EA201590397A8 - Способствующие экспрессии антигенных последовательностей у listeria партнеры для гибридизации, представляющие собой сигнальные пептиды, и способы их получения и применения - Google Patents
Способствующие экспрессии антигенных последовательностей у listeria партнеры для гибридизации, представляющие собой сигнальные пептиды, и способы их получения и примененияInfo
- Publication number
- EA201590397A8 EA201590397A8 EA201590397A EA201590397A EA201590397A8 EA 201590397 A8 EA201590397 A8 EA 201590397A8 EA 201590397 A EA201590397 A EA 201590397A EA 201590397 A EA201590397 A EA 201590397A EA 201590397 A8 EA201590397 A8 EA 201590397A8
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- partners
- hybridization
- signal peptides
- listeria
- contributing
- Prior art date
Links
- 238000009396 hybridization Methods 0.000 title abstract 3
- 108010076504 Protein Sorting Signals Proteins 0.000 title abstract 2
- 241000186781 Listeria Species 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000005431 Molecular Chaperones Human genes 0.000 abstract 1
- 108010006519 Molecular Chaperones Proteins 0.000 abstract 1
- 230000005867 T cell response Effects 0.000 abstract 1
- 241000607479 Yersinia pestis Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 238000013459 approach Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000172 cytosol Anatomy 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261746237P | 2012-12-27 | 2012-12-27 | |
| US201361780744P | 2013-03-13 | 2013-03-13 | |
| PCT/US2013/078119 WO2014106123A1 (en) | 2012-12-27 | 2013-12-27 | Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201590397A1 EA201590397A1 (ru) | 2016-02-29 |
| EA201590397A8 true EA201590397A8 (ru) | 2016-08-31 |
Family
ID=51017446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201590397A EA201590397A8 (ru) | 2012-12-27 | 2013-12-27 | Способствующие экспрессии антигенных последовательностей у listeria партнеры для гибридизации, представляющие собой сигнальные пептиды, и способы их получения и применения |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9663557B2 (enExample) |
| EP (1) | EP2938627B1 (enExample) |
| JP (2) | JP2016503655A (enExample) |
| KR (1) | KR102160322B1 (enExample) |
| CN (1) | CN104955835B (enExample) |
| AU (2) | AU2013370210B2 (enExample) |
| BR (1) | BR112015015076A2 (enExample) |
| CA (1) | CA2888727A1 (enExample) |
| EA (1) | EA201590397A8 (enExample) |
| MX (1) | MX2015008329A (enExample) |
| SG (2) | SG10201700916SA (enExample) |
| WO (1) | WO2014106123A1 (enExample) |
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| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| EP2853269B1 (en) | 2008-05-19 | 2019-05-01 | Advaxis, Inc. | Dual delivery system for heterologous antigens comprising a recombinant Listeria strain attenuated by mutation of dal/dat and deletion of ActA comprising a nucleic acid molecule encoding an listeriolysin O - prostate specific anigen fusion protein |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| CN103282048B (zh) | 2010-10-01 | 2017-05-17 | 宾夕法尼亚大学理事会 | 李斯特菌疫苗载体用于在寄生虫感染的个体中扭转免疫无应答的用途 |
| CA2829960A1 (en) | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| KR20140134695A (ko) | 2012-03-12 | 2014-11-24 | 어드박시스, 인크. | 리스테리아 백신 치료 후 억제 세포 기능 저해 |
| MA40344A (fr) | 2014-07-18 | 2016-01-21 | Advaxis Inc | Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer |
| US10925945B2 (en) | 2014-10-13 | 2021-02-23 | Providence Health & Services-Oregon | Bacterial vaccines deficient in the 2-C-methyl-D-erythritol-4-phosphate pathway and methods of preparation and use thereof |
| US10765699B2 (en) | 2015-02-06 | 2020-09-08 | National University Of Singapore | Methods for enhancing efficacy of therapeutic immune cells |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| MA44378A (fr) | 2015-04-13 | 2019-01-23 | Aduro Biotech Inc | Protéines de fusion immunogènes pour le traitement du cancer |
| KR20180002640A (ko) * | 2015-04-13 | 2018-01-08 | 아두로 바이오테크, 인코포레이티드 | 표피 성장 인자 수용체 변형 iii-메소텔린 융합체 및 이를 이용하는 방법 |
| EP3298031B1 (en) * | 2015-05-18 | 2020-10-21 | BiOMVis Srl | Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof |
| KR102883915B1 (ko) | 2015-12-16 | 2025-11-18 | 시애틀 프로젝트 코포레이션 | 신생항원 동정, 제조, 및 용도 |
| CN114751950B (zh) * | 2016-03-18 | 2025-04-18 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
| US11440958B2 (en) | 2016-11-22 | 2022-09-13 | National University Of Singapore | Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies |
| CN111247241A (zh) | 2017-08-10 | 2020-06-05 | 新加坡国立大学 | T细胞受体缺陷型嵌合抗原受体t细胞和其使用方法 |
| CN111356760A (zh) | 2017-09-19 | 2020-06-30 | 阿德瓦希斯公司 | 细菌或李斯特菌菌株的冻干组合物和方法 |
| WO2019075112A1 (en) | 2017-10-10 | 2019-04-18 | Gritstone Oncology, Inc. | IDENTIFICATION OF NEO-ANTIGENS USING HOT POINTS |
| KR20260008173A (ko) | 2017-11-22 | 2026-01-15 | 시애틀 프로젝트 코포레이션 | 신생항원에 대한 접합 에피토프 제시 감소 |
| EP3536706A1 (en) | 2018-03-09 | 2019-09-11 | BiOMVis Srl | Fusion proteins for the outer membrane vesicle (omv) delivery of heterologous polypeptides and immunogenic compositions thereof |
| EP3762719A1 (en) | 2018-03-09 | 2021-01-13 | Advaxis, Inc. | Compositions and methods for evaluating attenuation and infectivity of listeria strains |
| US20210239681A1 (en) | 2018-04-27 | 2021-08-05 | Advaxis, Inc. | Compositions and methods for evaluating potency of listeria-based immunotherapeutics |
| CN110408634B (zh) | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
| EP3784776A4 (en) | 2018-05-23 | 2022-01-26 | National University of Singapore | Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies |
| EP3725371A1 (en) | 2019-04-18 | 2020-10-21 | BiOMVis Srl | Method for the production of outer membrane vesicles and immunogenic compositions thereof |
| CN110499324A (zh) * | 2019-09-02 | 2019-11-26 | 中生康元生物科技(北京)有限公司 | 一种用于鉴定肿瘤新抗原的细菌表达载体及筛选鉴定肿瘤新抗原的方法 |
| CA3184128A1 (en) | 2020-06-23 | 2021-12-30 | Kathleen Barnes | Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes |
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| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US5552284A (en) | 1991-03-29 | 1996-09-03 | Genentech, Inc. | Detection of interleukin-8 receptors by nudeic acid hybridization |
| IT1262895B (it) | 1992-03-02 | 1996-07-22 | Proteina estratta da ceppi citotossici di helicobacter pylori, gene che la esprime, uso della proteina come vaccino o diagnostico. | |
| US6379943B1 (en) | 1999-03-05 | 2002-04-30 | Merck & Co., Inc. | High-efficiency Cre/loxp based system for construction of adenovirus vectors |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US5888530A (en) | 1995-07-21 | 1999-03-30 | The General Hospital Corporation | Method of enhancing delivery of a pharmaceutical formulation |
| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| EP1303299B1 (en) * | 2000-03-29 | 2010-07-28 | The Trustees of The University of Pennsylvania | Use of prokaryotic pest-like peptides for enhancing immunogenicity of antigens |
| AU2001290860A1 (en) | 2000-09-21 | 2002-04-02 | The Regents Of The University Of California | Spas-1 cancer antigen |
| WO2003102168A1 (en) * | 2002-05-29 | 2003-12-11 | The Regents Of The University Of California | Attenuated listeria spp. and methods for using the same |
| AU2003259109A1 (en) | 2002-07-12 | 2004-02-02 | The Johns Hopkins University | Mesothelin vaccines and model systems |
| US20050281783A1 (en) | 2003-10-15 | 2005-12-22 | Kinch Michael S | Listeria-based EphA2 vaccines |
| US7842289B2 (en) * | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| US7858097B2 (en) * | 2004-08-13 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free Listeria strains and methods for constructing and using same |
| WO2007117371A2 (en) | 2006-03-01 | 2007-10-18 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
| EP2860253B1 (en) | 2006-03-01 | 2018-08-01 | Aduro Biotech, Inc. | Engineered listeria and methods of use thereof |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| WO2008008311A1 (en) | 2006-07-10 | 2008-01-17 | The Trustees Of The University Of Pennsylvania | Methods for administering tumor vaccines |
| JP2010534058A (ja) * | 2007-04-16 | 2010-11-04 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 抗生物質耐性のないリステリア菌およびその構築および使用方法 |
| CN102076843A (zh) * | 2008-05-19 | 2011-05-25 | 艾杜罗生物科技公司 | 包含prfa*突变体李斯特菌的组合物及其使用方法 |
| GB201010389D0 (en) | 2010-06-21 | 2010-08-04 | Ist Superiore Sanita | Antibody derivatives |
| SI2640842T1 (sl) | 2010-11-17 | 2018-09-28 | Aduro Biotech, Inc. | Postopki in sestavki za induciranje imunskega odziva na EGFRvIII |
| CA2829960A1 (en) * | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| KR20140134695A (ko) * | 2012-03-12 | 2014-11-24 | 어드박시스, 인크. | 리스테리아 백신 치료 후 억제 세포 기능 저해 |
-
2013
- 2013-12-27 MX MX2015008329A patent/MX2015008329A/es unknown
- 2013-12-27 CN CN201380068458.4A patent/CN104955835B/zh not_active Expired - Fee Related
- 2013-12-27 SG SG10201700916SA patent/SG10201700916SA/en unknown
- 2013-12-27 EP EP13869448.4A patent/EP2938627B1/en not_active Not-in-force
- 2013-12-27 JP JP2015550820A patent/JP2016503655A/ja active Pending
- 2013-12-27 US US14/142,614 patent/US9663557B2/en not_active Expired - Fee Related
- 2013-12-27 KR KR1020157015490A patent/KR102160322B1/ko not_active Expired - Fee Related
- 2013-12-27 EA EA201590397A patent/EA201590397A8/ru unknown
- 2013-12-27 SG SG11201502792TA patent/SG11201502792TA/en unknown
- 2013-12-27 WO PCT/US2013/078119 patent/WO2014106123A1/en not_active Ceased
- 2013-12-27 CA CA2888727A patent/CA2888727A1/en not_active Abandoned
- 2013-12-27 AU AU2013370210A patent/AU2013370210B2/en not_active Ceased
- 2013-12-27 BR BR112015015076A patent/BR112015015076A2/pt active Search and Examination
-
2017
- 2017-05-18 US US15/599,441 patent/US20170253637A1/en not_active Abandoned
-
2018
- 2018-04-06 JP JP2018074066A patent/JP6671408B2/ja not_active Expired - Fee Related
- 2018-05-21 AU AU2018203555A patent/AU2018203555A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2938627A4 (en) | 2016-12-14 |
| SG11201502792TA (en) | 2015-05-28 |
| AU2013370210B2 (en) | 2018-06-14 |
| JP6671408B2 (ja) | 2020-03-25 |
| WO2014106123A1 (en) | 2014-07-03 |
| BR112015015076A2 (pt) | 2018-10-30 |
| KR20150099738A (ko) | 2015-09-01 |
| EP2938627B1 (en) | 2019-03-20 |
| EP2938627A1 (en) | 2015-11-04 |
| US20170253637A1 (en) | 2017-09-07 |
| WO2014106123A8 (en) | 2016-06-16 |
| US9663557B2 (en) | 2017-05-30 |
| AU2018203555A1 (en) | 2018-06-07 |
| CN104955835A (zh) | 2015-09-30 |
| US20140186387A1 (en) | 2014-07-03 |
| CA2888727A1 (en) | 2014-07-03 |
| HK1215260A1 (zh) | 2016-08-19 |
| EA201590397A1 (ru) | 2016-02-29 |
| JP2018135355A (ja) | 2018-08-30 |
| CN104955835B (zh) | 2020-04-17 |
| SG10201700916SA (en) | 2017-03-30 |
| JP2016503655A (ja) | 2016-02-08 |
| AU2013370210A1 (en) | 2015-06-18 |
| MX2015008329A (es) | 2016-03-01 |
| AU2013370210A8 (en) | 2016-06-23 |
| KR102160322B1 (ko) | 2020-09-25 |
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