JP2020529434A5 - - Google Patents
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- JP2020529434A5 JP2020529434A5 JP2020505844A JP2020505844A JP2020529434A5 JP 2020529434 A5 JP2020529434 A5 JP 2020529434A5 JP 2020505844 A JP2020505844 A JP 2020505844A JP 2020505844 A JP2020505844 A JP 2020505844A JP 2020529434 A5 JP2020529434 A5 JP 2020529434A5
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- 239000003112 inhibitor Substances 0.000 claims 24
- 102000003816 Interleukin-13 Human genes 0.000 claims 18
- 108090000176 Interleukin-13 Proteins 0.000 claims 18
- 102000004388 Interleukin-4 Human genes 0.000 claims 15
- 108090000978 Interleukin-4 Proteins 0.000 claims 15
- 230000037361 pathway Effects 0.000 claims 15
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 6
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 239000013566 allergen Substances 0.000 claims 4
- 102100021935 C-C motif chemokine 26 Human genes 0.000 claims 3
- 108010083698 Chemokine CCL26 Proteins 0.000 claims 3
- 102000013888 Eosinophil-Derived Neurotoxin Human genes 0.000 claims 3
- 108010050456 Eosinophil-Derived Neurotoxin Proteins 0.000 claims 3
- 108010002616 Interleukin-5 Proteins 0.000 claims 3
- 102100039897 Interleukin-5 Human genes 0.000 claims 3
- 239000000090 biomarker Substances 0.000 claims 3
- 239000003246 corticosteroid Substances 0.000 claims 3
- 229960001334 corticosteroids Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102100023698 C-C motif chemokine 17 Human genes 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 101000978362 Homo sapiens C-C motif chemokine 17 Proteins 0.000 claims 2
- 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims 2
- 240000005979 Hordeum vulgare Species 0.000 claims 2
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 206010030164 Oesophageal dilatation Diseases 0.000 claims 2
- 102100037765 Periostin Human genes 0.000 claims 2
- 101710199268 Periostin Proteins 0.000 claims 2
- 102100031294 Thymic stromal lymphopoietin Human genes 0.000 claims 2
- 208000030961 allergic reaction Diseases 0.000 claims 2
- 230000010339 dilation Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000003979 eosinophil Anatomy 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 239000013568 food allergen Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940126409 proton pump inhibitor Drugs 0.000 claims 2
- 239000000612 proton pump inhibitor Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 210000000115 thoracic cavity Anatomy 0.000 claims 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 244000099147 Ananas comosus Species 0.000 claims 1
- 235000007119 Ananas comosus Nutrition 0.000 claims 1
- 244000105624 Arachis hypogaea Species 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- 102000002171 Interleukin-4/interleukin-13 Human genes 0.000 claims 1
- 108050009538 Interleukin-4/interleukin-13 Proteins 0.000 claims 1
- 244000141359 Malus pumila Species 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 235000021307 Triticum Nutrition 0.000 claims 1
- 244000098338 Triticum aestivum Species 0.000 claims 1
- 240000008042 Zea mays Species 0.000 claims 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
- 208000002205 allergic conjunctivitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 235000021016 apples Nutrition 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000024998 atopic conjunctivitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 235000015278 beef Nutrition 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 235000013330 chicken meat Nutrition 0.000 claims 1
- 235000005822 corn Nutrition 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 235000021045 dietary change Nutrition 0.000 claims 1
- 230000000378 dietary effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 229950003468 dupilumab Drugs 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 244000013123 dwarf bean Species 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 235000019688 fish Nutrition 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 235000021331 green beans Nutrition 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125369 inhaled corticosteroids Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 235000014571 nuts Nutrition 0.000 claims 1
- 229940124624 oral corticosteroid Drugs 0.000 claims 1
- 235000020232 peanut Nutrition 0.000 claims 1
- 235000015277 pork Nutrition 0.000 claims 1
- BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 claims 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 235000015170 shellfish Nutrition 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 1
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023192683A JP2024016237A (ja) | 2017-08-04 | 2023-11-13 | 活動性好酸球性食道炎を治療する方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762541242P | 2017-08-04 | 2017-08-04 | |
| US62/541,242 | 2017-08-04 | ||
| US201762561593P | 2017-09-21 | 2017-09-21 | |
| US62/561,593 | 2017-09-21 | ||
| EP18305252 | 2018-03-08 | ||
| EP18305252.1 | 2018-03-08 | ||
| PCT/US2018/045195 WO2019028367A1 (en) | 2017-08-04 | 2018-08-03 | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023192683A Division JP2024016237A (ja) | 2017-08-04 | 2023-11-13 | 活動性好酸球性食道炎を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020529434A JP2020529434A (ja) | 2020-10-08 |
| JP2020529434A5 true JP2020529434A5 (enExample) | 2021-09-02 |
| JP7417515B2 JP7417515B2 (ja) | 2024-01-18 |
Family
ID=63113646
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020505844A Active JP7417515B2 (ja) | 2017-08-04 | 2018-08-03 | 活動性好酸球性食道炎を治療する方法 |
| JP2023192683A Pending JP2024016237A (ja) | 2017-08-04 | 2023-11-13 | 活動性好酸球性食道炎を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023192683A Pending JP2024016237A (ja) | 2017-08-04 | 2023-11-13 | 活動性好酸球性食道炎を治療する方法 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3661551A1 (enExample) |
| JP (2) | JP7417515B2 (enExample) |
| KR (2) | KR20240152980A (enExample) |
| CN (1) | CN111032084A (enExample) |
| AU (2) | AU2018311981B2 (enExample) |
| CA (1) | CA3071528A1 (enExample) |
| IL (2) | IL315556A (enExample) |
| MA (1) | MA49744A (enExample) |
| MX (2) | MX2020001305A (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250154267A2 (en) * | 2020-05-22 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor |
| IL316470A (en) * | 2022-04-29 | 2024-12-01 | Akeso Biopharma Inc | Anti-human il-4ra antibody and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI682781B (zh) * | 2013-07-11 | 2020-01-21 | 美商再生元醫藥公司 | 藉由投與ｉｌ－４ｒ抑制劑治療嗜酸性食道炎的方法 |
| AR098155A1 (es) * | 2013-10-23 | 2016-05-04 | Genentech Inc | Métodos para diagnosticar y tratar trastornos eosinofílicos |
| AU2016231122A1 (en) * | 2015-03-11 | 2017-09-07 | Glaxosmithkline Intellectual Property Development Limited | TSLP binding proteins |
-
2018
- 2018-08-02 IL IL315556A patent/IL315556A/en unknown
- 2018-08-03 CA CA3071528A patent/CA3071528A1/en active Pending
- 2018-08-03 CN CN201880050334.6A patent/CN111032084A/zh active Pending
- 2018-08-03 KR KR1020247034392A patent/KR20240152980A/ko active Pending
- 2018-08-03 MX MX2020001305A patent/MX2020001305A/es unknown
- 2018-08-03 JP JP2020505844A patent/JP7417515B2/ja active Active
- 2018-08-03 EP EP18750578.9A patent/EP3661551A1/en active Pending
- 2018-08-03 AU AU2018311981A patent/AU2018311981B2/en active Active
- 2018-08-03 MA MA049744A patent/MA49744A/fr unknown
- 2018-08-03 KR KR1020207006346A patent/KR102719720B1/ko active Active
- 2018-08-03 IL IL272245A patent/IL272245B2/en unknown
-
2020
- 2020-01-31 MX MX2024012777A patent/MX2024012777A/es unknown
-
2023
- 2023-11-13 JP JP2023192683A patent/JP2024016237A/ja active Pending
-
2025
- 2025-02-12 AU AU2025200955A patent/AU2025200955A1/en active Pending
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