GB884847A - Mercapto compounds - Google Patents

Mercapto compounds

Info

Publication number
GB884847A
GB884847A GB12453/59A GB1245359A GB884847A GB 884847 A GB884847 A GB 884847A GB 12453/59 A GB12453/59 A GB 12453/59A GB 1245359 A GB1245359 A GB 1245359A GB 884847 A GB884847 A GB 884847A
Authority
GB
United Kingdom
Prior art keywords
amino
group
nitro
aminoalkylamino
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12453/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB884847A publication Critical patent/GB884847A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/70Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention comprises amino - phenyl - mercapto-pyridines of the formula <FORM:0884847/IV (b)/1> and salts thereof, in which Ph represents a phenyl radical optionally bearing halogen, C1-6 alkyl, C1-6 alkoxy, amino or aminoalkylamino, especially tertiaryaminoalkylamino, substituents and R is an amino or aminoalkylamino group, preferably in the para-position. The compounds are prepared by treating 3-mercapto pyridine suitably in the form of its alkali-metal salt or in the presence of a condensing agent capable of forming a metal salt, with an appropriate halophenyl compound wherein the halogen atom is activated by an ortho or para nitro group such as p-nitro-chloro or p-nitro-bromo-benzene and reducing the resulting nitro compound, e.g. by nascent hydrogen or catalytic hydrogenation. Alternatively the compounds are prepared by reacting a 3-halo-pyridine with an amino-, acetylamino- or nitro-, mercapto-benzene, suitably in the form of a metal salt, or in the presence of a condensing agent forming such a salt and if necessary converting the acetylamino- or nitrosubstituent to an amino group. A free amino group in the product may be converted into an amino-alkylamino group by treating with an aryl-sulphonyl halide, e.g. p-toluenesulphochloride and reacting the resulting sulphonamide with an aminoalkylhalide, e.g. diethylaminoethyl chloride, in the presence of a condensing agent. Preferred products include p-amino-, o-amino, o : p-diamino, o-chloro-p-amino-, o-amino-p-chloro- and o-amino-p-methyl-, 3-phenylmercaptopyridine. The products are used pharmaceutically. Nitrophenylmercapto - pyridines corresponding to the above amino compounds and 3-(o-toluenesulphonylamino - phenylmercapto) - pyridine are obtained as intermediate products in the examples.ALSO:Pharmaceutical compositions having tranquilizing activity comprise compounds of the formula <FORM:0884847/VI/1> or salts thereof wherein Ph indicates a phenylene radical optionally bearing halogen, C1-6 alkyl C1-6 alkoxy, amine or aminoalkylamino, e.g. diethylaminoethylamino, substituents and R is an amino or aminoalkylamino radical (see Group IV (b)), together with a pharmaceutical carrier. The preparations suitably take the form of tablets, dragees, solutions, suspensions or emulsions and in addition to the carrier material may contain other therapeutically valuable substances.
GB12453/59A 1958-04-14 1959-04-13 Mercapto compounds Expired GB884847A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH884847X 1958-04-14

Publications (1)

Publication Number Publication Date
GB884847A true GB884847A (en) 1961-12-20

Family

ID=4545189

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12453/59A Expired GB884847A (en) 1958-04-14 1959-04-13 Mercapto compounds

Country Status (1)

Country Link
GB (1) GB884847A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A2 (en) * 1982-07-28 1984-02-08 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US6939885B2 (en) 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
JP2005526857A (en) * 2002-05-24 2005-09-08 ミレニアム・ファーマシューティカルズ・インコーポレイテッド CCR9 inhibitors and methods of use thereof
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
EP0100158A2 (en) * 1982-07-28 1984-02-08 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US7999109B2 (en) 2002-05-24 2011-08-16 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
US9035096B2 (en) 2002-05-24 2015-05-19 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
JP2005526857A (en) * 2002-05-24 2005-09-08 ミレニアム・ファーマシューティカルズ・インコーポレイテッド CCR9 inhibitors and methods of use thereof
US8030517B2 (en) 2002-05-24 2011-10-04 Millennium Pharmaceuticals, Inc. CCR9 inhibitors and methods of use thereof
US8642808B2 (en) 2002-11-18 2014-02-04 Chemocentryx, Inc. Bis-aryl sulfonamides
US7582661B2 (en) 2002-11-18 2009-09-01 Chemocentryx, Inc. Aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7335653B2 (en) 2002-11-18 2008-02-26 Chemocentryx, Inc. Bis-aryl sulfonamides
US8211896B2 (en) 2002-11-18 2012-07-03 Chemocentryx, Inc. Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US6939885B2 (en) 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
US9890148B2 (en) 2002-11-18 2018-02-13 Chemocentryx, Inc. Aryl sulfonamides
US10364240B2 (en) 2002-11-18 2019-07-30 ChemoCentryx. Inc. Aryl sulfonamides
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides

Similar Documents

Publication Publication Date Title
GB1194835A (en) Novel 1-Amidino-3-Phenyl-Urea Derivatives, the preparation thereof and Compositions containing the same
ES8201167A1 (en) Cephalosporin derivatives, processes for their manufacture, pharmaceutical compositions containing them and intermediates therefor.
GB884847A (en) Mercapto compounds
GB1462036A (en) Aminoindane derivatives
GB1398201A (en) N-sulphenylated carbamidoximes a process for their preparation and their fungicidal and bactericidal use
GB1321424A (en) N-phenyl-n-disubstituted aminoalkyl-2-amino indanes
GB866843A (en) Sulphonamidopyrimidines
GB986562A (en) New 2-oxo-tetrahydro-imidazole compounds and processes for preparing them
GB1418247A (en) Sulphonyloxy-phenylureas process for their preparation and their use as herbicides
GB1461957A (en) Production of 1chloroanthraquinone
GB951026A (en) The manufacture of sulphonamides
GB912789A (en) N-substitutedphenylsulfonyl-n-cycloalkylureas and processes for preparing same
GB1449802A (en) Piperazine derivatives and compositions containing them for treating parkinsons disease
Tanaka et al. N-Acyl-1-chloro-2, 2, 2-trifluoroethylamine as a 2, 2, 2-Trifluoroethylamine-Building Block.
GB1110378A (en) Novel acetylenic amines and a process for the manufacture thereof
GB1090986A (en) Sulphur-containing oxime carbamates
GB987438A (en) N,n-disubstituted-1,3-diamino-propanes and 2-propanols
GB1307223A (en) Pesticidal compositions
GB935202A (en) New sulphonylureas and process for preparing same
GB1301715A (en)
GB879194A (en) New mercapto compounds and process for their manufacture
JPS6176465A (en) 4-methyl-5-thioformamidinomethylimidazole dihydrochloride
GB973027A (en) New hydrazones and process for preparing same
GB997475A (en) Improvements in or relating to sulphonamides
GB852422A (en) New urea derivatives and process for their manufacture