|
US2851458A
(en)
|
1955-06-08 |
1958-09-09 |
Burroughs Wellcome Co |
Diquaternary compounds and the manufacture thereof
|
|
US4678500A
(en)
|
1984-06-29 |
1987-07-07 |
E. I. Du Pont De Nemours And Company |
Herbicidal 2,6-disubstituted benzylsulfonamides and benzenesulfamates
|
|
US5177075A
(en)
|
1988-08-19 |
1993-01-05 |
Warner-Lambert Company |
Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
|
|
US4942163A
(en)
|
1989-03-07 |
1990-07-17 |
E. I. Du Pont De Nemours And Company |
1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
|
|
ATE404539T1
(de)
|
1997-10-02 |
2008-08-15 |
Eisai R&D Man Co Ltd |
Kondensierte pyridinderivate
|
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
JPWO2002094790A1
(ja)
|
2001-05-23 |
2004-09-09 |
三菱ウェルファーマ株式会社 |
縮合ヘテロ環化合物およびその医薬用途
|
|
CA2461202C
(en)
|
2001-09-21 |
2011-07-12 |
Donald Pinto |
Lactam-containing compounds and derivatives thereof as factor xa inhibitors
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
MXPA05000983A
(es)
|
2002-07-24 |
2005-08-18 |
Kyorin Seiyaku Kk |
Derivados de 4-(aril substituido)-5-hidroxiisoquinolinona.
|
|
JP4520406B2
(ja)
|
2002-10-01 |
2010-08-04 |
田辺三菱製薬株式会社 |
イソキノリン化合物及びその医薬用途
|
|
EA010408B1
(ru)
|
2002-10-23 |
2008-08-29 |
Гленмарк Фармасьютикалс Лтд. |
Трициклические соединения для лечения воспалительных и аллергических нарушений, способы их приготовления и содержащие их фармацевтические составы
|
|
US7501412B2
(en)
*
|
2002-11-22 |
2009-03-10 |
Mitsubishi Tanabe Pharma Corporation |
Isoquinoline compounds and medicinal use thereof
|
|
ATE496893T1
(de)
|
2002-12-20 |
2011-02-15 |
X Ceptor Therapeutics Inc |
Isochinolinonderivate und deren verwendung als medikamente
|
|
ES2320771T3
(es)
|
2003-04-16 |
2009-05-28 |
Bristol-Myers Squibb Company |
Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c.
|
|
TW200536830A
(en)
*
|
2004-02-06 |
2005-11-16 |
Chugai Pharmaceutical Co Ltd |
1-(2H)-isoquinolone derivative
|
|
WO2005075432A1
(ja)
|
2004-02-06 |
2005-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
１−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用
|
|
WO2005113540A1
(ja)
|
2004-05-20 |
2005-12-01 |
Mitsubishi Pharma Corporation |
イソキノリン化合物及びその医薬用途
|
|
WO2006045010A2
(en)
|
2004-10-20 |
2006-04-27 |
Resverlogix Corp. |
Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
|
|
ES2611604T3
(es)
|
2004-10-22 |
2017-05-09 |
Janssen Pharmaceutica Nv |
Inhibidores de la c fms quinasa
|
|
JP2008524131A
(ja)
|
2004-12-16 |
2008-07-10 |
エフ．ホフマン−ラ ロシュ アーゲー |
抗肥満薬としてのピペラジニルピリジン誘導体
|
|
TWI389897B
(zh)
|
2005-02-22 |
2013-03-21 |
Chugai Pharmaceutical Co Ltd |
1- (2H) -isoquinolinone derivatives
|
|
SI1864976T1
(sl)
|
2005-03-31 |
2012-12-31 |
Astellas Pharma Inc. |
Propan-1,3-dionski derivat ali njegova sol
|
|
CA2617213C
(en)
|
2005-07-29 |
2014-01-28 |
Resverlogix Corp. |
Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
|
|
CN101316592A
(zh)
|
2005-08-24 |
2008-12-03 |
伊诺泰克制药公司 |
茚并异喹啉酮类似物及其用法
|
|
JP2009539963A
(ja)
*
|
2006-06-15 |
2009-11-19 |
クドス ファーマシューティカルズ リミテッド |
Ｐａｒｐ阻害剤
|
|
AU2007292155B2
(en)
|
2006-09-05 |
2012-11-01 |
Kyowa Kirin Co., Ltd. |
Imidazole derivative
|
|
US7772180B2
(en)
|
2006-11-09 |
2010-08-10 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
WO2008092231A1
(en)
|
2007-02-01 |
2008-08-07 |
Resverlogix Corp. |
Compounds for the prevention and treatment of cardiovascular diseases
|
|
FR2919286A1
(fr)
|
2007-07-27 |
2009-01-30 |
Sanofi Aventis Sa |
Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
|
|
US20090054392A1
(en)
*
|
2007-08-20 |
2009-02-26 |
Wyeth |
Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
|
|
WO2009027650A1
(en)
|
2007-08-24 |
2009-03-05 |
The Institute Of Cancer: Royal Cancer Hospital |
Materials and methods for exploiting synthetic lethality in brca-associated cancers
|
|
CN101854924A
(zh)
|
2007-11-05 |
2010-10-06 |
诺瓦提斯公司 |
测量wnt活化以及治疗wnt相关癌症的方法和组合物
|
|
DE102008019838A1
(de)
|
2008-04-19 |
2009-12-10 |
Boehringer Ingelheim International Gmbh |
Neue Arylsulfonylglycin-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
|
|
CA2722035C
(en)
|
2008-04-22 |
2016-10-11 |
Janssen Pharmaceutica Nv |
Quinoline or isoquinoline substituted p2x7 antagonists
|
|
JP5743897B2
(ja)
|
2008-11-20 |
2015-07-01 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ |
化合物
|
|
SG174252A1
(en)
|
2009-03-06 |
2011-10-28 |
Hoffmann La Roche |
Heterocyclic antiviral compounds
|
|
NZ755378A
(en)
|
2009-03-18 |
2022-07-29 |
Resverlogix Corp |
Novel quinazolinones and related compounds for use as anti-inflammatory agents
|
|
KR20190091564A
(ko)
|
2009-04-22 |
2019-08-06 |
리스버로직스 코퍼레이션 |
신규한 소염제
|
|
TWI499418B
(zh)
|
2009-05-21 |
2015-09-11 |
Nerviano Medical Sciences Srl |
異喹啉－１（２ｈ）－酮衍生物
|
|
EP2488520B1
(en)
|
2009-10-13 |
2015-09-02 |
Merck Sharp & Dohme B.V. |
Condensed azine-derivatives for the treatment of diseases related to the acetylcholine receptor
|
|
CA2799579A1
(en)
|
2010-05-21 |
2011-11-24 |
Intellikine, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
CN102947274A
(zh)
|
2010-06-17 |
2013-02-27 |
诺瓦提斯公司 |
联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
|
|
EP2731940B1
(en)
|
2011-07-13 |
2015-08-19 |
Novartis AG |
4 - piperidinyl compounds for use as tankyrase inhibitors
|
|
CN103814032A
(zh)
|
2011-07-13 |
2014-05-21 |
诺华股份有限公司 |
用作端锚聚合酶抑制剂的4-氧代-3,5,7,8-四氢-4H-吡喃并[4,3-d]嘧啶基化合物
|
|
US9181266B2
(en)
|
2011-07-13 |
2015-11-10 |
Novartis Ag |
2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
|
|
IN2014CN04671A
(https=)
*
|
2011-11-25 |
2015-09-18 |
Nerviano Medical Sciences Srl |
|
|
IN2014DN06169A
(https=)
|
2011-12-31 |
2015-08-21 |
Beigene Ltd |
|
|
MX2014008071A
(es)
|
2011-12-31 |
2015-07-06 |
Beigene Ltd |
Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas.
|
|
HK1202543A1
(en)
|
2012-01-28 |
2015-10-02 |
Merck Patent Gmbh |
Azaheterocyclic compounds
|
|
WO2013116182A1
(en)
|
2012-01-31 |
2013-08-08 |
Boehringer Ingelheim International Gmbh |
Heterocyclic compounds as inhibitors of leukotriene production
|
|
KR20140121477A
(ko)
|
2012-02-09 |
2014-10-15 |
메르크 파텐트 게엠베하 |
Ｔａｎｋ 및 ｐａｒｐ 저해체로서의 테트라히드로-퀴나졸리논
|
|
US9340549B2
(en)
|
2012-03-05 |
2016-05-17 |
Amgen Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
CA2865511A1
(en)
|
2012-03-07 |
2013-09-12 |
Institute Of Cancer Research: Royal Cancer Hospital (The) |
3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
|
|
MX351149B
(es)
|
2012-03-28 |
2017-10-04 |
Merck Patent Gmbh |
Derivados biciclicos de pirazinona.
|
|
US20130281397A1
(en)
|
2012-04-19 |
2013-10-24 |
Rvx Therapeutics Inc. |
Treatment of diseases by epigenetic regulation
|
|
CN104271580B
(zh)
|
2012-05-04 |
2017-02-22 |
默克专利股份公司 |
吡咯并三嗪酮衍生物
|
|
WO2013177349A2
(en)
|
2012-05-25 |
2013-11-28 |
Glaxosmithkline Llc |
Quinazolinediones as tankyrase inhibitors
|
|
CN104540830A
(zh)
|
2012-06-07 |
2015-04-22 |
霍夫曼-拉罗奇有限公司 |
端锚聚合酶的吡唑并嘧啶酮和吡唑并吡啶酮抑制剂
|
|
WO2013182580A1
(en)
|
2012-06-07 |
2013-12-12 |
F. Hoffmann-La Roche Ag |
Pyrrolopyrimidone and pyrrolopyridone inhibitors of tankyrase
|
|
RU2014152790A
(ru)
|
2012-06-20 |
2016-08-10 |
Ф. Хоффманн-Ля Рош Аг |
Пирролопиразоновые ингибиторы танкиразы
|
|
HK1201066A1
(en)
|
2012-06-20 |
2015-08-21 |
霍夫曼-拉罗奇有限公司 |
Pyranopyridone inhibitors of tankyrase
|
|
EP2882714B1
(en)
|
2012-08-08 |
2019-11-13 |
Merck Patent GmbH |
(aza-)isoquinolinone derivatives
|
|
WO2014036022A1
(en)
|
2012-08-29 |
2014-03-06 |
Amgen Inc. |
Quinazolinone compounds and derivatives thereof
|
|
WO2014045101A1
(en)
|
2012-09-21 |
2014-03-27 |
Cellzome Gmbh |
Tetrazolo quinoxaline derivatives as tankyrase inhibitors
|
|
AR092211A1
(es)
|
2012-09-24 |
2015-04-08 |
Merck Patent Ges Mit Beschränkter Haftung |
Derivados de hidropirrolopirrol
|
|
JP6276769B2
(ja)
|
2012-09-26 |
2018-02-07 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ |
Ｐａｒｐインヒビターとしてのキナゾリノン誘導体
|
|
WO2014087165A1
(en)
|
2012-12-06 |
2014-06-12 |
University Of Bath |
Tankyrase inhibitors
|