JP2016528247A5 - - Google Patents
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- JP2016528247A5 JP2016528247A5 JP2016533986A JP2016533986A JP2016528247A5 JP 2016528247 A5 JP2016528247 A5 JP 2016528247A5 JP 2016533986 A JP2016533986 A JP 2016533986A JP 2016533986 A JP2016533986 A JP 2016533986A JP 2016528247 A5 JP2016528247 A5 JP 2016528247A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- heavy chain
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001413 amino acids Chemical class 0.000 claims description 84
- 201000008319 inclusion body myositis Diseases 0.000 claims description 57
- 239000005557 antagonist Substances 0.000 claims description 48
- 102000004472 Myostatin Human genes 0.000 claims description 47
- 108010056852 Myostatin Proteins 0.000 claims description 47
- 239000000203 mixture Substances 0.000 claims description 42
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims description 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 24
- 230000037396 body weight Effects 0.000 claims description 16
- 102000005962 receptors Human genes 0.000 claims description 8
- 108020003175 receptors Proteins 0.000 claims description 8
- 208000019505 Deglutition disease Diseases 0.000 claims description 4
- 239000002464 receptor antagonist Substances 0.000 claims description 4
- 229940044551 receptor antagonist Drugs 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- 206010061818 Disease progression Diseases 0.000 claims description 3
- 230000005750 disease progression Effects 0.000 claims description 3
- 239000012636 effector Substances 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 230000035772 mutation Effects 0.000 claims description 3
- 210000001364 upper extremity Anatomy 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 230000009747 swallowing Effects 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000004899 motility Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 34
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000003000 inclusion body Anatomy 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 230000001568 sexual effect Effects 0.000 description 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361865861P | 2013-08-14 | 2013-08-14 | |
| US61/865,861 | 2013-08-14 | ||
| US201461983567P | 2014-04-24 | 2014-04-24 | |
| US61/983,567 | 2014-04-24 | ||
| PCT/IB2014/063904 WO2015022658A2 (en) | 2013-08-14 | 2014-08-13 | Methods of treating sporadic inclusion body myositis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016528247A JP2016528247A (ja) | 2016-09-15 |
| JP2016528247A5 true JP2016528247A5 (OSRAM) | 2017-09-21 |
Family
ID=51492992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016533986A Pending JP2016528247A (ja) | 2013-08-14 | 2014-08-13 | 孤発性封入体筋炎を治療する方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20160200818A1 (OSRAM) |
| EP (1) | EP3033358A2 (OSRAM) |
| JP (1) | JP2016528247A (OSRAM) |
| KR (1) | KR20160042987A (OSRAM) |
| CN (1) | CN105960414A (OSRAM) |
| AU (2) | AU2014307589A1 (OSRAM) |
| BR (1) | BR112016002198A2 (OSRAM) |
| CA (1) | CA2918300A1 (OSRAM) |
| CL (1) | CL2016000341A1 (OSRAM) |
| HK (1) | HK1219280A1 (OSRAM) |
| IL (1) | IL243883A0 (OSRAM) |
| MX (1) | MX2016001969A (OSRAM) |
| PH (1) | PH12016500141A1 (OSRAM) |
| RU (1) | RU2016108652A (OSRAM) |
| SG (2) | SG11201600212VA (OSRAM) |
| TN (1) | TN2016000057A1 (OSRAM) |
| TW (1) | TW201536318A (OSRAM) |
| WO (1) | WO2015022658A2 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3811965A1 (en) | 2005-11-23 | 2021-04-28 | Acceleron Pharma, Inc. | Activin-actriia antagonists in use for promoting bone growth |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| EP2599495A1 (en) | 2007-02-01 | 2013-06-05 | Acceleron Pharma, Inc. | Activin-ActRIIa Antagonists and Uses for Treating or Preventing Breast Cancer |
| TW201940502A (zh) | 2007-02-02 | 2019-10-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| KR20200054317A (ko) | 2007-02-09 | 2020-05-19 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| CA2699936A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| HUE051137T2 (hu) | 2008-08-14 | 2021-03-01 | Acceleron Pharma Inc | GDF-csapdák |
| EP2440577A4 (en) | 2009-06-12 | 2013-01-23 | Acceleron Pharma Inc | SHORTEN ACTRIIB FC FUSION PROTEINS |
| US8710016B2 (en) | 2009-11-17 | 2014-04-29 | Acceleron Pharma, Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
| CN103298832A (zh) | 2010-11-08 | 2013-09-11 | 阿塞勒隆制药公司 | Actriia结合剂及其用途 |
| BR112013013354A2 (pt) | 2010-11-30 | 2020-10-06 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno capaz de se ligar a uma pluralidade de moléculas de antígeno repetidamente |
| SI2780368T1 (en) | 2011-11-14 | 2018-04-30 | Regeneron Pharmaceuticals, Inc. | INGREDIENTS AND PROCEDURES FOR INCREASING PURE MASS AND MICROWAVE WITH SPECIFIC ANTAGONISING OF GDF8 AND / OR ACTIVITY A |
| JP6501521B2 (ja) | 2012-08-24 | 2019-04-17 | 中外製薬株式会社 | ＦｃγＲＩＩｂ特異的Ｆｃ領域改変体 |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
| CA2908350C (en) | 2013-04-02 | 2023-08-08 | Futa Mimoto | Fc region variant |
| CN107135646B (zh) | 2014-06-13 | 2022-03-15 | 阿塞勒隆制药公司 | 用于治疗溃疡的方法和组合物 |
| TN2017000217A1 (en) * | 2014-12-08 | 2018-10-19 | Novartis Ag | Myostatin or activin antagonists for the treatment of sarcopenia |
| MY181199A (en) | 2014-12-19 | 2020-12-21 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| CN107108729A (zh) | 2015-02-05 | 2017-08-29 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il‑8‑结合抗体，及其应用 |
| IL255010B2 (en) * | 2015-04-15 | 2024-01-01 | Regeneron Pharma | Methods of increasing strength and functionality with gdf8 inhibitors |
| WO2017104783A1 (en) * | 2015-12-18 | 2017-06-22 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| KR102866147B1 (ko) | 2016-03-10 | 2025-09-30 | 악셀레론 파마 인코포레이티드 | 액티빈 타입 2 수용체 결합 단백질 및 이의 용도 |
| JP6527643B2 (ja) | 2016-08-05 | 2019-06-05 | 中外製薬株式会社 | Ｉｌ−８関連疾患の治療用又は予防用組成物 |
| JP7339159B2 (ja) | 2017-03-24 | 2023-09-05 | ノバルティス アーゲー | 心疾患の予防および治療方法 |
| EP3645564A1 (en) * | 2017-06-28 | 2020-05-06 | Novartis AG | Methods for preventing and treating urinary incontinence |
| AU2019226551B2 (en) | 2018-03-01 | 2025-02-06 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition |
| JP7505495B2 (ja) * | 2019-07-24 | 2024-06-25 | ソニーグループ株式会社 | 情報処理装置、情報処理方法および情報処理プログラム |
| EP4279594A4 (en) * | 2021-01-13 | 2024-11-27 | Astellas Pharma Inc. | BINDING OF MULTISPECIFIC ANTIBODIES TO ACTRIIA, ACTRIIB AND FN14 |
| CA3265879A1 (en) * | 2022-08-26 | 2024-02-29 | Versanis Bio, Inc. | ACTRII FIXED SINGLE-DOSE ANTIBODY TREATMENTS |
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-
2014
- 2014-08-13 AU AU2014307589A patent/AU2014307589A1/en not_active Abandoned
- 2014-08-13 HK HK16107243.2A patent/HK1219280A1/zh unknown
- 2014-08-13 RU RU2016108652A patent/RU2016108652A/ru not_active Application Discontinuation
- 2014-08-13 BR BR112016002198A patent/BR112016002198A2/pt not_active IP Right Cessation
- 2014-08-13 TN TN2016000057A patent/TN2016000057A1/en unknown
- 2014-08-13 JP JP2016533986A patent/JP2016528247A/ja active Pending
- 2014-08-13 EP EP14761413.5A patent/EP3033358A2/en not_active Ceased
- 2014-08-13 CA CA2918300A patent/CA2918300A1/en not_active Abandoned
- 2014-08-13 TW TW103127832A patent/TW201536318A/zh unknown
- 2014-08-13 MX MX2016001969A patent/MX2016001969A/es unknown
- 2014-08-13 SG SG11201600212VA patent/SG11201600212VA/en unknown
- 2014-08-13 CN CN201480056363.5A patent/CN105960414A/zh not_active Withdrawn
- 2014-08-13 KR KR1020167006266A patent/KR20160042987A/ko not_active Withdrawn
- 2014-08-13 WO PCT/IB2014/063904 patent/WO2015022658A2/en not_active Ceased
- 2014-08-13 US US14/911,333 patent/US20160200818A1/en not_active Abandoned
- 2014-08-13 SG SG10201801063TA patent/SG10201801063TA/en unknown
-
2016
- 2016-01-21 PH PH12016500141A patent/PH12016500141A1/en unknown
- 2016-02-01 IL IL243883A patent/IL243883A0/en unknown
- 2016-02-12 CL CL2016000341A patent/CL2016000341A1/es unknown
-
2017
- 2017-09-13 AU AU2017228600A patent/AU2017228600A1/en not_active Abandoned
- 2017-09-28 US US15/718,091 patent/US20180066061A1/en not_active Abandoned
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