JP2017507139A5 - - Google Patents

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Publication number
JP2017507139A5
JP2017507139A5 JP2016552595A JP2016552595A JP2017507139A5 JP 2017507139 A5 JP2017507139 A5 JP 2017507139A5 JP 2016552595 A JP2016552595 A JP 2016552595A JP 2016552595 A JP2016552595 A JP 2016552595A JP 2017507139 A5 JP2017507139 A5 JP 2017507139A5
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JP
Japan
Prior art keywords
maintenance doses
antagonist
laba
ics
antibody
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JP2016552595A
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English (en)
Japanese (ja)
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JP2017507139A (ja
JP6673840B2 (ja
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Priority claimed from PCT/US2015/016852 external-priority patent/WO2015127229A1/en
Publication of JP2017507139A publication Critical patent/JP2017507139A/ja
Publication of JP2017507139A5 publication Critical patent/JP2017507139A5/ja
Priority to JP2020036331A priority Critical patent/JP6893265B2/ja
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Publication of JP6673840B2 publication Critical patent/JP6673840B2/ja
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JP2016552595A 2014-02-21 2015-02-20 Il−4r拮抗薬の投与により喘息を処置または予防するための方法 Active JP6673840B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020036331A JP6893265B2 (ja) 2014-02-21 2020-03-04 Il−4r拮抗薬の投与により喘息を処置または予防するための方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461943019P 2014-02-21 2014-02-21
US61/943,019 2014-02-21
EP14306413 2014-09-15
EP14306413.7 2014-09-15
US201462077669P 2014-11-10 2014-11-10
US62/077,669 2014-11-10
PCT/US2015/016852 WO2015127229A1 (en) 2014-02-21 2015-02-20 Methods for treating or preventing asthma by administering an il-4r antagonist

Related Child Applications (1)

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JP2020036331A Division JP6893265B2 (ja) 2014-02-21 2020-03-04 Il−4r拮抗薬の投与により喘息を処置または予防するための方法

Publications (3)

Publication Number Publication Date
JP2017507139A JP2017507139A (ja) 2017-03-16
JP2017507139A5 true JP2017507139A5 (OSRAM) 2018-03-22
JP6673840B2 JP6673840B2 (ja) 2020-03-25

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ID=51570453

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016552595A Active JP6673840B2 (ja) 2014-02-21 2015-02-20 Il−4r拮抗薬の投与により喘息を処置または予防するための方法
JP2023139455A Active JP7636487B2 (ja) 2014-02-21 2023-08-30 Il-4r拮抗薬の投与により喘息を処置または予防するための方法
JP2025020415A Pending JP2025072593A (ja) 2014-02-21 2025-02-12 Il-4r拮抗薬の投与により喘息を処置または予防するための方法

Family Applications After (2)

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JP2023139455A Active JP7636487B2 (ja) 2014-02-21 2023-08-30 Il-4r拮抗薬の投与により喘息を処置または予防するための方法
JP2025020415A Pending JP2025072593A (ja) 2014-02-21 2025-02-12 Il-4r拮抗薬の投与により喘息を処置または予防するための方法

Country Status (15)

Country Link
US (3) US10137193B2 (OSRAM)
EP (3) EP4382164A3 (OSRAM)
JP (3) JP6673840B2 (OSRAM)
KR (4) KR20220029765A (OSRAM)
CN (1) CN106232140A (OSRAM)
AU (3) AU2015218808B2 (OSRAM)
CA (1) CA2940295A1 (OSRAM)
ES (2) ES2897631T3 (OSRAM)
HU (1) HUE065844T2 (OSRAM)
IL (1) IL315136A (OSRAM)
MX (2) MX384192B (OSRAM)
PL (2) PL3107575T3 (OSRAM)
PT (2) PT3107575T (OSRAM)
RU (1) RU2713406C2 (OSRAM)
WO (1) WO2015127229A1 (OSRAM)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
JP6306588B2 (ja) 2012-08-21 2018-04-04 サノフィ・バイオテクノロジー Il−4rアンタゴニストを投与することにより喘息を処置又は予防するための方法
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
EP3010539B1 (en) 2013-06-21 2019-07-24 Sanofi Biotechnology Methods for treating nasal polyposis by administering an il-4r antagonist
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
SMT202100119T1 (it) 2013-07-12 2021-05-07 Knopp Biosciences Llc Trattamento dei livelli elevati di eosinofili e/o basofili
IL315136A (en) * 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
EP3110848B1 (en) 2014-02-28 2024-02-14 Regeneron Pharmaceuticals, Inc. Methods for treating skin infection by administering an il-4r antagonist
JP6861630B2 (ja) 2014-11-14 2021-04-21 サノフィ・バイオテクノロジー Il−4rアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法
US20180056018A1 (en) * 2016-08-31 2018-03-01 Cephalon, Inc. Inhalation Systems, Devices and Methods
CN118141914A (zh) * 2016-09-01 2024-06-07 瑞泽恩制药公司 用于通过施用il-4r拮抗剂来预防或治疗变态反应的方法
KR20190053250A (ko) 2016-09-22 2019-05-17 리제너론 파아마슈티컬스, 인크. Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
TWI857389B (zh) * 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
EP3957752B1 (en) 2017-04-13 2025-08-20 Regeneron Pharmaceuticals, Inc. Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1
WO2019005898A1 (en) 2017-06-27 2019-01-03 Ohio State Innovation Foundation LIPONUCLEOTID THERAPY FOR COPD
EP3645010A4 (en) * 2017-06-27 2021-03-24 Ohio State Innovation Foundation NUCLEOTIDE-BASED THERAPY FOR ASTHMA
US11053309B2 (en) 2017-08-04 2021-07-06 Regeneron Pharmaceuticals, Inc. Methods for treating active eosinophilic esophagitis
EP4344706A3 (en) * 2017-10-30 2024-05-22 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
MA52624A (fr) 2018-05-13 2021-03-24 Regeneron Pharma Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r
TWI838388B (zh) * 2018-07-10 2024-04-11 美商雷傑納榮製藥公司 修飾結合分子以最小化已存在的交互作用
CN110872349A (zh) 2018-09-04 2020-03-10 三生国健药业(上海)股份有限公司 结合人il-4r的抗体、其制备方法和用途
CN110746507B (zh) 2018-12-25 2020-06-26 江苏荃信生物医药有限公司 抗人白介素4受体α单克隆抗体及其应用
MY209489A (en) * 2018-12-27 2025-07-12 Akeso Biopharma Inc Antibody against human il-4ra and use thereof
WO2020191346A1 (en) 2019-03-21 2020-09-24 Regeneron Pharmaceuticals, Inc. Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
EP3962515A1 (en) * 2019-05-01 2022-03-09 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-33 antagonist
EP3999114A1 (en) * 2019-07-16 2022-05-25 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
SG11202113310UA (en) 2019-08-05 2021-12-30 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r antagonist
EP4010001A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist
EP3992974A1 (en) 2020-11-02 2022-05-04 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
AU2020399975A1 (en) * 2019-12-09 2022-07-28 Sanofi Biotechnology Methods for treating digitally-identified IL-4/IL-13 related disorders
MX2023001140A (es) * 2020-08-05 2023-05-18 Areteia Therapeutics Inc Uso del dexpramipexol para el tratamiento de asma moderado a grave.
US20220169739A1 (en) * 2020-10-05 2022-06-02 Sanofi Biotechnology Methods for treating asthma in pediatric subjects by administering an il-4r antagonist
TW202313692A (zh) * 2021-08-26 2023-04-01 大陸商正大天晴藥業集團股份有限公司 抗il4r抗體的藥物組成物及其用途
CN117368487A (zh) * 2023-09-28 2024-01-09 首都医科大学附属北京同仁医院 一种利用局部IgE预测或评估奥马珠单抗在治疗复发性鼻息肉中疗效的方法和应用
US20250230251A1 (en) 2023-12-20 2025-07-17 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rb) and related methods

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8808015D0 (en) 1988-04-06 1988-05-05 Ritter M A Chemical compounds
AU643427B2 (en) 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
US5714146A (en) 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
EP0604693A1 (en) 1992-12-29 1994-07-06 Schering-Plough Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
MXPA02011682A (es) 2000-05-26 2003-05-14 Immunex Corp Uso de antagonistas de interleuquina-4 y composiciones de los mismos.
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US8178098B2 (en) 2001-04-03 2012-05-15 National Jewish Health Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies
WO2005047331A2 (en) 2003-11-07 2005-05-26 Immunex Corporation Antibodies that bind interleukin-4 receptor
AU2004309373A1 (en) 2003-12-22 2005-07-14 Amgen Inc. Methods for identifying functional antibodies
ATE395358T1 (de) 2004-02-27 2008-05-15 Regeneron Pharma Il-4/il-13-spezifische polypetide und deren therapeutische verwendung
US20090098142A1 (en) 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
TW200902555A (en) 2005-01-03 2009-01-16 Hoffmann La Roche Antibodies against IL-13 receptor alpha 1 and uses thereof
BRPI0710572A2 (pt) * 2006-01-24 2013-01-08 Domantis Ltd ligante, uso do ligante, mÉtodos para o tratamento de uma doenÇa alÉrgica, de asma e de cÂncer, para a inibiÇço de uma resposta imune do tipo th2, e administraÇço de tratamento anti-il-4 e tratamento anti-il-13, composiÇço farmacÊutica, dispositivo de dispensaÇço de droga, Ácido nucleico isolado ou recombinante, vetor, cÉlula hospedeira, mÉtodos para a produÇço de um ligante e de inibiÇço da proliferaÇço de cÉlulas
PL2374818T3 (pl) 2006-06-02 2013-05-31 Regeneron Pharma Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6
PL2069403T3 (pl) 2006-10-02 2015-08-31 Regeneron Pharma Przeciwciała ludzkie o wysokim powinowactwie wobec receptora ludzkiej IL-4
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
EP2022507A1 (en) 2007-08-07 2009-02-11 Universität Hamburg Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy
EP2050764A1 (en) * 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
EP2245064B1 (en) * 2007-12-21 2014-07-23 Medimmune Limited BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Ralpha)
US20120004205A1 (en) 2008-12-01 2012-01-05 Cincinnati Children's Hospital Medical Center Il-13 induced gene signature for eosinophilic esophagitis
WO2010120524A2 (en) 2009-03-31 2010-10-21 Altair Therapeutics, Inc. Methods of modulating an immune response to a viral infection
WO2011156000A2 (en) * 2010-06-07 2011-12-15 Aerovance, Inc. Use of il-4/il-13 antagonists to treat eosinophilic disorders
AU2011312191B2 (en) 2010-10-06 2015-07-02 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-interleukin-4 receptor (IL-4R) antibodies
HUE034005T2 (en) * 2010-10-15 2018-01-29 Medimmune Ltd Therapies for improving lung function
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
WO2013066780A2 (en) * 2011-11-01 2013-05-10 Medimmune, Llc Methods for reducing the frequency and severity of acute exacerbations of asthma
JP6306588B2 (ja) 2012-08-21 2018-04-04 サノフィ・バイオテクノロジー Il−4rアンタゴニストを投与することにより喘息を処置又は予防するための方法
ES2981062T3 (es) 2012-09-07 2024-10-07 Regeneron Pharma Métodos para el tratamiento de la dermatitis atópica administrando un antagonista de IL-4R
EP3010539B1 (en) 2013-06-21 2019-07-24 Sanofi Biotechnology Methods for treating nasal polyposis by administering an il-4r antagonist
IL315136A (en) 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
JP6861630B2 (ja) 2014-11-14 2021-04-21 サノフィ・バイオテクノロジー Il−4rアンタゴニストの投与により鼻ポリープを伴う慢性副鼻腔炎を処置する方法
EP4344706A3 (en) * 2017-10-30 2024-05-22 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
US20220169739A1 (en) 2020-10-05 2022-06-02 Sanofi Biotechnology Methods for treating asthma in pediatric subjects by administering an il-4r antagonist

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