JP2003533232A5 - - Google Patents
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- Publication number
- JP2003533232A5 JP2003533232A5 JP2001585612A JP2001585612A JP2003533232A5 JP 2003533232 A5 JP2003533232 A5 JP 2003533232A5 JP 2001585612 A JP2001585612 A JP 2001585612A JP 2001585612 A JP2001585612 A JP 2001585612A JP 2003533232 A5 JP2003533232 A5 JP 2003533232A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- mutation
- hcv
- ires
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 description 35
- 102000040430 polynucleotide Human genes 0.000 description 35
- 239000002157 polynucleotide Substances 0.000 description 35
- 230000035772 mutation Effects 0.000 description 16
- 210000004027 cell Anatomy 0.000 description 15
- 108091026890 Coding region Proteins 0.000 description 7
- 108010076039 Polyproteins Proteins 0.000 description 7
- 210000004962 mammalian cell Anatomy 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 5
- 238000001890 transfection Methods 0.000 description 5
- 230000037430 deletion Effects 0.000 description 4
- 238000012217 deletion Methods 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- 125000003729 nucleotide group Chemical group 0.000 description 4
- 101800001014 Non-structural protein 5A Proteins 0.000 description 3
- 210000003494 hepatocyte Anatomy 0.000 description 3
- 101710172711 Structural protein Proteins 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 230000003362 replicative effect Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000710188 Encephalomyocarditis virus Species 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- 241001045988 Neogene Species 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 208000037581 Persistent Infection Diseases 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 101150091879 neo gene Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/576,989 US7049428B1 (en) | 1998-03-04 | 2000-05-23 | HCV variants |
| US09/576,989 | 2000-05-23 | ||
| PCT/US2001/016822 WO2001089364A2 (en) | 2000-05-23 | 2001-05-23 | Hcv variants |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006339705A Division JP2007143553A (ja) | 2000-05-23 | 2006-12-18 | Ｈｃｖ変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003533232A JP2003533232A (ja) | 2003-11-11 |
| JP2003533232A5 true JP2003533232A5 (enExample) | 2007-02-08 |
| JP4095303B2 JP4095303B2 (ja) | 2008-06-04 |
Family
ID=24306833
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001585612A Expired - Lifetime JP4095303B2 (ja) | 2000-05-23 | 2001-05-23 | Ｈｃｖ変異体 |
| JP2006339705A Pending JP2007143553A (ja) | 2000-05-23 | 2006-12-18 | Ｈｃｖ変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006339705A Pending JP2007143553A (ja) | 2000-05-23 | 2006-12-18 | Ｈｃｖ変異体 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1296998B1 (enExample) |
| JP (2) | JP4095303B2 (enExample) |
| AT (1) | ATE525384T1 (enExample) |
| AU (1) | AU2001263407B9 (enExample) |
| CA (1) | CA2409873C (enExample) |
| DK (1) | DK1296998T3 (enExample) |
| ES (1) | ES2373642T3 (enExample) |
| IL (3) | IL152671A0 (enExample) |
| WO (1) | WO2001089364A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235394B1 (en) | 1995-08-29 | 2007-06-26 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
| AU2002218906B2 (en) | 2000-12-22 | 2006-08-03 | Boehringer Ingelheim (Canada) Ltd. | Self-replicating RNA molecule from hepatitis C virus |
| JP4299540B2 (ja) | 2001-01-23 | 2009-07-22 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | Ｃ型肝炎ウイルスレプリコンおよびレプリコン増強細胞 |
| ATE423785T1 (de) * | 2002-03-11 | 2009-03-15 | Lab 21 Ltd | Verfahren und zusammensetzungen zur identifikation und charakterisierung von hepatitis c |
| US7786287B2 (en) * | 2002-04-16 | 2010-08-31 | Merck & Co., Inc. | Hepatitis C virus assay systems |
| KR100502864B1 (ko) * | 2002-10-09 | 2005-07-22 | (주)팬바이오넷 | Ｃ형 간염바이러스의 복제 정량 리플리콘, 이를 포함하는세포주, 및 상기 세포주를 이용한 ｈｃｖ 저해제의 탐색방법 |
| CN1711352A (zh) * | 2002-11-13 | 2005-12-21 | 华盛顿大学 | 丙型肝炎病毒复制的高允许性细胞系 |
| EP1604020B1 (en) | 2003-02-13 | 2009-12-16 | Merck & Co., Inc. | Method to confer cell culture replication activity to different hepatitis c virus isolates |
| CN102659922B (zh) * | 2003-09-22 | 2013-11-06 | 株式会社绿多肽 | 来源于c型肝炎病毒的肽 |
| CA2543846C (en) | 2003-11-05 | 2011-04-12 | Merck & Co., Inc. | Hcv replicons containing ns5b from genotype 2b |
| US20090170063A1 (en) * | 2004-06-25 | 2009-07-02 | Advanced Life Science Institute, Inc. | Hcv rna having novel sequence |
| GB0421908D0 (en) | 2004-10-01 | 2004-11-03 | Angeletti P Ist Richerche Bio | New uses |
| EP2151495A4 (en) * | 2007-04-27 | 2010-06-02 | Advanced Life Science Inst Inc | HCV GENE |
| GB0716292D0 (en) | 2007-08-21 | 2007-09-26 | Biofocus Dpi Ltd | Imidazopyrazine compounds |
| CA2705787A1 (en) * | 2007-11-26 | 2009-06-25 | Novartis Ag | Methods of generating alphavirus particles |
| WO2011130125A1 (en) * | 2010-04-12 | 2011-10-20 | Viracine Therapeutics Corporation | Expression of positive sense single stranded rna virus and uses thereof |
| JP2015534821A (ja) | 2012-11-07 | 2015-12-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｃｖ遺伝子型６レプリコン |
| CN112225783B (zh) * | 2020-09-16 | 2021-08-31 | 东莞市朋志生物科技有限公司 | Hcv重组抗原及其突变体 |
-
2001
- 2001-05-23 AT AT01937697T patent/ATE525384T1/de not_active IP Right Cessation
- 2001-05-23 WO PCT/US2001/016822 patent/WO2001089364A2/en not_active Ceased
- 2001-05-23 IL IL15267101A patent/IL152671A0/xx unknown
- 2001-05-23 CA CA2409873A patent/CA2409873C/en not_active Expired - Lifetime
- 2001-05-23 DK DK01937697.9T patent/DK1296998T3/da active
- 2001-05-23 JP JP2001585612A patent/JP4095303B2/ja not_active Expired - Lifetime
- 2001-05-23 AU AU2001263407A patent/AU2001263407B9/en not_active Ceased
- 2001-05-23 EP EP01937697A patent/EP1296998B1/en not_active Expired - Lifetime
- 2001-05-23 ES ES01937697T patent/ES2373642T3/es not_active Expired - Lifetime
-
2002
- 2002-11-06 IL IL152671A patent/IL152671A/en active IP Right Grant
-
2006
- 2006-07-06 IL IL176731A patent/IL176731A/en active IP Right Grant
- 2006-12-18 JP JP2006339705A patent/JP2007143553A/ja active Pending
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