JP2009528065A5 - - Google Patents
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- Publication number
- JP2009528065A5 JP2009528065A5 JP2008557419A JP2008557419A JP2009528065A5 JP 2009528065 A5 JP2009528065 A5 JP 2009528065A5 JP 2008557419 A JP2008557419 A JP 2008557419A JP 2008557419 A JP2008557419 A JP 2008557419A JP 2009528065 A5 JP2009528065 A5 JP 2009528065A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- seq
- acta
- listeria bacterium
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims 16
- 102000040430 polynucleotide Human genes 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 16
- 241000186781 Listeria Species 0.000 claims 9
- 125000000539 amino acid group Chemical group 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000001018 virulence Effects 0.000 claims 4
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 claims 2
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 102000050405 human PSCA Human genes 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 239000004474 valine Substances 0.000 claims 2
- 102000015693 Actin Depolymerizing Factors Human genes 0.000 claims 1
- 108010038798 Actin Depolymerizing Factors Proteins 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 239000012678 infectious agent Substances 0.000 claims 1
- 101150046348 inlB gene Proteins 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 210000001539 phagocyte Anatomy 0.000 claims 1
- 150000003904 phospholipids Chemical group 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 101150093386 prfA gene Proteins 0.000 claims 1
- 101150027417 recU gene Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77847106P | 2006-03-01 | 2006-03-01 | |
| US60/778,471 | 2006-03-01 | ||
| US78457606P | 2006-03-21 | 2006-03-21 | |
| US60/784,576 | 2006-03-21 | ||
| US11/395,197 US7935804B2 (en) | 2006-03-01 | 2006-03-30 | Engineered Listeria and methods of use thereof |
| US11/395,197 | 2006-03-30 | ||
| US11/396,216 | 2006-03-30 | ||
| US11/396,216 US20070207171A1 (en) | 2006-03-01 | 2006-03-30 | Engineered listeria and methods of use thereof |
| PCT/US2007/005457 WO2007103225A2 (en) | 2006-03-01 | 2007-03-01 | Engineered listeria and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528065A JP2009528065A (ja) | 2009-08-06 |
| JP2009528065A5 true JP2009528065A5 (enExample) | 2010-04-15 |
| JP5347135B2 JP5347135B2 (ja) | 2013-11-20 |
Family
ID=38475431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557419A Expired - Fee Related JP5347135B2 (ja) | 2006-03-01 | 2007-03-01 | 遺伝子工学操作されたｌｉｓｔｅｒｉａおよびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1991263B8 (enExample) |
| JP (1) | JP5347135B2 (enExample) |
| DK (1) | DK1991263T3 (enExample) |
| ES (1) | ES2532942T3 (enExample) |
| GB (1) | GB2451014B (enExample) |
| PT (1) | PT1991263E (enExample) |
| SI (1) | SI1991263T1 (enExample) |
| WO (1) | WO2007103225A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| ES2741730T3 (es) * | 2008-05-19 | 2020-02-12 | Advaxis Inc | Sistema de administración doble para antígenos heterólogos que comprende una cepa de Listeria recombinante atenuada por la mutación de dal/dat y la deleción de ActA que comprende una molécula de ácido nucleico que codifica una proteína de fusión de listeriolisina O - antígeno prostático específico |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| WO2011149852A1 (en) * | 2010-05-23 | 2011-12-01 | Aduro Biotech | Methods and compositions using listeria for adjuvant treatment of cancer |
| WO2012138377A2 (en) | 2010-10-01 | 2012-10-11 | Trustees Of The University Of Pennsylvania | The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| ES2684684T3 (es) * | 2010-11-17 | 2018-10-04 | Aduro Biotech, Inc. | Métodos y composiciones para inducir una respuesta inmune al EGFRVIII |
| WO2012125551A1 (en) | 2011-03-11 | 2012-09-20 | Advaxis | Listeria-based adjuvants |
| EP2825195A4 (en) | 2012-03-12 | 2015-10-07 | Advaxis Inc | INHIBITION OF SUPPRESSOR CELL FUNCTION AFTER TREATMENT WITH A LISTERIAL VACCINE |
| HK1213008A1 (zh) | 2012-11-06 | 2016-06-24 | 艾杜罗生物科技公司 | 兼性减毒细菌种类及其制备和使用方法 |
| SG10201700916SA (en) | 2012-12-27 | 2017-03-30 | Aduro Biotech Inc | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
| US10925945B2 (en) | 2014-10-13 | 2021-02-23 | Providence Health & Services-Oregon | Bacterial vaccines deficient in the 2-C-methyl-D-erythritol-4-phosphate pathway and methods of preparation and use thereof |
| HK1250731A1 (zh) | 2015-04-13 | 2019-01-11 | 艾杜罗生物科技公司 | 用於治疗癌症的免疫原性融合蛋白 |
| SG11201708360TA (en) * | 2015-04-13 | 2017-11-29 | Aduro Biotech Inc | Epidermal growth factor receptor variant iii-mesothelin fusions and methods of using the same |
| EA201890149A1 (ru) | 2015-06-26 | 2018-07-31 | Сирус Корпорейшн | Композиции криопреципитатов и способы их получения |
| US10799533B2 (en) | 2015-10-23 | 2020-10-13 | Cerus Corporation | Plasma compositions and methods of use thereof |
| CN108601731A (zh) | 2015-12-16 | 2018-09-28 | 磨石肿瘤生物技术公司 | 新抗原的鉴别、制造及使用 |
| HUE058657T2 (hu) | 2016-06-23 | 2022-09-28 | Jiangsu Hengrui Medicine Co | Lag-3 antitest, antigénkötõ fragmentuma és gyógyszerészeti alkalmazása |
| AU2017382449B2 (en) | 2016-12-23 | 2024-10-24 | Cerus Corporation | Systems and methods for testing and screening using compound bound substrates |
| BR112019018273A2 (pt) | 2017-03-03 | 2020-07-14 | Cerus Corporation | kits e métodos para preparação de composições de plaquetas inativadas por patógenos |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| EP3714275A4 (en) | 2017-11-22 | 2021-10-27 | Gritstone bio, Inc. | REDUCTION OF JUNCTION EPITOPIC PRESENTATION FOR NEOANTIGENS |
| BR112020010499A2 (pt) | 2017-12-13 | 2020-11-24 | Inovio Pharmaceuticals, Inc. | vacinas de câncer de alvo de mesotelina e usos das mesmas |
| TWI821233B (zh) | 2017-12-29 | 2023-11-11 | 美商西勒斯股份有限公司 | 用於處理生物流體之方法、藉由該方法製備之病原體去活生物流體、及用於處理生物流體之系統 |
| CA3143213A1 (en) | 2019-06-22 | 2020-12-30 | Cerus Corporation | Biological fluid treatment systems |
| WO2020264421A1 (en) | 2019-06-28 | 2020-12-30 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551784B2 (en) | 1989-06-07 | 2003-04-22 | Affymetrix Inc | Method of comparing nucleic acid sequences |
| US5783415A (en) | 1991-03-29 | 1998-07-21 | Genentech, Inc. | Method of producing an IL-8 receptor polypeptide |
| IT1262895B (it) | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
| IL107366A (en) | 1992-10-23 | 2003-03-12 | Chugai Pharmaceutical Co Ltd | Genes coding for megakaryocyte potentiator |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US7662396B2 (en) * | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| WO1997003715A1 (en) | 1995-07-21 | 1997-02-06 | The General Hospital Corporation | Method and apparatus of enhancing the delivery of a pharmaceutical formulation |
| CA2241604C (en) | 1996-01-05 | 2010-03-30 | Ira Pastan | Mesothelium antigen and methods and kits for targeting it |
| US6809184B1 (en) | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
| US6855320B2 (en) * | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| JP2004500405A (ja) * | 2000-03-29 | 2004-01-08 | ザ トラスティーズ オブ ザ ユニバーシティー オブ ペンシルヴァニア | 抗原の免疫原性を増強するための組成物および方法 |
| DK1351709T3 (da) | 2000-06-09 | 2005-01-31 | Us Gov Health & Human Serv | Pegylering af linkere forbedrer antitumorvirkning og reducerer immunkonjugaters tokcitet |
| US7425449B2 (en) * | 2002-04-30 | 2008-09-16 | The Regents Of The University Of California | Site specific Listeria integration vectors and methods for using the same |
| WO2004084936A2 (en) | 2003-02-06 | 2004-10-07 | Cerus Corporation | Modified free-living microbes, vaccine compositions and methods of use thereof |
| PT1592441E (pt) | 2003-02-06 | 2012-05-21 | Aduro Biotech | Listeria atenuada relativamente à entrada em células não patogénicas, vacinas compreendendo a listeria e métodos para sua utilização |
| US20050147621A1 (en) | 2003-10-10 | 2005-07-07 | Higgins Darren E. | Use of bacterial 5' untranslated regions for nucleic acid expression |
| JP2007509067A (ja) | 2003-10-15 | 2007-04-12 | メディミューン，インコーポレーテッド | リステリアに基づくＥｐｈＡ２ワクチン |
| EP1708741B1 (en) * | 2003-12-24 | 2016-03-30 | Aduro Biotech | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| US20060135457A1 (en) * | 2004-08-13 | 2006-06-22 | Yvonne Paterson | Methods for constructing antibiotic resistance free vaccines |
| ES2684749T3 (es) * | 2004-08-13 | 2018-10-04 | The Trustees Of The University Of Pennsylvania | Métodos para construir vacunas sin resistencia a antibióticos |
-
2007
- 2007-03-01 EP EP07752174.8A patent/EP1991263B8/en not_active Not-in-force
- 2007-03-01 SI SI200731608T patent/SI1991263T1/sl unknown
- 2007-03-01 JP JP2008557419A patent/JP5347135B2/ja not_active Expired - Fee Related
- 2007-03-01 GB GB0817892A patent/GB2451014B/en not_active Expired - Fee Related
- 2007-03-01 WO PCT/US2007/005457 patent/WO2007103225A2/en not_active Ceased
- 2007-03-01 PT PT07752174T patent/PT1991263E/pt unknown
- 2007-03-01 ES ES07752174.8T patent/ES2532942T3/es active Active
- 2007-03-01 DK DK07752174T patent/DK1991263T3/en active
- 2007-03-01 EP EP14193181.6A patent/EP2860253B1/en not_active Not-in-force
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