JP2007518405A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2007518405A5 JP2007518405A5 JP2006547602A JP2006547602A JP2007518405A5 JP 2007518405 A5 JP2007518405 A5 JP 2007518405A5 JP 2006547602 A JP2006547602 A JP 2006547602A JP 2006547602 A JP2006547602 A JP 2006547602A JP 2007518405 A5 JP2007518405 A5 JP 2007518405A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- recombinant
- signal peptide
- antigen
- bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims 84
- 102000040430 polynucleotide Human genes 0.000 claims 84
- 239000002157 polynucleotide Substances 0.000 claims 84
- 241000186781 Listeria Species 0.000 claims 74
- 108090000765 processed proteins & peptides Proteins 0.000 claims 49
- 239000000427 antigen Substances 0.000 claims 48
- 102000036639 antigens Human genes 0.000 claims 48
- 108091007433 antigens Proteins 0.000 claims 48
- 229920001184 polypeptide Polymers 0.000 claims 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims 48
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 47
- 102000039446 nucleic acids Human genes 0.000 claims 37
- 108020004707 nucleic acids Proteins 0.000 claims 37
- 150000007523 nucleic acids Chemical class 0.000 claims 37
- 241000894006 Bacteria Species 0.000 claims 17
- 230000028993 immune response Effects 0.000 claims 12
- 230000001939 inductive effect Effects 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 11
- -1 H-Ras Proteins 0.000 claims 10
- 102000037865 fusion proteins Human genes 0.000 claims 9
- 108020001507 fusion proteins Proteins 0.000 claims 9
- 208000035473 Communicable disease Diseases 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 8
- 230000001580 bacterial effect Effects 0.000 claims 7
- 101710148893 Internalin B Proteins 0.000 claims 6
- 241000186779 Listeria monocytogenes Species 0.000 claims 6
- 102000003735 Mesothelin Human genes 0.000 claims 6
- 108090000015 Mesothelin Proteins 0.000 claims 6
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 4
- 101710113436 GTPase KRas Proteins 0.000 claims 4
- 102100039788 GTPase NRas Human genes 0.000 claims 4
- 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 claims 4
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 4
- 101001114052 Homo sapiens P antigen family member 4 Proteins 0.000 claims 4
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 4
- 101000621309 Homo sapiens Wilms tumor protein Proteins 0.000 claims 4
- 102100022430 Melanocyte protein PMEL Human genes 0.000 claims 4
- 102100023240 P antigen family member 4 Human genes 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 102000035195 Peptidases Human genes 0.000 claims 4
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 4
- 101800001271 Surface protein Proteins 0.000 claims 4
- 108010002687 Survivin Proteins 0.000 claims 4
- 102000000763 Survivin Human genes 0.000 claims 4
- 102100022748 Wilms tumor protein Human genes 0.000 claims 4
- 230000000890 antigenic effect Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 235000019833 protease Nutrition 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 101150085476 secA1 gene Proteins 0.000 claims 4
- 101150082315 spas-1 gene Proteins 0.000 claims 4
- 101150006301 SECA2 gene Proteins 0.000 claims 3
- 230000002950 deficient Effects 0.000 claims 3
- 230000002163 immunogen Effects 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 claims 2
- 241000193738 Bacillus anthracis Species 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims 2
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 claims 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims 2
- 241000194035 Lactococcus lactis Species 0.000 claims 2
- 101710194807 Protective antigen Proteins 0.000 claims 2
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 2
- 108010032166 TARP Proteins 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 229940065181 bacillus anthracis Drugs 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000001539 phagocyte Anatomy 0.000 claims 2
- 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 108010014186 ras Proteins Proteins 0.000 claims 2
- 102000016914 ras Proteins Human genes 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 241000194036 Lactococcus Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53259803P | 2003-12-24 | 2003-12-24 | |
| US60/532,598 | 2003-12-24 | ||
| US54151504P | 2004-02-02 | 2004-02-02 | |
| US60/541,515 | 2004-02-02 | ||
| US10/773,792 US7691393B2 (en) | 2003-02-06 | 2004-02-06 | Listeria attenuated for entry into non-phagocytic cells, vaccines comprising the Listeria, and methods of use thereof |
| US10/773,618 | 2004-02-06 | ||
| US10/773,618 US7833775B2 (en) | 2003-02-06 | 2004-02-06 | Modified free-living microbes, vaccine compositions and methods of use thereof |
| US10/773,792 | 2004-02-06 | ||
| US55674404P | 2004-03-26 | 2004-03-26 | |
| US60/556,744 | 2004-03-26 | ||
| US10/883,599 US7695725B2 (en) | 2003-02-06 | 2004-06-30 | Modified free-living microbes, vaccine compositions and methods of use thereof |
| US10/883,599 | 2004-06-30 | ||
| USPCT/US2004/023881 | 2004-07-23 | ||
| PCT/US2004/023881 WO2005009463A2 (en) | 2003-07-24 | 2004-07-23 | Antigen-presenting cell vaccines and methods of use thereof |
| US59937704P | 2004-08-05 | 2004-08-05 | |
| US60/599,377 | 2004-08-05 | ||
| US61528704P | 2004-10-01 | 2004-10-01 | |
| US60/615,287 | 2004-10-01 | ||
| US61675004P | 2004-10-06 | 2004-10-06 | |
| US60/616,750 | 2004-10-06 | ||
| PCT/US2004/044080 WO2005071088A2 (en) | 2003-12-24 | 2004-12-23 | Recombinant nucleic acid molecules encoding fusion proteins comprising antigens and bacterial secretory signal polypeptides, expression cassettes, and bacteria, and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011115257A Division JP2011155988A (ja) | 2003-12-24 | 2011-05-23 | 抗原および細菌分泌シグナルポリペプチドを含む融合タンパク質をコードする組換え核酸分子、発現カセット、および細菌、ならびにこれらを使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007518405A JP2007518405A (ja) | 2007-07-12 |
| JP2007518405A5 true JP2007518405A5 (enExample) | 2008-02-14 |
| JP5532280B2 JP5532280B2 (ja) | 2014-06-25 |
Family
ID=44588533
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006547602A Expired - Fee Related JP5532280B2 (ja) | 2003-12-24 | 2004-12-23 | 抗原および細菌分泌シグナルポリペプチドを含む融合タンパク質をコードする組換え核酸分子、発現カセット、および細菌、ならびにこれらを使用する方法 |
| JP2011115257A Withdrawn JP2011155988A (ja) | 2003-12-24 | 2011-05-23 | 抗原および細菌分泌シグナルポリペプチドを含む融合タンパク質をコードする組換え核酸分子、発現カセット、および細菌、ならびにこれらを使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011115257A Withdrawn JP2011155988A (ja) | 2003-12-24 | 2011-05-23 | 抗原および細菌分泌シグナルポリペプチドを含む融合タンパク質をコードする組換え核酸分子、発現カセット、および細菌、ならびにこれらを使用する方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (2) | JP5532280B2 (enExample) |
| CN (1) | CN1921884B (enExample) |
| TW (1) | TW200530399A (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2535421T3 (es) * | 2011-03-22 | 2015-05-11 | Mucosis B.V. | Composiciones inmunogénicas en forma particulada y métodos para producir las mismas |
| CN102766601B (zh) * | 2011-11-17 | 2015-12-16 | 中山大学肿瘤防治中心 | 含有可诱导型癌基因的细胞系及其建立方法、应用 |
| EP3763383A1 (en) * | 2013-12-16 | 2021-01-13 | Massachusetts Institute Of Technology | Micromolded or 3-d printed pulsatile release vaccine formulations |
| LT3037530T (lt) * | 2014-12-22 | 2017-04-10 | Sandoz Ag | Sekos variantai |
| CN105039381B (zh) * | 2015-07-21 | 2018-02-13 | 齐鲁工业大学 | 一种麦芽糖诱导型海藻糖合酶合成工程菌及其制备方法与应用 |
| CN107229842A (zh) * | 2017-06-02 | 2017-10-03 | 肖传乐 | 一种基于局部图的三代测序序列校正方法 |
| CN115894639B (zh) * | 2022-11-03 | 2024-05-14 | 大连医诺生物股份有限公司 | 一种辅助侵染蛋白残基突变体蛋白、其重组体及在外泌酶固定化工艺中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830702A (en) * | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| FR2686896B1 (fr) * | 1992-01-31 | 1995-01-06 | Pasteur Institut | Mutant attenue de listeria monocytogenes; souche recombinante de listeria monocytogenes, utilisation comme vecteurs heterologues d'antigenes vaccinal et utilisation comme vaccin ou composition diagnostique. |
| DE19949594A1 (de) * | 1999-10-14 | 2001-04-26 | Deutsches Krebsforsch | Rekombinante attenuierte Listerien zur Immuntherapie |
-
2004
- 2004-12-23 TW TW093140281A patent/TW200530399A/zh unknown
- 2004-12-23 JP JP2006547602A patent/JP5532280B2/ja not_active Expired - Fee Related
- 2004-12-23 CN CN200480042020XA patent/CN1921884B/zh not_active Expired - Fee Related
-
2011
- 2011-05-23 JP JP2011115257A patent/JP2011155988A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1303299B1 (en) | Use of prokaryotic pest-like peptides for enhancing immunogenicity of antigens | |
| JP2017513502A5 (enExample) | ||
| JP2009528065A5 (enExample) | ||
| CN106061995A (zh) | Uspa2蛋白质构建体及其用途 | |
| KR20110045010A (ko) | Ｃ형 간염의 치료를 위한 조성물 및 방법 | |
| WO2012172277A4 (en) | Simian adenovirus and hybrid adenoviral vectors | |
| CA2818353A1 (en) | Methods and compositions for inducing an immune response to egfrviii | |
| JP2016503655A5 (enExample) | ||
| JP2011516070A5 (enExample) | ||
| JP2011502165A (ja) | 鞭毛細菌に対する免疫応答を強化する組成物および方法 | |
| WO2001045639A2 (en) | Methods for protecting against lethal infection with bacillus anthracis | |
| AU2014256457A1 (en) | Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene WT1 | |
| US9982024B2 (en) | CyaA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses | |
| JP2007518405A5 (enExample) | ||
| AU2017264901A1 (en) | Combination prime: boost therapy | |
| JP5097544B2 (ja) | 炭疽菌からの防御抗原の調製 | |
| JP6213969B2 (ja) | 免疫原性ポリペプチド表層発現ビフィズス菌 | |
| EP4196158A1 (en) | Salmonella vaccine for the treatment of coronavirus | |
| EP2483409B1 (en) | LACTOBACILLUS glyceraldehyde-3-phosphate dehydrogenase PROMOTERS AND USES THEREOF | |
| EP2874657B1 (en) | Hpv/cyaa-based chimeric proteins and their uses in the induction of immune responses against hpv infection and hpv-induced disorders | |
| RU2006126673A (ru) | Рекомбинантные молекулы нуклеиновой кислоты, экспрессирующие кассеты, бактерии и способы их применения | |
| JP2006514606A (ja) | 疎水性タンパク質の発現 | |
| Chuekwon et al. | Immune response to the dual antigen vaccine of Actinobacillus pleuropneumoniae in a mouse model | |
| US20090220517A1 (en) | Method for producing epitomers and their uses on carrier microorganisms | |
| HK1208048B (en) | Cyaa-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses |