JP2016510326A5 - - Google Patents

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Publication number
JP2016510326A5
JP2016510326A5 JP2015553856A JP2015553856A JP2016510326A5 JP 2016510326 A5 JP2016510326 A5 JP 2016510326A5 JP 2015553856 A JP2015553856 A JP 2015553856A JP 2015553856 A JP2015553856 A JP 2015553856A JP 2016510326 A5 JP2016510326 A5 JP 2016510326A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
treatment
compound
cardiovascular disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015553856A
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English (en)
Japanese (ja)
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JP2016510326A (ja
JP6449171B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2014/012085 external-priority patent/WO2014113696A1/en
Publication of JP2016510326A publication Critical patent/JP2016510326A/ja
Publication of JP2016510326A5 publication Critical patent/JP2016510326A5/ja
Application granted granted Critical
Publication of JP6449171B2 publication Critical patent/JP6449171B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2015553856A 2013-01-18 2014-01-17 治療指数の改善されたニトロキシル供与体 Expired - Fee Related JP6449171B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361754237P 2013-01-18 2013-01-18
US61/754,237 2013-01-18
US201361782781P 2013-03-14 2013-03-14
US61/782,781 2013-03-14
PCT/US2014/012085 WO2014113696A1 (en) 2013-01-18 2014-01-17 Nitroxyl donors with improved therapeutic index

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2017005276A Division JP6311038B2 (ja) 2013-01-18 2017-01-16 治療指数の改善されたニトロキシル供与体
JP2018228317A Division JP6656345B2 (ja) 2013-01-18 2018-12-05 治療指数の改善されたニトロキシル供与体

Publications (3)

Publication Number Publication Date
JP2016510326A JP2016510326A (ja) 2016-04-07
JP2016510326A5 true JP2016510326A5 (OSRAM) 2017-02-23
JP6449171B2 JP6449171B2 (ja) 2019-01-09

Family

ID=50064795

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2015553856A Expired - Fee Related JP6449171B2 (ja) 2013-01-18 2014-01-17 治療指数の改善されたニトロキシル供与体
JP2015553858A Expired - Fee Related JP6533159B2 (ja) 2013-01-18 2014-01-17 ニトロキシル供与体を含む医薬組成物
JP2017005276A Expired - Fee Related JP6311038B2 (ja) 2013-01-18 2017-01-16 治療指数の改善されたニトロキシル供与体
JP2018228317A Active JP6656345B2 (ja) 2013-01-18 2018-12-05 治療指数の改善されたニトロキシル供与体
JP2019096869A Expired - Fee Related JP6801045B2 (ja) 2013-01-18 2019-05-23 ニトロキシル供与体を含む医薬組成物

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2015553858A Expired - Fee Related JP6533159B2 (ja) 2013-01-18 2014-01-17 ニトロキシル供与体を含む医薬組成物
JP2017005276A Expired - Fee Related JP6311038B2 (ja) 2013-01-18 2017-01-16 治療指数の改善されたニトロキシル供与体
JP2018228317A Active JP6656345B2 (ja) 2013-01-18 2018-12-05 治療指数の改善されたニトロキシル供与体
JP2019096869A Expired - Fee Related JP6801045B2 (ja) 2013-01-18 2019-05-23 ニトロキシル供与体を含む医薬組成物

Country Status (29)

Country Link
US (13) US8987326B2 (OSRAM)
EP (5) EP3427728B1 (OSRAM)
JP (5) JP6449171B2 (OSRAM)
KR (2) KR102177899B1 (OSRAM)
CN (4) CN105142627B (OSRAM)
AU (5) AU2014207404B2 (OSRAM)
BR (2) BR112015017251B1 (OSRAM)
CA (2) CA2898445C (OSRAM)
CY (3) CY1120535T1 (OSRAM)
DK (3) DK2945621T3 (OSRAM)
ES (4) ES2882279T3 (OSRAM)
HK (1) HK1251170B (OSRAM)
HR (3) HRP20182144T1 (OSRAM)
HU (3) HUE041861T2 (OSRAM)
IL (4) IL239906B (OSRAM)
LT (3) LT2945621T (OSRAM)
MX (2) MX363843B (OSRAM)
NZ (4) NZ709986A (OSRAM)
PL (3) PL3284463T3 (OSRAM)
PT (3) PT3284463T (OSRAM)
RS (3) RS59434B1 (OSRAM)
RU (3) RU2684916C2 (OSRAM)
SG (6) SG11201505568PA (OSRAM)
SI (3) SI3284463T1 (OSRAM)
SM (3) SMT201800088T1 (OSRAM)
TR (1) TR201802211T4 (OSRAM)
TW (3) TWI686193B (OSRAM)
WO (2) WO2014113696A1 (OSRAM)
ZA (2) ZA201505090B (OSRAM)

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PT2489350E (pt) 2006-03-17 2014-03-10 Univ Johns Hopkins Med Derivados de n-hidroxilsulfonamida como novos dadores de nitroxilo fisiologicamente úteis
US9181213B2 (en) 2011-10-17 2015-11-10 The Johns Hopkins University Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors
BR112015017251B1 (pt) 2013-01-18 2021-10-26 Cardioxyl Pharmaceuticals, Inc. Composições farmacêuticas compreendendo doadores de nitroxil, misturas e usos das referidas composições farmacêuticas
EP3126329B1 (en) 2014-01-17 2019-05-29 Cardioxyl Pharmaceuticals Inc. N-hydroxymethanesulfonamide nitroxyl donors
ES2749682T3 (es) 2014-05-27 2020-03-23 Cardioxyl Pharmaceuticals Inc Derivados de pirazolona como donadores de nitroxilo
US9464061B2 (en) 2014-05-27 2016-10-11 The Johns Hopkins University N-hydroxylamino-barbituric acid derivatives
US10456405B2 (en) 2015-09-07 2019-10-29 Zhejiang Huahai Pharmaceutical Co., Ltd Nitric oxide-releasing prodrug molecule of substituted quinazolines
EP3365328A1 (en) 2015-10-19 2018-08-29 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
WO2017070084A1 (en) 2015-10-19 2017-04-27 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
EP3490975B1 (en) 2016-07-28 2021-05-05 The Johns Hopkins University O-substituted hydroxamic acids
EP3565544A1 (en) 2017-01-03 2019-11-13 Cardioxyl Pharmaceuticals Inc. Method of administering nitroxyl donating compounds
WO2018193006A1 (en) * 2017-04-18 2018-10-25 Genfit Combination of elafibranor or derivatives thereof with an anti-nash, anti-fibrotic or anti-cholestatic agent
CN116283762B (zh) * 2023-03-28 2025-08-12 昆山市第一人民医院 一种用于制备白鲜碱的中间体化合物及其制备方法、白鲜碱的制备方法
WO2025043108A1 (en) 2023-08-23 2025-02-27 Bristol -Myers S Quibb Company Co-crystals of nitroxyl donating compounds

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