãŠã
è©²é µçŽ ãé åçªå·ïŒã«å¯ŸããŠå°ãªããšãïŒïŒïŒ ã®åäžæ§ãæããé åãå«ã¿ããã€
è©²é µçŽ ã®è¡æž åæžæãå¢å ãããããšãã§ãã該ååç©ããè©²é µçŽ ã®æµäœååŠçååŸãå¢å ãããããªããŒã§ãããçµæç©ã - åèšé µçŽ ã®è¡æž åæžæãå¢å ãããããšãã§ããåèšååç©ãããªãšãã¬ã³ã°ãªã³ãŒã«ã§ãããè«æ±é ïŒã«èšèŒã®çµæç©ã
- åèšããªãšãã¬ã³ã°ãªã³ãŒã«ããåèšé µçŽ ã®ïŒã€ä»¥äžã®ãªãžã³æ®åºãžã®ã³ã³ãžã¥ã²ãŒã·ã§ã³ãä»ããŠåèšé µçŽ ã«çµåããŠãããè«æ±é ïŒã«èšèŒã®çµæç©ã
- è «çãæããæ£è ã®æ²»çã«ããã䜿çšã®ããã®ãé åçªå·ïŒãšå°ãªããšãïŒïŒïŒ ã®åäžæ§ãæããé åãå«ãæå¹éã®ã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒãå«ãçµæç©ã
- åèšã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒããåèšã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒã®è¡æž åæžæãå¢å ãããããšãã§ããååç©ã«çµåããŠãããè«æ±é ïŒã«èšèŒã®çµæç©ã
- åèšã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒãããªãšãã¬ã³ã°ãªã³ãŒã«ã«ã³ã³ãžã¥ã²ãŒãããŠãããè«æ±é ïŒã«èšèŒã®çµæç©ã
- æå¹éã®ç¬¬ïŒã®æçæ²»çæ³ãšçµã¿åãããŠçšãããããè«æ±é ïŒã«èšèŒã®çµæç©ã
- åèšç¬¬ïŒã®æçæ²»çæ³ãå ç«ãã§ãã¯ãã€ã³ãé»å®³å€ã§ãããè«æ±é ïŒã«èšèŒã®çµæç©ã
- åèšå ç«ãã§ãã¯ãã€ã³ãé»å®³å€ããæïŒæäœãæïŒæäœããŸãã¯æâïŒæäœã§ãããè«æ±é ïŒã«èšèŒã®çµæç©ã
- åèšè «çã以äžãå«ããè«æ±é ïŒã«èšèŒã®çµæç©ïŒ
ïŒaïŒã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒéºäŒåã®æ¬ 倱ã
ïŒbïŒåç §ã¬ãã«ã«å¯ŸããŠå¢å ããã¬ãã«ã®ã¡ãã«ããªã¢ããã·ã³ããŸãã¯
ïŒcïŒåç §ã¬ãã«ã«å¯ŸããŠäœäžããã¬ãã«ã®ã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒã - åèšã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒéºäŒåã®æ¬ 倱ããæè²äœãã³ãïŒïœïŒïŒã«ãããçžåãªéºäŒåæ¬ å€±ãå«ããè«æ±é ïŒïŒã«èšèŒã®çµæç©ã
- åèšåç §ã¬ãã«ããåèšæ£è ã®å¥å šãªçµç¹ã«ãããã¬ãã«ã§ãããè«æ±é ïŒïŒã«èšèŒã®çµæç©ã
- åèšåç §ã¬ãã«ããå¥å šãªåäœã«ãããã¬ãã«ã§ãããè«æ±é ïŒïŒã«èšèŒã®çµæç©ã
- è «çãæããæ£è ã®æ²»çã«ããã䜿çšã®ããã®ãé åçªå·ïŒãšå°ãªããšãïŒïŒïŒ ã®åäžæ§ãæããé åãå«ãæå¹éã®é µçŽ ãå«ãçµæç©ã§ãã£ãŠã
åèšè «çããã¡ãã«ããªã¢ããã·ã³ãã¹ããªã©ãŒãŒéºäŒåã®æè²äœïŒïœïŒïŒã«ãããçžåãªéºäŒåæ¬ å€±ãå«ã¿ããã€
åèšé µçŽ ããã¡ãã«ããªã¢ããã·ã³ãã¡ãã«ããªãªããŒã¹âãã¹ãã§ãŒãããã³ã¢ããã³ã«å ãªã³é žå解ããããšãã§ãããçµæç©ã - åèšé µçŽ ããåèšé µçŽ ã®ïŒã€ä»¥äžã®ãªãžã³æ®åºãä»ããŠããªãšãã¬ã³ã°ãªã³ãŒã«ã«ã³ã³ãžã¥ã²ãŒãããŠãããè«æ±é ïŒïŒã«èšèŒã®çµæç©ã
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2022009836A JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | ã¢ããã·ã³ããã³ïŒãŸãã¯ã¡ãã«ããªã¢ããã·ã³ã®é µçŽ åªä»æ¯æžæ¹æ³ |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762609000P | 2017-12-21 | 2017-12-21 | |
US62/609,000 | 2017-12-21 | ||
PCT/US2018/066731 WO2019126455A1 (en) | 2017-12-21 | 2018-12-20 | Enzyme-mediated depletion of adenosine and/or methylthioadenosine |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022009836A Division JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | ã¢ããã·ã³ããã³ïŒãŸãã¯ã¡ãã«ããªã¢ããã·ã³ã®é µçŽ åªä»æ¯æžæ¹æ³ |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021506320A JP2021506320A (ja) | 2021-02-22 |
JP2021506320A5 true JP2021506320A5 (ja) | 2022-01-06 |
JP7016958B2 JP7016958B2 (ja) | 2022-02-07 |
Family
ID=66993826
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020534518A Active JP7016958B2 (ja) | 2017-12-21 | 2018-12-20 | ã¢ããã·ã³ããã³ïŒãŸãã¯ã¡ãã«ããªã¢ããã·ã³ã®é µçŽ åªä»æ¯æžæ¹æ³ |
JP2022009836A Active JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | ã¢ããã·ã³ããã³ïŒãŸãã¯ã¡ãã«ããªã¢ããã·ã³ã®é µçŽ åªä»æ¯æžæ¹æ³ |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022009836A Active JP7313497B2 (ja) | 2017-12-21 | 2022-01-26 | ã¢ããã·ã³ããã³ïŒãŸãã¯ã¡ãã«ããªã¢ããã·ã³ã®é µçŽ åªä»æ¯æžæ¹æ³ |
Country Status (6)
Country | Link |
---|---|
US (3) | US20210054350A1 (ja) |
EP (1) | EP3727420A4 (ja) |
JP (2) | JP7016958B2 (ja) |
AU (1) | AU2018393093A1 (ja) |
CA (1) | CA3122502A1 (ja) |
WO (1) | WO2019126455A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019126455A1 (en) * | 2017-12-21 | 2019-06-27 | Board Of Regents, The University Of Texas System | Enzyme-mediated depletion of adenosine and/or methylthioadenosine |
KR20220124718A (ko) | 2020-01-07 | 2022-09-14 | ë 볎ë ì€ëž 늬ì ìž ì€ëž ë ì ëë²ìí° ì€ëž í ì¬ì€ ìì€í | ì ì¹ë£ë¥Œ ìí ê°ì ë ìžê° ë©íž í°ì€ìë°ë žì /ìë°ë žì ê³ ê° íšì ë³ìŽì²Ž |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0733123T3 (da) * | 1993-12-29 | 2002-07-22 | Univ California | Fremgangsmåde til påvisning af methylthioadenosinphosphorylase-mangel i mammaliaceller |
US5840505A (en) | 1993-12-29 | 1998-11-24 | The Regents Of The University Of California | Method for inhibiting adenylosuccinate synthetase activity in methylthioadenosine phosphorylase deficient cells |
US6870037B1 (en) | 1995-07-03 | 2005-03-22 | Arch Development Corporation | Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders |
CN1321765A (zh) * | 2000-04-29 | 2001-11-14 | äžæµ·å執åºå åŒåæéå ¬åž | äžç§æ°çå€èœââ人ç²ç¡«åºè ºè·ç£·é žåé ¶37åçŒç è¿ç§å€èœçå€æ žè·é ž |
EP1594900A2 (en) * | 2003-02-14 | 2005-11-16 | Salmedix, Inc. | Compositions and methods for the detection and treatment of methylthioadenosine phosphorylase deficient cancers |
EP1991231A4 (en) | 2006-02-24 | 2010-01-06 | Ind Res Ltd | METHOD FOR THE TREATMENT OF DISEASES WITH NUCLEOSIDE PHOSPHORUSLASES AND NUCLEOSIDASES INHIBITORS |
GB0620715D0 (en) * | 2006-10-18 | 2006-11-29 | Univ Durham | Ethanol production |
EP2506015A1 (en) | 2011-04-01 | 2012-10-03 | UniversitÀt Regensburg | A prognostic and therapeutic signature for malignant melanoma |
US20180010132A1 (en) * | 2014-09-11 | 2018-01-11 | Novartis Ag | Inhibition of prmt5 to treat mtap-deficiency-related diseases |
WO2019126455A1 (en) * | 2017-12-21 | 2019-06-27 | Board Of Regents, The University Of Texas System | Enzyme-mediated depletion of adenosine and/or methylthioadenosine |
-
2018
- 2018-12-20 WO PCT/US2018/066731 patent/WO2019126455A1/en unknown
- 2018-12-20 JP JP2020534518A patent/JP7016958B2/ja active Active
- 2018-12-20 AU AU2018393093A patent/AU2018393093A1/en active Pending
- 2018-12-20 US US16/956,340 patent/US20210054350A1/en not_active Abandoned
- 2018-12-20 EP EP18890088.0A patent/EP3727420A4/en active Pending
- 2018-12-20 CA CA3122502A patent/CA3122502A1/en active Pending
-
2020
- 2020-11-17 US US16/950,622 patent/US11118167B2/en active Active
-
2022
- 2022-01-26 JP JP2022009836A patent/JP7313497B2/ja active Active
- 2022-11-10 US US18/054,347 patent/US20230227796A1/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Hutmacher et al. | Antibody-cytokine fusion proteins: Biopharmaceuticals with immunomodulatory properties for cancer therapy | |
KR100537292B1 (ko) | ë³ìŽ/í€ë©ëŒ ìŽíìì ì í©ì²Ž ë° ê·ž ì ìœíì ì¡°ì±ë¬Œ | |
Xu et al. | Targeting and therapy of carcinoembryonic antigen-expressing tumors in transgenic mice with an antibody-interleukin 2 fusion protein | |
US20220048971A1 (en) | Human alpha fetoprotein-specific t cell receptors and uses thereof | |
US11466088B2 (en) | VEGFR-2 car immune cells to treat cancers | |
JP2022521792A (ja) | çãæ²»çããããã®å ç«çæ³çäœµçš | |
KR20160048971A (ko) | ì¢ ì ì¹ë£ë¥Œ ìí í€ëë ë ê³ ê° íšìì í¬ì¬ | |
US20160176945A1 (en) | FGFR-FC Fusion Proteins and the Use Thereof | |
JP2021006046A (ja) | è «çã®æ²»çã®ããã®ãããã¬ãã³ãæ¯æžãããé µçŽ ã®æäž | |
KR20180030879A (ko) | ë³µë§ìì ì¹ë£íêž° ìí ì¡°ì±ë¬Œ ë° ë°©ë² | |
US20110059045A1 (en) | Pharmaceutical composition for cancer treatment | |
US20220370564A1 (en) | IL-10/fc Fusion Proteins Useful As Enhancers Of Immunotherapies | |
JP2021506320A5 (ja) | ||
JP7313497B2 (ja) | ã¢ããã·ã³ããã³ïŒãŸãã¯ã¡ãã«ããªã¢ããã·ã³ã®é µçŽ åªä»æ¯æžæ¹æ³ | |
JP2024520427A (ja) | ïœïœå€ç°ãæšçãšããïœçŽ°èå容äœããã³ãã®äœ¿çš | |
CN112533629A (zh) | ç»å䜿çšil-10è¯åäžåµåæååäœç»èçæ³çç»åç©åæ¹æ³ | |
WO1999061057A2 (en) | Molecules targeting cd40 and tumor cells | |
CN113677362A (zh) | çšäºå¢åŒºç»èå ç«çæ³çæ¹æ³ | |
Xiang | Targeting cytokines to tumors to induce active antitumor immune responses by recombinant fusion proteins | |
EP4412636A2 (en) | Novel interferon variants and bifunctional fusion molecules thereof | |
CN115304680A (zh) | åºäºPep42æ建çåç¹åŒæ§ç»èæ¥ååšååçå¶å€åå ¶åºçš | |
CN114828863A (zh) | èä¹äºéåç¬å°¿æ°šé žé ¶ä»¥åå ¶çšäºæ²»çççççšé | |
Xu et al. | Two tandem repeats of mHSP70407â426 enhance therapeutic antitumor effects of a recombined vascular endothelial growth factor (VEGF) protein vaccine | |
Zhang et al. | Gene-activating nanomedicine for the tumor-oriented infiltration of T cells to enhance immunotherapy against solid tumors | |
US11952402B2 (en) | Fusion protein containing trail and IgG binding domain and the uses thereof |