JP2016503655A5 - - Google Patents
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- Publication number
- JP2016503655A5 JP2016503655A5 JP2015550820A JP2015550820A JP2016503655A5 JP 2016503655 A5 JP2016503655 A5 JP 2016503655A5 JP 2015550820 A JP2015550820 A JP 2015550820A JP 2015550820 A JP2015550820 A JP 2015550820A JP 2016503655 A5 JP2016503655 A5 JP 2016503655A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- listeria
- residues
- polynucleotide
- secreted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000186781 Listeria Species 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 18
- 108091033319 polynucleotide Proteins 0.000 claims 18
- 239000002157 polynucleotide Substances 0.000 claims 18
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 101150023527 actA gene Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 241000607479 Yersinia pestis Species 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 101150082952 ACTA1 gene Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 101150046348 inlB gene Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 101150030499 lnt gene Proteins 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746237P | 2012-12-27 | 2012-12-27 | |
| US61/746,237 | 2012-12-27 | ||
| US201361780744P | 2013-03-13 | 2013-03-13 | |
| US61/780,744 | 2013-03-13 | ||
| PCT/US2013/078119 WO2014106123A1 (en) | 2012-12-27 | 2013-12-27 | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018074066A Division JP6671408B2 (ja) | 2012-12-27 | 2018-04-06 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016503655A JP2016503655A (ja) | 2016-02-08 |
| JP2016503655A5 true JP2016503655A5 (enExample) | 2017-02-16 |
Family
ID=51017446
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550820A Pending JP2016503655A (ja) | 2012-12-27 | 2013-12-27 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
| JP2018074066A Expired - Fee Related JP6671408B2 (ja) | 2012-12-27 | 2018-04-06 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018074066A Expired - Fee Related JP6671408B2 (ja) | 2012-12-27 | 2018-04-06 | リステリアの抗原配列の発現を容易にするシグナルペプチド融合パートナー、ならびにその調製方法およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9663557B2 (enExample) |
| EP (1) | EP2938627B1 (enExample) |
| JP (2) | JP2016503655A (enExample) |
| KR (1) | KR102160322B1 (enExample) |
| CN (1) | CN104955835B (enExample) |
| AU (2) | AU2013370210B2 (enExample) |
| BR (1) | BR112015015076A2 (enExample) |
| CA (1) | CA2888727A1 (enExample) |
| EA (1) | EA201590397A8 (enExample) |
| MX (1) | MX2015008329A (enExample) |
| SG (2) | SG11201502792TA (enExample) |
| WO (1) | WO2014106123A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009143167A2 (en) | 2008-05-19 | 2009-11-26 | Advaxis | Dual delivery system for heterologous antigens |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| CN107412756A (zh) | 2010-10-01 | 2017-12-01 | 宾夕法尼亚大学理事会 | 李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途 |
| WO2012125551A1 (en) | 2011-03-11 | 2012-09-20 | Advaxis | Listeria-based adjuvants |
| SG10201700392UA (en) | 2012-03-12 | 2017-03-30 | Advaxis Inc | Suppressor cell function inhibition following listeria vaccine treatment |
| KR20170052569A (ko) | 2014-07-18 | 2017-05-12 | 어드박시스, 인크. | 전립선암 치료용 pd-1 길항제 및 리스테리아 기반 백신의 병용 |
| WO2016061115A1 (en) | 2014-10-13 | 2016-04-21 | Providence Health & Services-Oregon D/B/A Providence Portland Medical Center | Bacterial vaccines deficient in the 2-c-methyl-d-erythritol-4-phosphate pathway and methods of preparation and use thereof |
| CN113713091A (zh) | 2015-02-06 | 2021-11-30 | 新加坡国立大学 | 工程免疫细胞及其用途和生产方法 |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| CN107750256A (zh) * | 2015-04-13 | 2018-03-02 | 艾杜罗生物科技公司 | 表皮生长因子受体变体iii‑间皮素融合物及其使用方法 |
| JP2018512165A (ja) | 2015-04-13 | 2018-05-17 | アデュロ バイオテック，インコーポレイテッド | 癌の治療のための免疫原性融合タンパク質 |
| EP3838918B1 (en) * | 2015-05-18 | 2022-08-31 | BiOMVis Srl | Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof |
| US20170199961A1 (en) | 2015-12-16 | 2017-07-13 | Gritstone Oncology, Inc. | Neoantigen Identification, Manufacture, and Use |
| EP3429596B1 (en) * | 2016-03-18 | 2022-08-31 | Immune Sensor, LLC | Cyclic di-nucleotide compounds and methods of use |
| CN118581046A (zh) | 2016-11-22 | 2024-09-03 | 新加坡国立大学 | 用于t细胞恶性肿瘤免疫疗法的cd7表达阻滞剂和嵌合抗原受体 |
| US11648269B2 (en) | 2017-08-10 | 2023-05-16 | National University Of Singapore | T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof |
| US11179339B2 (en) | 2017-09-19 | 2021-11-23 | Advaxis, Inc. | Compositions and methods for lyophilization of bacteria or listeria strains |
| ES3029080T3 (en) | 2017-10-10 | 2025-06-23 | Seattle Project Corp | Neoantigen identification using hotspots |
| US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
| EP3762719A1 (en) | 2018-03-09 | 2021-01-13 | Advaxis, Inc. | Compositions and methods for evaluating attenuation and infectivity of listeria strains |
| EP3536706A1 (en) | 2018-03-09 | 2019-09-11 | BiOMVis Srl | Fusion proteins for the outer membrane vesicle (omv) delivery of heterologous polypeptides and immunogenic compositions thereof |
| EP3785029A1 (en) | 2018-04-27 | 2021-03-03 | Advaxis, Inc. | Compositions and methods for evaluating potency of listeria-based immunotherapeutics |
| CN110408634B (zh) | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
| SG11202010996QA (en) | 2018-05-23 | 2020-12-30 | Nat Univ Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
| EP3725371A1 (en) | 2019-04-18 | 2020-10-21 | BiOMVis Srl | Method for the production of outer membrane vesicles and immunogenic compositions thereof |
| CN110499324A (zh) * | 2019-09-02 | 2019-11-26 | 中生康元生物科技(北京)有限公司 | 一种用于鉴定肿瘤新抗原的细菌表达载体及筛选鉴定肿瘤新抗原的方法 |
| JP2023532444A (ja) | 2020-06-23 | 2023-07-28 | ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド・ア・ボディ・コーポレイト | 呼吸器病原体を診断し、ｃｏｖｉｄ－１９に関連する転帰を予測する方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US5783415A (en) | 1991-03-29 | 1998-07-21 | Genentech, Inc. | Method of producing an IL-8 receptor polypeptide |
| IT1262895B (it) | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US7635479B2 (en) * | 2000-03-29 | 2009-12-22 | The Trustees Of The University Of Pennsylvania | Composition and methods for enhancing immunogenecity of antigens |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US5888530A (en) | 1995-07-21 | 1999-03-30 | The General Hospital Corporation | Method of enhancing delivery of a pharmaceutical formulation |
| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| WO2002024739A2 (en) | 2000-09-21 | 2002-03-28 | The Regents Of The University Of California | Spas-1 cancer antigen |
| CA2486980A1 (en) * | 2002-05-29 | 2003-12-11 | The Regents Of The University Of California | Attenuated listeria spp. and methods for using the same |
| WO2004006837A2 (en) | 2002-07-12 | 2004-01-22 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| EP1682173A4 (en) | 2003-10-15 | 2007-10-31 | Medimmune Inc | EPHA2 VACCINE ON LISTERIA BASE |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| US7858097B2 (en) * | 2004-08-13 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free Listeria strains and methods for constructing and using same |
| JP5347135B2 (ja) * | 2006-03-01 | 2013-11-20 | アドゥロ バイオテック | 遺伝子工学操作されたｌｉｓｔｅｒｉａおよびその使用方法 |
| WO2007117371A2 (en) | 2006-03-01 | 2007-10-18 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| WO2008008311A1 (en) | 2006-07-10 | 2008-01-17 | The Trustees Of The University Of Pennsylvania | Methods for administering tumor vaccines |
| JP2010534058A (ja) * | 2007-04-16 | 2010-11-04 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 抗生物質耐性のないリステリア菌およびその構築および使用方法 |
| CA2724649A1 (en) | 2008-05-19 | 2009-11-26 | Anza Therapeutics, Inc. | Compositions comprising prfa* mutant listeria and methods of use thereof |
| GB201010389D0 (en) | 2010-06-21 | 2010-08-04 | Ist Superiore Sanita | Antibody derivatives |
| SI2640842T1 (sl) | 2010-11-17 | 2018-09-28 | Aduro Biotech, Inc. | Postopki in sestavki za induciranje imunskega odziva na EGFRvIII |
| WO2012125551A1 (en) | 2011-03-11 | 2012-09-20 | Advaxis | Listeria-based adjuvants |
| SG10201700392UA (en) * | 2012-03-12 | 2017-03-30 | Advaxis Inc | Suppressor cell function inhibition following listeria vaccine treatment |
-
2013
- 2013-12-27 SG SG11201502792TA patent/SG11201502792TA/en unknown
- 2013-12-27 EA EA201590397A patent/EA201590397A8/ru unknown
- 2013-12-27 CA CA2888727A patent/CA2888727A1/en not_active Abandoned
- 2013-12-27 MX MX2015008329A patent/MX2015008329A/es unknown
- 2013-12-27 KR KR1020157015490A patent/KR102160322B1/ko not_active Expired - Fee Related
- 2013-12-27 US US14/142,614 patent/US9663557B2/en not_active Expired - Fee Related
- 2013-12-27 CN CN201380068458.4A patent/CN104955835B/zh not_active Expired - Fee Related
- 2013-12-27 EP EP13869448.4A patent/EP2938627B1/en not_active Not-in-force
- 2013-12-27 BR BR112015015076A patent/BR112015015076A2/pt active Search and Examination
- 2013-12-27 WO PCT/US2013/078119 patent/WO2014106123A1/en not_active Ceased
- 2013-12-27 JP JP2015550820A patent/JP2016503655A/ja active Pending
- 2013-12-27 SG SG10201700916SA patent/SG10201700916SA/en unknown
- 2013-12-27 AU AU2013370210A patent/AU2013370210B2/en not_active Ceased
-
2017
- 2017-05-18 US US15/599,441 patent/US20170253637A1/en not_active Abandoned
-
2018
- 2018-04-06 JP JP2018074066A patent/JP6671408B2/ja not_active Expired - Fee Related
- 2018-05-21 AU AU2018203555A patent/AU2018203555A1/en not_active Abandoned
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