JP6456392B2 - ３−アリール−５−置換イソキノリン−１−オン化合物及びその治療的使用 - Google Patents

３−アリール−５−置換イソキノリン−１−オン化合物及びその治療的使用 Download PDF

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JP6456392B2
JP6456392B2 JP2016542369A JP2016542369A JP6456392B2 JP 6456392 B2 JP6456392 B2 JP 6456392B2 JP 2016542369 A JP2016542369 A JP 2016542369A JP 2016542369 A JP2016542369 A JP 2016542369A JP 6456392 B2 JP6456392 B2 JP 6456392B2
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independently
present
compound according
nhr
cancer
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JP2016531153A (ja
JP2016531153A5 (https=
Inventor
アッシュワース，アラン
ロード，クリストファー，ジェイムズ
エリオット，リチャード，ジェイムズ，ローランド
ニクレスク−ドゥバツ，ダン
ポーター，ロデリック，アラン
アクイル，リーアン
ボッフェイ，レイモンド，ジョン
ベイフォード，メラニー，ジェイン
ファース−クラーク，スチュアート
ホプキンス，アンナ
ジャービス，アシュリー，ニコラス
ペリオー，トレバー，ロバート
スコーン，フィリップ，アラン
キー，レベカー，エリザベス
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インスティチュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル
インスティチュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル
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Priority claimed from GBGB1316173.2A external-priority patent/GB201316173D0/en
Priority claimed from GBGB1403496.1A external-priority patent/GB201403496D0/en
Priority claimed from GB201410387A external-priority patent/GB201410387D0/en
Application filed by インスティチュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル, インスティチュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル filed Critical インスティチュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル
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JP2016542369A 2013-09-11 2014-09-11 ３−アリール−５−置換イソキノリン−１−オン化合物及びその治療的使用 Expired - Fee Related JP6456392B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1316173.2A GB201316173D0 (en) 2013-09-11 2013-09-11 Compounds and their therapeutic use
GB1316173.2 2013-09-11
GB1403496.1 2014-02-27
GBGB1403496.1A GB201403496D0 (en) 2014-02-27 2014-02-27 Compounds and their therapeutic use
GB201410387A GB201410387D0 (en) 2014-06-11 2014-06-11 Compounds and their therapeutic use
GB1410387.3 2014-06-11
PCT/GB2014/052752 WO2015036759A1 (en) 2013-09-11 2014-09-11 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use

Publications (3)

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JP2016531153A JP2016531153A (ja) 2016-10-06
JP2016531153A5 JP2016531153A5 (https=) 2017-10-12
JP6456392B2 true JP6456392B2 (ja) 2019-01-23

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US (1) US9611223B2 (https=)
EP (1) EP3044221B1 (https=)
JP (1) JP6456392B2 (https=)
CN (1) CN105722835B (https=)
AU (1) AU2014320149A1 (https=)
CA (1) CA2922469A1 (https=)
DK (1) DK3044221T3 (https=)
ES (1) ES2666729T3 (https=)
NO (1) NO3044221T3 (https=)
WO (1) WO2015036759A1 (https=)

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BR112018008630A2 (pt) * 2015-11-06 2018-10-30 Neurocrine Biosciences Inc derivados de n-[2-(1-benzilpiperidin-4-il)etil]-4-(pirazin-2-il)-piperazina-1-carboxamida, seus usos, composição farmacêutica
EA039638B1 (ru) * 2016-01-06 2022-02-21 Нейрокрин Байосайенсиз, Инк. Антагонисты мускаринового рецептора 4 и способы их применения
CN107286169B (zh) * 2016-04-05 2020-11-24 北京四环制药有限公司 端锚聚合酶抑制剂
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
US12402885B2 (en) 2017-09-23 2025-09-02 Universität Zürich Medical occlusion device
CN110003049A (zh) * 2019-05-13 2019-07-12 苏州山青竹生物医药有限公司 一种制备4-氰基-1-茚酮的方法
CN110407740A (zh) * 2019-09-04 2019-11-05 上海毕得医药科技有限公司 一种3-溴-2-乙基吡啶的合成方法
CN114641242B (zh) 2019-09-26 2025-11-18 苏黎世大学 左心耳闭塞装置
US12486250B2 (en) 2019-12-06 2025-12-02 Neurocrine Biosciences, Inc. Muscarinic receptor 4 antagonists and methods of use
US12564408B2 (en) 2020-03-25 2026-03-03 Universitat Zurich Medical occluder delivery systems
WO2022235492A1 (en) * 2021-05-04 2022-11-10 Board Of Regents, The University Of Texas System Indanone and tetralone-keto or hydroxyl oximes as cancer therapeutics
IL314895A (en) * 2022-02-16 2024-10-01 Duke Street Bio Ltd Pharmaceutical compound
GB2634228A (en) * 2023-10-02 2025-04-09 Duke Street Bio Ltd PARP1 inhibitor compounds

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2851458A (en) 1955-06-08 1958-09-09 Burroughs Wellcome Co Diquaternary compounds and the manufacture thereof
US4678500A (en) 1984-06-29 1987-07-07 E. I. Du Pont De Nemours And Company Herbicidal 2,6-disubstituted benzylsulfonamides and benzenesulfamates
US5177075A (en) 1988-08-19 1993-01-05 Warner-Lambert Company Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process
US4942163A (en) 1989-03-07 1990-07-17 E. I. Du Pont De Nemours And Company 1(2H)-isoquinolinones and 1-isoquinolineamines as cancer chemotherapeutic agents
ATE404539T1 (de) 1997-10-02 2008-08-15 Eisai R&D Man Co Ltd Kondensierte pyridinderivate
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
EP1396488A1 (en) 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
CN104744461A (zh) 2001-09-21 2015-07-01 百时美施贵宝公司 含有内酰胺的化合物及其衍生物作为Xa因子的抑制剂
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
CA2493234A1 (en) 2002-07-24 2004-01-29 Kyorin Pharmaceutical Co., Ltd. 4-(substituted aryl)-5-hydroxyisoquinolinone derivative
TW200424188A (en) 2002-10-01 2004-11-16 Mitsubishi Pharma Corp Isoquinoline compound and pharmaceutical use thereof
EA010408B1 (ru) 2002-10-23 2008-08-29 Гленмарк Фармасьютикалс Лтд. Трициклические соединения для лечения воспалительных и аллергических нарушений, способы их приготовления и содержащие их фармацевтические составы
TW200412959A (en) * 2002-11-22 2004-08-01 Mitsubishi Pharma Corp Isoquinoline compounds and medicinal use thereof
WO2004058717A1 (en) 2002-12-20 2004-07-15 X-Ceptor Therapeutics, Inc. Isoquinolinone derivatives and their use as therapeutic agents
JP4733023B2 (ja) 2003-04-16 2011-07-27 ブリストル−マイヤーズ スクイブ カンパニー Ｃ型肝炎ウイルスの大環状イソキノリンペプチド阻害剤
TW200536830A (en) * 2004-02-06 2005-11-16 Chugai Pharmaceutical Co Ltd 1-(2H)-isoquinolone derivative
WO2005075432A1 (ja) 2004-02-06 2005-08-18 Chugai Seiyaku Kabushiki Kaisha １−（２ｈ）−イソキノロン誘導体およびその抗ガン剤としての使用
WO2005113540A1 (ja) 2004-05-20 2005-12-01 Mitsubishi Pharma Corporation イソキノリン化合物及びその医薬用途
WO2006045010A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
PT1807077T (pt) 2004-10-22 2017-01-06 Janssen Pharmaceutica Nv Inibidores de quinase c-fms
MX2007007027A (es) 2004-12-16 2007-07-04 Hoffmann La Roche Derivados piperazinilpiridina como agentes anti-obesidad.
TWI389897B (zh) 2005-02-22 2013-03-21 Chugai Pharmaceutical Co Ltd 1- (2H) -isoquinolinone derivatives
EP1864976B1 (en) 2005-03-31 2012-10-10 Astellas Pharma Inc. Propane-1,3-dion derivative or salt thereof
US8410109B2 (en) 2005-07-29 2013-04-02 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
CN101316592A (zh) 2005-08-24 2008-12-03 伊诺泰克制药公司 茚并异喹啉酮类似物及其用法
US20090181951A1 (en) * 2006-06-15 2009-07-16 Kudos Pharmaceuticals Limited Parp inhibitors
TWI386405B (zh) 2006-09-05 2013-02-21 咪唑衍生物
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PT2118074E (pt) 2007-02-01 2014-03-20 Resverlogix Corp Compostos para a prevenção e tratamento de doenças cardiovasculares
FR2919286A1 (fr) 2007-07-27 2009-01-30 Sanofi Aventis Sa Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
US20090054392A1 (en) 2007-08-20 2009-02-26 Wyeth Naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system
WO2009027650A1 (en) 2007-08-24 2009-03-05 The Institute Of Cancer: Royal Cancer Hospital Materials and methods for exploiting synthetic lethality in brca-associated cancers
US20100267626A1 (en) 2007-11-05 2010-10-21 Novartis Ag Methods and compositions for measuring wnt activation and for treating wnt-related cancers
DE102008019838A1 (de) 2008-04-19 2009-12-10 Boehringer Ingelheim International Gmbh Neue Arylsulfonylglycin-Derivate, deren Herstellung und deren Verwendung als Arzneimittel
KR101598397B1 (ko) 2008-04-22 2016-02-29 얀센 파마슈티카 엔.브이. 퀴놀린 또는 이소퀴놀린 치환된 피2엑스7 안타고니스트
AR074199A1 (es) 2008-11-20 2010-12-29 Glaxosmithkline Llc Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer.
MX2011008641A (es) 2009-03-06 2011-09-06 Hoffmann La Roche Compuestos heterociclicos antivirales.
KR101913109B1 (ko) 2009-03-18 2018-10-31 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
TWI499418B (zh) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
US8841289B2 (en) 2009-10-13 2014-09-23 Merck Sharp & Dohme B.V. Heterocyclic derivatives
CA2799579A1 (en) 2010-05-21 2011-11-24 Intellikine, Inc. Chemical compounds, compositions and methods for kinase modulation
JP2013528635A (ja) 2010-06-17 2013-07-11 ノバルティス アーゲー ビフェニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体
EP2731942B1 (en) 2011-07-13 2015-09-23 Novartis AG Novel 2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
AU2012282076A1 (en) 2011-07-13 2014-02-27 Novartis Ag 4 - piperidinyl compounds for use as tankyrase inhibitors
US9227982B2 (en) 2011-07-13 2016-01-05 Novartis Ag 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors
EA027800B1 (ru) 2011-11-25 2017-09-29 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Производные 3-фенилизохинолин-1(2h)-она в качестве ингибиторов parp-1
MX2014008071A (es) 2011-12-31 2015-07-06 Beigene Ltd Tetra o penta-piridoftalazinonas ciclicas fusionadas como inhibidores de poli(adenosin-difosfato-ribosa)polimerasas.
MX353578B (es) 2011-12-31 2018-01-19 Beigene Ltd Dihidrodiazpinocarbazolonas tetra o penta-ciclicas fusionadas como inhibidores de poli (adp-ribosa) polimerasa (parp).
JP2015505542A (ja) 2012-01-28 2015-02-23 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ アザ複素環式化合物
WO2013116182A1 (en) 2012-01-31 2013-08-08 Boehringer Ingelheim International Gmbh Heterocyclic compounds as inhibitors of leukotriene production
UA116627C2 (uk) 2012-02-09 2018-04-25 Мерк Патент Гмбх Похідні тетрагідрохіназоліну як інгібітори tank та parp
US9340549B2 (en) 2012-03-05 2016-05-17 Amgen Inc. Oxazolidinone compounds and derivatives thereof
WO2013132253A1 (en) 2012-03-07 2013-09-12 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
CA2868620C (en) 2012-03-28 2020-02-25 Dieter Dorsch Bicyclic pyrazinone derivatives
US20130281397A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
AU2013257018B2 (en) 2012-05-04 2017-02-16 Merck Patent Gmbh Pyrrolotriazinone derivatives
WO2013177349A2 (en) 2012-05-25 2013-11-28 Glaxosmithkline Llc Quinazolinediones as tankyrase inhibitors
CN104350056A (zh) 2012-06-07 2015-02-11 霍夫曼-拉罗奇有限公司 端锚聚合酶的吡咯并嘧啶酮和吡咯并吡啶酮抑制剂
CN104540830A (zh) 2012-06-07 2015-04-22 霍夫曼-拉罗奇有限公司 端锚聚合酶的吡唑并嘧啶酮和吡唑并吡啶酮抑制剂
HK1201066A1 (en) 2012-06-20 2015-08-21 霍夫曼-拉罗奇有限公司 Pyranopyridone inhibitors of tankyrase
EP2864330A1 (en) 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG Pyrrolopyrazone inhibitors of tankyrase
KR102083154B1 (ko) 2012-08-08 2020-03-02 메르크 파텐트 게엠베하 （아자―）이소퀴놀리논 유도체
EP2890696A1 (en) 2012-08-29 2015-07-08 Amgen, Inc. Quinazolinone compounds and derivatives thereof
WO2014045101A1 (en) 2012-09-21 2014-03-27 Cellzome Gmbh Tetrazolo quinoxaline derivatives as tankyrase inhibitors
AR092211A1 (es) 2012-09-24 2015-04-08 Merck Patent Ges Mit Beschränkter Haftung Derivados de hidropirrolopirrol
RU2650107C2 (ru) 2012-09-26 2018-04-09 Мерк Патент Гмбх Производные хиназолинона в качестве ингибиторов parp
WO2014087165A1 (en) 2012-12-06 2014-06-12 University Of Bath Tankyrase inhibitors

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