JP2016507499A5 - - Google Patents
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- JP2016507499A5 JP2016507499A5 JP2015549689A JP2015549689A JP2016507499A5 JP 2016507499 A5 JP2016507499 A5 JP 2016507499A5 JP 2015549689 A JP2015549689 A JP 2015549689A JP 2015549689 A JP2015549689 A JP 2015549689A JP 2016507499 A5 JP2016507499 A5 JP 2016507499A5
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- Prior art keywords
- polypeptide
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- antigen
- costimulatory
- terminus
- Prior art date
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- 229920001184 polypeptide Polymers 0.000 claims 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims 44
- 102000004196 processed proteins & peptides Human genes 0.000 claims 44
- 239000000427 antigen Substances 0.000 claims 20
- 102000036639 antigens Human genes 0.000 claims 20
- 108091007433 antigens Proteins 0.000 claims 20
- 230000000139 costimulatory effect Effects 0.000 claims 15
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 11
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 11
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 10
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 10
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 8
- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 8
- 230000003834 intracellular effect Effects 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- RJBDSRWGVYNDHL-XNJNKMBASA-N (2S,4R,5S,6S)-2-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E,2R,3S)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-5-amino-6-[(1S,2R)-2-[(2S,4R,5S,6S)-5-amino-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-1,3-dihydroxypropyl]-4-hydroxyoxane-2-carboxylic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3NC(C)=O)[C@H](O[C@@]3(C[C@@H](O)[C@H](N)[C@H](O3)[C@H](O)[C@@H](CO)O[C@@]3(C[C@@H](O)[C@H](N)[C@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H](O)\C=C\CCCCCCCCCCCCC RJBDSRWGVYNDHL-XNJNKMBASA-N 0.000 claims 2
- 102100027207 CD27 antigen Human genes 0.000 claims 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 claims 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 claims 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 2
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 claims 2
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 2
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 claims 2
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 2
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 claims 2
- 102000000440 Melanoma-associated antigen Human genes 0.000 claims 2
- 108050008953 Melanoma-associated antigen Proteins 0.000 claims 2
- 102100023123 Mucin-16 Human genes 0.000 claims 2
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 claims 2
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 claims 2
- 101710120463 Prostate stem cell antigen Proteins 0.000 claims 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 2
- 102100035703 Prostatic acid phosphatase Human genes 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 claims 2
- 108010043671 prostatic acid phosphatase Proteins 0.000 claims 2
- 102000007469 Actins Human genes 0.000 claims 1
- 108010085238 Actins Proteins 0.000 claims 1
- 102100024321 Alkaline phosphatase, placental type Human genes 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 102000024905 CD99 Human genes 0.000 claims 1
- 108060001253 CD99 Proteins 0.000 claims 1
- 102000016843 Calbindin 2 Human genes 0.000 claims 1
- 108010028326 Calbindin 2 Proteins 0.000 claims 1
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 1
- 102000007345 Chromogranins Human genes 0.000 claims 1
- 108010007718 Chromogranins Proteins 0.000 claims 1
- 102100035167 Coiled-coil domain-containing protein 54 Human genes 0.000 claims 1
- 102100036912 Desmin Human genes 0.000 claims 1
- 108010044052 Desmin Proteins 0.000 claims 1
- 101150029707 ERBB2 gene Proteins 0.000 claims 1
- 102400001368 Epidermal growth factor Human genes 0.000 claims 1
- 101800003838 Epidermal growth factor Proteins 0.000 claims 1
- 101710113436 GTPase KRas Proteins 0.000 claims 1
- 102000053171 Glial Fibrillary Acidic Human genes 0.000 claims 1
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 102100027893 Homeobox protein Nkx-2.1 Human genes 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101100061678 Homo sapiens CTLA4 gene Proteins 0.000 claims 1
- 101000737052 Homo sapiens Coiled-coil domain-containing protein 54 Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 claims 1
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 claims 1
- 101000620359 Homo sapiens Melanocyte protein PMEL Proteins 0.000 claims 1
- 101000583175 Homo sapiens Prolactin-inducible protein Proteins 0.000 claims 1
- 101001091538 Homo sapiens Pyruvate kinase PKM Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000824971 Homo sapiens Sperm surface protein Sp17 Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 108010047852 Integrin alphaVbeta3 Proteins 0.000 claims 1
- 102100032999 Integrin beta-3 Human genes 0.000 claims 1
- 108010044467 Isoenzymes Proteins 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 claims 1
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102000003735 Mesothelin Human genes 0.000 claims 1
- 108090000015 Mesothelin Proteins 0.000 claims 1
- 102100034256 Mucin-1 Human genes 0.000 claims 1
- 108010008707 Mucin-1 Proteins 0.000 claims 1
- 101001096236 Mus musculus Prolactin-inducible protein homolog Proteins 0.000 claims 1
- 102000008763 Neurofilament Proteins Human genes 0.000 claims 1
- 108010088373 Neurofilament Proteins Proteins 0.000 claims 1
- 108700020796 Oncogene Proteins 0.000 claims 1
- 102100030350 Prolactin-inducible protein Human genes 0.000 claims 1
- 102000013009 Pyruvate Kinase Human genes 0.000 claims 1
- 108020005115 Pyruvate Kinase Proteins 0.000 claims 1
- 102100034911 Pyruvate kinase PKM Human genes 0.000 claims 1
- 241000713810 Rat sarcoma virus Species 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100033504 Thyroglobulin Human genes 0.000 claims 1
- 108010034949 Thyroglobulin Proteins 0.000 claims 1
- 108010057966 Thyroid Nuclear Factor 1 Proteins 0.000 claims 1
- 102100034030 Transient receptor potential cation channel subfamily M member 8 Human genes 0.000 claims 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 102100033254 Tumor suppressor ARF Human genes 0.000 claims 1
- 101710102803 Tumor suppressor ARF Proteins 0.000 claims 1
- 102100039094 Tyrosinase Human genes 0.000 claims 1
- 108060008724 Tyrosinase Proteins 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 210000005045 desmin Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 229940116977 epidermal growth factor Drugs 0.000 claims 1
- 210000004955 epithelial membrane Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000005044 neurofilament Anatomy 0.000 claims 1
- 108010031345 placental alkaline phosphatase Proteins 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108010014186 ras Proteins Proteins 0.000 claims 1
- 102000016914 ras Proteins Human genes 0.000 claims 1
- -1 synaptophysis Proteins 0.000 claims 1
- 229960002175 thyroglobulin Drugs 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261740113P | 2012-12-20 | 2012-12-20 | |
| US61/740,113 | 2012-12-20 | ||
| US201361779925P | 2013-03-13 | 2013-03-13 | |
| US61/779,925 | 2013-03-13 | ||
| PCT/US2013/076486 WO2014100385A1 (en) | 2012-12-20 | 2013-12-19 | Chimeric antigen receptors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100931A Division JP6697026B2 (ja) | 2012-12-20 | 2018-05-25 | キメラ抗原受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016507499A JP2016507499A (ja) | 2016-03-10 |
| JP2016507499A5 true JP2016507499A5 (enExample) | 2017-02-09 |
| JP6422883B2 JP6422883B2 (ja) | 2018-11-21 |
Family
ID=50979209
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015549689A Active JP6422883B2 (ja) | 2012-12-20 | 2013-12-19 | キメラ抗原受容体 |
| JP2018100931A Active JP6697026B2 (ja) | 2012-12-20 | 2018-05-25 | キメラ抗原受容体 |
| JP2020076729A Active JP6992117B2 (ja) | 2012-12-20 | 2020-04-23 | キメラ抗原受容体 |
| JP2021199109A Pending JP2022033930A (ja) | 2012-12-20 | 2021-12-08 | キメラ抗原受容体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018100931A Active JP6697026B2 (ja) | 2012-12-20 | 2018-05-25 | キメラ抗原受容体 |
| JP2020076729A Active JP6992117B2 (ja) | 2012-12-20 | 2020-04-23 | キメラ抗原受容体 |
| JP2021199109A Pending JP2022033930A (ja) | 2012-12-20 | 2021-12-08 | キメラ抗原受容体 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10150816B2 (enExample) |
| EP (3) | EP2935321B1 (enExample) |
| JP (4) | JP6422883B2 (enExample) |
| KR (2) | KR102254978B1 (enExample) |
| CN (2) | CN110041432B (enExample) |
| AU (1) | AU2013204922B2 (enExample) |
| CA (2) | CA2895840C (enExample) |
| ES (2) | ES2864507T3 (enExample) |
| IL (1) | IL239500B (enExample) |
| SG (2) | SG11201504855WA (enExample) |
| WO (1) | WO2014100385A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| US20150320799A1 (en) | 2012-12-20 | 2015-11-12 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| SG11201505896YA (en) | 2013-02-20 | 2015-09-29 | Novartis Ag | Treatment of cancer using humanized anti-egfrviii chimeric antigen receptor |
| EP2970426B1 (en) * | 2013-03-15 | 2019-08-28 | Michael C. Milone | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| CN105518018B (zh) | 2013-03-15 | 2020-04-03 | 细胞基因公司 | 修饰的t淋巴细胞 |
| CN105246504A (zh) * | 2013-03-15 | 2016-01-13 | 纪念斯隆-凯特琳癌症中心 | 用于免疫疗法的组合物和方法 |
| KR102238226B1 (ko) | 2013-05-14 | 2021-04-09 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 가공된 키메라 항원 수용체 (ｃａｒ) ｔ-세포의 인간 적용 |
| WO2014190273A1 (en) | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| KR102375998B1 (ko) | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| SI3689899T1 (sl) | 2014-04-25 | 2022-01-31 | 2Seventy Bio, Inc. | MND promotor kimeričnih antigenskih receptorjev |
| EP3738597A1 (en) | 2014-04-25 | 2020-11-18 | Bluebird Bio, Inc. | Improved methods for manufacturing adoptive cell therapies |
| NZ726989A (en) | 2014-06-06 | 2020-08-28 | Bluebird Bio Inc | Improved t cell compositions |
| JP2017518053A (ja) | 2014-06-06 | 2017-07-06 | メモリアル スローン−ケタリング キャンサー センター | メソセリン標的化キメラ抗原受容体およびその使用 |
| MX2017000646A (es) | 2014-07-15 | 2017-04-27 | Juno Therapeutics Inc | Celulas geneticamente modificadas para terapia celular adoptiva. |
| CN107109420A (zh) | 2014-07-21 | 2017-08-29 | 诺华股份有限公司 | 使用cll－1嵌合抗原受体的癌症治疗 |
| WO2016014565A2 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| SG10201900455YA (en) * | 2014-07-24 | 2019-02-27 | Bluebird Bio Inc | Bcma chimeric antigen receptors |
| WO2016026143A1 (en) | 2014-08-22 | 2016-02-25 | Huiru Wang | Saccharide-based biomarkers and therapeutics |
| EP3189073B2 (en) * | 2014-09-04 | 2025-06-11 | Cellectis | Trophoblast glycoprotein (5t4, tpbg) specific chimeric antigen receptors for cancer immunotherapy |
| UA123764C2 (uk) * | 2014-09-15 | 2021-06-02 | МОЛМЕД СпА | Химерний рецептор антигену та його застосування при лікуванні пухлин, які експресують cd44 |
| HK1243441A1 (zh) * | 2014-11-05 | 2018-07-13 | Board Of Regents, The University Of Texas System | 基因修饰的免疫效应细胞和用於扩增免疫效应细胞的工程化细胞 |
| NZ733025A (en) | 2014-12-12 | 2022-01-28 | 2Seventy Bio Inc | Bcma chimeric antigen receptors |
| CA2973529A1 (en) | 2015-01-26 | 2016-08-04 | Cellectis | Cll1-specific multi-chain chimeric antigen receptor |
| US10557140B2 (en) | 2015-02-02 | 2020-02-11 | Industry-Academic Cooperation Foundation, Dankook University | CTLA-4-targeting trans-splicing ribozyme for delivery of chimeric antigen receptor, and use thereof |
| CN105985444B (zh) * | 2015-02-05 | 2024-02-13 | 博生吉安科细胞技术有限公司 | 一种嵌合抗原受体、以及快速构建嵌合抗原受体的方法及应用 |
| US10336810B2 (en) | 2015-02-12 | 2019-07-02 | University Health Network | Chimeric antigen receptors, encoding nucleic acids and methods of use thereof |
| EP3261651B1 (en) | 2015-02-27 | 2022-05-04 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| CA2976684C (en) * | 2015-03-02 | 2024-03-05 | Innovative Cellular Therapeutics CO., LTD. | Reducing immune tolerance induced by pd-l1 |
| CA2980038A1 (en) * | 2015-03-18 | 2016-09-22 | Memorial Sloan Kettering Cancer Center | Compositions and methods for targeting cd99 in haematopoietic and lymphoid malignancies |
| CA2984624A1 (en) * | 2015-03-18 | 2016-09-22 | Baylor College Of Medicine | Her2/erbb2 chimeric antigen receptor |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| US11655452B2 (en) * | 2015-06-25 | 2023-05-23 | Icell Gene Therapeutics Inc. | Chimeric antigen receptors (CARs), compositions and methods of use thereof |
| HK1255637A1 (zh) * | 2015-06-29 | 2019-08-23 | The Johns Hopkins University | 免疫检查点嵌合受体疗法 |
| MA42895A (fr) | 2015-07-15 | 2018-05-23 | Juno Therapeutics Inc | Cellules modifiées pour thérapie cellulaire adoptive |
| ES2877090T3 (es) | 2015-08-05 | 2021-11-16 | Cellabmed Inc | Receptor de antígenos quiméricos y células T en las que se expresa el receptor de antígenos quiméricos |
| GB201518816D0 (en) | 2015-10-23 | 2015-12-09 | Autolus Ltd | Receptor |
| BR112018009129A2 (pt) | 2015-11-04 | 2019-02-26 | J. PRICEMAN Saul | receptores de antígeno quimérico que visam her2 |
| US11479755B2 (en) | 2015-12-07 | 2022-10-25 | 2Seventy Bio, Inc. | T cell compositions |
| US10259876B2 (en) * | 2016-01-21 | 2019-04-16 | Pfizer Inc. | Chimeric antigen receptors targeting epidermal growth factor receptor variant III |
| CN105567640A (zh) * | 2016-01-27 | 2016-05-11 | 苏州佰通生物科技有限公司 | 一种嵌合抗原受体脂肪干细胞及其制备方法 |
| AU2017213661B2 (en) * | 2016-02-05 | 2022-06-02 | City Of Hope | Administration of engineered T cells for treatment of cancers in the central nervous system |
| WO2017139975A1 (en) | 2016-02-19 | 2017-08-24 | Huiru Wang | Antibodies against n-acetylglucosamine and n-acetyl-galactosamine |
| CN110699371A (zh) * | 2016-03-18 | 2020-01-17 | 江苏普瑞康生物医药科技有限公司 | 一种基于FcγRⅢa的嵌合基因及其用途 |
| EP4286522A3 (en) | 2016-03-23 | 2024-02-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins of pd-1 and 4-1bb |
| JP7282521B2 (ja) | 2016-04-08 | 2023-05-29 | パーデュー・リサーチ・ファウンデイション | Ｃａｒ ｔ細胞療法のための方法および組成物 |
| EP4353750A3 (en) * | 2016-06-24 | 2024-07-24 | iCell Gene Therapeutics LLC | Chimeric antigen receptors (cars), compositions and methods thereof |
| CN106279432B (zh) * | 2016-08-10 | 2019-09-20 | 深圳市再生之城生物医药技术有限公司 | 一种vc-car分子及在清除hiv-1感染细胞中的应用 |
| ES2916335T3 (es) | 2016-10-20 | 2022-06-30 | Celgene Corp | Receptores de antígeno quimérico heterodimerizable basados en cereblon |
| KR20240005168A (ko) | 2016-11-04 | 2024-01-11 | 2세븐티 바이오, 인코포레이티드 | 항-bcma car t 세포 조성물 |
| EP4653464A2 (en) | 2016-12-23 | 2025-11-26 | MacroGenics, Inc. | Adam9-binding molecules, and methods of use thereof |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
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2013
- 2013-04-12 AU AU2013204922A patent/AU2013204922B2/en not_active Ceased
- 2013-12-19 WO PCT/US2013/076486 patent/WO2014100385A1/en not_active Ceased
- 2013-12-19 SG SG11201504855WA patent/SG11201504855WA/en unknown
- 2013-12-19 ES ES18195425T patent/ES2864507T3/es active Active
- 2013-12-19 EP EP13865885.1A patent/EP2935321B1/en active Active
- 2013-12-19 US US14/653,650 patent/US10150816B2/en active Active
- 2013-12-19 CN CN201910327863.2A patent/CN110041432B/zh not_active Expired - Fee Related
- 2013-12-19 KR KR1020157019392A patent/KR102254978B1/ko not_active Expired - Fee Related
- 2013-12-19 ES ES13865885T patent/ES2703747T3/es active Active
- 2013-12-19 EP EP21157681.4A patent/EP3909976A1/en not_active Withdrawn
- 2013-12-19 JP JP2015549689A patent/JP6422883B2/ja active Active
- 2013-12-19 SG SG10201805411YA patent/SG10201805411YA/en unknown
- 2013-12-19 CN CN201380073452.6A patent/CN105246912B/zh not_active Expired - Fee Related
- 2013-12-19 CA CA2895840A patent/CA2895840C/en active Active
- 2013-12-19 KR KR1020217014635A patent/KR102361886B1/ko not_active Expired - Fee Related
- 2013-12-19 EP EP18195425.6A patent/EP3483177B1/en active Active
- 2013-12-19 CA CA3178119A patent/CA3178119A1/en active Pending
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2015
- 2015-06-18 IL IL239500A patent/IL239500B/en active IP Right Grant
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- 2018-10-30 US US16/175,747 patent/US11130820B2/en active Active
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- 2020-04-23 JP JP2020076729A patent/JP6992117B2/ja active Active
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- 2021-09-10 US US17/472,119 patent/US20220106404A1/en not_active Abandoned
- 2021-12-08 JP JP2021199109A patent/JP2022033930A/ja active Pending
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