JP2016528207A5 - - Google Patents

Download PDF

Info

Publication number
JP2016528207A5
JP2016528207A5 JP2016525486A JP2016525486A JP2016528207A5 JP 2016528207 A5 JP2016528207 A5 JP 2016528207A5 JP 2016525486 A JP2016525486 A JP 2016525486A JP 2016525486 A JP2016525486 A JP 2016525486A JP 2016528207 A5 JP2016528207 A5 JP 2016528207A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
inhibitor
subject
composition according
eoe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016525486A
Other languages
English (en)
Japanese (ja)
Other versions
JP6576339B2 (ja
JP2016528207A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/046170 external-priority patent/WO2015006571A1/en
Publication of JP2016528207A publication Critical patent/JP2016528207A/ja
Publication of JP2016528207A5 publication Critical patent/JP2016528207A5/ja
Application granted granted Critical
Publication of JP6576339B2 publication Critical patent/JP6576339B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016525486A 2013-07-11 2014-07-10 Il−4r阻害剤の投与による好酸球性食道炎を治療する方法 Active JP6576339B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361844978P 2013-07-11 2013-07-11
US61/844,978 2013-07-11
PCT/US2014/046170 WO2015006571A1 (en) 2013-07-11 2014-07-10 Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019149548A Division JP6837105B2 (ja) 2013-07-11 2019-08-19 Il−4r阻害剤の投与による好酸球性食道炎を治療する方法

Publications (3)

Publication Number Publication Date
JP2016528207A JP2016528207A (ja) 2016-09-15
JP2016528207A5 true JP2016528207A5 (enExample) 2017-08-17
JP6576339B2 JP6576339B2 (ja) 2019-09-18

Family

ID=51298948

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016525486A Active JP6576339B2 (ja) 2013-07-11 2014-07-10 Il−4r阻害剤の投与による好酸球性食道炎を治療する方法
JP2019149548A Active JP6837105B2 (ja) 2013-07-11 2019-08-19 Il−4r阻害剤の投与による好酸球性食道炎を治療する方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019149548A Active JP6837105B2 (ja) 2013-07-11 2019-08-19 Il−4r阻害剤の投与による好酸球性食道炎を治療する方法

Country Status (25)

Country Link
US (4) US9290574B2 (enExample)
EP (2) EP3659623A1 (enExample)
JP (2) JP6576339B2 (enExample)
KR (2) KR102333268B1 (enExample)
CN (2) CN105392497B (enExample)
AU (2) AU2014287196B2 (enExample)
CA (1) CA2917804C (enExample)
CY (1) CY1122909T1 (enExample)
DK (1) DK3019191T3 (enExample)
ES (1) ES2778902T3 (enExample)
HR (1) HRP20200628T1 (enExample)
HU (1) HUE049442T2 (enExample)
IL (1) IL279499B (enExample)
LT (1) LT3019191T (enExample)
MX (2) MX380220B (enExample)
NZ (1) NZ631031A (enExample)
PL (1) PL3019191T3 (enExample)
PT (1) PT3019191T (enExample)
RS (1) RS60151B1 (enExample)
RU (1) RU2679141C2 (enExample)
SG (2) SG10201802344YA (enExample)
SI (1) SI3019191T1 (enExample)
TW (2) TWI634900B (enExample)
WO (1) WO2015006571A1 (enExample)
ZA (1) ZA201508717B (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
EP2482822B1 (en) 2009-10-01 2018-08-01 Adare Pharmaceuticals, Inc. Orally administered corticosteroid compositions
IL312711A (en) 2012-08-21 2024-07-01 Regeneron Pharma Methods for the treatment or prevention of asthma through the administration of an antagonist to 4R-IL
KR102576903B1 (ko) 2012-09-07 2023-09-13 리제너론 파아마슈티컬스, 인크. Il-4r 길항제 투여로 아토피성 피부염을 치료하는 방법
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
KR102927870B1 (ko) 2014-02-28 2026-02-19 리제너론 파아마슈티컬스, 인크. Il-4r 길항제의 투여에 의한 피부 감염의 치료 방법
WO2016077675A1 (en) 2014-11-14 2016-05-19 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
JP6938383B2 (ja) 2015-04-02 2021-09-22 インターベット インターナショナル ベー. フェー. イヌインターロイキン4受容体アルファに対する抗体
CA3005696A1 (en) 2015-12-18 2017-06-22 Intervet International B.V. Caninized human antibodies to human and canine il-4r alpha
US11091556B2 (en) 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
KR20240052871A (ko) * 2016-04-27 2024-04-23 애브비 인코포레이티드 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
CN113372446A (zh) 2016-06-08 2021-09-10 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
JP2019193577A (ja) * 2016-09-01 2019-11-07 国立研究開発法人国立成育医療研究センター 好酸球性消化管疾患または食物蛋白誘発腸症の検査方法および検査キット
US11771743B2 (en) * 2016-09-01 2023-10-03 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an IL-4R antagonist
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
KR20190053250A (ko) * 2016-09-22 2019-05-17 리제너론 파아마슈티컬스, 인크. Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법
TWI857389B (zh) 2016-12-01 2024-10-01 美商再生元醫藥公司 治療發炎症狀的方法
JP7321939B2 (ja) 2017-04-13 2023-08-07 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Il33及びil1rl1をコードする遺伝子にリスクアレルを有する患者の炎症性肺疾患の処置及び阻害
AU2018263937A1 (en) * 2017-05-05 2019-12-05 Allakos Inc. Methods and compositions for treating inflammatory gastrointestinal disorders
WO2019028367A1 (en) * 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
IL315556A (en) * 2017-08-04 2024-11-01 Regeneron Pharma Methods for treating active eosinophilic esophagitis
EP3703818B1 (en) 2017-10-30 2023-11-01 Sanofi Biotechnology Il-4r antagonist for use in a method for treating or preventing asthma
US12226492B2 (en) 2017-12-29 2025-02-18 Cornell University Gene therapy for eosinophilic disorders
WO2019148405A1 (zh) * 2018-02-01 2019-08-08 北京凯因科技股份有限公司 IL-4Rα抗体及其用途
US20200381097A1 (en) * 2018-02-21 2020-12-03 Adare Pharmaceuticals Us, L.P. Methods of treating eosinophilic esophagitis
MA52624A (fr) 2018-05-13 2021-03-24 Regeneron Pharma Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r
CN113101364B (zh) * 2018-05-29 2023-12-01 康诺亚生物医药科技(成都)有限公司 一种自免疫抑制剂的开发和应用
CN110872349A (zh) * 2018-09-04 2020-03-10 三生国健药业(上海)股份有限公司 结合人il-4r的抗体、其制备方法和用途
CN111494625B (zh) 2018-12-25 2022-06-21 江苏荃信生物医药股份有限公司 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物
WO2020135710A1 (zh) * 2018-12-27 2020-07-02 中山康方生物医药有限公司 抗人il-4ra的抗体及其用途
SG11202109002XA (en) 2019-03-21 2021-09-29 Regeneron Pharma Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
CA3147436A1 (en) 2019-07-16 2021-01-21 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
AU2020325021B2 (en) 2019-08-05 2024-05-30 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
EP4010373A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
IL293487A (en) 2019-12-09 2022-08-01 Sanofi Biotechnology Methods for the treatment of digitally identified il-4/il-13-related disorders
EP3992974A1 (en) 2020-11-02 2022-05-04 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
MX2022007677A (es) 2019-12-20 2022-07-19 Intervet Int Bv Anticuerpos para receptor alfa de interleucina-4 canino.
CN114829396A (zh) 2019-12-20 2022-07-29 英特维特国际股份有限公司 用于治疗特应性皮炎的双特异性犬源化抗体和双特异性结合伴体
IL298257A (en) * 2020-05-22 2023-01-01 Regeneron Pharma Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
US20240002518A1 (en) 2020-10-15 2024-01-04 Intervet Inc. Caninized rat antibodies to canine interleukin-31 receptor alpha
EP4240350A4 (en) * 2020-11-09 2024-09-18 Arena Pharmaceuticals, Inc. <sup2/>? <sub2/>?1?methods of treating conditions related to the s1preceptor
CN114805572B (zh) * 2021-01-22 2022-12-13 上海济煜医药科技有限公司 抗原结合蛋白及其应用
MX2023010837A (es) 2021-03-17 2023-09-29 Receptos Llc Métodos de tratamiento de la dermatitis atopica.
US20240368249A1 (en) 2021-08-20 2024-11-07 Intervet Inc. Fusion proteins for treating atopic dermatitis
JP2025516245A (ja) * 2022-04-29 2025-05-27 中山康方生物医▲藥▼有限公司 抗ヒトil-4raの抗体及びその使用
CA3259540A1 (en) * 2022-07-08 2024-01-11 Regeneron Pharmaceuticals, Inc. Methods for treating eosinophilic esophagitis in pediatric by administering an il-4r antagonist
CN121002060A (zh) 2023-02-13 2025-11-21 英特维特国际股份有限公司 犬il-13的犬抗体
EP4665756A1 (en) 2023-02-13 2025-12-24 Intervet International B.V. Canine antibodies to canine il-4
KR20250150541A (ko) * 2023-02-17 2025-10-20 아포지 테라퓨틱스, 인크. 인터류킨 4 수용체 알파에 결합하는 항체 및 사용 방법
US20250230251A1 (en) 2023-12-20 2025-07-17 Bristol-Myers Squibb Company Antibodies targeting il-18 receptor beta (il-18rb) and related methods

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8808015D0 (en) 1988-04-06 1988-05-05 Ritter M A Chemical compounds
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
BR9205967A (pt) 1991-05-03 1994-07-26 Seragen Inc Moléculas marcadas com receptor de interleucina tratamento de artrite inflamatória
JP3315427B2 (ja) 1992-03-05 2002-08-19 大日本除蟲菊株式会社 皮膚炎治療剤
US5714146A (en) 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
EP0604693A1 (en) 1992-12-29 1994-07-06 Schering-Plough Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same
ZA946875B (en) 1993-09-07 1995-07-06 Smithkline Beecham Corp Recombinant il4 antibodies useful in treatment of il4 mediated disorders
US6849614B1 (en) 1998-07-28 2005-02-01 Ecosmart Technologies, Inc. Synergistic and residual pesticidal compositions containing plant essential oils
AU766492B2 (en) 1998-09-18 2003-10-16 Dynavax Technologies Corporation Methods of treating IgE-associated disorders and compositions for use therein
WO2001092340A2 (en) 2000-05-26 2001-12-06 Immunex Corporation Use of interleukin-4 antagonists and compositions thereof
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
AU2001267917A1 (en) 2000-07-26 2002-02-05 Kenjirou Tsuchida Antipruritic compositions and compositions promoting wound healing
US6391531B1 (en) 2000-11-06 2002-05-21 Eastman Kodak Company Low silver radiographic film and imaging assembly for thoracic imaging
RU2283665C2 (ru) 2000-12-22 2006-09-20 Сосьете Де Продюи Нестле С.А. Индуцирование толерантности
US20030103938A1 (en) 2001-05-09 2003-06-05 Alk-Abello A/S Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio
US20050031609A1 (en) 2001-05-11 2005-02-10 Thomas Hultsch Compositions for use in treating ige-associated disorders
CA2447795A1 (en) 2001-05-23 2002-11-28 Duotol Ab Suppression of allergic reactions by transdermal administration of allergens in conjunction with or conjugated to toxin subunits or fragments thereof
AU2002357770B2 (en) 2001-11-30 2008-07-31 Biogen Ma Inc. Antibodies against monocyte chemotactic proteins
ATE435239T1 (de) 2002-03-29 2009-07-15 Schering Corp Menschliche monoklonale antikörper gegen interleukin-5 sowie diese umfassende verfahren und zusammensetzungen
EP1581166A2 (en) * 2003-01-07 2005-10-05 Children's Hospital Medical Center Cytokine inhibition of eosinophils
EP1592777A4 (en) 2003-02-01 2008-06-04 Tanox Inc METHOD OF GENERATING HIGH-ANTIBODY ANTIBODIES
US7923209B2 (en) 2003-03-14 2011-04-12 Anergis, S.A. Allergen peptide fragments and use thereof
NZ547588A (en) 2003-11-07 2009-05-31 Immunex Corp Antibodies that bind interleukin-4 receptor
CA2550933A1 (en) 2003-12-22 2005-07-14 Amgen Inc. Methods for identifying functional antibodies
EP1723173B1 (en) 2004-02-27 2008-05-14 Regeneron Pharmaceuticals, Inc. Il-4/il-13 specific polypeptides and therapeutic uses thereof
CN1922204A (zh) * 2004-02-27 2007-02-28 瑞泽恩制药公司 Il-4/il-13特异性的多肽和其治疗应用
JP4365697B2 (ja) 2004-03-05 2009-11-18 三菱重工業株式会社 印刷機の廃液再生装置及び廃液再生方法
US20090098142A1 (en) 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
JP5234445B2 (ja) 2004-10-05 2013-07-10 源一郎 杣 薬剤
WO2006083390A2 (en) 2004-12-07 2006-08-10 Children's Hospital Medical Center Eotaxin-3 in eosinophilic esophagitis
US8592548B2 (en) 2004-12-22 2013-11-26 Sabic Innovative Plastics Ip B.V. Method to prepare bis(haloimides)
TW200902555A (en) 2005-01-03 2009-01-16 Hoffmann La Roche Antibodies against IL-13 receptor alpha 1 and uses thereof
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
JP4221018B2 (ja) 2006-08-31 2009-02-12 トヨタ自動車株式会社 頭部保護エアバッグ装置
LT2769992T (lt) 2006-10-02 2021-04-12 Regeneron Pharmaceuticals, Inc. Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
KR100844828B1 (ko) 2006-11-24 2008-07-08 주식회사알에프윈도우 안테나를 내장한 궤환 간섭신호 제거 무선중계장치
SI2132230T1 (sl) 2007-03-22 2014-07-31 Genentech, Inc. Apoptotska protitelesa, ki veĹľejo membransko-vezan IgE
EP2022507A1 (en) 2007-08-07 2009-02-11 Universität Hamburg Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy
US8637239B2 (en) 2007-11-05 2014-01-28 The Board Of Trustees Of The University Of Illinois Minimally-invasive measurement of esophageal inflammation
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
US20090264392A1 (en) 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
US20110301046A1 (en) 2008-12-01 2011-12-08 Children's Hospital Medical Center Methods of Determining Efficacy of Glucocorticoid Treatment of Eosinophilic Esophagitis
US20120088814A1 (en) 2009-03-31 2012-04-12 Isis Pharmaceuticals, Inc. Methods of modulating an immune response to a viral infection
FR2946632B1 (fr) 2009-06-11 2015-05-29 Sidel Participations Installation de convoyage comprenant au moins un couloir courbe
US8497528B2 (en) 2010-05-06 2013-07-30 Taiwan Semiconductor Manufacturing Company, Ltd. Method for fabricating a strained structure
BR112012005117A2 (pt) 2009-09-07 2016-05-03 Dbv Tech método de tratamento de esofagite eosinofílica
US8993347B2 (en) 2009-12-17 2015-03-31 Cornell University Methods for detecting antibodies in mucosal samples and device for sampling mucosal material
ES2894936T3 (es) 2010-06-24 2022-02-16 Viropharma Biologics Llc Métodos de tratamiento para la inflamación del esófago
CN106267189B (zh) 2010-10-06 2021-02-26 瑞泽恩制药公司 含有抗白介素-4受体(il-4r)的抗体的稳定制剂
KR101962483B1 (ko) 2010-11-17 2019-03-29 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
RU2453303C1 (ru) 2010-12-23 2012-06-20 Общество с ограниченной ответственностью "ЦитоНИР" (ООО "ЦитоНИР") Фармацевтическая композиция для лечения атопического дерматита
WO2012094643A2 (en) 2011-01-06 2012-07-12 Children's Hospital Medical Center Esophageal cytokine expression profiles in eosinophilic esophagitis
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
EP2723899B1 (en) 2011-06-21 2020-11-18 Children's Hospital Medical Center Diagnostic methods for eosinophilic esophagitis
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
US20140303067A1 (en) 2011-10-06 2014-10-09 N.V. Nutricia Treatment of eosinophilic esophagitis
KR20140113667A (ko) * 2011-12-16 2014-09-24 아토픽스 테라퓨릭스 리미티드 호산구성 식도염의 치료를 위한 crth2 길항제 및 양성자 펌프 저해제의 조합
US20130243750A1 (en) 2012-01-31 2013-09-19 Genentech, Inc. Anti-ige antibodies and methods using same
WO2013155010A1 (en) 2012-04-09 2013-10-17 Children's Hospital Medical Center Non-invasive biomarkers for eosinophilic esophagitis
IL312711A (en) 2012-08-21 2024-07-01 Regeneron Pharma Methods for the treatment or prevention of asthma through the administration of an antagonist to 4R-IL
KR102576903B1 (ko) 2012-09-07 2023-09-13 리제너론 파아마슈티컬스, 인크. Il-4r 길항제 투여로 아토피성 피부염을 치료하는 방법
US10132809B2 (en) 2012-10-10 2018-11-20 Rhote Island Hospital Differential expression of protein markers for the diagnosis and treatment of eosinophilic esophagitis
US9963513B2 (en) 2013-02-05 2018-05-08 Engmab Sàrl Method for the selection of antibodies against BCMA
TWI755763B (zh) 2013-06-04 2022-02-21 美商再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
KR20210132232A (ko) 2013-06-21 2021-11-03 사노피 바이오테크놀로지 Il-4r 길항제를 투여함에 의한 비용종증의 치료 방법
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
BR112016008694A2 (pt) 2013-10-23 2017-10-03 Genentech Inc Métodos de previsão da reação de pacientes com asma, de previsão da capacidade de reação de pacientes com asma, de identificação de pacientes com asma, de tratamento de pacientes portadores de asma e de tratamento de asma, uso de um kit e kit
RU2552929C1 (ru) 2013-11-14 2015-06-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний
IL315136A (en) 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
KR102927870B1 (ko) 2014-02-28 2026-02-19 리제너론 파아마슈티컬스, 인크. Il-4r 길항제의 투여에 의한 피부 감염의 치료 방법
WO2016077675A1 (en) 2014-11-14 2016-05-19 Sanofi Biotechnology Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist
EP3268032A1 (en) 2015-03-11 2018-01-17 GlaxoSmithKline Intellectual Property Development Limited Tslp binding proteins
AU2017220184B2 (en) 2016-02-19 2024-04-18 Regeneron Pharmaceuticals, Inc. Methods for enhancing efficacy of a vaccine by administering an IL-4R antagonist
KR20240052871A (ko) 2016-04-27 2024-04-23 애브비 인코포레이티드 항-il-13 항체를 이용한 il-13 활성이 유해한 질환의 치료 방법
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
US11771743B2 (en) 2016-09-01 2023-10-03 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an IL-4R antagonist
US10485844B2 (en) 2016-09-22 2019-11-26 Regeneron Pharmaceuticals, Inc. Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor
KR20190053250A (ko) 2016-09-22 2019-05-17 리제너론 파아마슈티컬스, 인크. Il-4r 저해제 투여에 의한 중증 아토피 피부염의 치료 방법
JP2020507605A (ja) 2017-02-17 2020-03-12 フレッド ハッチンソン キャンサー リサーチ センター Bcma関連癌および自己免疫疾患の治療のための併用療法
US20200179511A1 (en) 2017-04-28 2020-06-11 Novartis Ag Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor
AU2018263937A1 (en) 2017-05-05 2019-12-05 Allakos Inc. Methods and compositions for treating inflammatory gastrointestinal disorders
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
RU2698048C2 (ru) 2017-10-03 2019-08-21 Закрытое Акционерное Общество "Биокад" МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα
EP3703818B1 (en) 2017-10-30 2023-11-01 Sanofi Biotechnology Il-4r antagonist for use in a method for treating or preventing asthma
US20200381097A1 (en) 2018-02-21 2020-12-03 Adare Pharmaceuticals Us, L.P. Methods of treating eosinophilic esophagitis
MA52624A (fr) 2018-05-13 2021-03-24 Regeneron Pharma Méthodes de traitement de la dermatite atopique par administration d'un inhibiteur de l'il-4r
JPWO2019240288A1 (ja) 2018-06-14 2021-07-26 味の素株式会社 抗体に対する親和性物質、および生体直交性官能基を有する化合物またはその塩
SG11202109002XA (en) 2019-03-21 2021-09-29 Regeneron Pharma Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
EP4010373A1 (en) 2019-08-05 2022-06-15 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an il-4r antagonist
AU2020325021B2 (en) 2019-08-05 2024-05-30 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R antagonist
IL293487A (en) 2019-12-09 2022-08-01 Sanofi Biotechnology Methods for the treatment of digitally identified il-4/il-13-related disorders
KR20220158821A (ko) 2020-03-27 2022-12-01 리제너론 파아마슈티컬스, 인크. Il-4r 길항제를 투여함에 의해 아토피 피부염을 치료하기 위한 방법
IL298257A (en) 2020-05-22 2023-01-01 Regeneron Pharma Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
MX2023003942A (es) 2020-10-05 2023-06-02 Sanofi Biotechnology Metodos para el tratamiento del asma en sujetos pediatricos mediante la administracion de un antagonista del il-4r.
MX2023007945A (es) 2021-01-08 2023-09-21 Regeneron Pharma Metodos para tratar la alergia al cacahuate y mejorar la inmunoterapia especifica de alergeno del cacahuate mediante la administracion de un antagonista de il-4r.
CA3259540A1 (en) 2022-07-08 2024-01-11 Regeneron Pharmaceuticals, Inc. Methods for treating eosinophilic esophagitis in pediatric by administering an il-4r antagonist
CN121001741A (zh) 2023-03-27 2025-11-21 瑞泽恩制药公司 用于通过施用il-4r拮抗剂治疗嗜酸粒细胞性胃肠炎的方法

Similar Documents

Publication Publication Date Title
RU2016104400A (ru) Способы лечения эозинофильного эзофагита с помощью ингибитора ил-4р
JP7503335B2 (ja) Cd8+t細胞の誘導のための組成物および方法
Bel et al. New anti-eosinophil drugs for asthma and COPD: targeting the trait!
JP2016521713A5 (enExample)
Kuhn et al. IL-6 stimulates intestinal epithelial proliferation and repair after injury
JP2022526738A5 (enExample)
Tan et al. Novel biologicals for the treatment of allergic diseases and asthma
JP6389950B2 (ja) 細菌株を含む組成物
Disteldorf et al. CXCL5 drives neutrophil recruitment in TH17-mediated GN
JP6439037B2 (ja) 細菌株を含む組成物
IL273678B2 (en) Methods for treating allergy and improving allergen-specific immunotherapy by administering an IL-4R inhibitor
JP2012021001A5 (enExample)
JP2006523682A5 (enExample)
JP2017535511A (ja) 細菌株を含む組成物
Folli et al. New insights into airway remodelling in asthma and its possible modulation
Lamot et al. The'head-to-head'comparison of etanercept and infliximab in treating children with juvenile idiopathic arthritis
AU2025200955A1 (en) Methods for treating active eosinophilic esophagitis
JP2020529434A5 (enExample)
Lianto et al. Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease
JP2012530755A (ja) 医薬品
Dougherty Jr et al. Emerging therapeutic options for eosinophilic esophagitis
RU2022119098A (ru) Способы лечения активного эозинофильного эзофагита
Jackson et al. Mouse models of eosinophilic esophagitis: molecular and translational insights
Bordea et al. Eosinophilic esophagitis
NZ779309A (en) Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy