SG10202112259VA - Methods and compositions for treating inflammatory gastrointestinal disorders - Google Patents

Methods and compositions for treating inflammatory gastrointestinal disorders

Info

Publication number
SG10202112259VA
SG10202112259VA SG10202112259VA SG10202112259VA SG10202112259VA SG 10202112259V A SG10202112259V A SG 10202112259VA SG 10202112259V A SG10202112259V A SG 10202112259VA SG 10202112259V A SG10202112259V A SG 10202112259VA SG 10202112259V A SG10202112259V A SG 10202112259VA
Authority
SG
Singapore
Prior art keywords
compositions
methods
gastrointestinal disorders
treating inflammatory
inflammatory gastrointestinal
Prior art date
Application number
SG10202112259VA
Inventor
Christopher Robert Bebbington
Bradford Andrew Youngblood
Nenad Tomasevic
Emily C Brock
Original Assignee
Allakos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allakos Inc filed Critical Allakos Inc
Publication of SG10202112259VA publication Critical patent/SG10202112259VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111Immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111Immunoglobulin superfamily
    • A61K39/001113CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/215Coronaviridae, e.g. avian infectious bronchitis virus
    • A61K39/225Porcine transmissible gastroenteritis virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • General Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10202112259VA 2017-05-05 2018-05-04 Methods and compositions for treating inflammatory gastrointestinal disorders SG10202112259VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762502480P 2017-05-05 2017-05-05
US201762572337P 2017-10-13 2017-10-13

Publications (1)

Publication Number Publication Date
SG10202112259VA true SG10202112259VA (en) 2021-12-30

Family

ID=64016746

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202112259VA SG10202112259VA (en) 2017-05-05 2018-05-04 Methods and compositions for treating inflammatory gastrointestinal disorders
SG11201910206Q SG11201910206QA (en) 2017-05-05 2018-05-04 Methods and compositions for treating inflammatory gastrointestinal disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201910206Q SG11201910206QA (en) 2017-05-05 2018-05-04 Methods and compositions for treating inflammatory gastrointestinal disorders

Country Status (13)

Country Link
US (1) US20200270344A1 (en)
EP (1) EP3618872A4 (en)
JP (2) JP7346304B2 (en)
KR (1) KR20200015511A (en)
CN (1) CN111246880A (en)
AU (1) AU2018263937A1 (en)
BR (1) BR112019022957A2 (en)
CA (1) CA3062430A1 (en)
IL (1) IL270304B1 (en)
MX (1) MX2019013136A (en)
SG (2) SG10202112259VA (en)
WO (1) WO2018204871A1 (en)
ZA (1) ZA201907372B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2987797A1 (en) 2015-06-17 2016-12-22 Christopher Robert Bebbington Methods and compositions for treating fibrotic diseases
CA3062415A1 (en) 2017-05-05 2018-11-08 Christopher Robert Bebbington Methods and compositions for treating allergic ocular diseases
KR20210126084A (en) * 2019-02-15 2021-10-19 알라코스 인크. Methods and compositions for treating mast cell gastritis, mast cell esophagitis, mast cell enteritis, mast cell duodenitis and/or mast cell gastroenteritis
KR20220044203A (en) * 2019-08-02 2022-04-06 알라코스 인크. Methods of Administering Anti-SIGLEC-8 Antibodies and Corticosteroids
JP2022553378A (en) * 2019-10-24 2022-12-22 アラコス インコーポレイテッド Methods and compositions for treating irritable bowel syndrome and functional dyspepsia
WO2023141097A1 (en) * 2022-01-24 2023-07-27 Children's Hospital Medical Center Methods of treating eosinophilic colitis
CN117187180B (en) * 2023-11-03 2024-01-26 四川大学 Th17 cell, culture method and application thereof and induction liquid thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745421B2 (en) * 2004-05-25 2010-06-29 The Johns Hopkins University Methods and compositions for treating diseases and disorders associated with Siglec-8 expressing cells
EP4119579A1 (en) * 2007-05-31 2023-01-18 Genmab A/S Stable igg4 antibodies
EP2373687B1 (en) * 2008-12-03 2016-10-26 Genmab A/S Igg4 antibody variants having modifications in the constant region
EP2465873A1 (en) * 2010-12-16 2012-06-20 Deutsches Rheuma-Forschungszentrum Berlin Eosinophils as a therapeutic target
US9345763B2 (en) * 2011-06-23 2016-05-24 Children's Hospital Medical Center Methods of treating allergic inflammatory conditions by administering an anti-cadherin-like 26-based therapeutic
EP2817417B1 (en) * 2012-02-24 2017-10-25 Children's Hospital Medical Center Esophageal microrna expression profiles in eosinophilic esophagitis
TWI682781B (en) * 2013-07-11 2020-01-21 美商再生元醫藥公司 Methods for treating eosinophilic esophagitis by administering an il-4r inhibitor
SG10201808835QA (en) * 2013-12-09 2018-11-29 Allakos Inc Anti-siglec-8 antibodies and methods of use thereof
EP4014995A1 (en) * 2014-02-28 2022-06-22 Allakos Inc. Methods and compositions for treating siglec-8 associated diseases
CA2987797A1 (en) * 2015-06-17 2016-12-22 Christopher Robert Bebbington Methods and compositions for treating fibrotic diseases
CA3062415A1 (en) * 2017-05-05 2018-11-08 Christopher Robert Bebbington Methods and compositions for treating allergic ocular diseases
KR20210126084A (en) * 2019-02-15 2021-10-19 알라코스 인크. Methods and compositions for treating mast cell gastritis, mast cell esophagitis, mast cell enteritis, mast cell duodenitis and/or mast cell gastroenteritis
US20220226333A1 (en) * 2019-06-07 2022-07-21 Epithelion Science Biotech, S.L. Irsogladine for the treatment of eosinophilic gastrointestinal diseases
KR20220044203A (en) * 2019-08-02 2022-04-06 알라코스 인크. Methods of Administering Anti-SIGLEC-8 Antibodies and Corticosteroids
JP2022553378A (en) * 2019-10-24 2022-12-22 アラコス インコーポレイテッド Methods and compositions for treating irritable bowel syndrome and functional dyspepsia

Also Published As

Publication number Publication date
IL270304B1 (en) 2024-03-01
CA3062430A1 (en) 2018-11-08
JP2023099232A (en) 2023-07-11
ZA201907372B (en) 2024-04-24
US20200270344A1 (en) 2020-08-27
AU2018263937A1 (en) 2019-12-05
BR112019022957A2 (en) 2020-05-19
JP2020518645A (en) 2020-06-25
MX2019013136A (en) 2020-07-14
SG11201910206QA (en) 2019-11-28
JP7346304B2 (en) 2023-09-19
WO2018204871A1 (en) 2018-11-08
IL270304A (en) 2019-12-31
EP3618872A4 (en) 2021-06-30
KR20200015511A (en) 2020-02-12
EP3618872A1 (en) 2020-03-11
CN111246880A (en) 2020-06-05

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