JP2016503655A5 - - Google Patents
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- Publication number
- JP2016503655A5 JP2016503655A5 JP2015550820A JP2015550820A JP2016503655A5 JP 2016503655 A5 JP2016503655 A5 JP 2016503655A5 JP 2015550820 A JP2015550820 A JP 2015550820A JP 2015550820 A JP2015550820 A JP 2015550820A JP 2016503655 A5 JP2016503655 A5 JP 2016503655A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- listeria
- residues
- polynucleotide
- secreted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000186781 Listeria Species 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 18
- 108091033319 polynucleotide Proteins 0.000 claims 18
- 239000002157 polynucleotide Substances 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 101150023527 actA gene Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 241000607479 Yersinia pestis Species 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 101150082952 ACTA1 gene Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 101150046348 inlB gene Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 101150030499 lnt gene Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746237P | 2012-12-27 | 2012-12-27 | |
| US61/746,237 | 2012-12-27 | ||
| US201361780744P | 2013-03-13 | 2013-03-13 | |
| US61/780,744 | 2013-03-13 | ||
| PCT/US2013/078119 WO2014106123A1 (en) | 2012-12-27 | 2013-12-27 | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018074066A Division JP6671408B2 (ja) | 2012-12-27 | 2018-04-06 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016503655A JP2016503655A (ja) | 2016-02-08 |
| JP2016503655A5 true JP2016503655A5 (enExample) | 2017-02-16 |
Family
ID=51017446
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550820A Pending JP2016503655A (ja) | 2012-12-27 | 2013-12-27 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
| JP2018074066A Expired - Fee Related JP6671408B2 (ja) | 2012-12-27 | 2018-04-06 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018074066A Expired - Fee Related JP6671408B2 (ja) | 2012-12-27 | 2018-04-06 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9663557B2 (enExample) |
| EP (1) | EP2938627B1 (enExample) |
| JP (2) | JP2016503655A (enExample) |
| KR (1) | KR102160322B1 (enExample) |
| CN (1) | CN104955835B (enExample) |
| AU (2) | AU2013370210B2 (enExample) |
| BR (1) | BR112015015076A2 (enExample) |
| CA (1) | CA2888727A1 (enExample) |
| EA (1) | EA201590397A8 (enExample) |
| MX (1) | MX2015008329A (enExample) |
| SG (2) | SG10201700916SA (enExample) |
| WO (1) | WO2014106123A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| US20110129499A1 (en) | 2008-05-19 | 2011-06-02 | Paulo Maciag | Dual delivery system for heterologous antigens |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| WO2012138377A2 (en) | 2010-10-01 | 2012-10-11 | Trustees Of The University Of Pennsylvania | The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| CA2829960A1 (en) | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| WO2013138337A1 (en) | 2012-03-12 | 2013-09-19 | Advaxis | Suppressor cell function inhibition following listeria vaccine treatment |
| CA2955612C (en) | 2014-07-18 | 2022-05-17 | Advaxis, Inc. | Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer |
| WO2016061115A1 (en) | 2014-10-13 | 2016-04-21 | Providence Health & Services-Oregon D/B/A Providence Portland Medical Center | Bacterial vaccines deficient in the 2-c-methyl-d-erythritol-4-phosphate pathway and methods of preparation and use thereof |
| KR102763121B1 (ko) | 2015-02-06 | 2025-02-04 | 내셔널 유니버시티 오브 싱가포르 | 치료적 면역 세포의 효능의 향상 방법 |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| CA2982543A1 (en) | 2015-04-13 | 2016-10-20 | Aduro Biotech, Inc. | Immunogenic fusion proteins for the treatment of cancer |
| MX2017013174A (es) * | 2015-04-13 | 2018-04-11 | Aduro Biotech Inc | Fusiones de variante iii del receptor de factor de crecimiento epidermico-mesotelina y métodos para usar los mismos. |
| AU2016262823A1 (en) | 2015-05-18 | 2017-12-07 | Universita' Degli Studi Di Trento | Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof |
| ES2970865T3 (es) | 2015-12-16 | 2024-05-31 | Gritstone Bio Inc | Identificación, fabricación y uso de neoantígenos |
| NZ746112A (en) * | 2016-03-18 | 2023-01-27 | Immune Sensor Llc | Cyclic di-nucleotide compounds and methods of use |
| NZ752984A (en) | 2016-11-22 | 2026-03-27 | Nat Univ Singapore | Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies |
| US20190038733A1 (en) | 2017-08-10 | 2019-02-07 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof |
| AU2018336988B2 (en) | 2017-09-19 | 2023-06-22 | Advaxis, Inc. | Compositions and methods for lyophilization of bacteria or Listeria strains |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
| AU2019231783B2 (en) | 2018-03-09 | 2023-11-16 | Advaxis, Inc. | Compositions and methods for evaluating attenuation and infectivity of Listeria strains |
| EP3536706A1 (en) | 2018-03-09 | 2019-09-11 | BiOMVis Srl | Fusion proteins for the outer membrane vesicle (omv) delivery of heterologous polypeptides and immunogenic compositions thereof |
| US20210239681A1 (en) | 2018-04-27 | 2021-08-05 | Advaxis, Inc. | Compositions and methods for evaluating potency of listeria-based immunotherapeutics |
| CN110408634B (zh) | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
| EP3784776A4 (en) | 2018-05-23 | 2022-01-26 | National University of Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
| EP3725371A1 (en) | 2019-04-18 | 2020-10-21 | BiOMVis Srl | Method for the production of outer membrane vesicles and immunogenic compositions thereof |
| CN110499324A (zh) * | 2019-09-02 | 2019-11-26 | 中生康元生物科技(北京)有限公司 | 一种用于鉴定肿瘤新抗原的细菌表达载体及筛选鉴定肿瘤新抗原的方法 |
| EP4168593A4 (en) | 2020-06-23 | 2024-11-27 | The Regents of the University of Colorado, a body corporate | METHODS FOR DIAGNOSIS OF RESPIRATORY PATHOGENS AND PREDICTION OF EVOLUTIONS ASSOCIATED WITH COVID-19 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US5571702A (en) | 1991-03-29 | 1996-11-05 | Genentech, Inc. | Amplification method for detection of human PF4A receptors |
| IT1262895B (it) | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| WO1997003715A1 (en) | 1995-07-21 | 1997-02-06 | The General Hospital Corporation | Method and apparatus of enhancing the delivery of a pharmaceutical formulation |
| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| AU2001255196A1 (en) * | 2000-03-29 | 2001-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
| CA2460014A1 (en) | 2000-09-21 | 2002-03-28 | The Regents Of The University Of California | Spas-1 cancer antigen |
| US7794728B2 (en) | 2002-05-29 | 2010-09-14 | The Regents Of The University Of California | Attenuated Listeria spp. and methods for using the same |
| CA2492160A1 (en) | 2002-07-12 | 2004-01-22 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| EP1682173A4 (en) | 2003-10-15 | 2007-10-31 | Medimmune Inc | EPHA2 VACCINE ON LISTERIA BASE |
| US7842289B2 (en) * | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| US7858097B2 (en) | 2004-08-13 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free Listeria strains and methods for constructing and using same |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| EP2860253B1 (en) * | 2006-03-01 | 2018-08-01 | Aduro Biotech, Inc. | Engineered listeria and methods of use thereof |
| WO2007117371A2 (en) | 2006-03-01 | 2007-10-18 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
| US20080124354A1 (en) | 2006-07-10 | 2008-05-29 | Yvonne Paterson | Methods for administering tumor vaccines |
| JP2010534058A (ja) * | 2007-04-16 | 2010-11-04 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 抗生物質耐性のないリステリア菌およびその構築および使用方法 |
| EP2283112B1 (en) * | 2008-05-19 | 2016-10-12 | Aduro Biotech | Compositions comprising prfa*mutant listeria and methods of use thereof |
| GB201010389D0 (en) | 2010-06-21 | 2010-08-04 | Ist Superiore Sanita | Antibody derivatives |
| SMT201800444T1 (it) | 2010-11-17 | 2018-09-13 | Aduro Biotech Inc | Metodi e composizioni per indurre una risposta immunitaria contro egfrviii |
| CA2829960A1 (en) | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| WO2013138337A1 (en) | 2012-03-12 | 2013-09-19 | Advaxis | Suppressor cell function inhibition following listeria vaccine treatment |
-
2013
- 2013-12-27 SG SG10201700916SA patent/SG10201700916SA/en unknown
- 2013-12-27 US US14/142,614 patent/US9663557B2/en not_active Expired - Fee Related
- 2013-12-27 AU AU2013370210A patent/AU2013370210B2/en not_active Ceased
- 2013-12-27 MX MX2015008329A patent/MX2015008329A/es unknown
- 2013-12-27 SG SG11201502792TA patent/SG11201502792TA/en unknown
- 2013-12-27 JP JP2015550820A patent/JP2016503655A/ja active Pending
- 2013-12-27 CA CA2888727A patent/CA2888727A1/en not_active Abandoned
- 2013-12-27 CN CN201380068458.4A patent/CN104955835B/zh not_active Expired - Fee Related
- 2013-12-27 KR KR1020157015490A patent/KR102160322B1/ko not_active Expired - Fee Related
- 2013-12-27 BR BR112015015076A patent/BR112015015076A2/pt active Search and Examination
- 2013-12-27 EP EP13869448.4A patent/EP2938627B1/en not_active Not-in-force
- 2013-12-27 WO PCT/US2013/078119 patent/WO2014106123A1/en not_active Ceased
- 2013-12-27 EA EA201590397A patent/EA201590397A8/ru unknown
-
2017
- 2017-05-18 US US15/599,441 patent/US20170253637A1/en not_active Abandoned
-
2018
- 2018-04-06 JP JP2018074066A patent/JP6671408B2/ja not_active Expired - Fee Related
- 2018-05-21 AU AU2018203555A patent/AU2018203555A1/en not_active Abandoned