CN105722835B - 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 - Google Patents

3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 Download PDF

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CN105722835B
CN105722835B CN201480061828.6A CN201480061828A CN105722835B CN 105722835 B CN105722835 B CN 105722835B CN 201480061828 A CN201480061828 A CN 201480061828A CN 105722835 B CN105722835 B CN 105722835B
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CN105722835A (zh
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艾伦·艾史沃斯
克勒斯托弗·詹姆斯·洛德
理查德·詹姆斯·罗兰·埃利奥特
丹·尼库列斯库-杜瓦斯
罗德里克·艾伦·波特
里恩·阿吉尔
雷蒙德·约翰·博费
梅拉妮·杰恩·拜福德
斯图尔特·弗思-克拉克
安娜·霍普金斯
阿什利·尼古拉斯·加尔维斯
特雷弗·罗伯特·佩里奥尔
菲利普·艾伦·斯科恩
丽贝卡·伊丽莎白·基
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Institute of Cancer Research Royal Cancer Hospital
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Institute of Cancer Research Royal Cancer Hospital
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Priority claimed from GBGB1403496.1A external-priority patent/GB201403496D0/en
Priority claimed from GB201410387A external-priority patent/GB201410387D0/en
Application filed by Institute of Cancer Research Royal Cancer Hospital filed Critical Institute of Cancer Research Royal Cancer Hospital
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CN201480061828.6A 2013-09-11 2014-09-11 3-芳基-5-取代的-异喹啉-1-酮化合物及它们的疗法应用 Expired - Fee Related CN105722835B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1316173.2A GB201316173D0 (en) 2013-09-11 2013-09-11 Compounds and their therapeutic use
GB1316173.2 2013-09-11
GBGB1403496.1A GB201403496D0 (en) 2014-02-27 2014-02-27 Compounds and their therapeutic use
GB1403496.1 2014-02-27
GB1410387.3 2014-06-11
GB201410387A GB201410387D0 (en) 2014-06-11 2014-06-11 Compounds and their therapeutic use
PCT/GB2014/052752 WO2015036759A1 (en) 2013-09-11 2014-09-11 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use

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CN105722835A CN105722835A (zh) 2016-06-29
CN105722835B true CN105722835B (zh) 2018-07-31

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EP (1) EP3044221B1 (https=)
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AU (1) AU2014320149A1 (https=)
CA (1) CA2922469A1 (https=)
DK (1) DK3044221T3 (https=)
ES (1) ES2666729T3 (https=)
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EP3371164B1 (en) * 2015-11-06 2022-03-16 Neurocrine Biosciences, Inc. N-[2-(1-benzylpiperidin-4-yl)ethyl]-4-(pyrazin-2-yl)-piperazine-1-carboxamide derivatives and related compounds as muscarinic receptor 4 (m4) antagonists for treating neurological diseases
EA039638B1 (ru) * 2016-01-06 2022-02-21 Нейрокрин Байосайенсиз, Инк. Антагонисты мускаринового рецептора 4 и способы их применения
CN107286169B (zh) * 2016-04-05 2020-11-24 北京四环制药有限公司 端锚聚合酶抑制剂
GB201615282D0 (en) * 2016-09-08 2016-10-26 Univ Bath Tankyrase inhibitors
EP3459469A1 (en) 2017-09-23 2019-03-27 Universität Zürich Medical occluder device
US12402885B2 (en) 2017-09-23 2025-09-02 Universität Zürich Medical occlusion device
CN110003049A (zh) * 2019-05-13 2019-07-12 苏州山青竹生物医药有限公司 一种制备4-氰基-1-茚酮的方法
CN110407740A (zh) * 2019-09-04 2019-11-05 上海毕得医药科技有限公司 一种3-溴-2-乙基吡啶的合成方法
CN114641242B (zh) 2019-09-26 2025-11-18 苏黎世大学 左心耳闭塞装置
EP4069367B1 (en) 2019-12-06 2024-05-15 Neurocrine Biosciences, Inc. Muscarinic receptor 4 antagonists and methods of use
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