|
US2851458A
(en)
|
1955-06-08 |
1958-09-09 |
Burroughs Wellcome Co |
Diquaternary compounds and the manufacture thereof
|
|
US4678500A
(en)
|
1984-06-29 |
1987-07-07 |
E. I. Du Pont De Nemours And Company |
Herbicidal 2,6-disubstituted benzylsulfonamides and benzenesulfamates
|
|
US5177075A
(en)
|
1988-08-19 |
1993-01-05 |
Warner-Lambert Company |
Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
|
|
US4942163A
(en)
|
1989-03-07 |
1990-07-17 |
E. I. Du Pont De Nemours And Company |
1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
|
|
ATE404539T1
(de)
|
1997-10-02 |
2008-08-15 |
Eisai R&D Man Co Ltd |
Kondensierte pyridinderivate
|
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
|
EP1396488A1
(en)
|
2001-05-23 |
2004-03-10 |
Mitsubishi Pharma Corporation |
Fused heterocyclic compound and medicinal use thereof
|
|
CN104744461A
(zh)
|
2001-09-21 |
2015-07-01 |
百时美施贵宝公司 |
含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
|
|
MY140680A
(en)
|
2002-05-20 |
2010-01-15 |
Bristol Myers Squibb Co |
Hepatitis c virus inhibitors
|
|
CA2493234A1
(en)
|
2002-07-24 |
2004-01-29 |
Kyorin Pharmaceutical Co., Ltd. |
4-(substituted aryl)-5-hydroxyisoquinolinone derivative
|
|
TW200424188A
(en)
|
2002-10-01 |
2004-11-16 |
Mitsubishi Pharma Corp |
Isoquinoline compound and pharmaceutical use thereof
|
|
EA010408B1
(ru)
|
2002-10-23 |
2008-08-29 |
Гленмарк Фармасьютикалс Лтд. |
Трициклические соединения для лечения воспалительных и аллергических нарушений, способы их приготовления и содержащие их фармацевтические составы
|
|
TW200412959A
(en)
*
|
2002-11-22 |
2004-08-01 |
Mitsubishi Pharma Corp |
Isoquinoline compounds and medicinal use thereof
|
|
WO2004058717A1
(en)
|
2002-12-20 |
2004-07-15 |
X-Ceptor Therapeutics, Inc. |
Isoquinolinone derivatives and their use as therapeutic agents
|
|
JP4733023B2
(ja)
|
2003-04-16 |
2011-07-27 |
ブリストル−マイヤーズ スクイブ カンパニー |
Ｃ型肝炎ウイルスの大環状イソキノリンペプチド阻害剤
|
|
TW200536830A
(en)
*
|
2004-02-06 |
2005-11-16 |
Chugai Pharmaceutical Co Ltd |
1-(2H)-isoquinolone derivative
|
|
WO2005075432A1
(ja)
|
2004-02-06 |
2005-08-18 |
Chugai Seiyaku Kabushiki Kaisha |
１−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用
|
|
WO2005113540A1
(ja)
|
2004-05-20 |
2005-12-01 |
Mitsubishi Pharma Corporation |
イソキノリン化合物及びその医薬用途
|
|
WO2006045010A2
(en)
|
2004-10-20 |
2006-04-27 |
Resverlogix Corp. |
Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
|
|
PT1807077T
(pt)
|
2004-10-22 |
2017-01-06 |
Janssen Pharmaceutica Nv |
Inibidores de quinase c-fms
|
|
MX2007007027A
(es)
|
2004-12-16 |
2007-07-04 |
Hoffmann La Roche |
Derivados piperazinilpiridina como agentes anti-obesidad.
|
|
TWI389897B
(zh)
|
2005-02-22 |
2013-03-21 |
Chugai Pharmaceutical Co Ltd |
1- (2H) -isoquinolinone derivatives
|
|
EP1864976B1
(en)
|
2005-03-31 |
2012-10-10 |
Astellas Pharma Inc. |
Propane-1,3-dion derivative or salt thereof
|
|
US8410109B2
(en)
|
2005-07-29 |
2013-04-02 |
Resverlogix Corp. |
Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
|
|
CN101316592A
(zh)
|
2005-08-24 |
2008-12-03 |
伊诺泰克制药公司 |
茚并异喹啉酮类似物及其用法
|
|
US20090181951A1
(en)
*
|
2006-06-15 |
2009-07-16 |
Kudos Pharmaceuticals Limited |
Parp inhibitors
|
|
TWI386405B
(zh)
|
2006-09-05 |
2013-02-21 |
|
咪唑衍生物
|
|
US7772180B2
(en)
|
2006-11-09 |
2010-08-10 |
Bristol-Myers Squibb Company |
Hepatitis C virus inhibitors
|
|
PT2118074E
(pt)
|
2007-02-01 |
2014-03-20 |
Resverlogix Corp |
Compostos para a prevenção e tratamento de doenças cardiovasculares
|
|
FR2919286A1
(fr)
|
2007-07-27 |
2009-01-30 |
Sanofi Aventis Sa |
Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
|
|
US20090054392A1
(en)
|
2007-08-20 |
2009-02-26 |
Wyeth |
Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
|
|
WO2009027650A1
(en)
|
2007-08-24 |
2009-03-05 |
The Institute Of Cancer: Royal Cancer Hospital |
Materials and methods for exploiting synthetic lethality in brca-associated cancers
|
|
US20100267626A1
(en)
|
2007-11-05 |
2010-10-21 |
Novartis Ag |
Methods and compositions for measuring wnt activation and for treating wnt-related cancers
|
|
DE102008019838A1
(de)
|
2008-04-19 |
2009-12-10 |
Boehringer Ingelheim International Gmbh |
Neue Arylsulfonylglycin-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
|
|
KR101598397B1
(ko)
|
2008-04-22 |
2016-02-29 |
얀센 파마슈티카 엔.브이. |
퀴놀린 또는 이소퀴놀린 치환된 피2엑스7 안타고니스트
|
|
AR074199A1
(es)
|
2008-11-20 |
2010-12-29 |
Glaxosmithkline Llc |
Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer.
|
|
MX2011008641A
(es)
|
2009-03-06 |
2011-09-06 |
Hoffmann La Roche |
Compuestos heterociclicos antivirales.
|
|
KR101913109B1
(ko)
|
2009-03-18 |
2018-10-31 |
리스버로직스 코퍼레이션 |
신규한 소염제
|
|
US9757368B2
(en)
|
2009-04-22 |
2017-09-12 |
Resverlogix Corp. |
Anti-inflammatory agents
|
|
TWI499418B
(zh)
*
|
2009-05-21 |
2015-09-11 |
Nerviano Medical Sciences Srl |
異喹啉－１（２ｈ）－酮衍生物
|
|
US8841289B2
(en)
|
2009-10-13 |
2014-09-23 |
Merck Sharp & Dohme B.V. |
Heterocyclic derivatives
|
|
CA2799579A1
(en)
|
2010-05-21 |
2011-11-24 |
Intellikine, Inc. |
Chemical compounds, compositions and methods for kinase modulation
|
|
JP2013528635A
(ja)
|
2010-06-17 |
2013-07-11 |
ノバルティス アーゲー |
ビフェニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
|
|
EP2731942B1
(en)
|
2011-07-13 |
2015-09-23 |
Novartis AG |
Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
|
|
AU2012282076A1
(en)
|
2011-07-13 |
2014-02-27 |
Novartis Ag |
4 - piperidinyl compounds for use as tankyrase inhibitors
|
|
US9227982B2
(en)
|
2011-07-13 |
2016-01-05 |
Novartis Ag |
4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors
|
|
EA027800B1
(ru)
|
2011-11-25 |
2017-09-29 |
НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. |
Производные 3-фенилизохинолин-1(2h)-она в качестве ингибиторов parp-1
|
|
MX2014008071A
(es)
|
2011-12-31 |
2015-07-06 |
Beigene Ltd |
Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas.
|
|
MX353578B
(es)
|
2011-12-31 |
2018-01-19 |
Beigene Ltd |
Dihidrodiazpinocarbazolonas tetra o penta-ciclicas fusionadas como inhibidores de poli (adp-ribosa) polimerasa (parp).
|
|
JP2015505542A
(ja)
|
2012-01-28 |
2015-02-23 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ |
アザ複素環式化合物
|
|
WO2013116182A1
(en)
|
2012-01-31 |
2013-08-08 |
Boehringer Ingelheim International Gmbh |
Heterocyclic compounds as inhibitors of leukotriene production
|
|
UA116627C2
(uk)
|
2012-02-09 |
2018-04-25 |
Мерк Патент Гмбх |
Похідні тетрагідрохіназоліну як інгібітори tank та parp
|
|
US9340549B2
(en)
|
2012-03-05 |
2016-05-17 |
Amgen Inc. |
Oxazolidinone compounds and derivatives thereof
|
|
WO2013132253A1
(en)
|
2012-03-07 |
2013-09-12 |
Institute Of Cancer Research: Royal Cancer Hospital (The) |
3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
|
|
CA2868620C
(en)
|
2012-03-28 |
2020-02-25 |
Dieter Dorsch |
Bicyclic pyrazinone derivatives
|
|
US20130281397A1
(en)
|
2012-04-19 |
2013-10-24 |
Rvx Therapeutics Inc. |
Treatment of diseases by epigenetic regulation
|
|
AU2013257018B2
(en)
|
2012-05-04 |
2017-02-16 |
Merck Patent Gmbh |
Pyrrolotriazinone derivatives
|
|
WO2013177349A2
(en)
|
2012-05-25 |
2013-11-28 |
Glaxosmithkline Llc |
Quinazolinediones as tankyrase inhibitors
|
|
CN104350056A
(zh)
|
2012-06-07 |
2015-02-11 |
霍夫曼-拉罗奇有限公司 |
端锚聚合酶的吡咯并嘧啶酮和吡咯并吡啶酮抑制剂
|
|
CN104540830A
(zh)
|
2012-06-07 |
2015-04-22 |
霍夫曼-拉罗奇有限公司 |
端锚聚合酶的吡唑并嘧啶酮和吡唑并吡啶酮抑制剂
|
|
HK1201066A1
(en)
|
2012-06-20 |
2015-08-21 |
霍夫曼-拉罗奇有限公司 |
Pyranopyridone inhibitors of tankyrase
|
|
EP2864330A1
(en)
|
2012-06-20 |
2015-04-29 |
F. Hoffmann-La Roche AG |
Pyrrolopyrazone inhibitors of tankyrase
|
|
KR102083154B1
(ko)
|
2012-08-08 |
2020-03-02 |
메르크 파텐트 게엠베하 |
（아자―）이소퀴놀리논 유도체
|
|
EP2890696A1
(en)
|
2012-08-29 |
2015-07-08 |
Amgen, Inc. |
Quinazolinone compounds and derivatives thereof
|
|
WO2014045101A1
(en)
|
2012-09-21 |
2014-03-27 |
Cellzome Gmbh |
Tetrazolo quinoxaline derivatives as tankyrase inhibitors
|
|
AR092211A1
(es)
|
2012-09-24 |
2015-04-08 |
Merck Patent Ges Mit Beschränkter Haftung |
Derivados de hidropirrolopirrol
|
|
RU2650107C2
(ru)
|
2012-09-26 |
2018-04-09 |
Мерк Патент Гмбх |
Производные хиназолинона в качестве ингибиторов parp
|
|
WO2014087165A1
(en)
|
2012-12-06 |
2014-06-12 |
University Of Bath |
Tankyrase inhibitors
|