JP2016513710A5 - - Google Patents
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- Publication number
- JP2016513710A5 JP2016513710A5 JP2016502526A JP2016502526A JP2016513710A5 JP 2016513710 A5 JP2016513710 A5 JP 2016513710A5 JP 2016502526 A JP2016502526 A JP 2016502526A JP 2016502526 A JP2016502526 A JP 2016502526A JP 2016513710 A5 JP2016513710 A5 JP 2016513710A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- mrna
- mrna encoding
- composition
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108020004999 messenger RNA Proteins 0.000 claims description 94
- 238000000034 method Methods 0.000 claims description 46
- 239000002502 liposome Substances 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 26
- 150000002632 lipids Chemical class 0.000 claims description 18
- 210000004027 cell Anatomy 0.000 claims description 15
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 12
- 235000012000 cholesterol Nutrition 0.000 claims description 6
- 230000007935 neutral effect Effects 0.000 claims description 6
- 101001043352 Homo sapiens Lysyl oxidase homolog 2 Proteins 0.000 claims description 4
- 102100021948 Lysyl oxidase homolog 2 Human genes 0.000 claims description 4
- 108020003175 receptors Proteins 0.000 claims description 4
- 102000005962 receptors Human genes 0.000 claims description 4
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 claims description 2
- 101000719121 Arabidopsis thaliana Protein MEI2-like 1 Proteins 0.000 claims description 2
- 102100028043 Fibroblast growth factor 3 Human genes 0.000 claims description 2
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims description 2
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims description 2
- 101000857677 Homo sapiens Runt-related transcription factor 1 Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 108050002021 Integrator complex subunit 2 Proteins 0.000 claims description 2
- 108010041012 Integrin alpha4 Proteins 0.000 claims description 2
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims description 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims description 2
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims description 2
- 102100025373 Runt-related transcription factor 1 Human genes 0.000 claims description 2
- 239000012190 activator Substances 0.000 claims description 2
- 230000002494 anti-cea effect Effects 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims description 2
- 108091008726 retinoic acid receptors α Proteins 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims 3
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 cationic lipid Chemical class 0.000 description 3
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361784903P | 2013-03-14 | 2013-03-14 | |
| US61/784,903 | 2013-03-14 | ||
| US201361920165P | 2013-12-23 | 2013-12-23 | |
| US61/920,165 | 2013-12-23 | ||
| PCT/US2014/027717 WO2014152774A1 (en) | 2013-03-14 | 2014-03-14 | Methods and compositions for delivering mrna coded antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089393A Division JP7058547B2 (ja) | 2013-03-14 | 2018-05-07 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016513710A JP2016513710A (ja) | 2016-05-16 |
| JP2016513710A5 true JP2016513710A5 (enExample) | 2017-04-13 |
| JP6399560B2 JP6399560B2 (ja) | 2018-10-03 |
Family
ID=50489425
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016502526A Active JP6399560B2 (ja) | 2013-03-14 | 2014-03-14 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
| JP2018089393A Active JP7058547B2 (ja) | 2013-03-14 | 2018-05-07 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
| JP2021005561A Active JP7256831B2 (ja) | 2013-03-14 | 2021-01-18 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
| JP2023057800A Active JP7607694B2 (ja) | 2013-03-14 | 2023-03-31 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089393A Active JP7058547B2 (ja) | 2013-03-14 | 2018-05-07 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
| JP2021005561A Active JP7256831B2 (ja) | 2013-03-14 | 2021-01-18 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
| JP2023057800A Active JP7607694B2 (ja) | 2013-03-14 | 2023-03-31 | ｍＲＮＡによってコードされる抗体を送達するための方法及び組成物 |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10087247B2 (enExample) |
| EP (2) | EP2970456B1 (enExample) |
| JP (4) | JP6399560B2 (enExample) |
| CN (1) | CN105209490A (enExample) |
| AU (4) | AU2014239184B2 (enExample) |
| BR (1) | BR112015022855A2 (enExample) |
| CA (1) | CA2903880A1 (enExample) |
| CY (1) | CY1124670T1 (enExample) |
| DK (1) | DK2970456T3 (enExample) |
| EA (1) | EA201591293A1 (enExample) |
| ES (1) | ES2882110T3 (enExample) |
| HR (1) | HRP20211119T1 (enExample) |
| HU (1) | HUE055044T2 (enExample) |
| LT (1) | LT2970456T (enExample) |
| MX (1) | MX2015011947A (enExample) |
| PL (1) | PL2970456T3 (enExample) |
| PT (1) | PT2970456T (enExample) |
| RS (1) | RS62565B1 (enExample) |
| SI (1) | SI2970456T1 (enExample) |
| SM (1) | SMT202100430T1 (enExample) |
| WO (1) | WO2014152774A1 (enExample) |
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| JP6184945B2 (ja) | 2011-06-08 | 2017-08-23 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ｍＲＮＡ送達のための脂質ナノ粒子組成物および方法 |
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