SG11201907580SA - Combination therapies for treatment of bcma-related cancers and autoimmune disorders - Google Patents

Combination therapies for treatment of bcma-related cancers and autoimmune disorders

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Publication number
SG11201907580SA
SG11201907580SA SG11201907580SA SG11201907580SA SG11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA SG 11201907580S A SG11201907580S A SG 11201907580SA
Authority
SG
Singapore
Prior art keywords
international
bcma
seattle
rule
combination
Prior art date
Application number
SG11201907580SA
Inventor
Stanley Riddell
Damian Green
Tyler Hill
Original Assignee
Hutchinson Fred Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchinson Fred Cancer Res filed Critical Hutchinson Fred Cancer Res
Publication of SG11201907580SA publication Critical patent/SG11201907580SA/en

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date IiiimmoimiolollmonolomolEmolmoolliflovoimIE (10) International Publication Number WO 2018/151836 Al 23 August 2018 (23.08.2018) WIPOIPCT (51) International Patent Classification: (72) Inventors: RIDDELL, Stanley, R.; 1763 268th Place SE, A61K 31/55 (2006.01) A61P 35/02 (2006.01) Sammamish, WA 98075 (US). GREEN, Damian; 2746 NE A61K 39/395 (2006.01) A61P 37/00 (2006.01) 88th Street, Seattle, WA 98115 (US). HILL, Tuler; 1315 A61K 35/17 (2015.01) A61K 45/06 (2006.01) N 88th Street, Seattle, WA 98103 (US). A61P 37/02 (2006.01) Cl 2N 15/62 (2006.01) A61P 35/00 (2006.01) (74) Agent: PEPE, Jeffrey, C. et al.; Seed Intellectual Property, Law Group LLP, 701 Fifth Avenue, Suite 5400, Seattle, WA (21) International Application Number: PCT/US2018/000050 (22) International Filing Date: 16 February 2018 (16.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/460,612 17 February 2017 (17.02.2017) US 62/582,270 06 November 2017 (06.11.2017) US (71) Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER [US/US]; 1100 Fairview Avenue North, Seattle, WA 98109 (US). 98104-7064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (54) Title: COMBINATION THERAPIES FOR TREATMENT OF BCMA-RELATED CANCERS AND AUTOIMMUNE DISORDERS C113ST 0mg/kg C113ST 3C mg/kg FMC63 30mg/kg •• , ;A.,. 49043001ft 4 , 0PC4 A 1 4 . A Oe ? 49$1 VP 4VQ30:0101 )40: C g C :4' 114. I I GC kr) 00 O 1-1 1-1 N C 0 ( .2 H FIG. 7B (57) : The present disclosure relates to methods for using BCMA-specific binding molecules (such as a BCMA-specific chimeric antigen receptor or antibody) in combination with y-secretase inhibitors, which can be done concurrently or sequentially, to treat or prevent a B-cell related proliferative disease, such as a cancer or autoimmune disease, or the like. A BCMA-specific binding molecule in combination with y-secretase inhibitor can be used in, for example, adoptive immunotherapy. [Continued on next page] WO 2018/151836 Al MIDEDIMOMOIDEIREE3110111MOROMEEN GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
SG11201907580SA 2017-02-17 2018-02-16 Combination therapies for treatment of bcma-related cancers and autoimmune disorders SG11201907580SA (en)

Applications Claiming Priority (3)

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