JP2019514974A5 - - Google Patents
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- Publication number
- JP2019514974A5 JP2019514974A5 JP2018558238A JP2018558238A JP2019514974A5 JP 2019514974 A5 JP2019514974 A5 JP 2019514974A5 JP 2018558238 A JP2018558238 A JP 2018558238A JP 2018558238 A JP2018558238 A JP 2018558238A JP 2019514974 A5 JP2019514974 A5 JP 2019514974A5
- Authority
- JP
- Japan
- Prior art keywords
- weeks
- dose
- vedolizumab
- administered
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 41
- 229960000485 methotrexate Drugs 0.000 claims description 41
- 208000011231 Crohn disease Diseases 0.000 claims description 33
- 229960004914 vedolizumab Drugs 0.000 claims description 32
- 229960002964 adalimumab Drugs 0.000 claims description 28
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 21
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 12
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 12
- 238000002648 combination therapy Methods 0.000 claims description 9
- 239000003246 corticosteroid Substances 0.000 claims description 9
- 229960000598 infliximab Drugs 0.000 claims description 8
- 238000001802 infusion Methods 0.000 claims description 8
- 238000001990 intravenous administration Methods 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 7
- 239000002955 immunomodulating agent Substances 0.000 claims description 6
- 229940121354 immunomodulator Drugs 0.000 claims description 6
- 230000002584 immunomodulator Effects 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 229960003115 certolizumab pegol Drugs 0.000 claims description 4
- 229960001743 golimumab Drugs 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 3
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 2
- 229960004436 budesonide Drugs 0.000 claims description 2
- 229960004618 prednisone Drugs 0.000 claims description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims description 2
- 238000010254 subcutaneous injection Methods 0.000 claims description 2
- 239000007929 subcutaneous injection Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- -1 SEQ ID NO: 2 amino acid Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 67
- 238000011295 triple combination therapy Methods 0.000 description 17
- 239000000890 drug combination Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022107008A JP7474287B2 (ja) | 2016-05-04 | 2022-07-01 | 炎症性腸疾患の治療を目的とする三剤併用療法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662331813P | 2016-05-04 | 2016-05-04 | |
| US62/331,813 | 2016-05-04 | ||
| PCT/US2017/031089 WO2017192867A1 (en) | 2016-05-04 | 2017-05-04 | Triple combination therapy for treating inflammatory bowel disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022107008A Division JP7474287B2 (ja) | 2016-05-04 | 2022-07-01 | 炎症性腸疾患の治療を目的とする三剤併用療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514974A JP2019514974A (ja) | 2019-06-06 |
| JP2019514974A5 true JP2019514974A5 (OSRAM) | 2020-06-25 |
| JP7162533B2 JP7162533B2 (ja) | 2022-10-28 |
Family
ID=58710089
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018558238A Active JP7162533B2 (ja) | 2016-05-04 | 2017-05-04 | 炎症性腸疾患の治療を目的とする三剤併用療法 |
| JP2022107008A Active JP7474287B2 (ja) | 2016-05-04 | 2022-07-01 | 炎症性腸疾患の治療を目的とする三剤併用療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022107008A Active JP7474287B2 (ja) | 2016-05-04 | 2022-07-01 | 炎症性腸疾患の治療を目的とする三剤併用療法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10918716B2 (OSRAM) |
| EP (1) | EP3452070A1 (OSRAM) |
| JP (2) | JP7162533B2 (OSRAM) |
| MA (1) | MA44864A (OSRAM) |
| WO (1) | WO2017192867A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101875155B1 (ko) | 2011-05-02 | 2018-07-09 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| UA116189C2 (uk) * | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2016086147A1 (en) | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| WO2017192867A1 (en) | 2016-05-04 | 2017-11-09 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating inflammatory bowel disease |
| MA45245A (fr) | 2016-06-12 | 2019-04-17 | Millennium Pharm Inc | Méthode de traitement de maladie intestinale inflammatoire |
| EP3956358A4 (en) * | 2019-04-17 | 2023-01-25 | Millennium Pharmaceuticals, Inc. | COMBINATION THERAPY WITH ALPHA4BETA7 INHIBITOR AND IL-23 INHIBITOR |
| EP4068295B1 (en) * | 2021-03-29 | 2025-04-30 | Siemens Healthineers AG | Clinical decision support system for estimating drug-related treatment optimization concerning inflammatory diseases |
| WO2022266302A1 (en) * | 2021-06-17 | 2022-12-22 | Prometheus Laboratories Inc. | Systems and methods for improved targeted therapy |
| CN113402583B (zh) * | 2021-06-19 | 2023-03-21 | 江西农业大学 | Qgk三肽及其应用 |
| CN114225025B (zh) * | 2021-12-29 | 2022-07-26 | 贵州酵德生物科技有限公司 | 含有益生菌的制剂在治疗肠胃疾病中的应用 |
| AU2024282654A1 (en) | 2023-05-30 | 2025-12-04 | Paragon Therapeutics, Inc. | Alpha4beta7 integrin antibody compositions and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT808367E (pt) | 1995-02-10 | 2007-10-22 | Millennium Pharm Inc | Adressinas vasculares da mucosa e suas utilizações |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| AU2006316629A1 (en) | 2005-11-17 | 2007-05-31 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with alpha 4 beta 7 integrin |
| KR101875155B1 (ko) | 2011-05-02 | 2018-07-09 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| WO2016086147A1 (en) | 2014-11-26 | 2016-06-02 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the treatment of fistulizing crohn's disease |
| US20170360926A1 (en) | 2014-12-24 | 2017-12-21 | Millennium Pharmaceuticals, Inc. | PREDICTING OUTCOME OF TREATMENT WITH AN ANTI-alpha4beta7 INTEGRIN ANTIBODY |
| WO2017192867A1 (en) | 2016-05-04 | 2017-11-09 | Millennium Pharmaceuticals, Inc. | Triple combination therapy for treating inflammatory bowel disease |
-
2017
- 2017-05-04 WO PCT/US2017/031089 patent/WO2017192867A1/en not_active Ceased
- 2017-05-04 US US16/098,572 patent/US10918716B2/en active Active
- 2017-05-04 MA MA044864A patent/MA44864A/fr unknown
- 2017-05-04 JP JP2018558238A patent/JP7162533B2/ja active Active
- 2017-05-04 EP EP17724180.9A patent/EP3452070A1/en active Pending
-
2021
- 2021-01-19 US US17/152,585 patent/US12246064B2/en active Active
-
2022
- 2022-07-01 JP JP2022107008A patent/JP7474287B2/ja active Active
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