JP2015517529A5 - - Google Patents

Info

Publication number

JP2015517529A5

JP2015517529A5 JP2015512830A JP2015512830A JP2015517529A5 JP 2015517529 A5 JP2015517529 A5 JP 2015517529A5 JP 2015512830 A JP2015512830 A JP 2015512830A JP 2015512830 A JP2015512830 A JP 2015512830A JP 2015517529 A5 JP2015517529 A5 JP 2015517529A5

Authority

JP

Japan

Prior art keywords

seq

notch2

antibody

cancer

light chain

Prior art date

2013-05-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 108010029751 Notch2 Receptor Proteins 0.000 claims description 112
• 102000001756 Notch2 Receptor Human genes 0.000 claims description 112
• 239000003814 drug Substances 0.000 claims description 39
• 206010028980 Neoplasm Diseases 0.000 claims description 25
• 201000011510 cancer Diseases 0.000 claims description 25
• 229940124597 therapeutic agent Drugs 0.000 claims description 25
• 239000013612 plasmid Substances 0.000 claims description 12
• 101000577199 Homo sapiens Neurogenic locus notch homolog protein 2 Proteins 0.000 claims description 9
• 102000046883 human NOTCH2 Human genes 0.000 claims description 9
• 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims description 8
• 206010009944 Colon cancer Diseases 0.000 claims description 8
• 101000577202 Homo sapiens Neurogenic locus notch homolog protein 3 Proteins 0.000 claims description 6
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
• 150000001413 amino acids Chemical class 0.000 claims description 6
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 6
• 229960004316 cisplatin Drugs 0.000 claims description 6
• 238000002648 combination therapy Methods 0.000 claims description 6
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical group COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 6
• 229960005420 etoposide Drugs 0.000 claims description 6
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims description 6
• 229960005277 gemcitabine Drugs 0.000 claims description 6
• 201000005202 lung cancer Diseases 0.000 claims description 6
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• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
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• 206010038389 Renal cancer Diseases 0.000 claims description 4
• 229940028652 abraxane Drugs 0.000 claims description 4
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• 208000029742 colonic neoplasm Diseases 0.000 claims description 4
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• 201000007270 liver cancer Diseases 0.000 claims description 4
• 208000014018 liver neoplasm Diseases 0.000 claims description 4
• QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical group C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims description 4
• 229960005079 pemetrexed Drugs 0.000 claims description 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 4
• 206010005003 Bladder cancer Diseases 0.000 claims description 2
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• 206010014733 Endometrial cancer Diseases 0.000 claims description 2
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• 206010033128 Ovarian cancer Diseases 0.000 claims description 2
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• 206010060862 Prostate cancer Diseases 0.000 claims description 2
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• 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
• 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
• 208000002517 adenoid cystic carcinoma Diseases 0.000 claims description 2
• 239000002246 antineoplastic agent Substances 0.000 claims description 2
• 201000010881 cervical cancer Diseases 0.000 claims description 2
• 229940127089 cytotoxic agent Drugs 0.000 claims description 2
• 206010017758 gastric cancer Diseases 0.000 claims description 2
• 208000005017 glioblastoma Diseases 0.000 claims description 2
• 201000010536 head and neck cancer Diseases 0.000 claims description 2
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 2
• 201000001441 melanoma Diseases 0.000 claims description 2
• 201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 claims description 2
• 201000011549 stomach cancer Diseases 0.000 claims description 2
• 201000002510 thyroid cancer Diseases 0.000 claims description 2
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
• 239000003795 chemical substances by application Substances 0.000 claims 17
• 229940079593 drug Drugs 0.000 claims 8
• 238000000034 method Methods 0.000 description 44
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
• 108010029756 Notch3 Receptor Proteins 0.000 description 2
• 230000009870 specific binding Effects 0.000 description 2
• 230000000694 effects Effects 0.000 description 1
• 231100001274 therapeutic index Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000003442 weekly effect Effects 0.000 description 1