GB884847A - Mercapto compounds - Google Patents
Mercapto compoundsInfo
- Publication number
- GB884847A GB884847A GB12453/59A GB1245359A GB884847A GB 884847 A GB884847 A GB 884847A GB 12453/59 A GB12453/59 A GB 12453/59A GB 1245359 A GB1245359 A GB 1245359A GB 884847 A GB884847 A GB 884847A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- group
- nitro
- aminoalkylamino
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
The invention comprises amino - phenyl - mercapto-pyridines of the formula <FORM:0884847/IV (b)/1> and salts thereof, in which Ph represents a phenyl radical optionally bearing halogen, C1-6 alkyl, C1-6 alkoxy, amino or aminoalkylamino, especially tertiaryaminoalkylamino, substituents and R is an amino or aminoalkylamino group, preferably in the para-position. The compounds are prepared by treating 3-mercapto pyridine suitably in the form of its alkali-metal salt or in the presence of a condensing agent capable of forming a metal salt, with an appropriate halophenyl compound wherein the halogen atom is activated by an ortho or para nitro group such as p-nitro-chloro or p-nitro-bromo-benzene and reducing the resulting nitro compound, e.g. by nascent hydrogen or catalytic hydrogenation. Alternatively the compounds are prepared by reacting a 3-halo-pyridine with an amino-, acetylamino- or nitro-, mercapto-benzene, suitably in the form of a metal salt, or in the presence of a condensing agent forming such a salt and if necessary converting the acetylamino- or nitrosubstituent to an amino group. A free amino group in the product may be converted into an amino-alkylamino group by treating with an aryl-sulphonyl halide, e.g. p-toluenesulphochloride and reacting the resulting sulphonamide with an aminoalkylhalide, e.g. diethylaminoethyl chloride, in the presence of a condensing agent. Preferred products include p-amino-, o-amino, o : p-diamino, o-chloro-p-amino-, o-amino-p-chloro- and o-amino-p-methyl-, 3-phenylmercaptopyridine. The products are used pharmaceutically. Nitrophenylmercapto - pyridines corresponding to the above amino compounds and 3-(o-toluenesulphonylamino - phenylmercapto) - pyridine are obtained as intermediate products in the examples.ALSO:Pharmaceutical compositions having tranquilizing activity comprise compounds of the formula <FORM:0884847/VI/1> or salts thereof wherein Ph indicates a phenylene radical optionally bearing halogen, C1-6 alkyl C1-6 alkoxy, amine or aminoalkylamino, e.g. diethylaminoethylamino, substituents and R is an amino or aminoalkylamino radical (see Group IV (b)), together with a pharmaceutical carrier. The preparations suitably take the form of tablets, dragees, solutions, suspensions or emulsions and in addition to the carrier material may contain other therapeutically valuable substances.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH884847X | 1958-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB884847A true GB884847A (en) | 1961-12-20 |
Family
ID=4545189
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB12453/59A Expired GB884847A (en) | 1958-04-14 | 1959-04-13 | Mercapto compounds |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB884847A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0100158A2 (en) * | 1982-07-28 | 1984-02-08 | The Upjohn Company | (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters |
US6939885B2 (en) | 2002-11-18 | 2005-09-06 | Chemocentryx | Aryl sulfonamides |
JP2005526857A (en) * | 2002-05-24 | 2005-09-08 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | CCR9 inhibitors and methods of use thereof |
US7227035B2 (en) | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
-
1959
- 1959-04-13 GB GB12453/59A patent/GB884847A/en not_active Expired
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0100158A3 (en) * | 1982-07-28 | 1985-03-27 | The Upjohn Company | (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters |
EP0100158A2 (en) * | 1982-07-28 | 1984-02-08 | The Upjohn Company | (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters |
US7999109B2 (en) | 2002-05-24 | 2011-08-16 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
US9035096B2 (en) | 2002-05-24 | 2015-05-19 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
JP2005526857A (en) * | 2002-05-24 | 2005-09-08 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | CCR9 inhibitors and methods of use thereof |
US8030517B2 (en) | 2002-05-24 | 2011-10-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
US8642808B2 (en) | 2002-11-18 | 2014-02-04 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US7582661B2 (en) | 2002-11-18 | 2009-09-01 | Chemocentryx, Inc. | Aryl sulfonamides |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
US7335653B2 (en) | 2002-11-18 | 2008-02-26 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US8211896B2 (en) | 2002-11-18 | 2012-07-03 | Chemocentryx, Inc. | Aryl sulfonamides |
US7227035B2 (en) | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
US6939885B2 (en) | 2002-11-18 | 2005-09-06 | Chemocentryx | Aryl sulfonamides |
US9890148B2 (en) | 2002-11-18 | 2018-02-13 | Chemocentryx, Inc. | Aryl sulfonamides |
US10364240B2 (en) | 2002-11-18 | 2019-07-30 | ChemoCentryx. Inc. | Aryl sulfonamides |
US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
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