JP2018512402A5 - - Google Patents
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- Publication number
- JP2018512402A5 JP2018512402A5 JP2017548142A JP2017548142A JP2018512402A5 JP 2018512402 A5 JP2018512402 A5 JP 2018512402A5 JP 2017548142 A JP2017548142 A JP 2017548142A JP 2017548142 A JP2017548142 A JP 2017548142A JP 2018512402 A5 JP2018512402 A5 JP 2018512402A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoconjugate
- immune complex
- subject
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940127121 immunoconjugate Drugs 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 5
- 206010005003 Bladder cancer Diseases 0.000 claims 4
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 102000023732 binding proteins Human genes 0.000 claims 3
- 108091008324 binding proteins Proteins 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- 108700012359 toxins Proteins 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000004933 in situ carcinoma Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 108010006654 Bleomycin Proteins 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 238000002679 ablation Methods 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229960001561 bleomycin Drugs 0.000 claims 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 claims 1
- 229960004562 carboplatin Drugs 0.000 claims 1
- 190000008236 carboplatin Chemical compound 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 102000045551 human EPCAM Human genes 0.000 claims 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 claims 1
- 229960001101 ifosfamide Drugs 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000003439 radiotherapeutic effect Effects 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562132251P | 2015-03-12 | 2015-03-12 | |
| US62/132,251 | 2015-03-12 | ||
| US201562267386P | 2015-12-15 | 2015-12-15 | |
| US62/267,386 | 2015-12-15 | ||
| PCT/US2016/022085 WO2016145354A1 (en) | 2015-03-12 | 2016-03-11 | Dosing strategies for targeting epcam positive bladder cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512402A JP2018512402A (ja) | 2018-05-17 |
| JP2018512402A5 true JP2018512402A5 (OSRAM) | 2019-04-18 |
| JP6847846B2 JP6847846B2 (ja) | 2021-03-24 |
Family
ID=56879327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548142A Expired - Fee Related JP6847846B2 (ja) | 2015-03-12 | 2016-03-11 | Ｅｐｃａｍ陽性膀胱癌を標的とする投薬戦略 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10583198B2 (OSRAM) |
| EP (1) | EP3268041A4 (OSRAM) |
| JP (1) | JP6847846B2 (OSRAM) |
| CN (1) | CN107580501A (OSRAM) |
| AU (1) | AU2016228760B2 (OSRAM) |
| CA (1) | CA2979400A1 (OSRAM) |
| HK (1) | HK1249731A1 (OSRAM) |
| WO (1) | WO2016145354A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2829283T (pt) | 2003-04-30 | 2017-09-08 | Univ Zuerich | Método para tratamento do cancro utilizando uma imunotoxina |
| CN105764925A (zh) | 2013-10-02 | 2016-07-13 | 维文蒂亚生物公司 | 抗EpCAM抗体和使用方法 |
| WO2016145349A1 (en) | 2015-03-12 | 2016-09-15 | Viventia Bio Inc. | Methods of treatment for epcam positive bladder cancer |
| CA2979400A1 (en) | 2015-03-12 | 2016-09-15 | Viventia Bio Inc. | Dosing strategies for targeting epcam positive bladder cancer |
| WO2017156349A1 (en) | 2016-03-10 | 2017-09-14 | Cold Genesys, Inc. | Methods of treating solid or lymphatic tumors by combination therapy |
| EP4599893A3 (en) | 2017-04-14 | 2025-11-05 | CG Oncology, Inc. | Cg0070 for treating bcg resistant bladder carcinoma in situ |
| WO2023222024A1 (en) * | 2022-05-18 | 2023-11-23 | Bj Bioscience Inc. | Bispecific antibodies targeting epcam and cd3 |
| CN115109164A (zh) * | 2022-06-07 | 2022-09-27 | 博际生物医药科技(杭州)有限公司 | 靶向epcam和cd3的双特异性抗体 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5082767A (en) | 1989-02-27 | 1992-01-21 | Hatfield G Wesley | Codon pair utilization |
| IL98528A0 (en) | 1990-06-21 | 1992-07-15 | Merck & Co Inc | Pharmaceutical compositions containing hybrid for killing bladder cancer cells |
| US20030148463A1 (en) | 1997-04-14 | 2003-08-07 | Micromet Ag | Novel method for the production of anti-human antigen receptors and uses thereof |
| GB9709421D0 (en) | 1997-05-10 | 1997-07-02 | Zeneca Ltd | Chemical compounds |
| AU8040898A (en) | 1997-06-06 | 1998-12-21 | Tanox Pharma B.V. | Type-1 ribosome-inactivating protein |
| ES2590912T3 (es) | 1997-12-08 | 2016-11-24 | Merck Patent Gmbh | Proteínas de fusión heterodiméricas útiles para inmunoterapia dirigida y estimulación general del sistema inmunitario |
| US6280742B1 (en) | 1998-06-17 | 2001-08-28 | Zonagen, Inc. | Methods and materials for the treatment of prostatic carcinoma |
| DK1171468T3 (da) | 1999-04-09 | 2008-10-20 | Univ Zuerich | Fremgangsmåde til stabilisering af kimære immunoglobuliner eller immunoglobulinfragmenter, samt stabiliseret anti-EGP-2-scFv-fragment |
| GB9911569D0 (en) | 1999-05-18 | 1999-07-21 | Oxford Biomedica Ltd | Antibodies |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| DK1383785T3 (da) | 2001-05-03 | 2011-05-23 | Merck Patent Gmbh | Rekombinant tumorspecifikt antistof og anvendelse deraf |
| US20030148950A1 (en) | 2001-10-09 | 2003-08-07 | Li Xin | Kringle domain 1 of human hepatocyte growth factor and uses therefor |
| MXPA04003535A (es) | 2001-10-15 | 2005-06-20 | Immunomedics Inc | Proteinas de enlace para objetivos directos. |
| US20040022726A1 (en) | 2002-06-03 | 2004-02-05 | Goldenberg David M. | Methods and compositions for intravesical therapy of bladder cancer |
| SI21272A (sl) | 2002-07-31 | 2004-02-29 | LEK farmacevtska dru�ba d.d. | Sintetski gen za humani granulocitne kolonije stimulirajoči dejavnik za ekspresijo v E. coli |
| CA2424255A1 (en) | 2003-03-26 | 2004-09-26 | Claudio Di Paolo | Immunotoxins |
| PT2829283T (pt) | 2003-04-30 | 2017-09-08 | Univ Zuerich | Método para tratamento do cancro utilizando uma imunotoxina |
| EP1737961B1 (en) | 2004-03-19 | 2013-05-08 | Merck Patent GmbH | Modified bouganin proteins, cytotoxins and methods and uses thereof |
| PL1766017T3 (pl) | 2004-06-10 | 2015-08-31 | Viventia Bio Inc | Przeciwciało specyficzne wobec nowotworu |
| US20090171317A1 (en) | 2006-03-10 | 2009-07-02 | Ebrahim Versi | Self-Catheterization Device To Administes Compounds To The Bladder |
| WO2008052322A1 (en) | 2006-10-30 | 2008-05-08 | Viventia Biotech Inc. | Immunotoxγn fusions comprising an antibody fragment and a plant toxin linked by protease cleavable linkers |
| US8263744B2 (en) | 2007-04-19 | 2012-09-11 | Viventia Biotechnologies Inc. | Binding proteins that bind to EpCAM linked to an effector molecule |
| CA2700815A1 (en) | 2007-09-27 | 2009-04-02 | Viventia Biotech Inc. | Optimized nucleic acid sequences for the expression of vb4-845 |
| CA2618163A1 (en) | 2008-02-07 | 2009-08-07 | K. W. Michael Siu | Head and neck cancer biomarkers |
| EP2416805B1 (en) | 2009-04-08 | 2013-07-24 | Heinz Dr. Faulstich | Amatoxin antibody conjugates for the treatment of cancer |
| GB0909904D0 (en) | 2009-06-09 | 2009-07-22 | Affitech As | Product |
| WO2011116387A1 (en) | 2010-03-19 | 2011-09-22 | Tetragenetics, Inc. | Production of aglycosylated monoclonal antibodies in ciliates |
| CN103732259A (zh) | 2011-06-24 | 2014-04-16 | 森彻斯有限公司 | 细胞外靶向药物缀合物 |
| AU2014252683A1 (en) | 2013-04-12 | 2015-11-19 | Viventia Bio Inc. | Compositions and methods for detection and treatment of hepatocellular carcinoma |
| CN105764925A (zh) | 2013-10-02 | 2016-07-13 | 维文蒂亚生物公司 | 抗EpCAM抗体和使用方法 |
| WO2016145349A1 (en) | 2015-03-12 | 2016-09-15 | Viventia Bio Inc. | Methods of treatment for epcam positive bladder cancer |
| CA2979400A1 (en) | 2015-03-12 | 2016-09-15 | Viventia Bio Inc. | Dosing strategies for targeting epcam positive bladder cancer |
| WO2017040801A2 (en) | 2015-09-02 | 2017-03-09 | Viventia Bio Inc. | Methods for making and using an immunoconjugate for the treatment of cancer |
-
2016
- 2016-03-11 CA CA2979400A patent/CA2979400A1/en active Pending
- 2016-03-11 JP JP2017548142A patent/JP6847846B2/ja not_active Expired - Fee Related
- 2016-03-11 WO PCT/US2016/022085 patent/WO2016145354A1/en not_active Ceased
- 2016-03-11 US US15/557,369 patent/US10583198B2/en active Active
- 2016-03-11 EP EP16762631.6A patent/EP3268041A4/en not_active Withdrawn
- 2016-03-11 HK HK18108761.0A patent/HK1249731A1/zh unknown
- 2016-03-11 CN CN201680027485.0A patent/CN107580501A/zh active Pending
- 2016-03-11 AU AU2016228760A patent/AU2016228760B2/en not_active Ceased
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