JP2016513124A5 - - Google Patents

Download PDF

Info

Publication number
JP2016513124A5
JP2016513124A5 JP2015558976A JP2015558976A JP2016513124A5 JP 2016513124 A5 JP2016513124 A5 JP 2016513124A5 JP 2015558976 A JP2015558976 A JP 2015558976A JP 2015558976 A JP2015558976 A JP 2015558976A JP 2016513124 A5 JP2016513124 A5 JP 2016513124A5
Authority
JP
Japan
Prior art keywords
compound
salt
pharmaceutical composition
pharmaceutically acceptable
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015558976A
Other languages
English (en)
Japanese (ja)
Other versions
JP6277210B2 (ja
JP2016513124A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/017534 external-priority patent/WO2014130752A2/en
Publication of JP2016513124A publication Critical patent/JP2016513124A/ja
Publication of JP2016513124A5 publication Critical patent/JP2016513124A5/ja
Application granted granted Critical
Publication of JP6277210B2 publication Critical patent/JP6277210B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015558976A 2013-02-21 2014-02-21 二環式化合物 Expired - Fee Related JP6277210B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361767531P 2013-02-21 2013-02-21
US61/767,531 2013-02-21
PCT/US2014/017534 WO2014130752A2 (en) 2013-02-21 2014-02-21 Bicyclic compounds

Publications (3)

Publication Number Publication Date
JP2016513124A JP2016513124A (ja) 2016-05-12
JP2016513124A5 true JP2016513124A5 (OSRAM) 2017-03-16
JP6277210B2 JP6277210B2 (ja) 2018-02-07

Family

ID=50272738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015558976A Expired - Fee Related JP6277210B2 (ja) 2013-02-21 2014-02-21 二環式化合物

Country Status (34)

Country Link
US (3) US9115054B2 (OSRAM)
EP (1) EP2958888B1 (OSRAM)
JP (1) JP6277210B2 (OSRAM)
KR (1) KR102242265B1 (OSRAM)
CN (1) CN105026362B (OSRAM)
AR (1) AR094851A1 (OSRAM)
AU (1) AU2014218883B2 (OSRAM)
BR (1) BR112015019919A2 (OSRAM)
CA (1) CA2902168C (OSRAM)
CL (1) CL2015002358A1 (OSRAM)
CY (1) CY1118641T1 (OSRAM)
DK (1) DK2958888T3 (OSRAM)
EA (1) EA025294B1 (OSRAM)
ES (1) ES2613262T3 (OSRAM)
HR (1) HRP20170247T1 (OSRAM)
HU (1) HUE031626T2 (OSRAM)
IL (1) IL240613B (OSRAM)
LT (1) LT2958888T (OSRAM)
MA (1) MA38425B1 (OSRAM)
MX (1) MX2015010347A (OSRAM)
MY (1) MY173990A (OSRAM)
PE (1) PE20151746A1 (OSRAM)
PH (1) PH12015501793A1 (OSRAM)
PL (1) PL2958888T3 (OSRAM)
PT (1) PT2958888T (OSRAM)
RS (1) RS55703B1 (OSRAM)
SG (1) SG11201506408TA (OSRAM)
SI (1) SI2958888T1 (OSRAM)
SM (2) SMT201700115T1 (OSRAM)
TN (1) TN2015000356A1 (OSRAM)
TW (1) TWI613182B (OSRAM)
UY (1) UY35338A (OSRAM)
WO (1) WO2014130752A2 (OSRAM)
ZA (1) ZA201506965B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6617702B2 (ja) 2013-07-15 2019-12-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Fty720のアザサイクリック拘束アナログ
MA40082B1 (fr) 2014-08-20 2019-09-30 Bristol Myers Squibb Co Nouveau compose de substitution sphingosine phosphate utile traitement maladie rhumatisme
JP6853539B2 (ja) * 2015-09-24 2021-03-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 合成スフィンゴ脂質様分子、薬物、これらの合成方法、および処置方法
JP7029445B2 (ja) 2016-09-02 2022-03-03 ブリストル-マイヤーズ スクイブ カンパニー 置換された三環式ヘテロ環化合物
US11059784B2 (en) 2017-08-09 2021-07-13 Bristol-Myers Squibb Company Oxime ether compounds
WO2019032632A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company ALKYLPHENYL COMPOUNDS
WO2021062168A1 (en) * 2019-09-25 2021-04-01 The Regents Of The University Of California Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
WO2025083549A1 (en) 2023-10-16 2025-04-24 Sun Pharma Advanced Research Company Limited Methods and combinations of inhibitors of il-23 pathway and modulators of s1p signaling pathway for the treatment of autoimmune disorders

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200750A (en) 1977-01-07 1980-04-29 Westwood Pharmaceuticals Inc. 4-Substituted imidazo [1,2-a]quinoxalines
US6069143A (en) 1994-12-20 2000-05-30 Smithkline Beecham Corporation Fibrinogen receptor antagonists
DE60330047D1 (en) 2002-01-18 2009-12-24 Merck & Co Inc "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten"
WO2003062252A1 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Edg receptor agonists
WO2003061567A2 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
EP1482895A4 (en) 2002-03-01 2005-04-27 Merck & Co Inc AMINO ALKYL PHOSPHONATES AND RELATED COMPOUNDS AS EDG RECEPTOR AGONISTS
AU2003276043A1 (en) 2002-06-17 2003-12-31 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
PE20050158A1 (es) 2003-05-19 2005-05-12 Irm Llc Compuestos inmunosupresores y composiciones
CA2547198A1 (en) 2003-12-17 2005-06-30 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
WO2006047195A2 (en) 2004-10-22 2006-05-04 Merck & Co., Inc. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as s1p receptor agonists
US7754703B2 (en) 2005-02-14 2010-07-13 University Of Virginia Patent Foundation Cycloalkane-containing sphingosine 1-phosphate agonists
CA2598365A1 (en) 2005-02-18 2006-11-16 Innodia Inc. Analogs of 4-hydroxyisoleucine and uses thereof
CA2600886A1 (en) 2005-03-08 2006-09-14 Biota Scientific Management Pty Ltd. Bicyclic nucleosides and nucleotides as therapeutic agents
CN101146529B (zh) 2005-03-23 2012-08-29 埃科特莱茵药品有限公司 新颖噻吩衍生物作为鞘氨醇-1-磷酸酯-1受体激动剂
KR20070121013A (ko) 2005-04-22 2007-12-26 다이이찌 산쿄 가부시키가이샤 헤테로 고리 화합물
EP1893591A1 (en) 2005-06-08 2008-03-05 Novartis AG POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS
WO2007024922A1 (en) 2005-08-23 2007-03-01 Irm Llc Immunosuppressant compounds and compositions
KR101294014B1 (ko) 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
EP1986623A2 (en) 2006-01-27 2008-11-05 University Of Virginia Patent Foundation Method for treatment of neuropathic pain
WO2007088450A2 (en) 2006-02-01 2007-08-09 Pfizer Products Inc. Chromane antagonist of the h-3 receptor
TW200806633A (en) 2006-03-21 2008-02-01 Epix Pharm Inc S1P receptor modulating compounds and use thereof
CA2645639A1 (en) 2006-03-23 2007-10-04 Merck & Co. Inc. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP2003132B1 (en) 2006-04-03 2014-03-05 Astellas Pharma Inc. Oxadiazole derivatives as S1P1 agonists
JP2009269819A (ja) 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk アミン化合物
CL2007002594A1 (es) 2006-09-08 2008-06-06 Actelion Pharmaceuticals Ltd Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
CN101610674A (zh) * 2006-12-21 2009-12-23 艾博特公司 鞘氨醇-1-磷酸酯受体激动剂和拮抗剂化合物
UY30829A1 (es) * 2006-12-21 2008-07-31 Abbott Lab Compuestos agonistas y antagonistas del receptor de esfinfosina-1-fosfato
US8217027B2 (en) 2006-12-21 2012-07-10 Abbott Laboratories Sphingosine-1-phosphate receptor agonist and antagonist compounds
GB0625648D0 (en) 2006-12-21 2007-01-31 Glaxo Group Ltd Compounds
KR101174191B1 (ko) 2007-02-02 2012-08-14 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료용 taar1 리간드로서 2-아미노옥사졸린
DK2125797T3 (da) 2007-03-16 2014-02-10 Actelion Pharmaceuticals Ltd Aminopyridinderivater som s1p1/edg1-receptoragonister
CA2696863C (en) 2007-10-04 2016-10-18 Anna Quattropani Oxadiazole derivatives
CA2700917A1 (en) 2007-11-01 2009-05-07 Actelion Pharmaceuticals Ltd Novel pyrimidine derivatives
GB0725105D0 (en) 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
US8153686B2 (en) 2008-04-01 2012-04-10 Theravance, Inc. Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
CA2739901A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
US8741923B2 (en) 2008-12-18 2014-06-03 Merck Serono Sa Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis
EP2202232A1 (en) 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
EP2210890A1 (en) 2009-01-19 2010-07-28 Almirall, S.A. Oxadiazole derivatives as S1P1 receptor agonists
WO2010085582A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
JP2012515787A (ja) 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー 自己免疫疾患および炎症性疾患の処置におけるs1pアゴニストとしての置換オキサジアゾール誘導体
US8389509B2 (en) 2009-01-23 2013-03-05 Bristol-Myers Squibb Company Substituted pyrazole compounds
JP2012517445A (ja) 2009-02-10 2012-08-02 アボット・ラボラトリーズ S1p受容体アゴニストおよびアンタゴニストを調製するための方法
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
ES2759949T3 (es) 2009-10-29 2020-05-12 Bristol Myers Squibb Co Compuestos heterocíclicos tricíclicos
EP2560969B1 (en) 2010-04-23 2015-08-12 Bristol-Myers Squibb Company 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists
CN102260178A (zh) 2010-05-25 2011-11-30 中国医学科学院药物研究所 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途
CN102260177A (zh) 2010-05-25 2011-11-30 中国医学科学院药物研究所 丙二醇类衍生物、其制备方法和其药物组合物与用途
US8822510B2 (en) 2010-07-20 2014-09-02 Bristol-Myers Squibb Company Substituted 3-phenyl-1,2,4-Oxadiazole compounds
ES2548258T3 (es) 2010-09-24 2015-10-15 Bristol-Myers Squibb Company Compuestos de oxadiazol sustituidos y su uso como agonistas de S1P1
ES2525298T3 (es) 2010-11-03 2014-12-19 Bristol-Myers Squibb Company Compuestos heterocíclicos como agonistas del S1P1 para el tratamiento de enfermedades autoinmunes y vasculares
WO2012129073A2 (en) * 2011-03-18 2012-09-27 University Of Virginia Patent Foundation Compositions and methods for tissue engineering and cell based therapies
EP2541155B1 (en) 2011-04-26 2016-02-24 Panasonic Intellectual Property Management Co., Ltd. Heating system, and heating system control method
GB201107325D0 (en) * 2011-05-04 2011-06-15 Glaxosmithkline Llc Novel compounds
JP6129159B2 (ja) 2011-05-13 2017-05-17 レセプトス エルエルシー 選択的複素環式スフィンゴシン1−リン酸受容体モジュレーター
JP6324380B2 (ja) 2012-07-27 2018-05-16 バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. S1p調節剤および/またはatx調節剤である化合物

Similar Documents

Publication Publication Date Title
JP2016513124A5 (OSRAM)
RU2016105581A (ru) Способ лечения острого, хронического и подострого кашля и непреодолимого желания откашляться
MX381180B (es) Compuestos aminopirazina con propiedades antagonistas a2a.
EP4275756A3 (en) Bipyrazole derivatives as jak inhibitors
JP2016539134A5 (OSRAM)
AR101177A1 (es) Inhibidores de la syk
JP2010174019A5 (OSRAM)
JP2017514910A5 (OSRAM)
EA201690287A1 (ru) 1,4-дизамещенные аналоги пиридазин хинолина и способы лечения состояний, связанных с smn-дефицитом
RU2014135436A (ru) Комбинация ингибитора rtk с антиэстрогеном и ее применение для лечения рака
JP2016510326A5 (OSRAM)
IL292465B2 (en) Neuroactive compounds and methods of use thereof
JP2015526391A5 (OSRAM)
RU2019121667A (ru) Аминопиразолы в качестве селективных ингибиторов янус-киназы
JP2013518036A5 (OSRAM)
JP2017511377A5 (OSRAM)
JP2019516739A5 (OSRAM)
RU2017106172A (ru) Применение антагонистов cxcr2 для предотвращения и/или лечения периферической невропатии, вызванной химиотерапией (cipn)
RU2016132762A (ru) Фармацевтические композиции, содержащие 15-гэпк, и способы лечения астмы и заболеваний легких с их применением
Tigyi et al. Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential
JP2014513065A5 (OSRAM)
BR112015019919A2 (pt) compostos bicíclicos
EP4414037A3 (en) Morphinan derivatives for the treatment of opioid delta receptor agonist-related diseases
RU2015135824A (ru) Бициклические соединения пиримидона в качестве ингибиторов lp-pla2
BR112012022632A2 (pt) Medicamento compreendendo agonista de ep4