JP2016506968A - 胎盤由来のナチュラルキラー細胞 - Google Patents
胎盤由来のナチュラルキラー細胞 Download PDFInfo
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- JP2016506968A JP2016506968A JP2015556222A JP2015556222A JP2016506968A JP 2016506968 A JP2016506968 A JP 2016506968A JP 2015556222 A JP2015556222 A JP 2015556222A JP 2015556222 A JP2015556222 A JP 2015556222A JP 2016506968 A JP2016506968 A JP 2016506968A
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- cells
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- 0 Nc1cccc(C(C(*C(CCC(N2)=O)C2=O)C2)=O)c1C2=O Chemical compound Nc1cccc(C(C(*C(CCC(N2)=O)C2=O)C2)=O)c1C2=O 0.000 description 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/418—Antigens related to induction of tolerance to non-self
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/05—Adjuvants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361761176P | 2013-02-05 | 2013-02-05 | |
| US61/761,176 | 2013-02-05 | ||
| US201361780115P | 2013-03-13 | 2013-03-13 | |
| US61/780,115 | 2013-03-13 | ||
| PCT/US2014/014632 WO2014123879A1 (en) | 2013-02-05 | 2014-02-04 | Natural killer cells from placenta |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018189593A Division JP2019048809A (ja) | 2013-02-05 | 2018-10-05 | 胎盤由来のナチュラルキラー細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016506968A true JP2016506968A (ja) | 2016-03-07 |
| JP2016506968A5 JP2016506968A5 (cg-RX-API-DMAC7.html) | 2017-06-29 |
Family
ID=51300079
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015556222A Pending JP2016506968A (ja) | 2013-02-05 | 2014-02-04 | 胎盤由来のナチュラルキラー細胞 |
| JP2018189593A Pending JP2019048809A (ja) | 2013-02-05 | 2018-10-05 | 胎盤由来のナチュラルキラー細胞 |
| JP2020129197A Withdrawn JP2020196724A (ja) | 2013-02-05 | 2020-07-30 | 胎盤由来のナチュラルキラー細胞 |
| JP2022104464A Pending JP2022130600A (ja) | 2013-02-05 | 2022-06-29 | 胎盤由来のナチュラルキラー細胞 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018189593A Pending JP2019048809A (ja) | 2013-02-05 | 2018-10-05 | 胎盤由来のナチュラルキラー細胞 |
| JP2020129197A Withdrawn JP2020196724A (ja) | 2013-02-05 | 2020-07-30 | 胎盤由来のナチュラルキラー細胞 |
| JP2022104464A Pending JP2022130600A (ja) | 2013-02-05 | 2022-06-29 | 胎盤由来のナチュラルキラー細胞 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9763983B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2953635A4 (cg-RX-API-DMAC7.html) |
| JP (4) | JP2016506968A (cg-RX-API-DMAC7.html) |
| CN (3) | CN115137753A (cg-RX-API-DMAC7.html) |
| AU (4) | AU2014215458A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1218515A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014123879A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2941519C (en) * | 2014-03-07 | 2022-09-06 | Emercell Sas | Pooled nk cells from ombilical cord blood and their uses for the treatment of cancer and chronic infectious disease |
| WO2018126074A1 (en) * | 2016-12-30 | 2018-07-05 | Celularity, Inc. | Genetically modified natural killer cells |
| AU2018354189A1 (en) * | 2017-10-24 | 2020-04-23 | Crispr Therapeutics Ag | Compositions and methods for the depletion of CD117+ cells |
| MY199514A (en) * | 2018-02-01 | 2023-11-02 | Nkmax Co Ltd | Method of producing natural killer cells and composition for treating cancer |
| WO2020189232A1 (ja) | 2019-03-15 | 2020-09-24 | 日本製鉄株式会社 | レール |
| CN112029721A (zh) * | 2020-09-09 | 2020-12-04 | 广东昭泰体内生物医药科技有限公司 | 一种活性增强型nk细胞的制备方法 |
| WO2023275880A1 (en) * | 2021-06-30 | 2023-01-05 | Regrow Biosciences Private Limited | Method of obtaining hsc population, t cell population and nk cell population and compositions thereof |
| CN113804661B (zh) * | 2021-08-12 | 2024-08-27 | 深圳市锦欣医疗科技创新中心有限公司 | 一种评估子宫内膜容受性的试剂盒及方法 |
| WO2025050133A1 (en) * | 2023-09-01 | 2025-03-06 | Northeastern University | Isolation and expansion of natural killer cells using fluorescence-activated droplet sorting |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06510672A (ja) * | 1991-11-05 | 1994-12-01 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | サプレッサーおよび前駆細胞 |
| JP2010518096A (ja) * | 2007-02-12 | 2010-05-27 | アンスロジェネシス コーポレーション | 胎盤幹細胞を使用した炎症性疾患の治療 |
| US20110280849A1 (en) * | 2010-03-26 | 2011-11-17 | Anthrogenesis Corporation | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| WO2012083021A1 (en) * | 2010-12-17 | 2012-06-21 | Anthrogenesis Corporation | Treatment of immune-related diseases and disorders using amnion derived adherent cells |
| WO2012094905A1 (zh) * | 2011-01-14 | 2012-07-19 | 中国人民解放军军事医学科学院附属医院 | 基于b7-1-pe40kdel外毒素融合基因的dna疫苗及其用途 |
Family Cites Families (306)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862002A (en) | 1962-05-08 | 1975-01-21 | Sanfar Lab Inc | Production of physiologically active placental substances |
| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| NZ226750A (en) | 1987-10-29 | 1990-09-26 | Amrad Corp Ltd | Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| GB8803697D0 (en) | 1988-02-17 | 1988-03-16 | Deltanine Research Ltd | Clinical developments using amniotic membrane cells |
| US5284766A (en) | 1989-02-10 | 1994-02-08 | Kao Corporation | Bed material for cell culture |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5605822A (en) | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| US5763266A (en) | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| US5399493A (en) | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| AU633958B2 (en) | 1989-07-25 | 1993-02-11 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| EP0747485B1 (en) | 1989-11-06 | 1998-12-02 | Cell Genesys, Inc. | Production of proteins using homologous recombination |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5733542A (en) | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US6010696A (en) | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5190556A (en) | 1991-03-19 | 1993-03-02 | O.B. Tech, Inc. | Cord cutter sampler |
| US5744361A (en) | 1991-04-09 | 1998-04-28 | Indiana University | Expansion of human hematopoietic progenitor cells in a liquid medium |
| WO1993003139A1 (fr) | 1991-08-08 | 1993-02-18 | Kao Corporation | Support pour la culture de cellules, production de ce support et production d'un amas de cellules au moyen de ce support |
| EP0529751A1 (en) | 1991-08-09 | 1993-03-03 | W.R. Grace & Co.-Conn. | Cell culture substrate, test material for cell culture and preparations thereof |
| AU2515992A (en) | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5356373A (en) | 1991-11-15 | 1994-10-18 | Miles Inc. | Method and apparatus for autologous transfusions in premature infants |
| US6057123A (en) | 1991-12-23 | 2000-05-02 | British Biotech Pharmaceuticals Limited | Stem cell inhibiting proteins |
| EP0590156A4 (en) | 1992-03-31 | 1994-07-13 | Toray Industries | Novel, physiologically active protein and hemopoietic stem cell growth promoter |
| US5436151A (en) | 1992-04-03 | 1995-07-25 | Regents Of The University Of Minnesota | Method for culturing human hematopoietic stem cells in vitro |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| AU4543193A (en) | 1992-06-22 | 1994-01-24 | Henry E. Young | Scar inhibitory factor and use thereof |
| US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5693482A (en) | 1992-07-27 | 1997-12-02 | California Institute Of Technology | Neural chest stem cell assay |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| AU5603894A (en) | 1992-11-16 | 1994-06-08 | Applied Immune Sciences, Inc. | Pluripotential quiescent stem cell population |
| US5772992A (en) | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
| CA2159506A1 (en) | 1993-03-31 | 1994-10-13 | Vladimir Kozlov | Inhibitor of stem cell proliferation and uses thereof |
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US5698579A (en) | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
| US5372581A (en) | 1993-07-21 | 1994-12-13 | Minneapolis Children's Services Corporation | Method and apparatus for placental blood collection |
| IL107483A0 (en) | 1993-11-03 | 1994-02-27 | Yeda Res & Dev | Bone marrow transplantation |
| US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US6288030B1 (en) | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| US6001654A (en) | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| EP0952792B1 (en) | 1994-06-06 | 2003-08-27 | Case Western Reserve University | Biomatrix for tissue regeneration |
| US6174333B1 (en) | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| DE4422667A1 (de) | 1994-06-30 | 1996-01-04 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Züchtung hämatopoetischer Vorläuferzellen |
| US6103522A (en) | 1994-07-20 | 2000-08-15 | Fred Hutchinson Cancer Research Center | Human marrow stromal cell lines which sustain hematopoiesis |
| US5516532A (en) | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US5827742A (en) | 1994-09-01 | 1998-10-27 | Beth Israel Deaconess Medical Center, Inc. | Method of selecting pluripotent hematopioetic progenitor cells |
| US5665557A (en) | 1994-11-14 | 1997-09-09 | Systemix, Inc. | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof |
| DE69527540T2 (de) | 1994-11-16 | 2003-01-30 | Amgen Inc., Thousand Oaks | Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US6011000A (en) | 1995-03-03 | 2000-01-04 | Perrine; Susan P. | Compositions for the treatment of blood disorders |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US5716616A (en) | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| US5733541A (en) | 1995-04-21 | 1998-03-31 | The Regent Of The University Of Michigan | Hematopoietic cells: compositions and methods |
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| HUP9801443A3 (en) | 1995-04-27 | 2001-11-28 | Procter & Gamble | Carrier substrate treated with high internal water phase inverse emulsion made with an organopolysiloxane-polyoxyalkylene emulsifier |
| US5925567A (en) | 1995-05-19 | 1999-07-20 | T. Breeders, Inc. | Selective expansion of target cell populations |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5830708A (en) | 1995-06-06 | 1998-11-03 | Advanced Tissue Sciences, Inc. | Methods for production of a naturally secreted extracellular matrix |
| AU6223296A (en) | 1995-06-07 | 1996-12-30 | Novartis Ag | Methods for obtaining compositions enriched for hematopoieti c stem cells and antibodies for use therein |
| US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5654381A (en) | 1995-06-16 | 1997-08-05 | Massachusetts Institute Of Technology | Functionalized polyester graft copolymers |
| US5877299A (en) | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5858782A (en) | 1995-11-13 | 1999-01-12 | Regents Of The University Of Michigan | Functional human hematopoietic cells |
| AU1119397A (en) | 1995-11-14 | 1997-06-05 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
| JP3781433B2 (ja) | 1995-11-16 | 2006-05-31 | ケース ウエスターン リザーブ ユニバーシティ | ヒト間葉幹細胞の試験管内軟骨形成誘導 |
| US6337387B1 (en) | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| US5716794A (en) | 1996-03-29 | 1998-02-10 | Xybernaut Corporation | Celiac antigen |
| JP2000508911A (ja) | 1996-04-19 | 2000-07-18 | オシリス セラピューティクス,インコーポレイテッド | 間葉幹細胞を用いる骨の再生および増強 |
| EP0953040A4 (en) | 1996-04-26 | 2001-12-12 | Univ Case Western Reserve | REGENERATION OF THE SKIN USING MESENCHYMAL STEM CELLS |
| US5919176A (en) | 1996-05-14 | 1999-07-06 | Children's Hospital Medical Center Of Northern California | Apparatus and method for collecting blood from an umbilical cord |
| US5798368A (en) | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
| HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| JP4065567B2 (ja) | 1996-07-24 | 2008-03-26 | セルジーン コーポレイション | 置換2―(2,6―ジオキソピペリジン―3―イル)フタルイミド類及び―1―オキソイソインドリン類ならびにTNFαレベルの減少方法 |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| SK17799A3 (en) | 1996-08-12 | 1999-11-08 | Celgene Corp | Cyano and carboxy derivatives of substituted styrenes, pharmaceutical composition containing same and their use |
| US5851984A (en) | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| US5916202A (en) | 1996-08-30 | 1999-06-29 | Haswell; John N. | Umbilical cord blood collection |
| US6227202B1 (en) | 1996-09-03 | 2001-05-08 | Maulana Azad Medical College | Method of organogenesis and tissue regeneration/repair using surgical techniques |
| US5945337A (en) | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| US5919702A (en) | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
| US5969105A (en) | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
| US6335195B1 (en) | 1997-01-28 | 2002-01-01 | Maret Corporation | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| DE69837491T2 (de) | 1997-07-03 | 2008-01-17 | Osiris Therapeutics, Inc. | Menschliche mesenchymale stammzellen aus peripherem blut |
| US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| ATE307195T1 (de) | 1997-07-14 | 2005-11-15 | Osiris Therapeutics Inc | Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen |
| US6077708A (en) | 1997-07-18 | 2000-06-20 | Collins; Paul C. | Method of determining progenitor cell content of a hematopoietic cell culture |
| US5879318A (en) | 1997-08-18 | 1999-03-09 | Npbi International B.V. | Method of and closed system for collecting and processing umbilical cord blood |
| AU9127098A (en) | 1997-09-04 | 1999-03-22 | Osiris Therapeutics, Inc. | Ligands that modulate differentiation of mesenchymal stem cells |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| US5955476A (en) | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
| US5874448A (en) | 1997-11-18 | 1999-02-23 | Celgene Corporation | Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels |
| US6248587B1 (en) | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
| US6059968A (en) | 1998-01-20 | 2000-05-09 | Baxter International Inc. | Systems for processing and storing placenta/umbilical cord blood |
| US6291240B1 (en) | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
| AU749675B2 (en) | 1998-03-13 | 2002-07-04 | Mesoblast International Sarl | Uses for human non-autologous mesenchymal stem cells |
| TR200101500T2 (tr) | 1998-03-16 | 2002-06-21 | Celgene Corporation | 2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuarn sitokinlerin inhibitörleri olarak kullanımı. |
| US6368636B1 (en) | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| PT1066052E (pt) | 1998-03-18 | 2006-06-30 | Osiris Therapeutics Inc | Celulas estaminais mesenquimatosas para a prevencao e tratamento |
| DK1066060T3 (da) | 1998-04-03 | 2003-11-24 | Osiris Therapeutics Inc | Mesenkymale stamceller som immunsuppresive midler |
| AU770319C (en) | 1998-05-04 | 2004-11-25 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
| EP1078042A1 (en) | 1998-05-22 | 2001-02-28 | Osiris Therapeutics, Inc. | Production of megakaryocytes by co-culturing human mesenchymal stem cells with cd34+ cells |
| US6387367B1 (en) | 1998-05-29 | 2002-05-14 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US6030836A (en) | 1998-06-08 | 2000-02-29 | Osiris Therapeutics, Inc. | Vitro maintenance of hematopoietic stem cells |
| JP2003505006A (ja) | 1998-06-08 | 2003-02-12 | オシリス セラピューティクス,インコーポレイテッド | ヒト間葉幹細胞の使用による造血幹細胞分化の調節 |
| US6713245B2 (en) | 1998-07-06 | 2004-03-30 | Diacrin, Inc. | Methods for storing neural cells such that they are suitable for transplantation |
| ES2198067T3 (es) | 1998-07-28 | 2004-01-16 | Synthes Ag Chur | Utilizacion de compuestos a base de creatina para tratar las celulas y los tejidos oseos y cartilaginosos. |
| US5958767A (en) | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
| JP3517359B2 (ja) | 1998-09-14 | 2004-04-12 | テルモ株式会社 | 細胞分離・回収装置および細胞の分離・回収方法 |
| CA2345397A1 (en) | 1998-09-23 | 2000-03-30 | Mount Sinai Hospital | Trophoblast cell preparations |
| EP1129176A4 (en) | 1998-11-09 | 2002-10-30 | Es Cell Int Pte Ltd | EMBRYONIC STEM CELLS |
| US6548299B1 (en) | 1999-11-12 | 2003-04-15 | Mark J. Pykett | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices |
| ATE383417T1 (de) | 1998-11-12 | 2008-01-15 | Cytomatrix Llc | Produktion lymphoider gewebsspezifischer zellen von hämatopoietischen vorläuferzellen in einem dreidimensionalen system |
| US6184035B1 (en) | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
| US6102871A (en) | 1998-11-23 | 2000-08-15 | Coe; Rosemarie O. | Blood collection funnel |
| US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
| DE69919029T2 (de) | 1998-12-24 | 2005-09-08 | Biosafe S.A. | Vorrichtung zur bluttrennung, insbesondere zur konzentrierung von hematopoietischen stammzellen |
| NZ513953A (en) | 1999-03-18 | 2001-09-28 | Celgene Corp | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
| US20030007954A1 (en) | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
| CA2370330C (en) | 1999-04-16 | 2009-01-20 | Wm. Marsh Rice University | Biodegradable poly(propylene fumarate) networks cross linked with poly(propylene fumarate)-diacrylate macromers |
| IN191359B (cg-RX-API-DMAC7.html) | 1999-04-20 | 2003-11-29 | Nat Inst Immunology | |
| WO2000073421A2 (en) | 1999-06-02 | 2000-12-07 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US6239157B1 (en) | 1999-09-10 | 2001-05-29 | Osiris Therapeutics, Inc. | Inhibition of osteoclastogenesis |
| US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| DE19954421A1 (de) | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Filmförmige Zubereitung zur biphasigen Freisetzung pharmakologisch wirksamer oder anderer Substanzen |
| DE10001172A1 (de) | 2000-01-13 | 2001-07-26 | Max Planck Gesellschaft | Templatieren von Feststoffpartikeln mit Polymermultischichten |
| EP1264877B1 (en) | 2000-03-16 | 2013-10-02 | Cellseed Inc. | Cell cultivation-support material, method of cocultivation of cells and cocultivated cell sheet obtained therefrom |
| WO2001075094A1 (en) | 2000-04-04 | 2001-10-11 | Thomas Jefferson University | Application of myeloid-origin cells to the nervous system |
| ATE332708T1 (de) | 2000-06-06 | 2006-08-15 | Glaxo Group Ltd | Krebsbehandlung zusammensetzung, welche ein antineoplastisches mittel und pde4 inhibitor enthält |
| US20050009876A1 (en) | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
| JP2002045174A (ja) | 2000-07-31 | 2002-02-12 | Inst Of Physical & Chemical Res | ナチュラルキラー細胞増殖法 |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| KR100915482B1 (ko) | 2000-12-06 | 2009-09-03 | 하리리 로버트 제이 | 태반 줄기 세포의 회수 방법 |
| US20080152629A1 (en) | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| EP2336299A1 (en) | 2001-02-14 | 2011-06-22 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| EP1491093B1 (en) | 2001-02-14 | 2013-07-31 | ABT Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| ES2548591T3 (es) | 2001-02-14 | 2015-10-19 | Anthrogenesis Corporation | Placenta post-parto de mamífero, su uso y células madre placentarias de la misma |
| US20020132343A1 (en) | 2001-03-19 | 2002-09-19 | Clark Lum | System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation |
| CA2396536A1 (en) | 2001-08-10 | 2003-02-10 | Saiko Uchida | Human stem cells originated from human amniotic mesenchymal cell layer |
| DE10139783C1 (de) | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| WO2003018780A1 (en) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| EP1288293A1 (en) | 2001-08-30 | 2003-03-05 | Norio Sakuragawa | Human neural stem cells originated from human amniotic mesenchymal cell layer |
| CN1195055C (zh) | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
| US20030068306A1 (en) | 2001-09-14 | 2003-04-10 | Dilber Mehmet Sirac | Medium |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| US8021876B2 (en) | 2001-11-15 | 2011-09-20 | Children's Medical Center Corporation | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof |
| JP3728750B2 (ja) | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
| US7799324B2 (en) | 2001-12-07 | 2010-09-21 | Geron Corporation | Using undifferentiated embryonic stem cells to control the immune system |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| US20040018178A1 (en) | 2002-01-22 | 2004-01-29 | Advanced Cell Technology | Stem cell-derived endothelial cells modified to disrupt tumor angiogenesis |
| NZ534643A (en) | 2002-02-13 | 2010-06-25 | Anthrogenesis Corp | Embryonic-like stem cells derived from post-partum mammalian placenta and uses and methods of treatment using said cells |
| US20030161818A1 (en) | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| EP1499347A2 (en) | 2002-03-15 | 2005-01-26 | Department of Veterans Affairs, Rehabilitation R&D Service | Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| MXPA04009996A (es) | 2002-04-12 | 2005-07-01 | Celgene Corp | Metodos para la identificacion de moduladores de la angiogenesis, compuestos descubiertos por los mismos, y metodos de tratamiento usando los compuestos. |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US20050118715A1 (en) | 2002-04-12 | 2005-06-02 | Hariri Robert J. | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP2005523328A (ja) | 2002-04-19 | 2005-08-04 | ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 胎盤由来の幹細胞及びその使用 |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| KR20050008757A (ko) | 2002-05-30 | 2005-01-21 | 셀진 코포레이션 | 세포 분화를 조절하고 골수증식성 질환 및 골수형성이상증후군을 치료하기 위하여 jnk 또는 mkk 저해제를사용하는 방법 |
| US7422736B2 (en) | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| EP1527161B1 (fr) | 2002-07-31 | 2015-10-28 | Yves Saint-Laurent Parfums | Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules |
| US20060147424A1 (en) | 2002-08-23 | 2006-07-06 | Norio Sakuragawa | Human bone stem cells |
| US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| BR0316695A (pt) | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
| EP2277992A3 (en) | 2003-02-11 | 2011-03-02 | John E. Davies | Progenitor cells from Wharton's jelly of human umbilical cord |
| CA2515594A1 (en) | 2003-02-13 | 2004-08-26 | Anthrogenesis Corporation | Use of umbilical cord blood to treat individuals having a disease, disorder or condition |
| CN101123977A (zh) * | 2003-03-25 | 2008-02-13 | 海里康公司 | 用于诱导治疗应答的组合物 |
| WO2004087896A2 (en) | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
| CN1548529A (zh) | 2003-05-09 | 2004-11-24 | 中国人民解放军军事医学科学院基础医 | 一种人胎盘间充质干细胞的分离方法 |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| PL1641916T3 (pl) | 2003-06-27 | 2016-08-31 | Depuy Synthes Products Inc | Regeneracja i naprawa tkanki nerwowej z wykorzystaniem komórek poporodowych |
| US7569385B2 (en) | 2003-08-14 | 2009-08-04 | The Regents Of The University Of California | Multipotent amniotic fetal stem cells |
| UA83504C2 (en) | 2003-09-04 | 2008-07-25 | Селджин Корпорейшн | Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| US20050089513A1 (en) | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| EP1682654A2 (en) | 2003-11-10 | 2006-07-26 | Amgen Inc. | Methods of using g-csf mobilized c-kit+cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathy |
| KR100560340B1 (ko) | 2003-11-11 | 2006-03-14 | 한훈 | 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법 |
| JP2005151907A (ja) | 2003-11-27 | 2005-06-16 | Shigeo Saito | 胎盤又は羊膜由来ヒト幹細胞及びその樹立方法並びに臓器への分化誘導方法 |
| EP1694328A4 (en) | 2003-12-02 | 2010-02-17 | Celgene Corp | METHOD AND COMPOSITIONS FOR THE TREATMENT AND SUPPLY OF HEMOGLOBINOPATHY AND ANEMIA |
| TWI338714B (en) | 2003-12-02 | 2011-03-11 | Cathay General Hospital | Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid |
| US20050176139A1 (en) | 2004-01-12 | 2005-08-11 | Yao-Chang Chen | Placental stem cell and methods thereof |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| US20050239897A1 (en) | 2004-03-22 | 2005-10-27 | Pittenger Mark F | Mesenchymal stem cells and uses therefor |
| NZ550027A (en) | 2004-03-26 | 2009-03-31 | Celgene Corp | Systems and methods for providing a stem cell bank |
| WO2005105982A1 (de) | 2004-03-31 | 2005-11-10 | Reinhardt Schwartz-Albiez | Verfahren zur sequentiellen ex vivo expansion humaner postembryonaler stammzellen mit nachfolgender selektiver differenzierung |
| WO2005105992A1 (en) | 2004-04-21 | 2005-11-10 | New York Eye & Ear Infirmary | Chondrocyte culture formulations |
| JP2006006249A (ja) | 2004-06-28 | 2006-01-12 | Hiroshima Univ | 羊膜由来細胞の培養方法及びその利用 |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| WO2006015214A2 (en) | 2004-07-29 | 2006-02-09 | Steenblock Research Institute, Inc. | Umbilical cord stem cell composition & method of treating neurological diseases |
| JP5668208B2 (ja) | 2004-08-16 | 2015-02-12 | セルリサーチ コーポレイション ピーティイー リミテッド | 臍帯羊膜からの幹/前駆細胞の単離 |
| US7909806B2 (en) | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US8039258B2 (en) | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| WO2006101548A2 (en) | 2004-12-21 | 2006-09-28 | Ethicon, Inc. | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| WO2006083394A2 (en) | 2004-12-21 | 2006-08-10 | Ethicon, Inc. | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| ES2621847T3 (es) | 2004-12-23 | 2017-07-05 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido de cordón umbilical, y métodos de elaboración y uso de las mismas |
| WO2006071778A2 (en) | 2004-12-23 | 2006-07-06 | Ethicon Incorporated | Treatment of parkinson's disease and related disorders using postpartum derived cells |
| AU2006203990B2 (en) | 2005-01-07 | 2011-08-11 | Wake Forest University Health Sciences | Regeneration of pancreatic islets by amniotic fluid stem cell therapy |
| US7642091B2 (en) | 2005-02-24 | 2010-01-05 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| US20060222634A1 (en) | 2005-03-31 | 2006-10-05 | Clarke Diana L | Amnion-derived cell compositions, methods of making and uses thereof |
| CA2648506A1 (en) | 2005-04-16 | 2006-10-26 | Axordia Limited | Cytotrophoblast stem cell |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| EP1893249A2 (en) | 2005-06-10 | 2008-03-05 | Celgene Corporation | Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions |
| WO2007005807A2 (en) | 2005-06-30 | 2007-01-11 | Anthrogenesis Corporation | Repair of tympanic membrane using placenta derived collagen biofabric |
| US20070021762A1 (en) | 2005-07-13 | 2007-01-25 | Qing Liu | Ocular plug formed from placenta derived collagen biofabric |
| WO2007009062A2 (en) | 2005-07-13 | 2007-01-18 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
| WO2007011693A2 (en) | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| US20080226612A1 (en) | 2005-08-19 | 2008-09-18 | Bio Regenerate, Inc. | Compositions of Cells Enriched for Combinations of Various Stem and Progenitor Cell Populations, Methods of Use Thereof and Methods of Private Banking Thereof |
| EP1789435B1 (en) | 2005-09-12 | 2010-02-24 | Industry Foundation of Chonnam National University | A method for production of mature natural killer cell |
| WO2007037682A1 (en) | 2005-09-28 | 2007-04-05 | Ipd-Therapeutics B.V. | Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics. |
| MX343814B (es) | 2005-10-13 | 2016-11-24 | Anthrogenesis Corp | Inmunomodulación usando celulas madre de la placenta. |
| JP5203212B2 (ja) | 2005-10-13 | 2013-06-05 | アントフロゲネシス コーポレーション | 胎盤由来幹細胞からのオリゴデンドロサイトの産生 |
| CN100344757C (zh) | 2005-10-18 | 2007-10-24 | 天津昂赛细胞基因工程有限公司 | 人胎盘、脐带间充质干细胞库及其构建方法 |
| US9175261B2 (en) | 2005-12-16 | 2015-11-03 | DePuy Synthes Products, Inc. | Human umbilical cord tissue cells for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
| JP5179376B2 (ja) | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
| JP2009520466A (ja) | 2005-12-22 | 2009-05-28 | エニス,ジエーン | 凍結臍帯組織由来の生存可能な細胞 |
| JP5599568B2 (ja) | 2005-12-28 | 2014-10-01 | エシコン・インコーポレイテッド | 分娩後由来細胞を用いた末梢血管疾患の治療 |
| EP2471903B1 (en) | 2005-12-29 | 2018-02-14 | Anthrogenesis Corporation | Placental stem cell populations |
| EP1976978A2 (en) | 2005-12-29 | 2008-10-08 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| JP2009521931A (ja) | 2005-12-29 | 2009-06-11 | アントフロゲネシス コーポレーション | 胎盤幹細胞を収集及び保存するための改善された組成物、及び該組成物の使用方法 |
| US20070253931A1 (en) | 2006-01-12 | 2007-11-01 | Osiris Therapeutics, Inc. | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| US9944900B2 (en) | 2006-01-18 | 2018-04-17 | Hemacell Perfusion | Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells |
| NZ727755A (en) | 2006-01-23 | 2023-01-27 | Abt Holding Co | Mapc therapeutics without adjunctive immunosuppressive treatment |
| EP2035552A2 (en) | 2006-06-09 | 2009-03-18 | Anthrogenesis Corporation | Placental niche and use thereof to culture stem cells |
| US20070287176A1 (en) | 2006-06-13 | 2007-12-13 | Alireza Rezania | Chorionic villus derived cells |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| US8105634B2 (en) | 2006-08-15 | 2012-01-31 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
| US8122763B2 (en) | 2006-09-01 | 2012-02-28 | Avair, Llc | Breathing gas supply visual broadcast apparatus |
| US20080131522A1 (en) | 2006-10-03 | 2008-06-05 | Qing Liu | Use of placental biomaterial for ocular surgery |
| WO2008060377A2 (en) | 2006-10-04 | 2008-05-22 | Anthrogenesis Corporation | Placental or umbilical cord tissue compositions |
| CN104623642A (zh) | 2006-10-06 | 2015-05-20 | 人类起源公司 | 天然(端肽)胎盘胶原组合物 |
| EP2418271A3 (en) | 2006-10-23 | 2015-09-30 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| CN101611139B (zh) | 2006-11-13 | 2012-07-04 | 伊西康公司 | 利用微载体的产后来源的细胞的体外扩增 |
| JP2010518812A (ja) | 2007-02-12 | 2010-06-03 | アンスロジェネシス コーポレーション | 接着性胎盤幹細胞由来の肝細胞および軟骨細胞、ならびにcd34+、cd45−胎盤幹細胞の濃縮細胞集団 |
| DK2142642T3 (en) | 2007-03-27 | 2017-09-11 | Ipd-Therapeutics B V | METHODS AND AGENTS FOR STEM CELL PROLIFERATION AND SUBSEQUENT GENERATION AND EXPANSION OF PROGENITOR CELLS, AS WELL AS PRODUCTION OF EFFECT CELLS AS CLINICAL THERAPEUTICS |
| US20100172830A1 (en) | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| CN101978045A (zh) | 2007-09-26 | 2011-02-16 | 细胞基因细胞疗法公司 | 来自人胎盘灌洗液的血管生成细胞 |
| CN101878034B (zh) | 2007-09-28 | 2013-11-20 | 细胞基因细胞疗法公司 | 使用人胎盘灌洗液和人来自胎盘的中间体自然杀伤细胞的肿瘤抑制 |
| EP3345609A1 (en) | 2007-11-07 | 2018-07-11 | Anthrogenesis Corporation | Use of umbilical cord blood in the treatment of premature birth complications |
| US20090123442A1 (en) | 2007-11-09 | 2009-05-14 | Avaris Ab | Expanded nk cells |
| US8569060B2 (en) | 2008-01-08 | 2013-10-29 | The University Of Queensland | Method of producing a population of cells |
| KR101133185B1 (ko) | 2008-07-29 | 2012-04-06 | 서울대학교병원 | 자연살해세포의 증식방법 |
| KR20240052847A (ko) | 2008-08-20 | 2024-04-23 | 셀룰래리티 인코포레이티드 | 개선된 세포 조성물 및 그의 제조 방법 |
| JP5950577B2 (ja) | 2008-08-20 | 2016-07-13 | アンスロジェネシス コーポレーション | 単離胎盤細胞を使用した脳卒中の治療 |
| US8728805B2 (en) | 2008-08-22 | 2014-05-20 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| JP5652783B2 (ja) | 2008-09-08 | 2015-01-14 | 独立行政法人理化学研究所 | NKT細胞由来iPS細胞およびそれ由来のNKT細胞 |
| NZ592726A (en) | 2008-11-19 | 2012-12-21 | Anthrogenesis Corp | Amnion derived adherent cells |
| MX2011005230A (es) | 2008-11-21 | 2011-06-16 | Anthrogenesis Corp | Tratamiento de enfermedades, desordenes o condiciones del pulmon usando celulas de placenta. |
| CA2753208C (en) | 2009-02-20 | 2018-08-21 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| CA3110964A1 (en) | 2009-03-25 | 2010-09-30 | Xiaokui Zhang | Preventing a symptom of graft-versus-host disease using human placenta-derived intermediate natural killer cells |
| WO2010110734A1 (en) | 2009-03-26 | 2010-09-30 | Avaris Ab | Expansion of nk cells |
| US20100323446A1 (en) | 2009-06-05 | 2010-12-23 | Jill Renee Barnett | Method of collecting placental cells |
| AR077369A1 (es) | 2009-07-02 | 2011-08-24 | Anthrogenesis Corp | Metodopara producir eritrocitos sin celulas alimentadoras |
| US20120302462A1 (en) * | 2009-11-09 | 2012-11-29 | Bjorn Onfelt | System and Method for Detecting and Quantifying Active T-cells or Natural Killer Cells |
| US20130011376A1 (en) * | 2009-12-29 | 2013-01-10 | Gamida Cell Ltd. | Methods for Enhancing Natural Killer Cell Proliferation and Activity |
| ES2646750T3 (es) | 2010-01-26 | 2017-12-15 | Anthrogenesis Corporation | Tratamiento de cánceres relacionados con hueso utilizando células madre placentarias |
| WO2011103882A1 (en) * | 2010-02-24 | 2011-09-01 | Ingo Schmidt-Wolf | Method for the generation of a cik cell and nk cell population |
| LT2556145T (lt) | 2010-04-07 | 2016-11-10 | Anthrogenesis Corporation | Angiogenezė naudojant placentos kamienines ląsteles |
| MX2012011543A (es) | 2010-04-08 | 2013-05-06 | Anthrogenesis Corp | Tratamiento de sarcoidosis empleando celulas madre placentarias. |
| JP5996533B2 (ja) | 2010-07-13 | 2016-09-21 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞を生成させる方法 |
| US9862928B2 (en) | 2010-12-03 | 2018-01-09 | Regents Of The University Of Minnesota | Generation of natural killer cells and lymphoid tissue inducer-like (LTi-like) NK-22 cells |
| WO2012080844A1 (en) | 2010-12-17 | 2012-06-21 | Biolamina Ab | Cell culture medium |
| AR084754A1 (es) | 2010-12-30 | 2013-06-05 | Anthrogenesis Corp | Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de uso |
| WO2012092480A1 (en) | 2010-12-30 | 2012-07-05 | Anthirogenesis Corporation | Compositions comprising amnion derived adherent cells and platelet-rich plasma |
| KR20210052587A (ko) | 2010-12-30 | 2021-05-10 | 안트로제네시스 코포레이션 | 세포의 동결보존 및 캡슐화 방법 |
| US8969315B2 (en) | 2010-12-31 | 2015-03-03 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
| EP2686421B1 (en) | 2011-03-18 | 2020-12-23 | Glycostem Therapeutics B.V. | Generation of nk cells and nk-cell progenitors |
| EP2714059B1 (en) | 2011-06-01 | 2018-10-03 | Celularity, Inc. | Treatment of pain using placental stem cells |
-
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- 2020-05-26 AU AU2020203463A patent/AU2020203463A1/en not_active Abandoned
- 2020-07-30 JP JP2020129197A patent/JP2020196724A/ja not_active Withdrawn
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- 2022-05-26 AU AU2022203581A patent/AU2022203581A1/en not_active Abandoned
- 2022-06-29 JP JP2022104464A patent/JP2022130600A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06510672A (ja) * | 1991-11-05 | 1994-12-01 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | サプレッサーおよび前駆細胞 |
| JP2010518096A (ja) * | 2007-02-12 | 2010-05-27 | アンスロジェネシス コーポレーション | 胎盤幹細胞を使用した炎症性疾患の治療 |
| US20110280849A1 (en) * | 2010-03-26 | 2011-11-17 | Anthrogenesis Corporation | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| WO2012083021A1 (en) * | 2010-12-17 | 2012-06-21 | Anthrogenesis Corporation | Treatment of immune-related diseases and disorders using amnion derived adherent cells |
| WO2012094905A1 (zh) * | 2011-01-14 | 2012-07-19 | 中国人民解放军军事医学科学院附属医院 | 基于b7-1-pe40kdel外毒素融合基因的dna疫苗及其用途 |
Non-Patent Citations (1)
| Title |
|---|
| PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol. 28, JPN6017036257, 2011, pages 640 - 646, ISSN: 0003806787 * |
Also Published As
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| US9763983B2 (en) | 2017-09-19 |
| EP3622960A1 (en) | 2020-03-18 |
| AU2014215458A1 (en) | 2015-08-13 |
| JP2020196724A (ja) | 2020-12-10 |
| AU2018253575A1 (en) | 2018-11-22 |
| AU2020203463A1 (en) | 2020-06-18 |
| AU2022203581A1 (en) | 2022-06-16 |
| EP2953635A4 (en) | 2016-10-26 |
| EP2953635A1 (en) | 2015-12-16 |
| JP2022130600A (ja) | 2022-09-06 |
| CN105142651A (zh) | 2015-12-09 |
| CN115137753A (zh) | 2022-10-04 |
| US20150366910A1 (en) | 2015-12-24 |
| HK1218515A1 (zh) | 2017-02-24 |
| WO2014123879A1 (en) | 2014-08-14 |
| JP2019048809A (ja) | 2019-03-28 |
| CN115282165A (zh) | 2022-11-04 |
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