JP2016508136A5 - - Google Patents
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- JP2016508136A5 JP2016508136A5 JP2015549842A JP2015549842A JP2016508136A5 JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5 JP 2015549842 A JP2015549842 A JP 2015549842A JP 2015549842 A JP2015549842 A JP 2015549842A JP 2016508136 A5 JP2016508136 A5 JP 2016508136A5
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- JP
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- Prior art keywords
- linker
- self
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- compound
- destructing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261745448P | 2012-12-21 | 2012-12-21 | |
| US61/745,448 | 2012-12-21 | ||
| US201361785027P | 2013-03-14 | 2013-03-14 | |
| US61/785,027 | 2013-03-14 | ||
| PCT/US2013/077306 WO2014100762A1 (en) | 2012-12-21 | 2013-12-20 | Hydrophilic self-immolative linkers and conjugates thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016508136A JP2016508136A (ja) | 2016-03-17 |
| JP2016508136A5 true JP2016508136A5 (cg-RX-API-DMAC7.html) | 2018-06-14 |
| JP6482471B2 JP6482471B2 (ja) | 2019-03-13 |
Family
ID=50979293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549842A Expired - Fee Related JP6482471B2 (ja) | 2012-12-21 | 2013-12-20 | 親水性の自壊性リンカー及びそのコンジュゲート |
Country Status (23)
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| CN101678124A (zh) | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| TWI603741B (zh) | 2011-06-10 | 2017-11-01 | 梅爾莎納醫療公司 | 蛋白質-聚合物-藥物共軛體 |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| KR20150070318A (ko) | 2012-10-16 | 2015-06-24 | 엔도사이트, 인코포레이티드 | 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법 |
| BR112015014712A2 (pt) | 2012-12-21 | 2017-07-11 | Abgenomics Int Inc | ligadores de autoimolação hidrofílicos e seus conjugados |
| CN110143999B (zh) | 2013-03-15 | 2023-12-05 | 酵活英属哥伦比亚省公司 | 具细胞毒性和抗有丝分裂的化合物以及其使用方法 |
| KR102572149B1 (ko) | 2013-10-11 | 2023-08-30 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
| DK3054991T3 (da) | 2013-10-11 | 2019-05-06 | Mersana Therapeutics Inc | Protein-polymer-lægemiddelkonjugater |
| WO2015095952A1 (en) | 2013-12-27 | 2015-07-02 | The Centre For Drug Research And Development | Var2csa-drug conjugates |
| EP3086815B1 (en) | 2013-12-27 | 2022-02-09 | Zymeworks Inc. | Sulfonamide-containing linkage systems for drug conjugates |
| AU2015276821A1 (en) * | 2014-06-20 | 2017-01-12 | Abgenomics International Inc. | Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof |
| TW201625315A (zh) * | 2014-06-20 | 2016-07-16 | 台醫國際股份有限公司 | Ｈｅｒ２抗體－藥物共軛物 |
| JP2017523958A (ja) * | 2014-06-20 | 2017-08-24 | バイオアライアンス コマンディテール フェンノートシャップ | 抗ｃｄ２２抗体−薬物コンジュゲート及びその使用方法 |
| PL3185908T3 (pl) * | 2014-08-28 | 2020-09-07 | Pfizer Inc. | Łączniki modulujące stabilność do stosowania z koniugatami przeciwciało-lek |
| DK3194421T3 (da) | 2014-09-17 | 2022-02-14 | Zymeworks Inc | Cytotoksiske og antimitotiske forbindelser samt fremgangsmåder til anvendelse heraf |
| CN107106701B (zh) | 2014-10-03 | 2020-11-06 | 西纳福克斯股份有限公司 | 磺酰胺接头、其缀合物及制备方法 |
| CA2969689A1 (en) * | 2014-12-03 | 2016-06-09 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| CN107207579B (zh) | 2015-03-31 | 2022-02-25 | 豪夫迈·罗氏有限公司 | 包含三聚体tnf家族配体的抗原结合分子 |
| JP6987641B2 (ja) | 2015-05-12 | 2022-01-05 | ブリンクバイオ インコーポレイテッド | シリコン系薬物複合体及びその使用方法 |
| US11173213B2 (en) * | 2015-06-29 | 2021-11-16 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| US10233212B2 (en) | 2015-11-03 | 2019-03-19 | Industrial Technology Research Institute | Compounds, linker-drugs and ligand-drug conjugates |
| IL260289B (en) | 2016-01-08 | 2022-08-01 | Bioalliance Cv | Tetravalent anti-psgl-1 antibodies and uses thereof |
| US10874746B2 (en) | 2016-02-08 | 2020-12-29 | Synaffix B.V. | Sulfamide linkers for use in bioconjugates |
| CN108883191B (zh) | 2016-02-08 | 2022-10-14 | 西纳福克斯股份有限公司 | 用于靶向cd30肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法 |
| EP3413915A1 (en) | 2016-02-08 | 2018-12-19 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting her2 tumours and method for improving therapeutic index of antibody-conjugates |
| WO2017137456A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Bioconjugates containing sulfamide linkers for use in treatment |
| WO2017137457A1 (en) | 2016-02-08 | 2017-08-17 | Synaffix B.V. | Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates |
| TW201806625A (zh) | 2016-03-30 | 2018-03-01 | 康瓦鐵克科技股份有限公司 | 經修飾之傷口敷料 |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
| MY199278A (en) | 2016-06-08 | 2023-10-24 | Abbvie Inc | Anti-b7-h3 antibodies and antibody drug conjugates |
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| JP2017523958A (ja) | 2014-06-20 | 2017-08-24 | バイオアライアンス コマンディテール フェンノートシャップ | 抗ｃｄ２２抗体−薬物コンジュゲート及びその使用方法 |
| TW201625315A (zh) | 2014-06-20 | 2016-07-16 | 台醫國際股份有限公司 | Ｈｅｒ２抗體－藥物共軛物 |
| AU2015276821A1 (en) | 2014-06-20 | 2017-01-12 | Abgenomics International Inc. | Anti-folate receptor aplha (FRA) antibody-drug conjugates and methods of using thereof |
| IL260289B (en) | 2016-01-08 | 2022-08-01 | Bioalliance Cv | Tetravalent anti-psgl-1 antibodies and uses thereof |
-
2013
- 2013-12-20 BR BR112015014712A patent/BR112015014712A2/pt not_active Application Discontinuation
- 2013-12-20 MY MYPI2015001576A patent/MY169117A/en unknown
- 2013-12-20 AR ARP130105028A patent/AR094280A1/es unknown
- 2013-12-20 DK DK13865282.1T patent/DK2935259T3/en active
- 2013-12-20 WO PCT/US2013/077306 patent/WO2014100762A1/en not_active Ceased
- 2013-12-20 JP JP2015549842A patent/JP6482471B2/ja not_active Expired - Fee Related
- 2013-12-20 CN CN201380073519.6A patent/CN105102455B/zh not_active Expired - Fee Related
- 2013-12-20 CA CA2896690A patent/CA2896690A1/en not_active Abandoned
- 2013-12-20 US US14/137,799 patent/US9089614B2/en not_active Expired - Fee Related
- 2013-12-20 TW TW102147572A patent/TWI716339B/zh not_active IP Right Cessation
- 2013-12-20 SG SG11201504887TA patent/SG11201504887TA/en unknown
- 2013-12-20 SG SG10201705150RA patent/SG10201705150RA/en unknown
- 2013-12-20 KR KR1020157019681A patent/KR20150119848A/ko not_active Abandoned
- 2013-12-20 AU AU2013364065A patent/AU2013364065B2/en not_active Ceased
- 2013-12-20 MX MX2015007918A patent/MX379355B/es unknown
- 2013-12-20 PT PT13865282T patent/PT2935259T/pt unknown
- 2013-12-20 US US14/654,486 patent/US9943610B2/en active Active
- 2013-12-20 NZ NZ630601A patent/NZ630601A/en not_active IP Right Cessation
- 2013-12-20 CN CN201810460861.6A patent/CN108546283A/zh active Pending
- 2013-12-20 EP EP13865282.1A patent/EP2935259B1/en active Active
- 2013-12-20 RU RU2015129800A patent/RU2015129800A/ru unknown
- 2013-12-20 KR KR1020217034685A patent/KR20210132742A/ko not_active Abandoned
- 2013-12-20 ES ES13865282T patent/ES2714951T3/es active Active
- 2013-12-20 RU RU2019105549A patent/RU2019105549A/ru unknown
-
2015
- 2015-06-17 US US14/742,621 patent/US9408923B2/en not_active Expired - Fee Related
- 2015-06-18 IL IL239506A patent/IL239506B/en active IP Right Grant
- 2015-06-18 CL CL2015001735A patent/CL2015001735A1/es unknown
- 2015-06-19 PH PH12015501422A patent/PH12015501422B1/en unknown
- 2015-07-09 ZA ZA2015/04941A patent/ZA201504941B/en unknown
-
2018
- 2018-03-13 US US15/920,229 patent/US20180264131A1/en not_active Abandoned
-
2020
- 2020-12-10 US US17/118,228 patent/US20210113710A1/en not_active Abandoned
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