ATE363470T1 - Arylsulfonamide - Google Patents
ArylsulfonamideInfo
- Publication number
- ATE363470T1 ATE363470T1 AT03796416T AT03796416T ATE363470T1 AT E363470 T1 ATE363470 T1 AT E363470T1 AT 03796416 T AT03796416 T AT 03796416T AT 03796416 T AT03796416 T AT 03796416T AT E363470 T1 ATE363470 T1 AT E363470T1
- Authority
- AT
- Austria
- Prior art keywords
- ccr9
- compounds
- antagonists
- inflammation
- assays
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
- Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Photoreceptors In Electrophotography (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42767002P | 2002-11-18 | 2002-11-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE363470T1 true ATE363470T1 (de) | 2007-06-15 |
Family
ID=32326578
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07004318T ATE517102T1 (de) | 2002-11-18 | 2003-11-17 | Arylsulfonamide |
AT03796416T ATE363470T1 (de) | 2002-11-18 | 2003-11-17 | Arylsulfonamide |
AT03816012T ATE384041T1 (de) | 2002-11-18 | 2003-11-18 | Bisarylsulfonamide |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07004318T ATE517102T1 (de) | 2002-11-18 | 2003-11-17 | Arylsulfonamide |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03816012T ATE384041T1 (de) | 2002-11-18 | 2003-11-18 | Bisarylsulfonamide |
Country Status (17)
Country | Link |
---|---|
US (7) | US6939885B2 (de) |
EP (4) | EP1562940B1 (de) |
JP (3) | JP4611746B2 (de) |
KR (3) | KR100874292B1 (de) |
CN (3) | CN100360526C (de) |
AT (3) | ATE517102T1 (de) |
AU (4) | AU2003298661B2 (de) |
CA (2) | CA2500492C (de) |
DE (2) | DE60314175T2 (de) |
DK (3) | DK1798223T4 (de) |
ES (3) | ES2286502T3 (de) |
HK (3) | HK1086839A1 (de) |
IL (2) | IL167714A (de) |
MX (1) | MXPA05005296A (de) |
PT (2) | PT1798223E (de) |
WO (2) | WO2004046092A2 (de) |
ZA (3) | ZA200503663B (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6329159B1 (en) | 1999-03-11 | 2001-12-11 | Millennium Pharmaceuticals, Inc. | Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function |
EP2399903A1 (de) | 2002-05-24 | 2011-12-28 | Millennium Pharmaceuticals, Inc. | CCR9-Hemmer und Verwendungsverfahren dafür |
US7227035B2 (en) * | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
ES2286502T3 (es) * | 2002-11-18 | 2007-12-01 | Chemocentryx, Inc. | Sulfonamidas de arilo. |
US7288538B2 (en) | 2003-02-20 | 2007-10-30 | Encysive Pharmaceuticals, Inc. | Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists |
CA2566387A1 (en) * | 2004-05-12 | 2005-12-01 | Chemocentryx, Inc. | Aryl sulfonamides as chemokine receptor ccr9 antagonists |
US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
WO2006076644A2 (en) * | 2005-01-14 | 2006-07-20 | Chemocentryx, Inc. | Heteroaryl sulfonamides and ccr2 |
WO2007014054A2 (en) * | 2005-07-22 | 2007-02-01 | Glaxo Group Limted | Benzenesulfonamide inhibitor of ccr2 chemokine receptor |
FI20055498A0 (fi) * | 2005-09-16 | 2005-09-16 | Biotie Therapies Corp | Sulfonamidijohdannaisia |
GB0526445D0 (en) * | 2005-12-23 | 2006-02-08 | Novartis Ag | Organic compounds |
WO2007087429A2 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Phenyl and pyridyl compounds for inflammation and immune-related uses |
KR100746342B1 (ko) | 2006-04-10 | 2007-08-03 | 한국과학기술원 | 구리 촉매 존재하에서 n―설포닐아미드 화합물의 제조방법 |
JP5266219B2 (ja) * | 2006-07-14 | 2013-08-21 | ケモセントリックス, インコーポレイテッド | トリアゾリルフェニルベンゼンスルホンアミド類 |
WO2008008374A2 (en) * | 2006-07-14 | 2008-01-17 | Chemocentryx, Inc. | Ccr2 inhibitors and methods of use thereof |
CN101511800B (zh) * | 2006-07-14 | 2013-02-27 | 坎莫森特里克斯公司 | 三唑基苯基苯磺酰胺 |
US8519135B2 (en) * | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
US7718683B2 (en) | 2006-07-14 | 2010-05-18 | Chemocentryx, Inc. | Triazolyl phenyl benzenesulfonamides |
CN101605759A (zh) * | 2007-02-06 | 2009-12-16 | 诺瓦提斯公司 | 作为ccr9活性抑制剂的1-苯磺酰基-1h-吲哚衍生物 |
BRPI0809498A2 (pt) * | 2007-04-02 | 2014-09-23 | Inst Oneworld Health | Compostos inibidores de cftr e seus usos |
US7776877B2 (en) * | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
KR101849560B1 (ko) * | 2007-07-12 | 2018-04-17 | 케모센트릭스, 인크. | 염증의 치료를 위한 ccr2 조절물질로서 융합된 헤테로아릴 피리딜과 페닐 벤젠술폰아마이드 |
US8288411B2 (en) * | 2007-09-24 | 2012-10-16 | Actelion Pharmaceuticals Ltd. | Pyrrolidines and piperidines as orexin receptor antagonists |
EP2207772A1 (de) * | 2007-10-05 | 2010-07-21 | Encysive Pharmaceuticals, Inc. | Thiophen-2-carbonsäureamidderivate als modulatoren des ccr9-rezeptors |
US8236838B2 (en) * | 2008-04-21 | 2012-08-07 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
WO2009131957A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
WO2010033626A1 (en) * | 2008-09-19 | 2010-03-25 | Institute For Oneworld Health | Compounds, compositions and methods comprising imidazole and triazole derivatives |
US20120129858A1 (en) * | 2009-04-20 | 2012-05-24 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyridazine sulfonamide derivatives |
US8343976B2 (en) * | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
CN101838240A (zh) * | 2010-06-11 | 2010-09-22 | 扬州康伊尔医药科技有限公司 | 抗病毒化合物中间体吡唑-3-羧酸酯的制备方法 |
UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
KR102014512B1 (ko) | 2011-05-02 | 2019-08-26 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 항-α4β7 항체에 대한 제형 |
BR112014001530B1 (pt) * | 2011-07-22 | 2022-05-31 | Chemocentryx, Inc | Formas polimórficas do sal de sódio de 4-terc-butiln-[4-cloro-2-(1-óxi-piridina-4-carbonil)- fenil]-benzeno sulfonamida, composição farmacêutica e método de produção da mesma |
CN103813793A (zh) * | 2011-07-22 | 2014-05-21 | 葛兰素史克知识产权开发有限公司 | 4-叔丁基-n-[4-氯-2-(1-氧基-吡啶-4-羰基)-苯基]-苯磺酰胺钠盐的多晶型 |
RS56023B1 (sr) * | 2011-07-22 | 2017-09-29 | Chemocentryx Inc | Kristalni oblik natrijumove soli 4-terc-butil-n-[4-hlor-2-(1-okso-piridin-4-karbonil)-fenil]-benzensulfonamida |
JP6302846B2 (ja) | 2012-02-22 | 2018-03-28 | サンフォード−バーンハム メディカル リサーチ インスティテュート | Tnap阻害剤としてのスルホンアミド化合物およびその使用 |
DK3263564T3 (da) * | 2012-02-29 | 2020-09-07 | Chemocentryx Inc | Aza-aryl-1h-pyrazol-1-yl-benzen-sulfonamider som ccr(9)- antagonister |
US9181190B2 (en) | 2012-07-04 | 2015-11-10 | Concert Pharmaceuticals, Inc. | Deuterated vercirnon |
UY35165A (es) | 2012-12-04 | 2014-06-30 | Takeda Pharmaceutical | Método profiláctico o terapéutico para el síndrome de sjogren |
EP2740458B1 (de) * | 2012-12-06 | 2016-08-03 | IP Gesellschaft für Management mbH | Verpackung, entahltend Formen des Natriumsalzes von 4-tert-butyl-N-[4-chlor-2-(1-oxy-pyridin-4-carbonyl)-phenyl]-benzensulfonamid |
US9969687B2 (en) | 2013-12-23 | 2018-05-15 | Norgine B.V. | Compounds useful as CCR9 modulators |
WO2015097122A1 (en) | 2013-12-23 | 2015-07-02 | Norgine B.V. | Benzene sulfonamides as ccr9 inhibitors |
EP2950011B1 (de) * | 2014-05-29 | 2019-08-28 | Panasonic Intellectual Property Corporation of America | Verfahren zur steuerung eines endgeräts zur fernsteuerung einer klimaanlage und endgerät |
IL251136B (en) * | 2014-10-06 | 2022-07-01 | Chemocentryx Inc | Combined treatment of c-c receptor inhibitors type 9 (ccr9) and integrin-blocking anti-alha4beta7 antibodies |
US20170327584A1 (en) | 2014-11-26 | 2017-11-16 | Millennium Pharmaceuticals, Inc. | Vedolizumab for the Treatment of Fistulizing Crohn's Disease |
MA41636A (fr) | 2015-03-06 | 2018-01-09 | Millennium Pharm Inc | Méthode de traitement de la cholangite sclérosante primitive |
BR112018014666B1 (pt) | 2016-01-20 | 2024-01-02 | Chemocentryx, Inc | Compostos de 2-oxindol, seu uso e composição farmacêutica |
CN117298268A (zh) | 2016-03-14 | 2023-12-29 | 千禧制药公司 | 治疗或预防移植物抗宿主疾病的方法 |
MX2018011169A (es) | 2016-03-14 | 2018-12-06 | Millennium Pharm Inc | Metodo para prevenir la enfermedad del injerto contra huesped. |
EA201990001A1 (ru) | 2016-06-07 | 2019-05-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
RU2022102328A (ru) | 2016-11-23 | 2022-04-01 | Хемоцентрикс, Инк. | Способ лечения фокально-сегментарного гломерулосклероза |
US10988466B2 (en) | 2017-03-23 | 2021-04-27 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
MX2019012749A (es) | 2017-04-28 | 2020-02-03 | Millennium Pharm Inc | Metodos para tratar trastornos pediatricos. |
AU2018347361A1 (en) | 2017-10-11 | 2020-04-30 | Chemocentryx, Inc. | Treatment of focal segmental glomerulosclerosis with CCR2 antagonists |
CN114206338A (zh) | 2019-07-10 | 2022-03-18 | 凯莫森特里克斯股份有限公司 | 作为pd-l1抑制剂的二氢化茚类 |
US10792360B1 (en) | 2019-11-21 | 2020-10-06 | Chemocentryx, Inc. | Compositions and methods for treating inflammatory bowel disease using CCR9 inhibitor and anti-TNF-alpha blocking antibodies |
TW202203916A (zh) * | 2020-03-31 | 2022-02-01 | 美商卡默森屈有限公司 | 使用ccr9抑制劑及抗il—23阻斷抗體治療發炎性腸道疾病的組成物及方法 |
Family Cites Families (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US72530A (en) * | 1867-12-24 | Augustus w | ||
US60460A (en) * | 1866-12-18 | barrabe | ||
US37928A (en) * | 1863-03-17 | Improvement in lamps | ||
US139390A (en) * | 1873-05-27 | Improvement in ore-washers | ||
US103202A (en) * | 1870-05-17 | Improvement in automatic railway-switches | ||
US65303A (en) * | 1867-05-28 | Improvement in wood-splitting machines | ||
US9116A (en) * | 1852-07-13 | Railroad-car brake | ||
US12680A (en) * | 1855-04-10 | Railroad-cab | ||
US13314A (en) * | 1855-07-24 | Parlor-stove | ||
US37905A (en) * | 1863-03-17 | Improvement in sheep-racks | ||
US2997368A (en) * | 1956-12-20 | 1961-08-22 | Barent Mark | Production of manganese hydroxide |
GB884847A (en) | 1958-04-14 | 1961-12-20 | Ciba Ltd | Mercapto compounds |
US3121075A (en) * | 1961-10-20 | 1964-02-11 | Hoffmann La Roche | Aminobenzodiazepines |
US3442946A (en) * | 1960-04-26 | 1969-05-06 | Hoffmann La Roche | 2-aminomercapto- and 2-aminoalkylcaptobenzophenone oximes |
US3336295A (en) * | 1960-12-02 | 1967-08-15 | Hoffmann La Roche | Hydroxy or alkoxy substituted 5-phenyl-3h-1, 4-benzodiazepin-2(1h)-ones |
CH491134A (de) | 1967-10-20 | 1970-05-31 | Sandoz Ag | Verfahren zur Herstellung neuer Chinazolinone |
US3534062A (en) * | 1967-05-16 | 1970-10-13 | Upjohn Co | Dibenzothiadiazocines |
US3551427A (en) | 1969-05-09 | 1970-12-29 | Sandoz Ag | 4-thienyl-2-(1h)-quinazolones |
CH561703A5 (en) | 1970-12-11 | 1975-05-15 | Hoffmann La Roche | 7-Iodobenzodiazepin-2-ones - sedatives etc prepd by cyclising iodobenzophenones with glycine (esters) |
GB1332697A (en) | 1970-12-21 | 1973-10-03 | Hoffmann La Roche | Benzodiazepine derivatives |
BE791902A (fr) | 1971-11-26 | 1973-05-24 | Wander Ag Dr A | Nouveaux derives de la thieno (3,2-c) (1)benzazepine, leur preparation et leur application comme medicaments |
CH585222A5 (en) | 1973-02-14 | 1977-02-28 | Wander Ag Dr A | Prepn. of antipsychotic heterocyclic piperazine derivs. - by reaction of heterocyclic ketones with metal piperazine complexes |
US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
FR2403330A1 (fr) * | 1977-06-16 | 1979-04-13 | Fabre Sa Pierre | Nouveaux derives de benzoyl-2-chloro-4-glycinanilides substitues, leur procede de preparation et leur application en tant que medicaments |
FR2449677B1 (fr) | 1979-02-26 | 1986-03-28 | Fabre Sa Pierre | Nouveaux derives de benzoyl-2 glycylanilides substitues, leur preparation et leur application en tant que medicaments anxiolytiques |
US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
JPS61113060A (ja) | 1984-11-08 | 1986-05-30 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料 |
DD251126A1 (de) * | 1984-12-21 | 1987-11-04 | Univ Berlin Humboldt | Verfahren zur herstellung neuer 2-arylsulfonamido-benzo- und -acetophenone und deren oxime, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
US5010195A (en) * | 1988-05-25 | 1991-04-23 | The Dow Chemical Company | Herbicidal alkoxy-1,2,4-triazolo(1,5-c)primidine-2-sulfonamides |
US4992091A (en) * | 1986-07-11 | 1991-02-12 | The Dow Chemical Company | Substituted pyrazolo[1,5-a]pyrimidine-2-sulfonamides and compositions and methods of controlling undesired vegetation |
US5021591A (en) * | 1986-07-11 | 1991-06-04 | The Dow Chemical Company | Pyrazolo[1,5-a]pyrimidine-2-sulfide compounds |
US4997940A (en) * | 1986-07-11 | 1991-03-05 | The Dow Chemical Company | Pyrazolo[1,5-a]pyrimidine-2-sulfonyl chloride and -2-sulfide compounds |
US4780488A (en) * | 1986-08-29 | 1988-10-25 | Ciba-Geigy Corporation | Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing polyoxyalkylene backbone units, and use thereof |
JPH0753725B2 (ja) * | 1987-10-08 | 1995-06-07 | 富山化学工業株式会社 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
DE3825041A1 (de) | 1988-07-20 | 1990-02-15 | Schering Ag | Pyrido(3,2-e)(1,2,4)triazolo(1,5-a)pyrimidin- 2-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider, pflanzenwachstumsregulierender und fungizider wirkung |
GB8820129D0 (en) * | 1988-08-24 | 1988-09-28 | Schering Agrochemicals Ltd | Fungicides |
GB8830182D0 (en) * | 1988-12-23 | 1989-02-22 | Shell Int Research | Heterocyclic herbicides |
US5217521A (en) * | 1989-12-22 | 1993-06-08 | Ciba-Geigy Corporation | Triazolylsulfonamides |
US5338755A (en) * | 1990-07-31 | 1994-08-16 | Elf Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
FR2679903B1 (fr) | 1991-08-02 | 1993-12-03 | Elf Sanofi | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. |
US5481005A (en) * | 1990-07-31 | 1996-01-02 | Sanofi | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present |
JPH04364168A (ja) | 1990-08-08 | 1992-12-16 | Taisho Pharmaceut Co Ltd | スルホンアミドピリジン化合物 |
DE4025818A1 (de) * | 1990-08-16 | 1992-02-20 | Bayer Ag | Phenylsulfonamid substituierte pyridinalken- und -aminooxyalkancarbonsaeure-derivate |
US5185348A (en) * | 1990-08-16 | 1993-02-09 | Bayer Aktiengesellschaft | Phenylsulphonamide substituted pyridinealkene- and -aminooxyalkanecarboxylic acid derivatives |
JPH06145145A (ja) | 1991-12-27 | 1994-05-24 | Ishihara Sangyo Kaisha Ltd | アミノトリフルオロメチルピリジン誘導体又はその塩、それらの製造方法及びそれらを含有するホスホリパーゼa▲2▼阻害剤、抗炎症剤並びに抗膵炎剤 |
EP0556673B1 (de) | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
GB2271770B (en) * | 1992-10-20 | 1996-08-07 | Kodak Ltd | Photographic couplers, photographic materials containing them and dyes derived therefrom |
NZ250916A (en) | 1993-02-27 | 1995-08-28 | Nihon Nohyaku Co Ltd | N-heteroaryl-n'-phenylureas, their use as acat inhibitors |
US5514555A (en) | 1993-03-12 | 1996-05-07 | Center For Blood Research, Inc. | Assays and therapeutic methods based on lymphocyte chemoattractants |
TW394761B (en) * | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
WO1995033462A1 (en) | 1994-06-02 | 1995-12-14 | Smithkline Beecham Corporation | Anti-inflammatory compounds |
US5571775A (en) * | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
FR2724654B1 (fr) | 1994-09-16 | 1997-12-12 | Roussel Uclaf | Nouveaux derives de l'acide gallique, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
GB9602166D0 (en) | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
US5780488A (en) * | 1996-04-03 | 1998-07-14 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
DE19629144A1 (de) * | 1996-07-19 | 1998-01-22 | Bayer Ag | Substituierte Triazoloazinsulfonamide |
DE69737656T2 (de) | 1996-09-10 | 2008-01-03 | Theodor Kocher Institut | Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung |
AR015104A1 (es) * | 1996-11-13 | 2001-04-18 | Dowelanco | Compuestos de n-arilsulfilimina sustituidos, utiles como catalizadores en la preparacion de compuestos de n-arilarilsulfonamida; proceso para preparar dichos compuestos y su uso para catalizar dicha preparacion. |
TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
SE9604786D0 (sv) | 1996-12-20 | 1996-12-20 | Astra Pharma Inc | New compounds |
US6696475B2 (en) | 1997-04-22 | 2004-02-24 | Neurosearch A/S | Substituted phenyl derivatives, their preparation and use |
ES2387211T3 (es) | 1997-05-07 | 2012-09-18 | University Of Pittsburgh | Inhibidores de proteínas isoprenil transferass |
US6316450B1 (en) * | 1997-07-11 | 2001-11-13 | Smithkline Beecham P.L.C. | Compounds |
US6297239B1 (en) * | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
WO1999032433A1 (en) | 1997-12-23 | 1999-07-01 | Warner-Lambert Company | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis |
EP1053227B1 (de) * | 1998-01-29 | 2008-11-05 | Amgen Inc. | Ppar-gamma modulatoren |
GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
CA2329777A1 (en) * | 1998-04-27 | 1999-11-04 | Dashyant Dhanak | Ccr-3 receptor antagonists |
WO1999055663A1 (en) | 1998-04-29 | 1999-11-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
US6136971A (en) * | 1998-07-17 | 2000-10-24 | Roche Colorado Corporation | Preparation of sulfonamides |
WO2000005214A2 (en) | 1998-07-24 | 2000-02-03 | Pfizer Inc. | Isoquinolines as urokinase inhibitors |
US6030408A (en) * | 1998-10-22 | 2000-02-29 | East West Medical Llp | Acupressure treatment device |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
EP3222619A1 (de) | 1999-04-15 | 2017-09-27 | Bristol-Myers Squibb Holdings Ireland | Cyclische proteintyrosinkinase-inhibitoren |
US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
NZ516455A (en) | 1999-06-30 | 2004-03-26 | Tularik Inc | Compounds for the modulation of PPARgamma activity |
JP2003506356A (ja) | 1999-07-30 | 2003-02-18 | バーテックス ファーマシューティカルズ インコーポレイテッド | 神経学的疾患の治療のための環状アミン誘導体 |
AU6870500A (en) | 1999-09-06 | 2001-04-10 | Takeda Chemical Industries Ltd. | Process for the preparation of 2,3-dihydroazepine derivatives |
IL148698A0 (en) | 1999-09-17 | 2002-09-12 | Cor Therapeutics Inc | INHIBITORS OF FACTOR Xa |
CZ2002961A3 (cs) | 1999-09-17 | 2002-08-14 | Millennium Pharmaceuticals, Inc. | Benzamidy a příbuzné sloučeniny pro inhibici faktoru Xa |
JP2001089412A (ja) | 1999-09-22 | 2001-04-03 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体またはその医薬的に許容される塩 |
GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
AU2001236605A1 (en) | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | Indole and benzimidazole inhibitors of factor xa |
WO2001056989A2 (en) | 2000-02-01 | 2001-08-09 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
EP1255743A1 (de) | 2000-02-01 | 2002-11-13 | Millenium Pharmaceuticals, Inc. | 3,4-dihydro-2h-benzo[1,4]oxazine als faktor xa inhibitoren |
JP4039856B2 (ja) | 2000-02-03 | 2008-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | インテグリン発現阻害剤 |
AU2001243158A1 (en) | 2000-02-18 | 2001-08-27 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
IL146010A0 (en) | 2000-02-18 | 2002-07-25 | Arch Dev Corp | Polyhydroxylated benzene-containing compounds |
JP3842976B2 (ja) | 2000-03-17 | 2006-11-08 | 富士通株式会社 | 分布帰還型半導体レーザとその製造方法 |
US6534062B2 (en) * | 2000-03-28 | 2003-03-18 | The Regents Of The University Of California | Methods for increasing a cytotoxic T lymphocyte response in vivo |
WO2001082916A2 (en) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Combination therapeutic compositions and methods of use |
JP2002031867A (ja) * | 2000-05-08 | 2002-01-31 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料の処理方法 |
WO2002000647A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
KR100771286B1 (ko) | 2000-06-28 | 2007-10-29 | 암젠 인크 | 퀴놀리닐 및 벤조티아졸릴 ppar-감마 조절물질 |
WO2002018326A1 (fr) | 2000-08-31 | 2002-03-07 | Wakunaga Pharmaceutical Co., Ltd. | Nouveaux derives d'acide propenohydroxamique |
AU2002213467A1 (en) * | 2000-10-11 | 2002-04-22 | Chemocentryx, Inc. | Modulation of ccr4 function |
US20020147198A1 (en) | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
AR032230A1 (es) | 2001-01-16 | 2003-10-29 | Sumitomo Chem Takeda Agro Co | Derivado sulfonamida conteniendo una composicion agricola y horticola |
US6656971B2 (en) | 2001-01-25 | 2003-12-02 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
CA2449628C (en) | 2001-06-07 | 2008-05-06 | Zheng Wei | Cell migration assay |
EP2399903A1 (de) * | 2002-05-24 | 2011-12-28 | Millennium Pharmaceuticals, Inc. | CCR9-Hemmer und Verwendungsverfahren dafür |
ES2286502T3 (es) * | 2002-11-18 | 2007-12-01 | Chemocentryx, Inc. | Sulfonamidas de arilo. |
US7227035B2 (en) * | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
US7741519B2 (en) * | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US20070021466A1 (en) * | 2002-11-18 | 2007-01-25 | Solomon Ungashe | CCR2 inhibitors and methods of use thereof |
US20060111351A1 (en) * | 2002-11-18 | 2006-05-25 | Solomon Ungashe | Aryl sulfonamides |
EP1643960A2 (de) | 2003-07-02 | 2006-04-12 | Merck & Co., Inc. | Arylsulfonamid-derivate |
US20080214672A1 (en) * | 2006-12-18 | 2008-09-04 | John Jessen Wright | Treatment of Asthma with Aryl Sulfonamides |
US9715915B2 (en) | 2014-10-30 | 2017-07-25 | Samsung Electronics Co., Ltd. | Magneto-resistive devices including a free layer having different magnetic properties during operations |
-
2003
- 2003-11-17 ES ES03796416T patent/ES2286502T3/es not_active Expired - Lifetime
- 2003-11-17 DK DK07004318.7T patent/DK1798223T4/da active
- 2003-11-17 EP EP03796416A patent/EP1562940B1/de not_active Expired - Lifetime
- 2003-11-17 US US10/716,170 patent/US6939885B2/en not_active Expired - Lifetime
- 2003-11-17 ES ES07004318.7T patent/ES2369720T5/es not_active Expired - Lifetime
- 2003-11-17 AU AU2003298661A patent/AU2003298661B2/en not_active Expired
- 2003-11-17 CN CNB2003801033356A patent/CN100360526C/zh not_active Expired - Lifetime
- 2003-11-17 DK DK03796416T patent/DK1562940T3/da active
- 2003-11-17 KR KR1020067025189A patent/KR100874292B1/ko active IP Right Grant
- 2003-11-17 CN CN2007101270116A patent/CN101077867B/zh not_active Expired - Lifetime
- 2003-11-17 AT AT07004318T patent/ATE517102T1/de active
- 2003-11-17 JP JP2004553842A patent/JP4611746B2/ja not_active Expired - Lifetime
- 2003-11-17 EP EP10009944A patent/EP2256116A3/de not_active Withdrawn
- 2003-11-17 PT PT07004318T patent/PT1798223E/pt unknown
- 2003-11-17 PT PT03796416T patent/PT1562940E/pt unknown
- 2003-11-17 AT AT03796416T patent/ATE363470T1/de active
- 2003-11-17 WO PCT/US2003/036766 patent/WO2004046092A2/en active IP Right Grant
- 2003-11-17 EP EP07004318.7A patent/EP1798223B2/de not_active Expired - Lifetime
- 2003-11-17 KR KR1020057005798A patent/KR100866456B1/ko active IP Right Grant
- 2003-11-17 CA CA2500492A patent/CA2500492C/en not_active Expired - Lifetime
- 2003-11-17 DE DE60314175T patent/DE60314175T2/de not_active Expired - Lifetime
- 2003-11-18 CN CN200380108668A patent/CN100582091C/zh not_active Expired - Lifetime
- 2003-11-18 JP JP2004569975A patent/JP2006510724A/ja active Pending
- 2003-11-18 ES ES03816012T patent/ES2299766T3/es not_active Expired - Lifetime
- 2003-11-18 CA CA002505590A patent/CA2505590A1/en not_active Abandoned
- 2003-11-18 EP EP03816012A patent/EP1567486B1/de not_active Expired - Lifetime
- 2003-11-18 WO PCT/US2003/037035 patent/WO2004085384A2/en active IP Right Grant
- 2003-11-18 KR KR1020057008974A patent/KR100780905B1/ko not_active IP Right Cessation
- 2003-11-18 MX MXPA05005296A patent/MXPA05005296A/es active IP Right Grant
- 2003-11-18 AT AT03816012T patent/ATE384041T1/de active
- 2003-11-18 DK DK03816012T patent/DK1567486T3/da active
- 2003-11-18 US US10/716,183 patent/US20040167113A1/en not_active Abandoned
- 2003-11-18 AU AU2003303942A patent/AU2003303942B9/en not_active Expired
- 2003-11-18 DE DE60318740T patent/DE60318740T2/de not_active Expired - Lifetime
-
2005
- 2005-01-27 US US11/046,565 patent/US7582661B2/en active Active
- 2005-03-29 IL IL167714A patent/IL167714A/en unknown
- 2005-05-06 ZA ZA2005/03663A patent/ZA200503663B/en unknown
- 2005-05-17 ZA ZA200503986A patent/ZA200503986B/xx unknown
- 2005-05-18 IL IL168661A patent/IL168661A/en active IP Right Grant
- 2005-05-18 ZA ZA200504015A patent/ZA200504015B/en unknown
-
2006
- 2006-06-19 HK HK06106974A patent/HK1086839A1/xx not_active IP Right Cessation
- 2006-06-19 HK HK08103764.0A patent/HK1113792A1/xx not_active IP Right Cessation
- 2006-08-18 HK HK06109180.5A patent/HK1088888A1/xx not_active IP Right Cessation
- 2006-11-17 JP JP2006311085A patent/JP4611962B2/ja not_active Expired - Lifetime
-
2007
- 2007-08-09 AU AU2007205711A patent/AU2007205711B2/en not_active Expired
-
2008
- 2008-07-02 US US12/166,844 patent/US20080293717A1/en not_active Abandoned
- 2008-10-15 US US12/251,829 patent/US20090118307A1/en not_active Abandoned
-
2009
- 2009-07-07 US US12/498,633 patent/US20090270616A1/en not_active Abandoned
-
2010
- 2010-05-11 AU AU2010201893A patent/AU2010201893A1/en not_active Ceased
- 2010-10-01 US US12/896,114 patent/US8211896B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE517102T1 (de) | Arylsulfonamide | |
MX2007008474A (es) | Sulfonamidas de heteroarilo y ccr2. | |
DE60328690D1 (de) | 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen | |
CO6180465A2 (es) | Triazolil fenil bencenosulfonamidas | |
WO2008008431A3 (en) | Heteroaryl sulfonamides and ccr2/ccr9 | |
ATE496905T1 (de) | Triazolyl-pyridyl-benzolsulfonamide als ccr2- oder ccr9-modulatoren zur behandlung von atherosklerose | |
WO2008008374A3 (en) | Ccr2 inhibitors and methods of use thereof | |
BRPI0411743A (pt) | método e composições para tratar doenças relacionadas a amilóides | |
ECSP066311A (es) | Derivados de la piperazina y su uso como agentes terapéuticos | |
NO20080408L (no) | Azaindazolforbindelser og anvendelse derav | |
BR0317377A (pt) | Derivados de 5-aminofenantridina como antagonistas de npy-5 | |
CY1116607T1 (el) | Ενωσεις αζαϊνδολιου και μεθοδοι χρησης |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1562940 Country of ref document: EP |