CN115052628A - 抗pd-1抗体在治疗肿瘤中的用途 - Google Patents
抗pd-1抗体在治疗肿瘤中的用途 Download PDFInfo
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- CN115052628A CN115052628A CN202180013152.3A CN202180013152A CN115052628A CN 115052628 A CN115052628 A CN 115052628A CN 202180013152 A CN202180013152 A CN 202180013152A CN 115052628 A CN115052628 A CN 115052628A
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- A61P35/00—Antineoplastic agents
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract
本发明公开了抗PD‑1抗体在治疗黑色素瘤中的用途。本发明还披露了用于检测BRAF、NRAS、CDK4/CCND1基因突变的试剂在预测黑色素瘤病人对单独施用抗PD‑1抗体和/或其抗原结合片段治疗的效果的检测试剂盒中的用途。
Description
PCT国内申请，说明书已公开。
Claims (20)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010090829.0A CN113244386A (zh) | 2020-02-13 | 2020-02-13 | 抗pd-1抗体在治疗肿瘤中的用途 |
| CN2020100908290 | 2020-02-13 | ||
| PCT/CN2021/076456 WO2021160151A1 (zh) | 2020-02-13 | 2021-02-10 | 抗pd-1抗体在治疗肿瘤中的用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115052628A true CN115052628A (zh) | 2022-09-13 |
Family
ID=77219857
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010090829.0A Pending CN113244386A (zh) | 2020-02-13 | 2020-02-13 | 抗pd-1抗体在治疗肿瘤中的用途 |
| CN202180013152.3A Pending CN115052628A (zh) | 2020-02-13 | 2021-02-10 | 抗pd-1抗体在治疗肿瘤中的用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010090829.0A Pending CN113244386A (zh) | 2020-02-13 | 2020-02-13 | 抗pd-1抗体在治疗肿瘤中的用途 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230082898A1 (zh) |
| EP (1) | EP4104856A4 (zh) |
| CN (2) | CN113244386A (zh) |
| WO (1) | WO2021160151A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022242621A1 (zh) * | 2021-05-17 | 2022-11-24 | 上海君实生物医药科技股份有限公司 | 治疗完全切除黏膜黑色素瘤的患者的药物及方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
| CA2790433A1 (en) * | 2004-10-25 | 2006-05-26 | Northwestern University | Anti-addl antibodies and uses thereof |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| US20160362489A1 (en) * | 2015-04-28 | 2016-12-15 | Bristol-Myers Squibb Company | Treatment of PD-L1-Positive Melanoma Using an Anti-PD-1 Antibody |
| WO2017129790A1 (en) * | 2016-01-28 | 2017-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of cancer |
| US11174252B2 (en) * | 2018-02-15 | 2021-11-16 | Nuvation Bio Inc. | Heterocyclic compounds as kinase inhibitors |
-
2020
- 2020-02-13 CN CN202010090829.0A patent/CN113244386A/zh active Pending
-
2021
- 2021-02-10 US US17/904,096 patent/US20230082898A1/en active Pending
- 2021-02-10 CN CN202180013152.3A patent/CN115052628A/zh active Pending
- 2021-02-10 EP EP21753897.4A patent/EP4104856A4/en active Pending
- 2021-02-10 WO PCT/CN2021/076456 patent/WO2021160151A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230082898A1 (en) | 2023-03-16 |
| EP4104856A1 (en) | 2022-12-21 |
| EP4104856A4 (en) | 2024-06-26 |
| WO2021160151A1 (zh) | 2021-08-19 |
| CN113244386A (zh) | 2021-08-13 |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination |