JP2011516070A5 - - Google Patents

Info

Publication number

JP2011516070A5

JP2011516070A5 JP2011503242A JP2011503242A JP2011516070A5 JP 2011516070 A5 JP2011516070 A5 JP 2011516070A5 JP 2011503242 A JP2011503242 A JP 2011503242A JP 2011503242 A JP2011503242 A JP 2011503242A JP 2011516070 A5 JP2011516070 A5 JP 2011516070A5

Authority

JP

Japan

Prior art keywords

common

protein

chikv

immunogenic

fragment

Prior art date

2009-04-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000623 proteins and genes Proteins 0.000 claims description 50
• 230000002163 immunogen Effects 0.000 claims description 31
• 108090000565 Capsid Proteins Proteins 0.000 claims description 11
• 102100023321 Ceruloplasmin Human genes 0.000 claims description 11
• 101710125507 Integrase/recombinase Proteins 0.000 claims description 10
• 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 claims description 10
• 210000000234 capsid Anatomy 0.000 claims description 10
• 230000028993 immune response Effects 0.000 claims description 6
• 239000002773 nucleotide Substances 0.000 claims description 2
• 125000003729 nucleotide group Chemical group 0.000 claims description 2
• 102000004169 proteins and genes Human genes 0.000 claims 49
• 239000012634 fragment Substances 0.000 claims 30
• 239000000203 mixture Substances 0.000 claims 24
• 102000039446 nucleic acids Human genes 0.000 claims 19
• 108020004707 nucleic acids Proteins 0.000 claims 19
• 150000007523 nucleic acids Chemical class 0.000 claims 19
• 108010008038 Synthetic Vaccines Proteins 0.000 claims 5
• 229940124551 recombinant vaccine Drugs 0.000 claims 5
• 102100034353 Integrase Human genes 0.000 claims 4
• 108010078428 env Gene Products Proteins 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 230000001939 inductive effect Effects 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 238000004520 electroporation Methods 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 description 6
• 108090000765 processed proteins & peptides Proteins 0.000 description 6
• 241001502567 Chikungunya virus Species 0.000 description 4
• 150000001413 amino acids Chemical group 0.000 description 4
• 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 3
• 108020004705 Codon Proteins 0.000 description 2
• 102100037850 Interferon gamma Human genes 0.000 description 2
• 108010074328 Interferon-gamma Proteins 0.000 description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 description 2
• 241000700605 Viruses Species 0.000 description 2
• 238000004458 analytical method Methods 0.000 description 2
• 230000005847 immunogenicity Effects 0.000 description 2
• 230000004044 response Effects 0.000 description 2
• 241000894006 Bacteria Species 0.000 description 1
• 101710132601 Capsid protein Proteins 0.000 description 1
• 108091035707 Consensus sequence Proteins 0.000 description 1
• 108020004414 DNA Proteins 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 230000024932 T cell mediated immunity Effects 0.000 description 1
• 238000000246 agarose gel electrophoresis Methods 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 238000012512 characterization method Methods 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• 230000003053 immunization Effects 0.000 description 1
• 238000002649 immunization Methods 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 238000000034 method Methods 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 238000005070 sampling Methods 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 238000012795 verification Methods 0.000 description 1