JP2016528207A5 - - Google Patents
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- JP2016528207A5 JP2016528207A5 JP2016525486A JP2016525486A JP2016528207A5 JP 2016528207 A5 JP2016528207 A5 JP 2016528207A5 JP 2016525486 A JP2016525486 A JP 2016525486A JP 2016525486 A JP2016525486 A JP 2016525486A JP 2016528207 A5 JP2016528207 A5 JP 2016528207A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 41
- 239000003112 inhibitor Substances 0.000 claims 21
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 20
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 20
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 18
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 210000003979 eosinophil Anatomy 0.000 claims 11
- 239000013568 food allergen Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 102000006440 Chemokine CCL26 Human genes 0.000 claims 7
- 108010083698 Chemokine CCL26 Proteins 0.000 claims 7
- 102000013888 Eosinophil-Derived Neurotoxin Human genes 0.000 claims 7
- 108010050456 Eosinophil-Derived Neurotoxin Proteins 0.000 claims 7
- 102000003816 Interleukin-13 Human genes 0.000 claims 7
- 108090000176 Interleukin-13 Proteins 0.000 claims 7
- 239000000090 biomarker Substances 0.000 claims 7
- 235000013305 food Nutrition 0.000 claims 7
- 208000024891 symptom Diseases 0.000 claims 7
- 206010020751 Hypersensitivity Diseases 0.000 claims 6
- 239000013566 allergen Substances 0.000 claims 6
- 208000030961 allergic reaction Diseases 0.000 claims 6
- 108010002616 Interleukin-5 Proteins 0.000 claims 5
- 102000000743 Interleukin-5 Human genes 0.000 claims 5
- 102100031294 Thymic stromal lymphopoietin Human genes 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108010029307 thymic stromal lymphopoietin Proteins 0.000 claims 5
- 241000251468 Actinopterygii Species 0.000 claims 4
- 244000099147 Ananas comosus Species 0.000 claims 4
- 235000007119 Ananas comosus Nutrition 0.000 claims 4
- 244000105624 Arachis hypogaea Species 0.000 claims 4
- 235000007319 Avena orientalis Nutrition 0.000 claims 4
- 244000075850 Avena orientalis Species 0.000 claims 4
- 241000196324 Embryophyta Species 0.000 claims 4
- 241000282326 Felis catus Species 0.000 claims 4
- 241000287828 Gallus gallus Species 0.000 claims 4
- 244000068988 Glycine max Species 0.000 claims 4
- 235000010469 Glycine max Nutrition 0.000 claims 4
- 241000238631 Hexapoda Species 0.000 claims 4
- 240000005979 Hordeum vulgare Species 0.000 claims 4
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 4
- 244000141359 Malus pumila Species 0.000 claims 4
- 102100037765 Periostin Human genes 0.000 claims 4
- 101710199268 Periostin Proteins 0.000 claims 4
- 241000009328 Perro Species 0.000 claims 4
- -1 TARC Proteins 0.000 claims 4
- 235000021307 Triticum Nutrition 0.000 claims 4
- 241000209140 Triticum Species 0.000 claims 4
- 240000008042 Zea mays Species 0.000 claims 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 4
- 235000021016 apples Nutrition 0.000 claims 4
- 235000015278 beef Nutrition 0.000 claims 4
- 235000013330 chicken meat Nutrition 0.000 claims 4
- 235000005822 corn Nutrition 0.000 claims 4
- 235000013365 dairy product Nutrition 0.000 claims 4
- 239000000428 dust Substances 0.000 claims 4
- 244000013123 dwarf bean Species 0.000 claims 4
- 235000013601 eggs Nutrition 0.000 claims 4
- 235000019688 fish Nutrition 0.000 claims 4
- 235000021331 green beans Nutrition 0.000 claims 4
- 235000014571 nuts Nutrition 0.000 claims 4
- 235000020232 peanut Nutrition 0.000 claims 4
- 235000015277 pork Nutrition 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 235000015170 shellfish Nutrition 0.000 claims 4
- 208000004998 Abdominal Pain Diseases 0.000 claims 3
- 208000019505 Deglutition disease Diseases 0.000 claims 3
- 102000057955 Eosinophil Cationic Human genes 0.000 claims 3
- 206010067171 Regurgitation Diseases 0.000 claims 3
- 206010047700 Vomiting Diseases 0.000 claims 3
- 208000022531 anorexia Diseases 0.000 claims 3
- 206010061428 decreased appetite Diseases 0.000 claims 3
- 201000006549 dyspepsia Diseases 0.000 claims 3
- 210000003238 esophagus Anatomy 0.000 claims 3
- 208000024798 heartburn Diseases 0.000 claims 3
- 230000008595 infiltration Effects 0.000 claims 3
- 238000001764 infiltration Methods 0.000 claims 3
- 230000008719 thickening Effects 0.000 claims 3
- 230000008673 vomiting Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 101710191360 Eosinophil cationic protein Proteins 0.000 claims 2
- 102000004388 Interleukin-4 Human genes 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 230000002992 thymic effect Effects 0.000 claims 2
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 108700016749 Eosinophil Cationic Proteins 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229950003468 dupilumab Drugs 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 claims 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 claims 1
- 239000000612 proton pump inhibitor Substances 0.000 claims 1
- 229940126409 proton pump inhibitor Drugs 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 1
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361844978P | 2013-07-11 | 2013-07-11 | |
| US61/844,978 | 2013-07-11 | ||
| PCT/US2014/046170 WO2015006571A1 (en) | 2013-07-11 | 2014-07-10 | Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149548A Division JP6837105B2 (ja) | 2013-07-11 | 2019-08-19 | Ｉｌ−４ｒ阻害剤の投与による好酸球性食道炎を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016528207A JP2016528207A (ja) | 2016-09-15 |
| JP2016528207A5 true JP2016528207A5 (enExample) | 2017-08-17 |
| JP6576339B2 JP6576339B2 (ja) | 2019-09-18 |
Family
ID=51298948
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016525486A Active JP6576339B2 (ja) | 2013-07-11 | 2014-07-10 | Ｉｌ−４ｒ阻害剤の投与による好酸球性食道炎を治療する方法 |
| JP2019149548A Active JP6837105B2 (ja) | 2013-07-11 | 2019-08-19 | Ｉｌ−４ｒ阻害剤の投与による好酸球性食道炎を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019149548A Active JP6837105B2 (ja) | 2013-07-11 | 2019-08-19 | Ｉｌ−４ｒ阻害剤の投与による好酸球性食道炎を治療する方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US9290574B2 (enExample) |
| EP (2) | EP3659623A1 (enExample) |
| JP (2) | JP6576339B2 (enExample) |
| KR (2) | KR102398718B1 (enExample) |
| CN (2) | CN105392497B (enExample) |
| AU (2) | AU2014287196B2 (enExample) |
| CA (1) | CA2917804C (enExample) |
| CY (1) | CY1122909T1 (enExample) |
| DK (1) | DK3019191T3 (enExample) |
| ES (1) | ES2778902T3 (enExample) |
| HR (1) | HRP20200628T1 (enExample) |
| HU (1) | HUE049442T2 (enExample) |
| IL (1) | IL279499B (enExample) |
| LT (1) | LT3019191T (enExample) |
| MX (2) | MX380220B (enExample) |
| NZ (1) | NZ631031A (enExample) |
| PL (1) | PL3019191T3 (enExample) |
| PT (1) | PT3019191T (enExample) |
| RS (1) | RS60151B1 (enExample) |
| RU (1) | RU2679141C2 (enExample) |
| SG (2) | SG10201802344YA (enExample) |
| SI (1) | SI3019191T1 (enExample) |
| TW (2) | TWI682781B (enExample) |
| WO (1) | WO2015006571A1 (enExample) |
| ZA (1) | ZA201508717B (enExample) |
Families Citing this family (52)
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| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| PT3403654T (pt) | 2009-10-01 | 2019-09-05 | Adare Dev I L P | Composições de corticosteroide administradas oralmente |
| HUE064945T2 (hu) | 2012-08-21 | 2024-04-28 | Sanofi Biotechnology | Eljárások asztma kezelésére vagy megelõzésére IL-4R antagonista beadásával |
| TWI633891B (zh) | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑以治療過敏及增強過敏原－特異之免疫療法的方法 |
| TWI682781B (zh) | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| RU2704999C2 (ru) | 2014-02-28 | 2019-11-01 | Ридженерон Фармасьютикалз, Инк. | Способ лечения кожной инфекции путем введения антагониста il-4r |
| EP3218412A1 (en) | 2014-11-14 | 2017-09-20 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| WO2016156588A1 (en) * | 2015-04-02 | 2016-10-06 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| JP7008020B2 (ja) | 2015-12-18 | 2022-01-25 | インターベット インターナショナル ベー． フェー． | ヒトおよびイヌｉｌ－４ｒアルファに対するイヌ化ヒト抗体 |
| WO2017189805A1 (en) | 2016-04-27 | 2017-11-02 | Abbvie Inc. | Methods of treatment of diseases in which il-13 activity is detrimental using anti-il-13 antibodies |
| CN113372446A (zh) | 2016-06-08 | 2021-09-10 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
| TWI777515B (zh) | 2016-08-18 | 2022-09-11 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
| JP2019193577A (ja) * | 2016-09-01 | 2019-11-07 | 国立研究開発法人国立成育医療研究センター | 好酸球性消化管疾患または食物蛋白誘発腸症の検査方法および検査キット |
| EP4442323A3 (en) * | 2016-09-01 | 2025-01-01 | Regeneron Pharmaceuticals, Inc. | Methods for preventing or treating allergy by administering an il-4r antagonist |
| AU2017332732B2 (en) * | 2016-09-22 | 2024-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
| TWI857389B (zh) | 2016-12-01 | 2024-10-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
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| SG10202112259VA (en) * | 2017-05-05 | 2021-12-30 | Allakos Inc | Methods and compositions for treating inflammatory gastrointestinal disorders |
| US11053309B2 (en) * | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
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| MA46269B1 (fr) | 2017-08-18 | 2024-05-31 | Regeneron Pharma | Méthodes de traitement d'une dermatite atopique sévère par administration d'un inhibiteur des il-4r |
| HUE064655T2 (hu) | 2017-10-30 | 2024-04-28 | Sanofi Biotechnology | IL-4R antagonista asztma kezelésére vagy megelõzésére szolgáló eljárásban |
| EP3732194A1 (en) | 2017-12-29 | 2020-11-04 | Cornell University | Gene therapy for eosinophilic disorders |
| RU2758092C1 (ru) * | 2018-02-01 | 2021-10-26 | Бэйцзин Кавин Текнолоджи Шеа-Холдинг Ко., Лтд. | АНТИТЕЛО К IL-4Rα И ЕГО ПРИМЕНЕНИЕ |
| RU2020128551A (ru) * | 2018-02-21 | 2022-03-21 | АДЭР ФАРМАСЬЮТИКАЛЗ ЮЭс, Л.П. | Способы ведения эозинофильного эзофагита |
| CN112153982A (zh) | 2018-05-13 | 2020-12-29 | 瑞泽恩制药公司 | 用于通过施用il-4r抑制剂治疗特应性皮炎的方法 |
| CN113101364B (zh) * | 2018-05-29 | 2023-12-01 | 康诺亚生物医药科技（成都）有限公司 | 一种自免疫抑制剂的开发和应用 |
| CN110872349A (zh) * | 2018-09-04 | 2020-03-10 | 三生国健药业（上海）股份有限公司 | 结合人il-4r的抗体、其制备方法和用途 |
| CN111518211B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 抗人白介素4受体α单克隆抗体的制药用途 |
| SG11202107007VA (en) * | 2018-12-27 | 2021-07-29 | Akeso Biopharma Inc | Antibody against human il-4ra and use thereof |
| MX2021011141A (es) | 2019-03-21 | 2022-01-19 | Regeneron Pharma | Combinacion de inhibidores de la via de il-4/il-13 y ablacion de celulas plasmaticas para el tratamiento de alergia. |
| MX2022000649A (es) | 2019-07-16 | 2022-06-08 | Sanofi Biotechnology | Metodos para tratar o prevenir el asma mediante la administracion de un antagonista de il-4r. |
| AU2020326713A1 (en) | 2019-08-05 | 2022-02-17 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
| EP4010001A1 (en) | 2019-08-05 | 2022-06-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist |
| US11723974B2 (en) | 2019-12-09 | 2023-08-15 | Sanofi-Aventis Biotechnology | Methods for treating digitally identified IL-4/IL-13-related disorders by administering an anti-IL4R-alpha antibody |
| EP3992974A1 (en) | 2020-11-02 | 2022-05-04 | Sanofi Biotechnology | Methods for treating digitally-identified il-4/il-13 related disorders |
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| US20250154267A2 (en) * | 2020-05-22 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor |
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