JP2017537105A5 - - Google Patents
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- Publication number
- JP2017537105A5 JP2017537105A5 JP2017528845A JP2017528845A JP2017537105A5 JP 2017537105 A5 JP2017537105 A5 JP 2017537105A5 JP 2017528845 A JP2017528845 A JP 2017528845A JP 2017528845 A JP2017528845 A JP 2017528845A JP 2017537105 A5 JP2017537105 A5 JP 2017537105A5
- Authority
- JP
- Japan
- Prior art keywords
- humanized antibody
- therapeutic agent
- seq
- intravenous infusion
- subsequent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 claims 17
- 229940124597 therapeutic agent Drugs 0.000 claims 14
- 238000001802 infusion Methods 0.000 claims 11
- 238000001990 intravenous administration Methods 0.000 claims 11
- 206010016717 Fistula Diseases 0.000 claims 9
- 230000003890 fistula Effects 0.000 claims 9
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000035876 healing Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 102000006495 integrins Human genes 0.000 claims 2
- 108010044426 integrins Proteins 0.000 claims 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102100024484 Codanin-1 Human genes 0.000 claims 1
- 101000980888 Homo sapiens Codanin-1 Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010002156 anal fistula Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960001428 mercaptopurine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 229960004914 vedolizumab Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021153317A JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084815P | 2014-11-26 | 2014-11-26 | |
| US62/084,815 | 2014-11-26 | ||
| PCT/US2015/062705 WO2016086147A1 (en) | 2014-11-26 | 2015-11-25 | Vedolizumab for the treatment of fistulizing crohn's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153317A Division JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017537105A JP2017537105A (ja) | 2017-12-14 |
| JP2017537105A5 true JP2017537105A5 (OSRAM) | 2019-01-10 |
Family
ID=54834962
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528845A Withdrawn JP2017537105A (ja) | 2014-11-26 | 2015-11-25 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2021153317A Active JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A Pending JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021153317A Active JP7579227B2 (ja) | 2014-11-26 | 2021-09-21 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
| JP2024127719A Pending JP2024161423A (ja) | 2014-11-26 | 2024-08-02 | 瘻孔を伴うクローン病の治療用ベドリズマブ |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US20170327584A1 (OSRAM) |
| EP (2) | EP3224280A1 (OSRAM) |
| JP (3) | JP2017537105A (OSRAM) |
| WO (1) | WO2016086147A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2016086147A1 (en) * | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| JP7069032B2 (ja) | 2016-03-24 | 2022-05-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | がん免疫治療における胃腸の免疫関連有害事象の治療方法 |
| WO2017192867A1 (en) | 2016-05-04 | 2017-11-09 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating inflammatory bowel disease |
| MA45245A (fr) * | 2016-06-12 | 2019-04-17 | Millennium Pharm Inc | Méthode de traitement de maladie intestinale inflammatoire |
| EP3552632B1 (en) | 2016-12-07 | 2023-07-12 | Stelic Institute & Co., Inc. | Medicinal composition for treating and preventing inflammatory bowel disease |
| US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| US12171764B2 (en) | 2018-06-20 | 2024-12-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| WO2019246313A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| RS66976B1 (sr) * | 2019-10-16 | 2025-07-31 | Morphic Therapeutic Inc | Inhibiranje ljudskog integrina alfa4beta7 |
| JP2023518394A (ja) | 2020-03-18 | 2023-05-01 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 瘻孔を治療するための装置及び方法 |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| WO1989007142A1 (en) | 1988-02-05 | 1989-08-10 | Morrison Sherie L | Domain-modified constant region antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP0590058B1 (en) | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
| WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| PT808367E (pt) | 1995-02-10 | 2007-10-22 | Millennium Pharm Inc | Adressinas vasculares da mucosa e suas utilizações |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| NZ566263A (en) | 2002-05-24 | 2009-09-25 | Millennium Pharm Inc | CCR9 inhibitors and methods of use thereof |
| ATE363470T1 (de) | 2002-11-18 | 2007-06-15 | Chemocentryx Inc | Arylsulfonamide |
| CN1956738B (zh) | 2004-01-09 | 2013-05-29 | 辉瑞大药厂 | MAdCAM抗体 |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| SI1784426T1 (sl) | 2004-09-03 | 2012-03-30 | Genentech Inc | Humanizirani antagonisti proti beta in njihove uporabe |
| AU2006316629A1 (en) | 2005-11-17 | 2007-05-31 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with alpha 4 beta 7 integrin |
| EP2152318A4 (en) * | 2007-06-01 | 2011-12-07 | Abbott Biotech Ltd | COMPOSITIONS AND USES FOR THE TREATMENT OF PSORIASIS AND CROHN'S DISEASE |
| KR101391472B1 (ko) | 2009-03-20 | 2014-05-07 | 암젠 인크 | 알파-4-베타-7 이종이량체 특이적 길항제 항체 |
| KR101875155B1 (ko) | 2011-05-02 | 2018-07-09 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| JP6436580B2 (ja) * | 2012-06-04 | 2018-12-12 | ガウラブ アグラーワル， | クローン病および関連する状態および感染症を処置するための組成物および方法 |
| WO2016086147A1 (en) * | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| WO2017192867A1 (en) | 2016-05-04 | 2017-11-09 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating inflammatory bowel disease |
| MA45245A (fr) | 2016-06-12 | 2019-04-17 | Millennium Pharm Inc | Méthode de traitement de maladie intestinale inflammatoire |
| KR20190141148A (ko) | 2017-04-28 | 2019-12-23 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 소아 장애를 치료하는 방법 |
| US20200087401A1 (en) | 2017-05-26 | 2020-03-19 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of chronic pouchitis |
-
2015
- 2015-11-25 WO PCT/US2015/062705 patent/WO2016086147A1/en not_active Ceased
- 2015-11-25 US US15/529,308 patent/US20170327584A1/en not_active Abandoned
- 2015-11-25 JP JP2017528845A patent/JP2017537105A/ja not_active Withdrawn
- 2015-11-25 EP EP15805720.8A patent/EP3224280A1/en not_active Withdrawn
- 2015-11-25 EP EP19174177.6A patent/EP3581585A1/en active Pending
-
2019
- 2019-03-11 US US16/297,990 patent/US11884731B2/en active Active
-
2021
- 2021-09-21 JP JP2021153317A patent/JP7579227B2/ja active Active
-
2023
- 2023-12-11 US US18/535,781 patent/US20240376210A1/en active Pending
-
2024
- 2024-08-02 JP JP2024127719A patent/JP2024161423A/ja active Pending
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