JP6277210B2 - 二環式化合物 - Google Patents
二環式化合物 Download PDFInfo
- Publication number
- JP6277210B2 JP6277210B2 JP2015558976A JP2015558976A JP6277210B2 JP 6277210 B2 JP6277210 B2 JP 6277210B2 JP 2015558976 A JP2015558976 A JP 2015558976A JP 2015558976 A JP2015558976 A JP 2015558976A JP 6277210 B2 JP6277210 B2 JP 6277210B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- mmol
- salt
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- -1 Bicyclic compound Chemical class 0.000 title description 65
- 150000001875 compounds Chemical class 0.000 claims description 298
- 150000003839 salts Chemical class 0.000 claims description 103
- 239000007787 solid Substances 0.000 claims description 55
- 230000000694 effects Effects 0.000 claims description 38
- 239000008194 pharmaceutical composition Substances 0.000 claims description 36
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
- 239000003937 drug carrier Substances 0.000 claims description 20
- 208000023275 Autoimmune disease Diseases 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 17
- 206010025135 lupus erythematosus Diseases 0.000 claims description 12
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 11
- 201000006417 multiple sclerosis Diseases 0.000 claims description 11
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 9
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 4
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 4
- 208000037976 chronic inflammation Diseases 0.000 claims description 4
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 171
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 161
- 235000002639 sodium chloride Nutrition 0.000 description 101
- 239000000203 mixture Substances 0.000 description 96
- 239000000243 solution Substances 0.000 description 94
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 76
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 66
- 238000001144 powder X-ray diffraction data Methods 0.000 description 65
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 61
- 235000019439 ethyl acetate Nutrition 0.000 description 61
- 150000003840 hydrochlorides Chemical class 0.000 description 55
- 239000000543 intermediate Substances 0.000 description 47
- 210000004027 cell Anatomy 0.000 description 46
- DUYSYHSSBDVJSM-KRWOKUGFSA-N sphingosine 1-phosphate Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O DUYSYHSSBDVJSM-KRWOKUGFSA-N 0.000 description 43
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 41
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 36
- 239000011541 reaction mixture Substances 0.000 description 35
- 239000002904 solvent Substances 0.000 description 33
- 229910019142 PO4 Inorganic materials 0.000 description 31
- 238000004128 high performance liquid chromatography Methods 0.000 description 31
- 230000014759 maintenance of location Effects 0.000 description 31
- 235000021317 phosphate Nutrition 0.000 description 31
- 239000010452 phosphate Substances 0.000 description 30
- 230000002829 reductive effect Effects 0.000 description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 29
- IWYDHOAUDWTVEP-SSDOTTSWSA-N (R)-mandelic acid Chemical class OC(=O)[C@H](O)C1=CC=CC=C1 IWYDHOAUDWTVEP-SSDOTTSWSA-N 0.000 description 28
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 28
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 27
- 238000006243 chemical reaction Methods 0.000 description 25
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 24
- 238000003756 stirring Methods 0.000 description 23
- 150000004682 monohydrates Chemical class 0.000 description 21
- 238000000034 method Methods 0.000 description 20
- 102000004169 proteins and genes Human genes 0.000 description 20
- 108090000623 proteins and genes Proteins 0.000 description 20
- 239000000741 silica gel Substances 0.000 description 20
- 229910002027 silica gel Inorganic materials 0.000 description 20
- 238000003556 assay Methods 0.000 description 19
- 239000003814 drug Substances 0.000 description 19
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 18
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 18
- 210000004698 lymphocyte Anatomy 0.000 description 18
- 238000004519 manufacturing process Methods 0.000 description 18
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 17
- 239000000725 suspension Substances 0.000 description 17
- 241000699670 Mus sp. Species 0.000 description 16
- 239000003085 diluting agent Substances 0.000 description 16
- 239000003921 oil Substances 0.000 description 16
- 235000019198 oils Nutrition 0.000 description 16
- 241001465754 Metazoa Species 0.000 description 15
- 229910052739 hydrogen Inorganic materials 0.000 description 15
- 239000012044 organic layer Substances 0.000 description 15
- 238000000746 purification Methods 0.000 description 15
- 239000003981 vehicle Substances 0.000 description 15
- 239000000556 agonist Substances 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 13
- 239000013078 crystal Chemical group 0.000 description 13
- 235000019441 ethanol Nutrition 0.000 description 13
- 239000007788 liquid Substances 0.000 description 13
- 229910052757 nitrogen Inorganic materials 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 229920006395 saturated elastomer Polymers 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 11
- 239000002253 acid Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 238000009472 formulation Methods 0.000 description 11
- 230000002265 prevention Effects 0.000 description 11
- 102000005962 receptors Human genes 0.000 description 11
- 108020003175 receptors Proteins 0.000 description 11
- 239000012453 solvate Substances 0.000 description 11
- 239000003826 tablet Substances 0.000 description 11
- 210000001519 tissue Anatomy 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 10
- 241000124008 Mammalia Species 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 description 10
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 description 10
- 239000002671 adjuvant Substances 0.000 description 10
- 206010009887 colitis Diseases 0.000 description 10
- 238000010828 elution Methods 0.000 description 10
- 238000003818 flash chromatography Methods 0.000 description 10
- 230000002685 pulmonary effect Effects 0.000 description 10
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 9
- OKKJLVBELUTLKV-MZCSYVLQSA-N Deuterated methanol Chemical compound [2H]OC([2H])([2H])[2H] OKKJLVBELUTLKV-MZCSYVLQSA-N 0.000 description 9
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 9
- 230000001363 autoimmune Effects 0.000 description 9
- 239000013058 crude material Substances 0.000 description 9
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 9
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 description 8
- OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 208000006673 asthma Diseases 0.000 description 8
- 239000000872 buffer Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000003995 emulsifying agent Substances 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 238000002054 transplantation Methods 0.000 description 8
- 208000019553 vascular disease Diseases 0.000 description 8
- 208000003456 Juvenile Arthritis Diseases 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- 239000010410 layer Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 210000000056 organ Anatomy 0.000 description 7
- 230000026731 phosphorylation Effects 0.000 description 7
- 238000006366 phosphorylation reaction Methods 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- 239000000651 prodrug Substances 0.000 description 7
- 229940002612 prodrug Drugs 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 239000011780 sodium chloride Substances 0.000 description 7
- XOFLBQFBSOEHOG-UUOKFMHZSA-N γS-GTP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=S)[C@@H](O)[C@H]1O XOFLBQFBSOEHOG-UUOKFMHZSA-N 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 6
- 229920000858 Cyclodextrin Polymers 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 239000007900 aqueous suspension Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000002178 crystalline material Substances 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 208000027866 inflammatory disease Diseases 0.000 description 6
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 231100000252 nontoxic Toxicity 0.000 description 6
- 230000003000 nontoxic effect Effects 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 229940124597 therapeutic agent Drugs 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 6
- 239000000080 wetting agent Substances 0.000 description 6
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 5
- PDBXHPORMXSXKO-UHFFFAOYSA-N 8-benzyl-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]-1,3-dimethylpurine-2,6-dione;hydron;chloride Chemical class Cl.N=1C=2N(C)C(=O)N(C)C(=O)C=2N(CCN(CCO)CC)C=1CC1=CC=CC=C1 PDBXHPORMXSXKO-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 201000004681 Psoriasis Diseases 0.000 description 5
- 206010061924 Pulmonary toxicity Diseases 0.000 description 5
- BPMMYKAHRIEVDH-VOQZNFBZSA-N [(1r,3s)-1-amino-3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]cyclopentyl]methanol Chemical compound C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2[C@H]1CC[C@](N)(CO)C1 BPMMYKAHRIEVDH-VOQZNFBZSA-N 0.000 description 5
- 230000000996 additive effect Effects 0.000 description 5
- 230000001476 alcoholic effect Effects 0.000 description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 5
- 239000002775 capsule Substances 0.000 description 5
- 239000007859 condensation product Substances 0.000 description 5
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 229960003957 dexamethasone Drugs 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 235000019197 fats Nutrition 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000003599 food sweetener Nutrition 0.000 description 5
- 238000004108 freeze drying Methods 0.000 description 5
- DKAGJZJALZXOOV-UHFFFAOYSA-N hydrate;hydrochloride Chemical compound O.Cl DKAGJZJALZXOOV-UHFFFAOYSA-N 0.000 description 5
- 210000000987 immune system Anatomy 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 239000002953 phosphate buffered saline Substances 0.000 description 5
- 231100000374 pneumotoxicity Toxicity 0.000 description 5
- 229940068886 polyethylene glycol 300 Drugs 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 239000012279 sodium borohydride Substances 0.000 description 5
- 229910000033 sodium borohydride Inorganic materials 0.000 description 5
- 230000002269 spontaneous effect Effects 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 5
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- ZZMYWYZPNZRYPX-SANMLTNESA-N (2r)-2-amino-2-[5-[4-[2-(4-phenylphenyl)ethoxy]-3-(trifluoromethyl)phenyl]-1h-imidazol-2-yl]propan-1-ol Chemical compound N1C([C@@](N)(CO)C)=NC=C1C(C=C1C(F)(F)F)=CC=C1OCCC1=CC=C(C=2C=CC=CC=2)C=C1 ZZMYWYZPNZRYPX-SANMLTNESA-N 0.000 description 4
- HXBKFSNTNCFTHX-QHGLUPRGSA-N (3s)-1-amino-3-(4-bromophenyl)cyclopentane-1-carboxylic acid Chemical compound C1C(N)(C(O)=O)CC[C@@H]1C1=CC=C(Br)C=C1 HXBKFSNTNCFTHX-QHGLUPRGSA-N 0.000 description 4
- AJKPXKHWCHZLSF-VIFPVBQESA-N (3s)-3-(4-bromophenyl)cyclopentan-1-one Chemical compound C1=CC(Br)=CC=C1[C@@H]1CC(=O)CC1 AJKPXKHWCHZLSF-VIFPVBQESA-N 0.000 description 4
- BHKKSKOHRFHHIN-MRVPVSSYSA-N 1-[[2-[(1R)-1-aminoethyl]-4-chlorophenyl]methyl]-2-sulfanylidene-5H-pyrrolo[3,2-d]pyrimidin-4-one Chemical compound N[C@H](C)C1=C(CN2C(NC(C3=C2C=CN3)=O)=S)C=CC(=C1)Cl BHKKSKOHRFHHIN-MRVPVSSYSA-N 0.000 description 4
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 4
- 108700031361 Brachyury Proteins 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 4
- 208000011231 Crohn disease Diseases 0.000 description 4
- BZKFMUIJRXWWQK-UHFFFAOYSA-N Cyclopentenone Chemical compound O=C1CCC=C1 BZKFMUIJRXWWQK-UHFFFAOYSA-N 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 4
- 206010061818 Disease progression Diseases 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 4
- 239000007995 HEPES buffer Substances 0.000 description 4
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 4
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 4
- 235000019483 Peanut oil Nutrition 0.000 description 4
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- BWKSEIHXZRSETR-VOQZNFBZSA-N [(1r,3s)-1-amino-3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]cyclopentyl]methyl dihydrogen phosphate Chemical compound C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2[C@H]1CC[C@](N)(COP(O)(O)=O)C1 BWKSEIHXZRSETR-VOQZNFBZSA-N 0.000 description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 4
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 239000012267 brine Substances 0.000 description 4
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000005750 disease progression Effects 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 239000002024 ethyl acetate extract Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 229940116298 l- malic acid Drugs 0.000 description 4
- 239000003446 ligand Substances 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 235000011090 malic acid Nutrition 0.000 description 4
- 238000010172 mouse model Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
- KJIFKLIQANRMOU-UHFFFAOYSA-N oxidanium;4-methylbenzenesulfonate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1 KJIFKLIQANRMOU-UHFFFAOYSA-N 0.000 description 4
- 239000000312 peanut oil Substances 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 238000000159 protein binding assay Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- GKJWLMMNYJYRMH-RHSMWYFYSA-N (5r,8r)-8-(6-oxo-7,8-dihydro-5h-naphthalen-2-yl)-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C1OC(=O)N[C@]11C[C@H](C=2C=C3CCC(=O)CC3=CC=2)CC1 GKJWLMMNYJYRMH-RHSMWYFYSA-N 0.000 description 3
- YWDMQBOJTQAWOO-GCXSUNMLSA-N (5r,8s)-8-(6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C([C@@H](C1)C=2C=C3CCC(CC3=CC=2)CCCCCC)C[C@@]21COC(=O)N2 YWDMQBOJTQAWOO-GCXSUNMLSA-N 0.000 description 3
- GKJWLMMNYJYRMH-WMLDXEAASA-N (5r,8s)-8-(6-oxo-7,8-dihydro-5h-naphthalen-2-yl)-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C1OC(=O)N[C@]11C[C@@H](C=2C=C3CCC(=O)CC3=CC=2)CC1 GKJWLMMNYJYRMH-WMLDXEAASA-N 0.000 description 3
- LNBAOWJYCPKZOS-LLTODGECSA-N (8s)-8-(4-bromophenyl)-1,3-diazaspiro[4.4]nonane-2,4-dione Chemical compound C1=CC(Br)=CC=C1[C@@H]1CC2(C(NC(=O)N2)=O)CC1 LNBAOWJYCPKZOS-LLTODGECSA-N 0.000 description 3
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 208000009137 Behcet syndrome Diseases 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 206010009900 Colitis ulcerative Diseases 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 208000009386 Experimental Arthritis Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010019663 Hepatic failure Diseases 0.000 description 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 108010005716 Interferon beta-1a Proteins 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
- 206010034277 Pemphigoid Diseases 0.000 description 3
- 206010037423 Pulmonary oedema Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 102100025750 Sphingosine 1-phosphate receptor 1 Human genes 0.000 description 3
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 3
- 201000006704 Ulcerative Colitis Diseases 0.000 description 3
- 206010046851 Uveitis Diseases 0.000 description 3
- BPMMYKAHRIEVDH-ZPMCFJSWSA-N [(1r,3r)-1-amino-3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]cyclopentyl]methanol Chemical compound C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2[C@@H]1CC[C@](N)(CO)C1 BPMMYKAHRIEVDH-ZPMCFJSWSA-N 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 235000019270 ammonium chloride Nutrition 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 208000037979 autoimmune inflammatory disease Diseases 0.000 description 3
- 125000002619 bicyclic group Chemical group 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 3
- 208000007118 chronic progressive multiple sclerosis Diseases 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 208000004921 cutaneous lupus erythematosus Diseases 0.000 description 3
- 229940097362 cyclodextrins Drugs 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 239000012458 free base Substances 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical class I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 206010023332 keratitis Diseases 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- 238000011694 lewis rat Methods 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 3
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 3
- 208000007903 liver failure Diseases 0.000 description 3
- 231100000835 liver failure Toxicity 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- DXRSYLNLGBXYNJ-ZWNOBZJWSA-N methyl (1r,3r)-1-amino-3-(4-bromophenyl)cyclopentane-1-carboxylate Chemical compound C1[C@](C(=O)OC)(N)CC[C@H]1C1=CC=C(Br)C=C1 DXRSYLNLGBXYNJ-ZWNOBZJWSA-N 0.000 description 3
- 239000004530 micro-emulsion Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000346 nonvolatile oil Substances 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
- 239000004006 olive oil Substances 0.000 description 3
- 235000008390 olive oil Nutrition 0.000 description 3
- TWHXWYVOWJCXSI-UHFFFAOYSA-N phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O TWHXWYVOWJCXSI-UHFFFAOYSA-N 0.000 description 3
- 238000000634 powder X-ray diffraction Methods 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 230000007047 pulmonary toxicity Effects 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 238000010791 quenching Methods 0.000 description 3
- 238000004007 reversed phase HPLC Methods 0.000 description 3
- 201000000306 sarcoidosis Diseases 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 3
- FVPNKZJQHZSTPV-DNVCBOLYSA-N tert-butyl 2-[4-[(5r,8r)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-8-yl]phenyl]acetate Chemical compound C1=CC(CC(=O)OC(C)(C)C)=CC=C1[C@H]1C[C@]2(NC(=O)OC2)CC1 FVPNKZJQHZSTPV-DNVCBOLYSA-N 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 210000003437 trachea Anatomy 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- OQSYMLDNKYLJGE-GFCCVEGCSA-N (2r)-2-hexyl-6-iodo-3,4-dihydro-2h-naphthalen-1-one Chemical compound IC1=CC=C2C(=O)[C@H](CCCCCC)CCC2=C1 OQSYMLDNKYLJGE-GFCCVEGCSA-N 0.000 description 2
- AJKPXKHWCHZLSF-SECBINFHSA-N (3r)-3-(4-bromophenyl)cyclopentan-1-one Chemical compound C1=CC(Br)=CC=C1[C@H]1CC(=O)CC1 AJKPXKHWCHZLSF-SECBINFHSA-N 0.000 description 2
- QBLFZIBJXUQVRF-UHFFFAOYSA-N (4-bromophenyl)boronic acid Chemical compound OB(O)C1=CC=C(Br)C=C1 QBLFZIBJXUQVRF-UHFFFAOYSA-N 0.000 description 2
- OOTMIYJRYRVSIC-ZWNOBZJWSA-N (5r,8r)-8-(4-bromophenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C1=CC(Br)=CC=C1[C@H]1C[C@]2(NC(=O)OC2)CC1 OOTMIYJRYRVSIC-ZWNOBZJWSA-N 0.000 description 2
- HIVPKYMYZGCUOY-DENIHFKCSA-N (5r,8r)-8-(6-pentoxynaphthalen-2-yl)-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C([C@H](C1)C2=CC3=CC=C(C=C3C=C2)OCCCCC)C[C@@]21COC(=O)N2 HIVPKYMYZGCUOY-DENIHFKCSA-N 0.000 description 2
- VQRSZQSVNKYHGM-JTHBVZDNSA-N (5r,8s)-8-(6-hexyl-7,8-dihydronaphthalen-2-yl)-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C([C@@H](C1)C2=CC=C3C=C(CCC3=C2)CCCCCC)C[C@@]21COC(=O)N2 VQRSZQSVNKYHGM-JTHBVZDNSA-N 0.000 description 2
- YWDMQBOJTQAWOO-FRGLQRNOSA-N (5r,8s)-8-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C([C@@H](C1)C=2C=C3CC[C@H](CC3=CC=2)CCCCCC)C[C@@]21COC(=O)N2 YWDMQBOJTQAWOO-FRGLQRNOSA-N 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- VRUSOGVWBNCRSU-AWEZNQCLSA-N 6-iodo-n-[(2s)-2-(methoxymethyl)pyrrolidin-1-yl]-3,4-dihydro-2h-naphthalen-1-imine Chemical compound COC[C@@H]1CCCN1N=C1C2=CC=C(I)C=C2CCC1 VRUSOGVWBNCRSU-AWEZNQCLSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- 208000032467 Aplastic anaemia Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 description 2
- 102100032937 CD40 ligand Human genes 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- 102000036530 EDG receptors Human genes 0.000 description 2
- 108091007263 EDG receptors Proteins 0.000 description 2
- 206010060742 Endocrine ophthalmopathy Diseases 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- 241000400611 Eucalyptus deanei Species 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 108010072051 Glatiramer Acetate Proteins 0.000 description 2
- 206010018364 Glomerulonephritis Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 108010005714 Interferon beta-1b Proteins 0.000 description 2
- 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 2
- 108700021006 Interleukin-1 receptor antagonist Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 2
- 208000005777 Lupus Nephritis Diseases 0.000 description 2
- 206010025327 Lymphopenia Diseases 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 206010029240 Neuritis Diseases 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 206010036105 Polyneuropathy Diseases 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 101710155454 Sphingosine 1-phosphate receptor 1 Proteins 0.000 description 2
- 102100025747 Sphingosine 1-phosphate receptor 3 Human genes 0.000 description 2
- 102100029802 Sphingosine 1-phosphate receptor 5 Human genes 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 2
- 208000001106 Takayasu Arteritis Diseases 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 206010052779 Transplant rejections Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010047115 Vasculitis Diseases 0.000 description 2
- 206010047642 Vitiligo Diseases 0.000 description 2
- MKDOHHWCOHETDN-ZYHUDNBSSA-N [(1r,3r)-1-amino-3-(4-bromophenyl)cyclopentyl]methanol Chemical compound C1[C@@](N)(CO)CC[C@H]1C1=CC=C(Br)C=C1 MKDOHHWCOHETDN-ZYHUDNBSSA-N 0.000 description 2
- BWKSEIHXZRSETR-ZPMCFJSWSA-N [(1r,3r)-1-amino-3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]cyclopentyl]methyl dihydrogen phosphate Chemical group C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2[C@@H]1CC[C@](N)(COP(O)(O)=O)C1 BWKSEIHXZRSETR-ZPMCFJSWSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 150000001447 alkali salts Chemical class 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 235000012501 ammonium carbonate Nutrition 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 239000005557 antagonist Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000012131 assay buffer Substances 0.000 description 2
- 239000000305 astragalus gummifer gum Substances 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- CBHOOMGKXCMKIR-UHFFFAOYSA-N azane;methanol Chemical compound N.OC CBHOOMGKXCMKIR-UHFFFAOYSA-N 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-M bisulphate group Chemical group S([O-])(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 2
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 235000010216 calcium carbonate Nutrition 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229910002091 carbon monoxide Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000036755 cellular response Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000004296 chiral HPLC Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 229940126214 compound 3 Drugs 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 2
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 2
- SWZTYAVBMYWFGS-UHFFFAOYSA-N fingolimod hydrochloride Chemical compound Cl.CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 SWZTYAVBMYWFGS-UHFFFAOYSA-N 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 102000037865 fusion proteins Human genes 0.000 description 2
- 108020001507 fusion proteins Proteins 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 230000003779 hair growth Effects 0.000 description 2
- VKCYHJWLYTUGCC-UHFFFAOYSA-N heptyl methyl ketone Natural products CCCCCCCC(C)=O VKCYHJWLYTUGCC-UHFFFAOYSA-N 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 150000004677 hydrates Chemical class 0.000 description 2
- 206010021198 ichthyosis Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 208000012947 ischemia reperfusion injury Diseases 0.000 description 2
- 208000023589 ischemic disease Diseases 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 210000005210 lymphoid organ Anatomy 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- DXRSYLNLGBXYNJ-NKUHCKNESA-N methyl (3s)-1-amino-3-(4-bromophenyl)cyclopentane-1-carboxylate Chemical compound C1C(C(=O)OC)(N)CC[C@@H]1C1=CC=C(Br)C=C1 DXRSYLNLGBXYNJ-NKUHCKNESA-N 0.000 description 2
- VYMRLVTXKZJSLY-OXYBSBDGSA-N methyl 1-amino-3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]cyclopentane-1-carboxylate Chemical compound C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2C1CCC(N)(C(=O)OC)C1 VYMRLVTXKZJSLY-OXYBSBDGSA-N 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 201000005962 mycosis fungoides Diseases 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000008389 polyethoxylated castor oil Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 208000019629 polyneuritis Diseases 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 201000001474 proteinuria Diseases 0.000 description 2
- 208000005333 pulmonary edema Diseases 0.000 description 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 230000033300 receptor internalization Effects 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 150000003902 salicylic acid esters Chemical class 0.000 description 2
- WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical compound OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- 229960002930 sirolimus Drugs 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 235000011069 sorbitan monooleate Nutrition 0.000 description 2
- 239000001593 sorbitan monooleate Substances 0.000 description 2
- 229940035049 sorbitan monooleate Drugs 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 2
- FVPNKZJQHZSTPV-HNAYVOBHSA-N tert-butyl 2-[4-[(5r,8s)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-8-yl]phenyl]acetate Chemical compound C1=CC(CC(=O)OC(C)(C)C)=CC=C1[C@@H]1C[C@]2(NC(=O)OC2)CC1 FVPNKZJQHZSTPV-HNAYVOBHSA-N 0.000 description 2
- QOGUTPAJFDLMSW-WMVAVLGLSA-N tert-butyl n-[(1r,3s)-3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]-1-(hydroxymethyl)cyclopentyl]carbamate Chemical compound C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2[C@H]1CC[C@@](CO)(NC(=O)OC(C)(C)C)C1 QOGUTPAJFDLMSW-WMVAVLGLSA-N 0.000 description 2
- NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical compound [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- AQRLNPVMDITEJU-UHFFFAOYSA-N triethylsilane Chemical compound CC[SiH](CC)CC AQRLNPVMDITEJU-UHFFFAOYSA-N 0.000 description 2
- PYOKUURKVVELLB-UHFFFAOYSA-N trimethyl orthoformate Chemical compound COC(OC)OC PYOKUURKVVELLB-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 150000003751 zinc Chemical class 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- 235000004835 α-tocopherol Nutrition 0.000 description 2
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical class CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
- RRKODOZNUZCUBN-CCAGOZQPSA-N (1z,3z)-cycloocta-1,3-diene Chemical compound C1CC\C=C/C=C\C1 RRKODOZNUZCUBN-CCAGOZQPSA-N 0.000 description 1
- UEPBHWJLMSHADB-CYBMUJFWSA-N (2r)-2-hexyl-6-iodo-1,2,3,4-tetrahydronaphthalene Chemical compound IC1=CC=C2C[C@H](CCCCCC)CCC2=C1 UEPBHWJLMSHADB-CYBMUJFWSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- BWSIKGOGLDNQBZ-LURJTMIESA-N (2s)-2-(methoxymethyl)pyrrolidin-1-amine Chemical compound COC[C@@H]1CCCN1N BWSIKGOGLDNQBZ-LURJTMIESA-N 0.000 description 1
- LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 1
- HXBKFSNTNCFTHX-PKEIRNPWSA-N (3r)-1-amino-3-(4-bromophenyl)cyclopentane-1-carboxylic acid Chemical compound C1C(N)(C(O)=O)CC[C@H]1C1=CC=C(Br)C=C1 HXBKFSNTNCFTHX-PKEIRNPWSA-N 0.000 description 1
- OOTMIYJRYRVSIC-GXFFZTMASA-N (5r,8s)-8-(4-bromophenyl)-3-oxa-1-azaspiro[4.4]nonan-2-one Chemical compound C1=CC(Br)=CC=C1[C@@H]1C[C@]2(NC(=O)OC2)CC1 OOTMIYJRYRVSIC-GXFFZTMASA-N 0.000 description 1
- HMLGSIZOMSVISS-ONJSNURVSA-N (7r)-7-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2,2-dimethylpropanoyloxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound N([C@@H]1C(N2C(=C(C=C)CSC21)C(O)=O)=O)C(=O)\C(=N/OCOC(=O)C(C)(C)C)C1=CSC(N)=N1 HMLGSIZOMSVISS-ONJSNURVSA-N 0.000 description 1
- LNBAOWJYCPKZOS-CGCSKFHYSA-N (8r)-8-(4-bromophenyl)-1,3-diazaspiro[4.4]nonane-2,4-dione Chemical compound C1=CC(Br)=CC=C1[C@H]1CC2(C(NC(=O)N2)=O)CC1 LNBAOWJYCPKZOS-CGCSKFHYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- DIOHEXPTUTVCNX-UHFFFAOYSA-N 1,1,1-trifluoro-n-phenyl-n-(trifluoromethylsulfonyl)methanesulfonamide Chemical compound FC(F)(F)S(=O)(=O)N(S(=O)(=O)C(F)(F)F)C1=CC=CC=C1 DIOHEXPTUTVCNX-UHFFFAOYSA-N 0.000 description 1
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical class CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
- ANOOTOPTCJRUPK-UHFFFAOYSA-N 1-iodohexane Chemical compound CCCCCCI ANOOTOPTCJRUPK-UHFFFAOYSA-N 0.000 description 1
- XHLHPRDBBAGVEG-UHFFFAOYSA-N 1-tetralone Chemical compound C1=CC=C2C(=O)CCCC2=C1 XHLHPRDBBAGVEG-UHFFFAOYSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- LJPUUXIGVUIMQN-IUODEOHRSA-N 2-[4-[(5r,8r)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-8-yl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1[C@H]1C[C@]2(NC(=O)OC2)CC1 LJPUUXIGVUIMQN-IUODEOHRSA-N 0.000 description 1
- LJPUUXIGVUIMQN-SWLSCSKDSA-N 2-[4-[(5r,8s)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-8-yl]phenyl]acetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1[C@@H]1C[C@]2(NC(=O)OC2)CC1 LJPUUXIGVUIMQN-SWLSCSKDSA-N 0.000 description 1
- WMPPDTMATNBGJN-UHFFFAOYSA-N 2-phenylethylbromide Chemical compound BrCCC1=CC=CC=C1 WMPPDTMATNBGJN-UHFFFAOYSA-N 0.000 description 1
- DZCTUQNUQANFRZ-QRIPLOBPSA-N 3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]cyclopentan-1-one Chemical compound C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2C1CCC(=O)C1 DZCTUQNUQANFRZ-QRIPLOBPSA-N 0.000 description 1
- ZRPLANDPDWYOMZ-UHFFFAOYSA-N 3-cyclopentylpropionic acid Chemical class OC(=O)CCC1CCCC1 ZRPLANDPDWYOMZ-UHFFFAOYSA-N 0.000 description 1
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical class OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 description 1
- MJZJYWCQPMNPRM-UHFFFAOYSA-N 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine Chemical compound CC1(C)N=C(N)N=C(N)N1OCCCOC1=CC(Cl)=C(Cl)C=C1Cl MJZJYWCQPMNPRM-UHFFFAOYSA-N 0.000 description 1
- BEVVUJBVEXJGKM-UHFFFAOYSA-N 6-amino-3,4-dihydro-2h-naphthalen-1-one Chemical compound O=C1CCCC2=CC(N)=CC=C21 BEVVUJBVEXJGKM-UHFFFAOYSA-N 0.000 description 1
- TUMAMZXVZVEYLU-UHFFFAOYSA-N 6-iodo-3,4-dihydro-2h-naphthalen-1-one Chemical compound O=C1CCCC2=CC(I)=CC=C21 TUMAMZXVZVEYLU-UHFFFAOYSA-N 0.000 description 1
- XGWFJBFNAQHLEF-UHFFFAOYSA-N 9-anthroic acid Chemical compound C1=CC=C2C(C(=O)O)=C(C=CC=C3)C3=CC2=C1 XGWFJBFNAQHLEF-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000009304 Acute Kidney Injury Diseases 0.000 description 1
- 208000007788 Acute Liver Failure Diseases 0.000 description 1
- 208000026872 Addison Disease Diseases 0.000 description 1
- 201000010000 Agranulocytosis Diseases 0.000 description 1
- 208000035285 Allergic Seasonal Rhinitis Diseases 0.000 description 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 206010065360 Anal prolapse Diseases 0.000 description 1
- 208000028185 Angioedema Diseases 0.000 description 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 1
- 206010003827 Autoimmune hepatitis Diseases 0.000 description 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000023328 Basedow disease Diseases 0.000 description 1
- 206010004659 Biliary cirrhosis Diseases 0.000 description 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 239000004255 Butylated hydroxyanisole Substances 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- BIJUGPJTLSFCST-IFMALSPDSA-N C(CCCC)OC=1C=C2C=CC(=CC2=CC1)[C@H]1C[C@@]2(COCN2)CC1 Chemical compound C(CCCC)OC=1C=C2C=CC(=CC2=CC1)[C@H]1C[C@@]2(COCN2)CC1 BIJUGPJTLSFCST-IFMALSPDSA-N 0.000 description 1
- GZKALBHTTDGAMC-PDDLGQBUSA-N CCCCCC[C@@H]1CCC2=C(C1)C=CC(=C2)C3CCCC(C3)N Chemical compound CCCCCC[C@@H]1CCC2=C(C1)C=CC(=C2)C3CCCC(C3)N GZKALBHTTDGAMC-PDDLGQBUSA-N 0.000 description 1
- 108010029697 CD40 Ligand Proteins 0.000 description 1
- 101150013553 CD40 gene Proteins 0.000 description 1
- 101100150085 Caenorhabditis elegans sphk-1 gene Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000031229 Cardiomyopathies Diseases 0.000 description 1
- 208000002177 Cataract Diseases 0.000 description 1
- 102100038196 Chitinase-3-like protein 1 Human genes 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010008609 Cholangitis sclerosing Diseases 0.000 description 1
- 208000002691 Choroiditis Diseases 0.000 description 1
- 206010009208 Cirrhosis alcoholic Diseases 0.000 description 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 description 1
- 208000015943 Coeliac disease Diseases 0.000 description 1
- 206010009895 Colitis ischaemic Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012441 Dermatitis bullous Diseases 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 description 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010014950 Eosinophilia Diseases 0.000 description 1
- 206010014954 Eosinophilic fasciitis Diseases 0.000 description 1
- 206010014989 Epidermolysis bullosa Diseases 0.000 description 1
- 108010008165 Etanercept Proteins 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010016717 Fistula Diseases 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 208000007465 Giant cell arteritis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000024869 Goodpasture syndrome Diseases 0.000 description 1
- 208000009329 Graft vs Host Disease Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 description 1
- 229910004373 HOAc Inorganic materials 0.000 description 1
- 208000001204 Hashimoto Disease Diseases 0.000 description 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 1
- 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 1
- 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 description 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 description 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 101000693265 Homo sapiens Sphingosine 1-phosphate receptor 1 Proteins 0.000 description 1
- 101000693269 Homo sapiens Sphingosine 1-phosphate receptor 3 Proteins 0.000 description 1
- 101000653759 Homo sapiens Sphingosine 1-phosphate receptor 5 Proteins 0.000 description 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 description 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 206010021074 Hypoplastic anaemia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 101150101999 IL6 gene Proteins 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 201000003838 Idiopathic interstitial pneumonia Diseases 0.000 description 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 description 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 description 1
- 206010021263 IgA nephropathy Diseases 0.000 description 1
- 208000021330 IgG4-related disease Diseases 0.000 description 1
- 208000037142 IgG4-related systemic disease Diseases 0.000 description 1
- 208000004187 Immunoglobulin G4-Related Disease Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 229940127449 Integrin Receptor Antagonists Drugs 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 1
- 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 1
- 108090000978 Interleukin-4 Proteins 0.000 description 1
- 108010002616 Interleukin-5 Proteins 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- 201000002287 Keratoconus Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- 150000000994 L-ascorbates Chemical class 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 208000012309 Linear IgA disease Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- MQHWFIOJQSCFNM-UHFFFAOYSA-L Magnesium salicylate Chemical compound [Mg+2].OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O MQHWFIOJQSCFNM-UHFFFAOYSA-L 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 description 1
- 208000027530 Meniere disease Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 description 1
- 206010027910 Mononeuritis Diseases 0.000 description 1
- 101100508567 Mus musculus Il7 gene Proteins 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- HTLZVHNRZJPSMI-UHFFFAOYSA-N N-ethylpiperidine Chemical compound CCN1CCCCC1 HTLZVHNRZJPSMI-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- GQVOVTJYSXNBNL-DVBLDUDYSA-N N[C@]1(C[C@@H](CC1)C1=CC=C(C=C1)Br)CO.BrC1=CC=C(C=C1)[C@H]1C[C@@]2(COC(N2)=O)CC1 Chemical compound N[C@]1(C[C@@H](CC1)C1=CC=C(C=C1)Br)CO.BrC1=CC=C(C=C1)[C@H]1C[C@@]2(COC(N2)=O)CC1 GQVOVTJYSXNBNL-DVBLDUDYSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 206010051606 Necrotising colitis Diseases 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- LGNNHRXWJGKAQJ-XWYDFWQOSA-N O=C1N[C@@]2(CO1)C[C@H](CC2)C2=CC=C(C=C2)CC(=O)O.O=C2CC=1C=CC(=CC1CC2)[C@@H]2C[C@@]1(COC(N1)=O)CC2 Chemical compound O=C1N[C@@]2(CO1)C[C@H](CC2)C2=CC=C(C=C2)CC(=O)O.O=C2CC=1C=CC(=CC1CC2)[C@@H]2C[C@@]1(COC(N1)=O)CC2 LGNNHRXWJGKAQJ-XWYDFWQOSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 241000721454 Pemphigus Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical class [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 206010065159 Polychondritis Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000003971 Posterior uveitis Diseases 0.000 description 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 description 1
- 206010036774 Proctitis Diseases 0.000 description 1
- 206010067063 Progressive relapsing multiple sclerosis Diseases 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
- 108010007568 Protamines Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 description 1
- 206010037128 Pseudomembranous colitis Diseases 0.000 description 1
- 208000020410 Psoriasis-related juvenile idiopathic arthritis Diseases 0.000 description 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 description 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 description 1
- 208000006311 Pyoderma Diseases 0.000 description 1
- 230000010799 Receptor Interactions Effects 0.000 description 1
- 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 description 1
- 208000033626 Renal failure acute Diseases 0.000 description 1
- 208000002200 Respiratory Hypersensitivity Diseases 0.000 description 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 238000011579 SCID mouse model Methods 0.000 description 1
- 206010039705 Scleritis Diseases 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 206010048908 Seasonal allergy Diseases 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 208000009359 Sezary Syndrome Diseases 0.000 description 1
- 208000021388 Sezary disease Diseases 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- 102100025749 Sphingosine 1-phosphate receptor 2 Human genes 0.000 description 1
- 101710155462 Sphingosine 1-phosphate receptor 2 Proteins 0.000 description 1
- 101710155457 Sphingosine 1-phosphate receptor 3 Proteins 0.000 description 1
- 102100029803 Sphingosine 1-phosphate receptor 4 Human genes 0.000 description 1
- 101710155458 Sphingosine 1-phosphate receptor 4 Proteins 0.000 description 1
- 101710155451 Sphingosine 1-phosphate receptor 5 Proteins 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 241000272534 Struthio camelus Species 0.000 description 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 description 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 208000001445 Uveomeningoencephalitic Syndrome Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000034705 Vogt-Koyanagi-Harada syndrome Diseases 0.000 description 1
- JVVXZOOGOGPDRZ-SLFFLAALSA-N [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine Chemical compound NC[C@]1(C)CCC[C@]2(C)C3=CC=C(C(C)C)C=C3CC[C@H]21 JVVXZOOGOGPDRZ-SLFFLAALSA-N 0.000 description 1
- JOJBKYUGLWAPQL-BZNPZCIMSA-N [(1r,3r,4s,5r)-4,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]boron Chemical compound C[C@H]1[C@H]([B])C[C@H]2C(C)(C)[C@@H]1C2 JOJBKYUGLWAPQL-BZNPZCIMSA-N 0.000 description 1
- MKDOHHWCOHETDN-CMPLNLGQSA-N [(1r,3s)-1-amino-3-(4-bromophenyl)cyclopentyl]methanol Chemical compound C1[C@@](N)(CO)CC[C@@H]1C1=CC=C(Br)C=C1 MKDOHHWCOHETDN-CMPLNLGQSA-N 0.000 description 1
- WERKSKAQRVDLDW-ANOHMWSOSA-N [(2s,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO WERKSKAQRVDLDW-ANOHMWSOSA-N 0.000 description 1
- BPMMYKAHRIEVDH-PPNDLDFTSA-N [1-amino-3-[(6r)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl]cyclopentyl]methanol Chemical compound C([C@H](CC1=CC=2)CCCCCC)CC1=CC=2C1CCC(N)(CO)C1 BPMMYKAHRIEVDH-PPNDLDFTSA-N 0.000 description 1
- MWRDWAYCYUNZRJ-WMLDXEAASA-N [6-[(5r,8s)-2-oxo-3-oxa-1-azaspiro[4.4]nonan-8-yl]-3,4-dihydronaphthalen-2-yl] trifluoromethanesulfonate Chemical compound C([C@@H](C1)C2=CC=C3C=C(CCC3=C2)OS(=O)(=O)C(F)(F)F)C[C@@]21COC(=O)N2 MWRDWAYCYUNZRJ-WMLDXEAASA-N 0.000 description 1
- MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 description 1
- 229960004748 abacavir Drugs 0.000 description 1
- 229960003697 abatacept Drugs 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 description 1
- AUALQMFGWLZREY-UHFFFAOYSA-N acetonitrile;methanol Chemical compound OC.CC#N AUALQMFGWLZREY-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 150000008043 acidic salts Chemical class 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000009798 acute exacerbation Effects 0.000 description 1
- 201000011040 acute kidney failure Diseases 0.000 description 1
- 208000012998 acute renal failure Diseases 0.000 description 1
- 229960002964 adalimumab Drugs 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical class OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 1
- 206010064930 age-related macular degeneration Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000010085 airway hyperresponsiveness Effects 0.000 description 1
- 208000010002 alcoholic liver cirrhosis Diseases 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 201000009961 allergic asthma Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 208000004631 alopecia areata Diseases 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 208000008445 altitude sickness Diseases 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 229940063655 aluminum stearate Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229960004238 anakinra Drugs 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-L aspartate group Chemical class N[C@@H](CC(=O)[O-])C(=O)[O-] CKLJMWTZIZZHCS-REOHCLBHSA-L 0.000 description 1
- 239000012911 assay medium Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- AUJRCFUBUPVWSZ-XTZHGVARSA-M auranofin Chemical compound CCP(CC)(CC)=[Au]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O AUJRCFUBUPVWSZ-XTZHGVARSA-M 0.000 description 1
- 229960005207 auranofin Drugs 0.000 description 1
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 description 1
- 229940003504 avonex Drugs 0.000 description 1
- 229960002170 azathioprine Drugs 0.000 description 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229940125717 barbiturate Drugs 0.000 description 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- UPABQMWFWCMOFV-UHFFFAOYSA-N benethamine Chemical compound C=1C=CC=CC=1CNCCC1=CC=CC=C1 UPABQMWFWCMOFV-UHFFFAOYSA-N 0.000 description 1
- JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical compound C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
- 150000008107 benzenesulfonic acids Chemical class 0.000 description 1
- 150000001558 benzoic acid derivatives Chemical class 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 229940021459 betaseron Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 229910000085 borane Inorganic materials 0.000 description 1
- 150000001642 boronic acid derivatives Chemical class 0.000 description 1
- OWVBKVUUDMFVCR-UHFFFAOYSA-M bromozinc(1+);tert-butyl acetate Chemical compound Br[Zn+].CC(C)(C)OC([CH2-])=O OWVBKVUUDMFVCR-UHFFFAOYSA-M 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- 229940043253 butylated hydroxyanisole Drugs 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical class C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 1
- 229960000590 celecoxib Drugs 0.000 description 1
- 230000004709 cell invasion Effects 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 208000010353 central nervous system vasculitis Diseases 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 1
- 230000000973 chemotherapeutic effect Effects 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000025302 chronic primary adrenal insufficiency Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 208000010247 contact dermatitis Diseases 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229940038717 copaxone Drugs 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 229960003280 cupric chloride Drugs 0.000 description 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 1
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclo-pentanone Natural products O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 description 1
- PSBABBDEUFNFKJ-UHFFFAOYSA-N cyclopent-2-en-1-ol Chemical compound OC1CCC=C1 PSBABBDEUFNFKJ-UHFFFAOYSA-N 0.000 description 1
- JBDSSBMEKXHSJF-UHFFFAOYSA-M cyclopentanecarboxylate Chemical compound [O-]C(=O)C1CCCC1 JBDSSBMEKXHSJF-UHFFFAOYSA-M 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 150000008050 dialkyl sulfates Chemical class 0.000 description 1
- LMEDOLJKVASKTP-UHFFFAOYSA-N dibutyl sulfate Chemical compound CCCCOS(=O)(=O)OCCCC LMEDOLJKVASKTP-UHFFFAOYSA-N 0.000 description 1
- DENRZWYUOJLTMF-UHFFFAOYSA-N diethyl sulfate Chemical compound CCOS(=O)(=O)OCC DENRZWYUOJLTMF-UHFFFAOYSA-N 0.000 description 1
- 229940008406 diethyl sulfate Drugs 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 229940043279 diisopropylamine Drugs 0.000 description 1
- FSBVERYRVPGNGG-UHFFFAOYSA-N dimagnesium dioxido-bis[[oxido(oxo)silyl]oxy]silane hydrate Chemical compound O.[Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O FSBVERYRVPGNGG-UHFFFAOYSA-N 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- GAFRWLVTHPVQGK-UHFFFAOYSA-N dipentyl sulfate Chemical compound CCCCCOS(=O)(=O)OCCCCC GAFRWLVTHPVQGK-UHFFFAOYSA-N 0.000 description 1
- CNTIXUGILVWVHR-UHFFFAOYSA-N diphosphoryl chloride Chemical compound ClP(Cl)(=O)OP(Cl)(Cl)=O CNTIXUGILVWVHR-UHFFFAOYSA-N 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- GUVUOGQBMYCBQP-UHFFFAOYSA-N dmpu Chemical compound CN1CCCN(C)C1=O GUVUOGQBMYCBQP-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical class CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 230000003828 downregulation Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 description 1
- 230000002449 erythroblastic effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000010437 erythropoiesis Effects 0.000 description 1
- 229960000403 etanercept Drugs 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical class CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000024711 extrinsic asthma Diseases 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000003890 fistula Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 229960003776 glatiramer acetate Drugs 0.000 description 1
- 239000003862 glucocorticoid Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 150000002315 glycerophosphates Chemical class 0.000 description 1
- 229940074045 glyceryl distearate Drugs 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 208000024908 graft versus host disease Diseases 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229960002706 gusperimus Drugs 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 206010019692 hepatic necrosis Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical class CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- UBHWBODXJBSFLH-UHFFFAOYSA-N hexadecan-1-ol;octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO.CCCCCCCCCCCCCCCCCCO UBHWBODXJBSFLH-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
- AILKHAQXUAOOFU-UHFFFAOYSA-N hexanenitrile Chemical compound CCCCCC#N AILKHAQXUAOOFU-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical class CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- VNDHXHMRJVTMTK-WZVRVNPQSA-H hexasodium 4-[[(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecahydroxy-10-(hydroxymethyl)-15,20,25,30,35-pentakis(4-sulfonatobutoxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-5-yl]methoxy]butane-1-sulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCCCCS([O-])(=O)=O)O[C@H]1[C@H](O)[C@H]2O VNDHXHMRJVTMTK-WZVRVNPQSA-H 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 229940048921 humira Drugs 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- HXJZHJLLMIGFCM-UHFFFAOYSA-N hydroxy-imino-di(propan-2-yloxy)-$l^{5}-phosphane Chemical compound CC(C)OP(N)(=O)OC(C)C HXJZHJLLMIGFCM-UHFFFAOYSA-N 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 1
- 229960004171 hydroxychloroquine Drugs 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 201000002597 ichthyosis vulgaris Diseases 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 229960000598 infliximab Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229960004461 interferon beta-1a Drugs 0.000 description 1
- 229960003161 interferon beta-1b Drugs 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 201000006334 interstitial nephritis Diseases 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003903 intestinal lesions Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 201000010659 intrinsic asthma Diseases 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- AMWUFXLSROXQFP-UHFFFAOYSA-N iron(3+);pentane-2,4-dione Chemical compound [Fe+3].CC(=O)CC(C)=O AMWUFXLSROXQFP-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 201000008222 ischemic colitis Diseases 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 201000010666 keratoconjunctivitis Diseases 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 229940054136 kineret Drugs 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 1
- 229960000681 leflunomide Drugs 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- GWNVDXQDILPJIG-NXOLIXFESA-N leukotriene C4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O GWNVDXQDILPJIG-NXOLIXFESA-N 0.000 description 1
- 201000011486 lichen planus Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229910003002 lithium salt Inorganic materials 0.000 description 1
- 159000000002 lithium salts Chemical class 0.000 description 1
- 231100000149 liver necrosis Toxicity 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000001077 lymphatic endothelium Anatomy 0.000 description 1
- 210000003563 lymphoid tissue Anatomy 0.000 description 1
- 231100001023 lymphopenia Toxicity 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 235000012245 magnesium oxide Nutrition 0.000 description 1
- 229940072082 magnesium salicylate Drugs 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- LZFCBBSYZJPPIV-UHFFFAOYSA-M magnesium;hexane;bromide Chemical compound [Mg+2].[Br-].CCCCC[CH2-] LZFCBBSYZJPPIV-UHFFFAOYSA-M 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 150000002688 maleic acid derivatives Chemical class 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 208000008585 mastocytosis Diseases 0.000 description 1
- 229960001929 meloxicam Drugs 0.000 description 1
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 1
- 229960001428 mercaptopurine Drugs 0.000 description 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 1
- 229960004963 mesalazine Drugs 0.000 description 1
- 201000008265 mesangial proliferative glomerulonephritis Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- UHNSRFWQBVXBSK-UHFFFAOYSA-N methanol;2,2,2-trifluoroacetic acid Chemical compound OC.OC(=O)C(F)(F)F UHNSRFWQBVXBSK-UHFFFAOYSA-N 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- DXLOKEVVKYIAPJ-SMDQHNSPSA-N methyl (1r,3s)-1-amino-3-(4-bromophenyl)cyclopentane-1-carboxylate;hydrochloride Chemical compound Cl.C1[C@](C(=O)OC)(N)CC[C@@H]1C1=CC=C(Br)C=C1 DXLOKEVVKYIAPJ-SMDQHNSPSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960004584 methylprednisolone Drugs 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 206010063344 microscopic polyangiitis Diseases 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 208000013734 mononeuritis simplex Diseases 0.000 description 1
- 201000005518 mononeuropathy Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 229940014456 mycophenolate Drugs 0.000 description 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- OKFDRAHPFKMAJH-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methanesulfonamido)dibenzofuran-1-carboxamide Chemical compound C=12C3=CC(NS(=O)(=O)C)=CC=C3OC2=C(OC(F)F)C=CC=1C(=O)NC1=C(Cl)C=NC=C1Cl OKFDRAHPFKMAJH-UHFFFAOYSA-N 0.000 description 1
- IDINUJSAMVOPCM-INIZCTEOSA-N n-[(1s)-2-[4-(3-aminopropylamino)butylamino]-1-hydroxy-2-oxoethyl]-7-(diaminomethylideneamino)heptanamide Chemical compound NCCCNCCCCNC(=O)[C@H](O)NC(=O)CCCCCCN=C(N)N IDINUJSAMVOPCM-INIZCTEOSA-N 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical class C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 description 1
- 230000010807 negative regulation of binding Effects 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 150000002814 niacins Chemical class 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000005937 nuclear translocation Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 229950000175 oglemilast Drugs 0.000 description 1
- 239000012053 oil suspension Substances 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 229940035567 orencia Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000003891 oxalate salts Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 description 1
- LXNAVEXFUKBNMK-UHFFFAOYSA-N palladium(II) acetate Substances [Pd].CC(O)=O.CC(O)=O LXNAVEXFUKBNMK-UHFFFAOYSA-N 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 238000012753 partial hepatectomy Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229960001639 penicillamine Drugs 0.000 description 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 125000005547 pivalate group Chemical group 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 201000004338 pollen allergy Diseases 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 201000006292 polyarteritis nodosa Diseases 0.000 description 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 description 1
- 208000005987 polymyositis Diseases 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 206010063401 primary progressive multiple sclerosis Diseases 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 229940072288 prograf Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229950008679 protamine sulfate Drugs 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229940099538 rapamune Drugs 0.000 description 1
- 238000011110 re-filtration Methods 0.000 description 1
- 229940038850 rebif Drugs 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940075993 receptor modulator Drugs 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 208000009169 relapsing polychondritis Diseases 0.000 description 1
- 229940116176 remicade Drugs 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 206010048628 rheumatoid vasculitis Diseases 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 229960004641 rituximab Drugs 0.000 description 1
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
- 229960000371 rofecoxib Drugs 0.000 description 1
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 description 1
- 229960002586 roflumilast Drugs 0.000 description 1
- HJORMJIFDVBMOB-UHFFFAOYSA-N rolipram Chemical compound COC1=CC=C(C2CC(=O)NC2)C=C1OC1CCCC1 HJORMJIFDVBMOB-UHFFFAOYSA-N 0.000 description 1
- 229950005741 rolipram Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229960000953 salsalate Drugs 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 208000010157 sclerosing cholangitis Diseases 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 201000008628 secondary progressive multiple sclerosis Diseases 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229960003323 siltuximab Drugs 0.000 description 1
- 238000004467 single crystal X-ray diffraction Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 229910001467 sodium calcium phosphate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 150000003410 sphingosines Chemical class 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000003900 succinic acid esters Chemical class 0.000 description 1
- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 229960001940 sulfasalazine Drugs 0.000 description 1
- NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940037128 systemic glucocorticoids Drugs 0.000 description 1
- 229960001967 tacrolimus Drugs 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 206010043207 temporal arteritis Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- MWRBWPQBGGARAY-UHFFFAOYSA-M tert-butyl acetate;chlorozinc(1+) Chemical compound [Zn+]Cl.CC(C)(C)OC([CH2-])=O MWRBWPQBGGARAY-UHFFFAOYSA-M 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003567 thiocyanates Chemical class 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000002723 toxicity assay Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 229940079023 tysabri Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical class CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 229960003824 ustekinumab Drugs 0.000 description 1
- 230000006459 vascular development Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/18—Polycyclic aromatic halogenated hydrocarbons
- C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
- C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
- C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Description
本発明は、S1P1活性のモジュレーターとして有用な二環式化合物(その塩およびプロドラッグを含む)を提供する。
本発明を、下記の添付する図面を参照して説明する。
本発明の第一の面は式(I)
の少なくとも1個の化合物および/またはその塩を提供する。
の構造を有する、式(I)の化合物および/またはその塩である。この態様に包含されるのは、式(IIa)および式(IIIa)の化合物である。
の構造を有する、式(I)の化合物および/またはその塩である。この態様に包含されるのは、式(IIb)および式(IIIb)の化合物である。
一つの態様は、式(IIb)の化合物および/またはその塩である。
一つの態様は、式(IIIa)の化合物および/またはその塩である。
一つの態様は、式(IIIb)の化合物および/またはその塩である。
一つの態様は、式(IIb)の化合物である。
一つの態様は、式(IIIa)の化合物である。
一つの態様は、式(IIIb)の化合物である。
一つの態様は、式(IIb)の化合物の1個以上の塩である。
一つの態様は、式(IIIa)の化合物の1個以上の塩である。
一つの態様は、式(IIIb)の化合物の1個以上の塩である。
一つの態様は、HCl塩としての式(IIIa)の化合物である。
一つの態様は、HCl塩としての式(IIIb)の化合物である。
一つの態様は、リン酸塩としての式(IIIa)の化合物である。
一つの態様は、リン酸塩としての式(IIIb)の化合物である。
一つの態様は、マロン酸塩としての式(III)の化合物である。
一つの態様は、マロン酸塩としての式(IIIa)の化合物である。
一つの態様は、マロン酸塩としての式(IIIb)の化合物である。
一つの態様は、HCl塩、リン酸塩およびマロン酸塩から選択される塩としての式(III)の化合物である。
一つの態様は、HCl塩、リン酸塩、L−リンゴ酸塩、マロン酸塩およびR−(+)−マンデル酸塩から選択される塩としての式(IIIb)の化合物である。
一つの態様において、実施例2の化合物
格子サイズ:
a=5.54Å
b=7.37Å
c=48.85Å
α=90.0°
β=90.0°
γ=90.0°
空間群:P212121
実施例2の分子/非対称ユニット:1
体積/単位格子中の分子の数=499Å3
密度(計算値)=1.098g/cm3、
ここで、実施例2の形態N−1の単位格子パラメータは、約−70℃の温度で測定する。
なおさらに別の態様において、実施例2のN−1形態は、実施例2の形態N−1の重量に基づき、少なくとも約90wt.%、好ましくは少なくとも約95wt.%、より好ましくは少なくとも約99wt.%を構成する。
一つの態様において、実施例2の化合物は塩酸塩として提供される。
格子サイズ:
a=6.30Å
b=6.42Å
c=55.28Å
α=90.0°
β=90.0°
γ=90.0°
空間群:P212121
実施例2の分子/非対称ユニット:1
体積/単位格子中の分子の数=560Å3
密度(計算値)=1.14g/cm3、
ここで、実施例2の一塩酸塩の形態H−1の単位格子パラメータは、約−70℃の温度で測定する。
なおさらなる態様において、実施例2の一塩酸塩のH−1形態は実質的に純粋である。
格子サイズ:
a=6.30Å
b=6.43Å
c=27.88Å
α=90.0°
β=96.0°
γ=90.0°
空間群:P21
実施例2の分子/非対称ユニット:1
体積/単位格子中の分子の数=562Å3
密度(計算値)=1.135g/cm3、
ここで、実施例2、HCl塩のH−2形態の単位格子パラメータは、約−70℃の温度で測定する。
なおさらに別の態様において、実施例2、HCl塩のH−2形態は、第三の結晶形態の重量に基づき、少なくとも約90wt.%、好ましくは少なくとも約95wt.%、より好ましくは少なくとも約99wt.%を構成する。
格子サイズ:
a=5.98Å
b=7.24Å
c=25.74Å
α=90.0°
β=91.7°
γ=90.0°
空間群:P21
実施例2の分子/非対称ユニット:1
体積/単位格子中の分子の数=556Å3
密度(計算値)=1.092g/cm3、
ここで、実施例2のHCl塩の形態N−3の単位格子パラメータは、約27℃の温度で測定する。
格子サイズ:
a=5.93Å
b=7.20Å
c=25.24Å
α=90.0°
β=90.2°
γ=90.0°
空間群:P21
実施例2の分子/非対称ユニット:1
体積/単位格子中の分子の数=538Å3
密度(計算値)=1.128g/cm3、
ここで、実施例2のHCl塩の形態N−3の単位格子パラメータは、約−70℃の温度で測定する。
なおさらに別の態様において、実施例2のHCl塩のN−3形態は、第四の結晶形態、形態N−3の重量に基づき、少なくとも約90wt.%、好ましくは少なくとも約95wt.%、より好ましくは少なくとも約99wt.%を構成する。
他の態様において、実施例2の結晶形態は、本質的に形態N−3からなる。この態様の結晶形態は、実施例2の形態N−3である結晶形態の重量に基づき、少なくとも約90wt.%、好ましくは少なくとも約95wt.%、より好ましくは少なくとも約99wt.%を構成し得る。
格子サイズ:
a=5.95Å
b=7.27Å
c=51.60Å
α=90.0°
β=90.0°
γ=90.0°
空間群:P212121
実施例2の分子/非対称ユニット:1
体積/単位格子中の分子の数=558Å3
密度(計算値)=1.088g/cm3、
ここで、実施例2、HCl塩の形態N−4の単位格子パラメータは、約27℃の温度で測定する。
格子サイズ:
a=5.92Å
b=7.25Å
c=50.61Å
α=90.0°
β=90.0°
γ=90.0°
空間群:P212121
実施例2の分子/非対称ユニット:1
体積/単位格子中の分子の数=543Å3
密度(計算値)=1.119g/cm3、
ここで、実施例2、HCl塩の形態N−4の単位格子パラメータは、約−70℃の温度で測定する。
なおさらに別の態様において、実施例2のHCl塩のN−4形態は、第四の結晶形態、形態N−4の重量に基づき、少なくとも約90wt.%、好ましくは少なくとも約95wt.%、より好ましくは少なくとも約99wt.%を構成する。
他の態様において、実施例2の結晶形態は、本質的に形態N−4からなる。この態様の結晶形態は、実施例2の形態N−4である結晶形態の重量に基づき、少なくとも約90wt.%、好ましくは少なくとも約95wt.%、より好ましくは少なくとも約99wt.%を構成し得る。
一つの態様において、実施例2の化合物はL−リンゴ酸塩として提供される。
一つの態様において、実施例2の化合物は、実施例2の化合物1モルあたり0.5モルのL−リンゴ酸を含むヘミL−リンゴ酸塩として提供される。
格子サイズ:
a=6.13Å
b=13.83Å
c=28.75Å
α=103.4°
β=94.0°
γ=92.6°
空間群:P1
実施例2の分子/非対称ユニット:4
体積/単位格子中の分子の数=591Å3
密度(計算値)=1.165g/cm3、
ここで、実施例2のヘミL−リンゴ酸塩の形態H−1の単位格子パラメータは、約−70℃の温度で測定する。
一つの態様において、実施例2の化合物は、マロン酸塩として提供される。
一つの態様において、実施例2の化合物は、実施例2の化合物1モルあたり0.5モルのマロン酸を含むヘミマロン酸塩として提供される。
格子サイズ:
a=14.73Å
b=6.27Å
c=25.36Å
α=90.0°
β=93.8°
γ=90.0°
空間群:P21
実施例2の分子/非対称ユニット:2
体積/単位格子中の分子の数=584Å3
密度(計算値)=1.137g/cm3、
ここで、形態H−1の単位格子パラメータは、約−70℃の温度で測定する。
一つの態様において、実施例2の化合物は、リン酸塩として提供される。
一つの態様において、実施例2の化合物は、1/3水和物リン酸塩として提供される。
格子サイズ:
a=59.12Å
b=6.89Å
c=16.62Å
α=90.0°
β=94.7°
γ=90.0°
空間群:C2
実施例2の分子/非対称ユニット:3
体積/単位格子中の分子の数=563Å3
密度(計算値)=1.181g/cm3、
ここで、形態H.33−1の単位格子パラメータは、約−70℃の温度で測定する。
一つの態様において、実施例2の化合物は、R−(+)−マンデル酸塩として提供される。
一つの態様において、実施例2の化合物は、一水和物R−(+)−マンデル酸として提供される。
格子サイズ:
a=6.31Å
b=10.03Å
c=21.79Å
α=98.2°
β=91.3°
γ=91.7°
空間群:P1
実施例2の分子/非対称ユニット:2
体積/単位格子中の分子の数=683Å3
密度(計算値)=1.171g/cm3、
ここで、実施例2、R−(+)−マンデル酸塩の形態N−1の単位格子パラメータは、約−70℃の温度で測定する。
なおさらに別の態様において、実施例2、R−(+)−マンデル酸塩のN−1形態は、実施例2、R−(+)−マンデル酸塩の形態N−1の重量に基づき、少なくとも約90wt.%、好ましくは少なくとも約95wt.%、より好ましくは少なくとも約99wt.%を構成する。
本発明の特色および利点は、次の詳細な記載から当業者はより容易に理解し得る。明瞭化の理由により、本明細書中に別の態様の状況で記載される本発明のある特色が、一つの態様を形成するために組み合わせてもよいことは認識される。反対に、簡潔さの理由のために、一つの態様の状況で記載されている本発明の種々の特色を、その下位の組み合わせを形成するために組み合わせてもよいこともまた認識される。例としてまたは好ましいとしてここに特定される態様は説明を意味するものであり、限定するものではない。
a) Wermuth, C.G. et al., The Practice of Medicinal Chemistry, Chapter 31, Academic Press (1996);
b) Bundgaard, H. ed., Design of Prodrugs, Elsevier (1985);
c) Bundgaard, H., Chapter 5, “Design and Application of Prodrugs”, Krogsgaard-Larsen, P. et al., eds., A Textbook of Drug Design and Development, pp. 113-191, Harwood Academic Publishers (1991);および
d) Testa, B. et al., Hydrolysis in Drug and Prodrug Metabolism, Wiley-VCH (2003)。
ヒト免疫系は、感染、疾患または死の原因となり得る微生物、ウイルスおよび寄生虫から体を守るために進化してきた。複雑な制御機構が、免疫系の種々の細胞組成が外来物質または生物を標的とするが、個体には永続的なまたは顕著な損傷をおこさないことを確実にする。現在、開始事象は十分には理解されていないが、自己免疫疾患状態において、免疫系は、その炎症性応答を罹患個体の臓器を標的とするように指示する。種々の自己免疫疾患が、優勢であるまたは最初の標的である罹患臓器または組織により典型的に特徴付けられており、例えば、リウマチ性関節炎の場合における関節、橋本甲状腺炎の場合における甲状腺、多発性硬化症の場合における中枢神経系、I型糖尿病の場合における膵臓および炎症性腸疾患の場合における腸である。それゆえに、免疫系または免疫系のある細胞型(例えばBリンパ球およびTリンパ球、T細胞)に作用する治療剤が、1種を超える自己免疫疾患に有用であり得ることが認められている。
条件C:カラム:YMC COMBISCREEN(登録商標)S5 50 x 4.6mm(直線状勾配で0〜100%溶媒Bを4分で、その後1〜4分100%Bを維持;溶媒A=水90%/MeOH 10%/H3PO4、0.2%;溶媒B=MeOH 90%/水10%/H3PO4 0.2%。流速:4mL/分;生成物を220nmで検出。
(1R,3S)−メチル1−アミノ−3−(4−ブロモフェニル)シクロペンタンカルボキシレート
ガラス耐圧容器中の、(S)−3−(4−ブロモフェニル)シクロペンタノン(I−1A、4.9g、20.49mmol)およびシアン化カリウム(1.935g、29.7mmol)のEtOH(40mL)および水(20mL)の混合物に、炭酸アンモニウム(4.92g、51.2mmol)を添加した。反応容器を密閉し、80℃で24時間加熱した油浴に入れ、白色固体を形成させた。反応容器を氷浴で冷却後、容器を開け、水(30ml)を添加して、さらなる固体を形成させた。固体を濾過により採取し、水(5ml)で2回洗浄し、高減圧下に乾燥させた。2バッチを合わせて、13.9gの(7S)−7−(4−ブロモフェニル)−1,3−ジアザスピロ[4.4]ノナン−2,4−ジオン)を得て、これをさらに精製することなく次反応で使用した。HPLC保持時間=0.82分(条件G) LC/MS M+Na=331, 2M+H=619
(1R,3R)−メチル1−アミノ−3−(4−ブロモフェニル)シクロペンタンカルボキシレート
(5R,7S)−7−(4−ブロモフェニル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン
((1R,3S)−1−アミノ−3−(4−ブロモフェニル)シクロペンチル)メタノール(11g、40.7mmol)およびピリジン(I−3A、3.29mL、40.7mmol)のジオキサン(300mL)中の混合物に1,1’−カルボニルジイミダゾール(19.81g、122mmol)を添加した。反応混合物を4時間撹拌した。反応混合物を酢酸エチルで希釈し、1M HCl、塩水および飽和NaHCO3で洗浄した。混合物を数回逆抽出した。有機層をMgSO4で乾燥し、濾過し、濃縮して、10.5gの所望の生成物を灰白色固体として得た。HPLC保持時間=0.87分(条件G). LC/MS M+1=297.9;1H NMR (400MHz, クロロホルム-d) δ 7.45 (d, J=8.6 Hz, 2H), 7.12 (d, J=8.4 Hz, 2H), 6.42 (br. s., 1H), 4.41-4.21 (m, 2H), 3.17-2.91 (m, 1H), 2.34 (dd, J=13.3, 7.4 Hz, 1H), 2.23-2.11 (m, 2H), 2.01-1.90 (m, 2H), 1.88-1.74 (m, 1H)
(5R,7R)−7−(4−ブロモフェニル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン
((1R,3R)−1−アミノ−3−(4−ブロモフェニル)シクロペンチル)メタノール(I−4A、3.19g、11.81mmol)をTHF(59.0ml)に溶解した。ピリジン(0.955ml、11.81mmol)および1,1’−カルボニルジイミダゾール(5.74g、35.4mmol)を少しずつ添加した。反応混合物を4時間撹拌し、LCMSで追跡した。反応完了後、混合物をEtOAcで希釈し、1M HClで洗浄した。水層をEtOAcで2回逆抽出した。有機層を合わせ、飽和NaClで洗浄し、MgSO4で乾燥し、濾過し、濃縮して、フラッシュクロマトグラフィー(24gシリカゲルカラム;溶離剤:ヘキサン2CV、続いて勾配〜100%EtOAcを15CVで)後に、(5R,7R)−7−(4−ブロモフェニル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン(2.5g、8.44mmol)を得た。HPLC保持時間=0.91分; LC/MS M+1=298. 1H NMR (400MHz, CDCl3) δ 7.46 (d, J=8.5 Hz, 2H), 7.09 (d, J=8.5 Hz, 2H), 5.72- 5.81 (m, 1H), 4.35 (dd, J=13Hz, 8Hz, 2H), 3.19-3.24 (m, 1H), 2.38-2.44 (m, 1H), 2.15-2.26 (m, 1H), 2.11-2.14 (m, 1H), 1.99-2.05 (m, 1H), 1.79-1.85 (m, 1H), 1.65-1.72 (m, 1H)
(5R,7S)−7−(6−オキソ−5,6,7,8−テトラヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン
2−(4−((5R,7S)−2−オキソ−3−オキサ−1−アザスピロ[4.4]ノナン−7−イル)フェニル)酢酸(I−5B、800mg、2.91mmol)のDCM(20mL)中の混合物に塩化オキサリル(1ml、11.42mmol)および数滴のDMFを添加した。1時間後、反応混合物を減圧下濃縮した。残渣をガラス耐圧容器中DCM(20mL)に再溶解した。顆粒状塩化アルミニウム(1550mg、11.62mmol)を添加し、反応混合物を−78℃に冷却した。エチレンを通して溶液を5分バブリングし、反応容器を密閉した。反応混合物を室温までゆっくり温め、4時間撹拌した。混合物を氷に注ぎ、ジクロロメタンで希釈し、1M HClで洗浄した。有機層をMgSO4で乾燥し、濾過し、濃縮した。粗物質をMeOH/DCM勾配(0〜10%MeOHを13CVで)を使用するシリカゲルカートリッジ(80g)で精製した。生成物含有フラクションを取得し、減圧下乾燥して、770mgの(5R,7S)−7−(6−オキソ−5,6,7,8−テトラヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オンを得た。HPLC保持時間=0.74分(条件G); LC/MS M+1=286:1H NMR (400MHz, クロロホルム-d) δ 7.20-7.00 (m, 3H), 5.49 (br. s., 1H), 4.45-4.25 (m, 2H), 3.59 (s, 2H), 3.08 (t, J=6.8 Hz, 3H), 2.58 (t, J=6.7 Hz, 2H), 2.38 (dd, J=13.2, 7.3 Hz, 1H), 2.27-2.11 (m, 2H), 2.05-1.92 (m, 2H), 1.92-1.74 (m, 1H)
6−((5R,7S)−2−オキソ−3−オキサ−1−アザスピロ[4.4]ノナン−7−イル)−3,4−ジヒドロナフタレン−2−イルトリフルオロメタンスルホン酸塩
(5R,7R)−7−(6−オキソ−5,6,7,8−テトラヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン
褐色液体tert−ブチル2−(4−((5R,7R)−2−オキソ−3−オキサ−1−アザスピロ[4.4]ノナン−7−イル)フェニル)アセテート(I−7A、2.35g、7.09mmol)をDCM(60mL)に溶解し、トリフルオロ酢酸(20mL、260mmol)を添加した。反応混合物を室温で1時間撹拌し、この時点で溶媒を減圧下除去した。得られた物質をDCM(60mL)で希釈し、酸/塩基抽出で精製し、減圧下に1時間置いた。得られた褐色ガム錠の2−(4−((5R,7R)−2−オキソ−3−オキサ−1−アザスピロ[4.4]ノナン−7−イル)フェニル)酢酸(1.952g、7.09mmol)をDCM(60mL)に溶解し、塩化オキサリル(1.862mL、21.27mmol)およびDMF(0.027mL、0.355mmol)を添加した。得られた溶液を、ガスの発生が止むまで(約30分)、室温で撹拌した。MeOHで反応停止させた一定量のLCMSは酸(RT=0.65分、条件I)の完全な消費と、唯一の生成物としてのメタノールクエンチ(RT=0.77分、条件I)による推定メチルエステルの出現を示した。溶媒を減圧下除去し、生成物を減圧下に置いた。褐色ガム状物をDCM(60mL)と共に封管に移した(完全に溶解せず、褐色懸濁液が得られる)。反応混合物を−78℃に冷却し、顆粒状塩化アルミニウム(2.84g、21.27mmol)を添加した。エチレンを溶液を通して7分バブリングし、チューブを密閉した。沈殿が形成し、反応混合物を−78℃で15分撹拌し、室温に到達させた。反応混合物を2時間、室温で撹拌し、減圧した。LCMS分析は出発物質の消失と、テトラロン生成物の出現を示した。反応混合物を氷に注ぎ、DCMで希釈し、氷が溶けるまで撹拌した。有機層を塩水で洗浄し、乾燥し、減圧下濃縮した。シリカゲルでの精製により、(5R,7R)−7−(6−オキソ−5,6,7,8−テトラヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン(1.05g、3.68mmol)を得た。HPLC保持時間=0.74分(条件I); LC/MS M+1=286;1H NMR (400MHz, クロロホルム-d) δ 7.23-7.11 (m, 3H), 5.68 (br. s., 1H), 4.45-4.30 (m, 2H), 3.59 (s, 2H), 3.31-3.18 (m, 1H), 3.08 (t, J=6.8 Hz, 2H), 2.58 (t, J=6.7 Hz, 2H), 2.42-2.39 (m, 1H), 2.32-2.15 (m, 2H), 2.09-1.99 (m, 1H), 1.91-1.83 (m, 1H), 1.82-1.72 (m, 1H)
(1−アミノ−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンチル)メタノール
メチル1−アミノ−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンタンカルボキシレート(I−8F、5.7g、16mmol)をEtOH(60mL)および塩化メチレン(15mL)に溶解した。水素化ホウ素ナトリウム(2.5g、67mmol)を添加した。混合物を室温で一夜撹拌した。塩酸(6N水性、40mL)を0℃でゆっくり添加して、pHを約1とした。混合物を室温で60分撹拌し、水酸化ナトリウム(20mLの水中10g)を添加して、pHを約12とした。混合物を室温で40分撹拌し、濃縮して有機溶媒を除去した。水性残渣を水(20mL)で希釈し、EtOAc(100mL、2×50mL)で抽出した。合わせた酢酸エチル抽出物を無水硫酸ナトリウムで乾燥し、炭で脱色し、セライト(登録商標)パッドで濾過し、減圧下濃縮して、(1−アミノ−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンチル)メタノール(5.0g、15mmol)を白色固体として得た。
中間体8をキラルSFC(カラム:Chiralpak(登録商標)AD-H 25 x 3cm、5μm;移動相:CO2/(MeOH+0.1%DEA)=88/12;流速:200mL/分;検出器波長:220nm;カラム温度:35℃)を使用して、F1(ピーク1)、F2(ピーク2およびピーク3)、F3(ピーク4))の3フラクションに分けた。第二フラクション(F2)を再びキラルSFC(カラム:Chiralpak(登録商標)AS-H 25 x 3cm、5μm;移動相:CO2/[MeOH−MeCN(1:1)+0.5%DEA]=88/12;流速:180mL/分;検出器波長:220nm;カラム温度:35℃)を使用して分割して、ピーク2およびピーク3を得た。全異性体は、LC/MS M+1=330を有する白色固体であった。
製造2A:(5R,7S)−7−(6−ヘキシル−7,8−ジヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン
(5R,7S)−7−(6−ヘキシル−7,8−ジヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン(2A、2.1g、5.94mmol)のDCM(10ml)の混合物を、((1R,2S,3R,5R)−2,6,6−トリメチルビシクロ[3.1.1]ヘプタn−3−イル)ボランのDCM(30ml)溶液に、−35℃で窒素下に滴下した(ボラン試薬は次のとおり製造した:S-Alpine-Boramine(8.4g、20.18mmol)のTHF(35ml)中のにBF3エーテラート(5.11ml、40.4mmol)を室温で添加した。混合物を室温で1.5時間撹拌し、窒素下濾過し、ケーキを冷THF(2×6ml)で洗浄した。濾液および洗液を合わせ、減圧下濃縮した。残渣にDCM(20ml)を添加し、溶液を再び濃縮した。得られた試薬をDCM(30ml)に再溶解し、ヒドロホウ素化工程に直接使用した)。−35℃〜−30℃で4時間、−25℃〜−20℃で2時間撹拌後、MeOH(3.6mL)を添加し、反応混合物を−10℃で10分、0℃で10分撹拌した。混合物をTHF(25ml)で希釈し、NaOH(6N、9.9ml、59.4mmol)、続いてH2O2(30%、6.07ml、59.4mmol)を滴下し、混合物を室温で16時間撹拌した。この混合物にDCM(100ml)および水(50ml)を添加した。全溶液をセライト(登録商標)パッドで濾過し、ケーキをDCMで洗浄した。2層を分離し、水層をDCM(50ml)で抽出し、これを有機層と合わせた。合わせた有機層を水(100ml)および塩水(100ml)で洗浄し、無水Na2SO4で乾燥し、減圧下濃縮した。粗物質をEtOAc/ヘキサン勾配(0〜50%EtOAcを55分で)を使用するシリカゲルカートリッジ(40g)で精製して、1.9g(86%)の(5R,7S)−7−(6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オンを、2異性体8:1比で得た。混合物をを、ジアステレオマーを分離することなく次工程で使用した。
(5R,7S)−7−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン(400mg、1.125mmol)のジオキサン(30mL)中の混合物に、NaOH水溶液(1N、20mL)を添加した。反応混合物を100℃で3日間加熱し、室温に冷却し、酢酸エチルで希釈し、水で洗浄した。有機層をMgSO4で乾燥し、濾過し、濃縮した。粗物質を、20%(2N NH3/MeOH)のDCM/DCM勾配(0〜75%の20%(2N NH3/MeOH)のDCM溶液を13CVで)を使用するシリカゲルカートリッジ(24g)で精製して、290mgの((1R,3S)−1−アミノ−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンチル)メタノールを得た。HPLC保持時間=10.09分(条件H); LC/MS M+1=330;1H NMR (400MHz, メタノール-d4) δ 7.03-6.91 (m, 3H), 3.54-3.41 (m, 2H), 3.01 (tt, J=11.1, 7.2 Hz, 1H), 2.87-2.69 (m, 3H), 2.34 (dd, J=16.2, 10.5 Hz, 1H), 2.20 (dd, J=13.0, 7.5 Hz, 1H), 2.07-1.84 (m, 3H), 1.83-1.60 (m, 3H), 1.60-1.48 (m, 1H), 1.47-1.25 (m, 11H), 1.00-0.88 (m, 3H)
実施例2、遊離塩基、形態N−1は、18ml THFおよび1.25ml H2Oの混合物に溶解した385mgの実施例2の化合物(20mg/ml)を含む原液の製造により得た。次いで、52μlの原液を蒸発乾固した。乾燥した物質に52μlの50:50比エタノール:ヘプタン溶液を添加した。得られた溶液を蒸発させて、結晶性物質を板状晶として得た。
実施例2の一水和物の一HCl塩、形態H−1を、3.2mgの実施例2の化合物を含む50:50水性メタノール(200μl)溶液を調製することにより得た。次に、400μlの0.025M HCl水溶液を撹拌しながら滴下した。得られた溶液を蒸発させて、結晶性物質を板状晶として得た。
実施例2の一水和物、一HCl塩、形態H−2は、3.2mgの実施例2を含む50:50水性THF(200μl)溶液を調製することにより得た。次に、400μlの0.025M HCl水溶液を撹拌しながら滴下した。溶液を蒸発して、実施例2の一HCl塩の一水和物H−2形態を板状晶として得た。
実施例2の一HCl塩、形態N−3を、3.2mgの実施例2を含むイソプロピルアルコール200μl溶液の調製により得た。次に、400μlの0.025Mアルコール性HCl溶液を撹拌しながら滴下した。溶液を蒸発して、実施例2の一HCl塩のN−3形態を板状晶として得た。
実施例2の一HCl塩、形態N−3を、3.2mgの実施例2の化合物を含む200μlの50:50 メタノール/THF溶液を調製することにより得た。次に、400μlの0.025Mアルコール性HCl溶液を撹拌しながら滴下した。得られた溶液を蒸発して、実施例2の一HCl塩のN−4形態を板状晶として得た。
一水和物、ヘミL−リンゴ酸塩、形態H−1を、3.2mgの実施例2の化合物を含む200μl 50:50水性THF溶液を調製することにより得た。次に、240μlの0.042Mアルコール性L−リンゴ酸溶液を撹拌しながら滴下した。得られた溶液を蒸発して、実施例2のヘミL−リンゴ酸塩のH−1形態を板状晶として得た。
The 一水和物、ヘミマロン酸塩、形態H−1を、3.2mgの実施例2の化合物を含む200μl 50:50水性THF溶液を調製することにより得た。次に、193μlの0.052Mアルコール性マロン酸溶液を撹拌しながら滴下した。得られた溶液を蒸発して、実施例2のヘミマロン酸塩のH−1形態を板状晶として得た。
1/3水和物、リン酸塩、形態H.33−1を、3.2mgの実施例2の化合物を含む200μl 50:50水性メタノール溶液を調製することにより得た。次に、136μlの0.073Mアルコール性リン酸溶液を撹拌しながら滴下した。得られた溶液を蒸発して、実施例2のリン酸塩のH.33−1形態を板状晶として得た。
R−(+)−マンデル酸塩、形態N−1を、実施例2の化合物および当モル量のR−(+)−マンデル酸を、メタノールとアセトニトリルの混合物に添加することにより調製した。溶液を蒸発して、実施例2の一R−(+)−マンデル酸塩のN−1形態を板状晶として得た。
((1R,3R)−1−アミノ−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンチル)メチル二水素リン酸エステル
((1R,3S)−1−アミノ−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンチル)メチル二水素リン酸エステル
代替的製造10A:tert−ブチル((1R,3S)−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)−1−(ヒドロキシメチル)シクロペンチル)カルバメート
撹拌中のtert−ブチル((1R,3S)−1−(((ビス(2−(トリメチルシリル)エトキシ)ホスホリル)オキシ)メチル)−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンチル)カルバメート(製造10B、500mg、0.704mmol)のジクロロメタン(6mL)溶液にTFA(6mL)を0℃でゆっくり添加した。混合物を室温で3時間撹拌し、90mLのヘプタンを添加した。溶液を減圧下濃縮した。次に、70mLのメタノールを固体残渣に添加し、1N NaOH水溶液(4mL)を添加した。HOAc(0.4mL)を60℃で添加して、溶液をpH4まで酸性化した。固体−液体混合物を60℃で1時間撹拌した。固体を分離し、メタノール、水、メタノール、酢酸エチルおよびメタノールで洗浄した。凍結乾燥により、((1R,3S)−1−アミノ−3−((R)−6−ヘキシル−5,6,7,8−テトラヒドロナフタレン−2−イル)シクロペンチル)メチル二水素リン酸エステル(257mg、0.619mmol、88%収率)を白色固体として得た。LC/MS M+1=410;1H NMR (400MHz, メタノール-d4)(+KOH) δ 7.00-6.86 (m, 3H), 3.78-3.62 (m, 2H), 3.09-2.97 (m, 1H), 2.84-2.67 (m, 3H), 2.38-2.22 (m, 2H), 2.03-1.74 (m, 4H), 1.73-1.60 (m, 2H), 1.50 (t, J=12.3 Hz, 1H), 1.44-1.27 (m, 11H), 0.95-0.86 (m, 3H)。
(1R,3R)−1−アミノ−3−(6−(ペンチルオキシ)ナフタレン−2−イル)シクロペンチル)メタノール
(5R,7R)−7−(6−(ペンチルオキシ)ナフタレン−2−イル)−3−オキサ−1−アザスピロ[4.4]ノナン−2−オン(36mg、0.102mmol)のジオキサン(2mL)および水(0.8mL)溶液に、LiOH(36.6mg、1.528mmol)を添加した。溶液を90℃に加熱し、15時間撹拌した。反応混合物を室温に冷却し、酢酸エチルに注加し、水で洗浄した。粗物質を逆相HPLC[カラム:Luna Axia 30×100mm;勾配時間:10分;流速=40ml/分;溶媒A=10%MeOH−90%水−0.1%TFA;溶媒B=90%MeOH〜10%水−0.1%TFA;開始%B=20;最終%B=100]。生成物含有フラクションを取得し、高減圧下で乾燥して、((1R,3R)−1−アミノ−3−(6−(ペンチルオキシ)ナフタレン−2−イル)シクロペンチル)メタノールTFA(31mg)を固体として得た。HPLC保持時間=0.90分(条件G); LC/MS M+1=328. 1H NMR (400MHz, メタノール-d4) δ 7.75-7.66 (m, 2H), 7.66-7.59 (m, 1H), 7.40-7.33 (m, 1H), 7.17 (d, J=2.6 Hz, 1H), 7.14-7.08 (m, 1H), 4.07 (t, J=6.5 Hz, 2H), 3.74-3.60 (m, 2H), 3.59-3.41 (m, 1H), 2.39-2.22 (m, 3H), 2.04-1.80 (m, 5H), 1.55-1.34 (m, 4H), 1.01-0.89 (m, 3H)
マウス全血リン酸化(WBP)アッセイ
式(III)の化合物は、式(II)の活性リン酸エステル化合物となるために、アルコールのリン酸化による生体内活性化を必要とする。Brinkmann, V. et al.(J. Biol. Chem. 277:21453-21457 (2002))によると、アミン担持炭素中心の立体異性配置が、このリン酸化が起こる相対的程度に影響し得る。
BALB/cマウスに実施例1の化合物、実施例2の化合物、化合物3および化合物4(10mg/kgを媒体、ポリエチレングリコール300、“PEG300”中の溶液または懸濁液として)を経口投与した。24時間目に採血し、乾燥血液スポット(DBS)カードにスポットし、WBPアッセイについて記載したように分析した。参考物質(親アルコールおよびリン酸エステル)をLC−MS/MSアッセイを最適化し、濃度での結果報告を可能にするために分析した。親アルコールおよびリン酸エステル化合物の両者を含むDBS標準曲線を調製し、実験サンプルと同じ方法で分析し、形成されたリン酸エステル化合物の量を定量するために最適化LC−MS/MSで分析した。表3の結果は、各処置群内の全動物の平均結果を表す(n=3)。リン酸エステル化合物濃度の値が大きいほど、親(アルコール)化合物からのリン酸エステル化合物形成が大きいことを示す。この試験において、実施例1〜2の化合物は、化合物3〜4よりも大きな程度でリン酸エステル形成に付されることが判明した。このインビボ試験の結果は、上記マウス全血リン酸化試験で得られた結果と一致する。
ヒト1P1を発現するCHO細胞から膜を調製した。細胞ペレット(1×109細胞/ペレット)を、20mM HEPES(4−(2−ヒドロキシエチル)−1−ピペラジンエタンスルホン酸)、pH7.5、50mM NaCl、2mM EDTA(エチレンジアミンテトラ酢酸)およびプロテアーゼ阻害剤カクテル(Roche)を含む緩衝液に懸濁し、Polytronホモジナイザーを使用して、氷上で破壊した。ホモジネートを20,000rpm(48,000g)で遠心分離し、上清を廃棄した。膜ペレットを、50mM HEPES、pH7.5、100mM NaCl、1mM MgCl2、2mM EDTAを含む緩衝液に再懸濁し、タンパク質濃度決定のち等分して−80℃で保存した。
化合物を384 FALCON(登録商標)V底プレート(0.5μl/ウェルを11点、3倍希釈)に載せた。S1P1/CHO細胞またはEDG3−Ga15−bla HEK293T細胞(EDG3等価S1P3)から調製した膜を化合物プレート(40μl/ウェル、最終タンパク質3μg/ウェル)にMULTIDROP(登録商標)で添加した。[35S]GTP(1250Ci/mmol、Perkin Elmer)をアッセイ緩衝液(20mM HEPES、pH7.5、10mM MgCl2、150mM NaCl、1mM EGTA(エチレングリコールテトラ酢酸)、1mM DTT(ジチオスレイトール)、10μM GDP、0.1%無脂肪酸BSAおよび10μg/mlサポニン)で0.4nMまで希釈した。40μlの[35S]GTP溶液を化合物プレートに最終濃度0.2nMで添加した。反応物を室温で45分維持した。インキュベーション終了時、化合物プレートの全ての混合物をMillipore 384ウェルFBフィルタープレートにVELOCITY11(登録商標)Vprep液体ハンドラーで移した。フィルタープレートを水で4回、マニフォールドEmblaプレート洗浄機で洗浄し、60℃で45分乾燥した。MicroScint 20シンチレーション液(30μl)をPackard TOPCOUNT(登録商標)での計数のために各ウェルに添加した。EC50を、試験した個々の化合物で得られたYmax(最大応答)の50%に対応するアゴニスト濃度と定義する。実施例10の化合物のEC50は、S1P1/CHO細胞から調製した膜を利用するアッセイで0.9nMと決定された。実施例10の化合物のEC50は、EDG3−Ga15−bla HEK293T細胞から調製した膜を利用するアッセイで>62,500nMと決定された。
GFP標識S1P1受容体を発現するCHO−K1細胞を、50μlアッセイ培地(F12とL−グルタミン、10%炭/デキストラン処理FBS、1×ペニシリン−ストレプトマイシン、1M HEPES)中、384ウェルポリ−D−リシン被覆組織培養プレートに、4×103細胞/ウェルで播種した。細胞プレートを、37℃/5%CO2で一夜インキュベートした。試験化合物を、化合物源プレートから、11点、3倍連続希釈で細胞プレートに導入し、アッセイプレートを37℃/5%CO2で45分インキュベートした。細胞を固定し、6%ホルムアルデヒドおよび15μg/ml Hoechst色素でPBS(無Ca2+/Mg2+)中、室温で15分染色した。細胞プレートをPBS(無Ca2+/Mg2+)で4回洗浄し、プレートシール前に50μl/PBSを添加した。Cellomics ARRAYSCAN(登録商標)VTIハイコンテンツイメージャーにより像を得た。内部対照化合物に対するEC50決定のためのデータ分析を、Array Scan上のCompartmental Analysis BioApplicationで行った。EC50を、試験した個々の化合物で得られたYmax(最大応答)の50%に対応するアゴニスト濃度と定義し、データのフィットのために4パラメータロジスティック方程式を使用して決定した。実施例9の化合物のEC50は、このアッセイで361nMと決定された。
ルイスラットに、媒体単独(ポリエチレングリコール300、“PEG300”)または2−アミノ−2−[2−(4−オクチルフェニル)エチル]−1,3−プロパンジオール塩酸塩(CAS: 162359-56-0)を媒体中の溶液として、試験品の遊離量を反映するように調節して0.1mg/kg、0.5mg/kgおよび3.0mg/kgの量で経口投与した。結果を表4aに示し、投与24時間後のリンパ球減少率は最大3.0mg/kgであった。リンパ球における減少パーセントは用量相関であるが、相関は直線的ではなく、用量の非比例的増加が、連続的に大きくなるリンパ球数の減少を誘発するために必要である。例えば、この試験において、13%の変化(69%減少から82%減少)を示すために、用量の5倍増加(0.1mg/kgから0.5mg/kg)が必要であった。さらに、この試験において、さらに7%の変化を示すために(82%減少から89%減少)、用量の6倍増加(0.5mg/kgから3.0mg/kg)が必要であった。BALB/cマウスに、媒体単独(ポリエチレングリコール300、“PEG300”)または実施例1の化合物、実施例2の化合物、化合物6、化合物8または比較化合物11を経口投与した。化合物を媒体中の溶液または懸濁液として投与し、塩形態を使用するときには、試験品の遊離量を反映するよう調節した。24時間目に採血し、血液リンパ球数をADVIA(登録商標)120 Hematology Analyzer(Siemens Healthcare Diagnostics)で測定した。結果を、測定時の媒体処置群と比較した、循環リンパ球の減少パーセンテージとして評価した。結果は、各処置群内の全動物の平均結果を表す(n=2〜4)。上記のマウスにおける血液リンパ球減少アッセイ(BLR)の結果を表4bに示す。
動物から得た気管支肺胞洗浄(BAL)液におけるタンパク質濃度の分析を使用して、肺副作用を評価した。BAL液におけるタンパク質濃度の増加は、肺浮腫のような望まない肺効果の指標である。実施例1の化合物、実施例2の化合物、化合物6、化合物8および化合物11を、30mg/kg投与量でマウスに投与した。投与24時間後、マウスを腹腔内バルビツレート過量で屠殺した。動物を背臥位に置き、皮膚を切開し、鈍的切開後気管を露出させた。気管を切開し、カテーテルを4〜6mm気管内に入れた。リン酸緩衝化食塩水(PBS;1mL/マウス)を肺に流し、吸引した。回収したBAL液中のBALタンパク質の濃度を、ADVIA(登録商標)120 Hematology Analyzer(Siemens Healthcare Diagnostics)で決定した。気管支肺胞洗浄液(BAL)アッセイの結果を表5に示す。結果は、各処置群内の全動物の平均結果を表す(n=2〜4)。
ラットアジュバント誘発関節炎モデルは、ヒトリウマチ性関節炎の動物モデルである。
雄ルイスラット(150〜175g;Harlan、n=8処置群)を、フロイント不完全アジュバント(sigma)中100μlの10mg/mlの新たに粉砕したマイコバクテリウム・ブチリカム(Mycobacterium butyricum)(Difco Laboratories)で、尾の付け根で免疫化した。動物に、免疫化の日から開始して、1日1回試験品(媒体中の溶液または懸濁液として)または媒体単独(ポリエチレングリコール300、“PEG300”)を投与した。後ろ足の体積を、水置換プレシスモメータ(Ugo Basile, Italy)で測定した。ベースライン足測定は、疾患発症前に行った(7日目から10日目の間)。足測定を、その後、20日目〜21日目の実験の最終日まで週に3回行った。動物が関係する全ての操作は、施設内動物実験委員会による審査および承認を受けた。
マウスT細胞移植誘発大腸炎アッセイは、ヒト大腸炎の動物モデルである。
大腸炎を、BALB/cマウス(3×105/マウス、i.p.)からのFACS分別CD4+CD45RB高T細胞の養子移植によりCB−17 SCIDマウスで誘発させた。疾患活動性を、最初の3週間は週に1回その後は3×/週、体重、軟便または下痢および直腸肛門脱に基づきモニターした。動物に、T細胞移植の日から開始して、試験品または媒体を隔日(q.o.d.)経口投与した。マウスを、T細胞再構成6週間後に屠殺し、H&E染色結腸組織の組織学的試験に基づき腸炎症を分析した。動物が関係する全ての操作は、施設内動物実験委員会による審査および承認を受けた。
自然発症エリテマトーデスのMRL/lprマウスモデルは、自然発症エリテマトーデスの動物モデルである。
雄MRL/lprマウス(14週齢;Jackson Laboratories;n=12〜13)に、実施例2の化合物(媒体中の溶液として)または媒体単独(ポリエチレングリコール300)を、0日目から開始して、11週間、週に2回経口投与した。尿タンパク質濃度(Albustixによる)を、0日目および実験の間測定した。表9は、25週齢で高タンパク尿濃度(100mg/dLを超える)を示すマウスの各処置群のパーセンテージを示す。さらなるマウス群は、デキサメサゾン(Dex)を連日単独でまたは週に2回の実施例2の化合物と組み合わせて経口投与された。尿タンパク質濃度(Albustixによる)を、0日目および実験の間測定した。表9は、24週齢で高タンパク尿濃度(100mg/dLを超える)を示すマウスの各処置群のパーセンテージを示す。動物が関係する全ての操作は、施設内動物実験委員会による審査および承認を受けた。
単結晶データを、Cu Kα照射(λ=1.5418Å)を使用して、Bruker-AXS APEX2 CCDシステムで集めた。測定した強度データの指標付けおよび加工を、APEX2ソフトウェアプログラムスイートで行った。特に断っている場合は、結晶を、データ取得中、Oxfordクライオシステムの冷気流で冷却した。構造を直接法により解明し、SHELXTLプログラムを使用して、観察される反射に基づき精密化した。算出された原子パラメータ(配位および温度因子)を、全マトリックス最小二乗により精密化した。精密化において最小化された関数はΣw(|Fo|−|Fc|)2であった。RはΣ||Fo|−|Fc||/Σ|Fo|として定義され、一方Rw=[Σw(|Fo|−|Fc|)2/Σw|Fo|2]1/2であり、ここで、wは観察される強度における誤差に基づく適当な重み関数である。典型的に、全ての非H原子を異方的に精密化し、N原子およびO原子に結合している以外のH−原子を幾何学的方法で計算し、ライディングモデルを使用して精密化した。
X線粉末回折(PXRD)データを、Bruker GADDS(General Area Detector Diffraction System)マニュアルカイプラットフォームゴニオメーターを使用して得た。粉末サンプルを、直径0.7mmの薄壁ガラスキャピラリーに入れ、キャピラリーをデータ取得中回転させた。サンプルから検出器までの距離を17cmに維持した。データをCu Kα照射(λ=1.5418Å)で、2.5<2θ<35°の範囲で、600秒のサンプル暴露時間で収集した。
Claims (12)
- 式(I)
の化合物および/またはその塩。 - Rが−OHである、請求項1に記載の化合物またはその塩。
- Rが−OP(O)(OH)2である、請求項1に記載の化合物またはその塩。
- 次の構造
- 次の構造
- 結晶性固体である、請求項5に記載の化合物またはその塩。
- 次の構造
- 次の構造
- 請求項2に記載の化合物またはその薬学的に許容される塩および薬学的に許容される担体を含む、医薬組成物。
- Gタンパク質共役受容体S1P1の活性と関係する疾患または障害を治療するための、請求項1に記載の化合物またはその薬学的に許容される塩を含む医薬組成物であって、哺乳動物患者に該医薬組成物を投与することを特徴とする、医薬組成物。
- 自己免疫性疾患または慢性炎症性疾患を治療するための、請求項1に記載の化合物またはその薬学的に許容される塩を含む医薬組成物であって、哺乳動物患者に該医薬組成物を投与することを特徴とする、医薬組成物。
- 自己免疫性疾患または慢性炎症性疾患が狼瘡、多発性硬化症、炎症性腸疾患およびリウマチ性関節炎から選択される、請求項11に記載の医薬組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361767531P | 2013-02-21 | 2013-02-21 | |
US61/767,531 | 2013-02-21 | ||
PCT/US2014/017534 WO2014130752A2 (en) | 2013-02-21 | 2014-02-21 | Bicyclic compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016513124A JP2016513124A (ja) | 2016-05-12 |
JP2016513124A5 JP2016513124A5 (ja) | 2017-03-16 |
JP6277210B2 true JP6277210B2 (ja) | 2018-02-07 |
Family
ID=50272738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015558976A Active JP6277210B2 (ja) | 2013-02-21 | 2014-02-21 | 二環式化合物 |
Country Status (35)
Country | Link |
---|---|
US (3) | US9115054B2 (ja) |
EP (1) | EP2958888B1 (ja) |
JP (1) | JP6277210B2 (ja) |
KR (1) | KR102242265B1 (ja) |
CN (1) | CN105026362B (ja) |
AR (1) | AR094851A1 (ja) |
AU (1) | AU2014218883B2 (ja) |
BR (1) | BR112015019919A2 (ja) |
CA (1) | CA2902168C (ja) |
CL (1) | CL2015002358A1 (ja) |
CY (1) | CY1118641T1 (ja) |
DK (1) | DK2958888T3 (ja) |
EA (1) | EA025294B1 (ja) |
ES (1) | ES2613262T3 (ja) |
HK (1) | HK1218111A1 (ja) |
HR (1) | HRP20170247T1 (ja) |
HU (1) | HUE031626T2 (ja) |
IL (1) | IL240613B (ja) |
LT (1) | LT2958888T (ja) |
MA (1) | MA38425B1 (ja) |
MX (1) | MX2015010347A (ja) |
MY (1) | MY173990A (ja) |
PE (1) | PE20151746A1 (ja) |
PH (1) | PH12015501793A1 (ja) |
PL (1) | PL2958888T3 (ja) |
PT (1) | PT2958888T (ja) |
RS (1) | RS55703B1 (ja) |
SG (1) | SG11201506408TA (ja) |
SI (1) | SI2958888T1 (ja) |
SM (1) | SMT201700115B (ja) |
TN (1) | TN2015000356A1 (ja) |
TW (1) | TWI613182B (ja) |
UY (1) | UY35338A (ja) |
WO (1) | WO2014130752A2 (ja) |
ZA (1) | ZA201506965B (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10077236B2 (en) | 2013-07-15 | 2018-09-18 | The Regents Of The University Of California | Azacyclic constrained analogs of FTY720 |
TWI689487B (zh) * | 2014-08-20 | 2020-04-01 | 美商必治妥美雅史谷比公司 | 經取代雙環化合物 |
WO2017053990A1 (en) * | 2015-09-24 | 2017-03-30 | The Regents Of The University Of California | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment |
EP3507278B1 (en) | 2016-09-02 | 2021-01-27 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
US11059784B2 (en) | 2017-08-09 | 2021-07-13 | Bristol-Myers Squibb Company | Oxime ether compounds |
WO2019032632A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | ALKYLPHENYL COMPOUNDS |
WO2021062168A1 (en) * | 2019-09-25 | 2021-04-01 | The Regents Of The University Of California | Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
US6069143A (en) | 1994-12-20 | 2000-05-30 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
WO2003061567A2 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Selective s1p1/edg1 receptor agonists |
CA2472715A1 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Edg receptor agonists |
DE60330047D1 (en) | 2002-01-18 | 2009-12-24 | Merck & Co Inc | "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten" |
EP1482895A4 (en) | 2002-03-01 | 2005-04-27 | Merck & Co Inc | AMINO ALKYL PHOSPHONATES AND RELATED COMPOUNDS AS EDG RECEPTOR AGONISTS |
CA2488117A1 (en) | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
AR044402A1 (es) | 2003-05-19 | 2005-09-14 | Irm Llc | Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen. |
EP1697333A4 (en) | 2003-12-17 | 2009-07-08 | Merck & Co Inc | 3,4-DISUSBSTITUTED PROPANOIC CARBOXYLATES AS S1P RECEPTOR AGONISTS (EDG) |
TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
AU2005299851B2 (en) | 2004-10-22 | 2011-03-17 | Merck Sharp & Dohme Corp. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists |
JP2008530135A (ja) | 2005-02-14 | 2008-08-07 | ユニバーシティ オブ バージニア パテント ファンデーション | アミノ基およびフェニル基で置換されたシクロアルカンならびに5員の複素環を含むスフィンゴシン=1−リン酸アゴニスト |
AU2006245438A1 (en) | 2005-02-18 | 2006-11-16 | Bellus Health (Innodia) Inc. | Analogs of 4-hydroxyisoleucine and uses thereof |
US8802840B2 (en) | 2005-03-08 | 2014-08-12 | Biota Scientific Management Pty Ltd. | Bicyclic nucleosides and nucleotides as therapeutic agents |
JP5072825B2 (ja) | 2005-03-23 | 2012-11-14 | アクテリオン ファーマシューティカルズ リミテッド | スフィンゴシン−1−ホスフェート−1受容体アゴニストとしての新規チオフェン誘導体 |
CA2605594A1 (en) | 2005-04-22 | 2006-11-02 | Daiichi Sankyo Company, Limited | Heterocyclic compound |
BRPI0612028A2 (pt) | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
CA2619101A1 (en) | 2005-08-23 | 2007-03-01 | Irm Llc | Immunosuppressant compounds and compositions |
RU2430913C2 (ru) | 2006-01-06 | 2011-10-10 | Сепракор Инк. | Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина |
MX2008009579A (es) | 2006-01-27 | 2008-09-25 | Univ Virginia | Metodo para el tratamiento de dolor neuropatico. |
WO2007088450A2 (en) | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Chromane antagonist of the h-3 receptor |
EP2010524A2 (en) | 2006-03-21 | 2009-01-07 | Epix Delaware, Inc. | S1p receptor modulating compounds |
EP2001472A2 (en) | 2006-03-23 | 2008-12-17 | Merck and Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
BRPI0709866B8 (pt) | 2006-04-03 | 2021-05-25 | Astellas Pharma Inc | compostos héteros e composição farmacêutica compreendendo ditos compostos |
JP2009269819A (ja) | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
KR101454937B1 (ko) | 2006-09-08 | 2014-10-27 | 액테리온 파마슈티칼 리미티드 | 면역조절제로서 피리딘-3-일 유도체 |
GB0625648D0 (en) | 2006-12-21 | 2007-01-31 | Glaxo Group Ltd | Compounds |
US8217027B2 (en) | 2006-12-21 | 2012-07-10 | Abbott Laboratories | Sphingosine-1-phosphate receptor agonist and antagonist compounds |
BRPI0720478A2 (pt) * | 2006-12-21 | 2014-01-14 | Abbott Laboratoires | Compostos agonistas e antagonistas do receptor esfingosina-1-fosfato |
CN101610674A (zh) * | 2006-12-21 | 2009-12-23 | 艾博特公司 | 鞘氨醇-1-磷酸酯受体激动剂和拮抗剂化合物 |
KR101174191B1 (ko) | 2007-02-02 | 2012-08-14 | 에프. 호프만-라 로슈 아게 | 중추 신경계 장애의 치료용 taar1 리간드로서 2-아미노옥사졸린 |
NZ580454A (en) | 2007-03-16 | 2011-05-27 | Actelion Pharmaceuticals Ltd | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
EA201070422A1 (ru) | 2007-10-04 | 2010-12-30 | Мерк Сероно С.А. | Производные оксадиазола |
JP5517944B2 (ja) | 2007-11-01 | 2014-06-11 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピリミジン誘導体 |
GB0725105D0 (en) | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
US8153686B2 (en) | 2008-04-01 | 2012-04-10 | Theravance, Inc. | Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists |
CA2739901A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators |
CN102245602B (zh) | 2008-12-18 | 2014-09-10 | 默克雪兰诺有限公司 | 用于治疗多发性硬化症的与恶二唑稠合的杂环衍生物 |
EP2202232A1 (en) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | 1,2,4-oxadiazole derivatives and their therapeutic use |
EP2210890A1 (en) | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
EP2382212B1 (en) | 2009-01-23 | 2014-07-16 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
JP2012515788A (ja) * | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および炎症性疾患の処置における、s1pアゴニストとしての置換オキサジアゾール誘導体 |
WO2010085584A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Pyrazole-i, 2, 4 -oxad iazole derivatives as s.phing0sine-1-ph0sphate agonists |
WO2010093616A1 (en) | 2009-02-10 | 2010-08-19 | Abbott Laboratories | Methods for preparing s1p receptor agonists and antagonists |
US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
AU2010319879A1 (en) | 2009-10-29 | 2012-06-14 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
EP2560969B1 (en) | 2010-04-23 | 2015-08-12 | Bristol-Myers Squibb Company | 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists |
CN102260177A (zh) | 2010-05-25 | 2011-11-30 | 中国医学科学院药物研究所 | 丙二醇类衍生物、其制备方法和其药物组合物与用途 |
CN102260178A (zh) | 2010-05-25 | 2011-11-30 | 中国医学科学院药物研究所 | 羟基丙二醇类衍生物、其制备方法和其药物组合物与用途 |
CN103124727B (zh) | 2010-07-20 | 2015-03-25 | 百时美施贵宝公司 | 取代的3-苯基-1,2,4-噁二唑化合物 |
WO2012040532A1 (en) | 2010-09-24 | 2012-03-29 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds and their use as s1p1 agonists |
WO2012061459A1 (en) | 2010-11-03 | 2012-05-10 | Bristol-Myers Squibb Company | Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases |
US9682078B2 (en) | 2011-03-18 | 2017-06-20 | University Of Virginia Patent Foundation | Compositions and methods for tissue engineering and cell based therapies |
WO2012147311A1 (ja) | 2011-04-26 | 2012-11-01 | パナソニック株式会社 | 暖房システム及び暖房システム制御方法 |
GB201107325D0 (en) * | 2011-05-04 | 2011-06-15 | Glaxosmithkline Llc | Novel compounds |
ES2758841T3 (es) | 2011-05-13 | 2020-05-06 | Celgene Int Ii Sarl | Moduladores heterocíclicos selectivos del receptor de la esfingosina-1-fosfato |
WO2014018891A1 (en) | 2012-07-27 | 2014-01-30 | Biogen Idec Ma Inc. | Compounds that are s1p modulating agents and/or atx modulating agents |
-
2014
- 2014-02-20 TW TW103105719A patent/TWI613182B/zh not_active IP Right Cessation
- 2014-02-20 UY UY0001035338A patent/UY35338A/es unknown
- 2014-02-20 US US14/185,164 patent/US9115054B2/en active Active
- 2014-02-21 AR ARP140100554A patent/AR094851A1/es unknown
- 2014-02-21 HU HUE14709822A patent/HUE031626T2/en unknown
- 2014-02-21 SI SI201430106A patent/SI2958888T1/sl unknown
- 2014-02-21 MA MA38425A patent/MA38425B1/fr unknown
- 2014-02-21 SG SG11201506408TA patent/SG11201506408TA/en unknown
- 2014-02-21 EP EP14709822.2A patent/EP2958888B1/en active Active
- 2014-02-21 LT LTEP14709822.2T patent/LT2958888T/lt unknown
- 2014-02-21 RS RS20170188A patent/RS55703B1/sr unknown
- 2014-02-21 AU AU2014218883A patent/AU2014218883B2/en not_active Ceased
- 2014-02-21 BR BR112015019919A patent/BR112015019919A2/pt not_active Application Discontinuation
- 2014-02-21 CA CA2902168A patent/CA2902168C/en not_active Expired - Fee Related
- 2014-02-21 EA EA201591409A patent/EA025294B1/ru not_active IP Right Cessation
- 2014-02-21 WO PCT/US2014/017534 patent/WO2014130752A2/en active Application Filing
- 2014-02-21 PT PT147098222T patent/PT2958888T/pt unknown
- 2014-02-21 CN CN201480009497.1A patent/CN105026362B/zh active Active
- 2014-02-21 PE PE2015001795A patent/PE20151746A1/es active IP Right Grant
- 2014-02-21 ES ES14709822.2T patent/ES2613262T3/es active Active
- 2014-02-21 MX MX2015010347A patent/MX2015010347A/es unknown
- 2014-02-21 MY MYPI2015702746A patent/MY173990A/en unknown
- 2014-02-21 KR KR1020157025410A patent/KR102242265B1/ko active IP Right Grant
- 2014-02-21 JP JP2015558976A patent/JP6277210B2/ja active Active
- 2014-02-21 DK DK14709822.2T patent/DK2958888T3/en active
- 2014-02-21 PL PL14709822T patent/PL2958888T3/pl unknown
-
2015
- 2015-07-14 US US14/798,498 patent/US9359286B2/en active Active
- 2015-08-14 PH PH12015501793A patent/PH12015501793A1/en unknown
- 2015-08-17 IL IL240613A patent/IL240613B/en active IP Right Grant
- 2015-08-18 TN TN2015000356A patent/TN2015000356A1/en unknown
- 2015-08-21 CL CL2015002358A patent/CL2015002358A1/es unknown
- 2015-09-18 ZA ZA2015/06965A patent/ZA201506965B/en unknown
-
2016
- 2016-05-06 US US15/148,222 patent/US9487481B2/en active Active
- 2016-05-27 HK HK16106055.1A patent/HK1218111A1/zh not_active IP Right Cessation
-
2017
- 2017-02-16 CY CY20171100216T patent/CY1118641T1/el unknown
- 2017-02-16 HR HRP20170247TT patent/HRP20170247T1/hr unknown
- 2017-02-21 SM SM201700115T patent/SMT201700115B/it unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6277210B2 (ja) | 二環式化合物 | |
JP2018531216A6 (ja) | 抗ウイルス性ベータ−アミノ酸エステルホスホジアミド化合物 | |
JP2018531216A (ja) | 抗ウイルス性ベータ−アミノ酸エステルホスホジアミド化合物 | |
EA026300B1 (ru) | Активаторы ampk и их применение в терапевтических целях | |
US11701373B2 (en) | Substituted bicyclic compounds | |
US11046646B2 (en) | Alkylphenyl compounds | |
JP7029445B2 (ja) | 置換された三環式ヘテロ環化合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20160219 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170210 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20170210 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20171219 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20171221 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180115 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6277210 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |