MX2015008329A - Compañeros de fusion de peptido, señal que facilita la expresion listeral de secuencias antigenicas y metodos de preparacion y uso de los mismos. - Google Patents

Compañeros de fusion de peptido, señal que facilita la expresion listeral de secuencias antigenicas y metodos de preparacion y uso de los mismos.

Info

Publication number
MX2015008329A
MX2015008329A MX2015008329A MX2015008329A MX2015008329A MX 2015008329 A MX2015008329 A MX 2015008329A MX 2015008329 A MX2015008329 A MX 2015008329A MX 2015008329 A MX2015008329 A MX 2015008329A MX 2015008329 A MX2015008329 A MX 2015008329A
Authority
MX
Mexico
Prior art keywords
fusion partners
listerial
expression
preparation
methods
Prior art date
Application number
MX2015008329A
Other languages
English (en)
Inventor
Peter M Lauer
Marcella Fasso
Dirk Brockstedt
Thomas W Dubensky
William G Hanson
Skoble Justin
Leong Meredith Lai Ling
Original Assignee
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aduro Biotech Inc filed Critical Aduro Biotech Inc
Publication of MX2015008329A publication Critical patent/MX2015008329A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona ácidos nucleicos, sistemas de expresión, y cepas de vacuna que proporcionan una expresión y secreción eficientes de antígenos de interés en el citosol de las células huésped, y respuestas efectivas de las células T CD4 y CD8 mediante la vinculación funcional de Listerial y otros péptidos señal bacterial/acompañantes de secreción como compañeros de fusión de terminal N en el marco de lectura transaccional con los antígenos de proteína codificados recombinantes. Estos compañeros de fusión terminal N se eliminan (ya sea por eliminación real, por mutación o por combinación de estos enfoques) para cualquiera de las secuencias nativas PEST a la secuencia, y/o para ciertos residuos hidrofóbicos.
MX2015008329A 2012-12-27 2013-12-27 Compañeros de fusion de peptido, señal que facilita la expresion listeral de secuencias antigenicas y metodos de preparacion y uso de los mismos. MX2015008329A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261746237P 2012-12-27 2012-12-27
US201361780744P 2013-03-13 2013-03-13
PCT/US2013/078119 WO2014106123A1 (en) 2012-12-27 2013-12-27 Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof

Publications (1)

Publication Number Publication Date
MX2015008329A true MX2015008329A (es) 2016-03-01

Family

ID=51017446

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008329A MX2015008329A (es) 2012-12-27 2013-12-27 Compañeros de fusion de peptido, señal que facilita la expresion listeral de secuencias antigenicas y metodos de preparacion y uso de los mismos.

Country Status (13)

Country Link
US (2) US9663557B2 (es)
EP (1) EP2938627B1 (es)
JP (2) JP2016503655A (es)
KR (1) KR102160322B1 (es)
CN (1) CN104955835B (es)
AU (2) AU2013370210B2 (es)
BR (1) BR112015015076A2 (es)
CA (1) CA2888727A1 (es)
EA (1) EA201590397A8 (es)
HK (1) HK1215260A1 (es)
MX (1) MX2015008329A (es)
SG (2) SG11201502792TA (es)
WO (1) WO2014106123A1 (es)

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US20110129499A1 (en) 2008-05-19 2011-06-02 Paulo Maciag Dual delivery system for heterologous antigens
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
JP5981436B2 (ja) 2010-10-01 2016-08-31 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 寄生的に感染している対象におけるワクチン不応答性を反転させるためのリステリアワクチンベクターの使用
EP2683400A4 (en) 2011-03-11 2014-09-17 Advaxis ADJUVANZIA ON LISTERIA BASE
US10058599B2 (en) 2012-03-12 2018-08-28 Advaxis, Inc. Suppressor cell function inhibition following Listeria vaccine treatment
SG11201701149SA (en) 2014-07-18 2017-04-27 Advaxis Inc Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
US10925945B2 (en) 2014-10-13 2021-02-23 Providence Health & Services-Oregon Bacterial vaccines deficient in the 2-C-methyl-D-erythritol-4-phosphate pathway and methods of preparation and use thereof
PT3253865T (pt) * 2015-02-06 2022-10-03 Nat Univ Singapore Métodos para melhorar a eficácia das células imunitárias terapêuticas
MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
US10105427B2 (en) * 2015-04-13 2018-10-23 Aduro Biotech, Inc. Epidermal growth factor receptor variant III-mesothelin fusions and methods of using the same
JP2018512165A (ja) * 2015-04-13 2018-05-17 アデュロ バイオテック，インコーポレイテッド 癌の治療のための免疫原性融合タンパク質
AU2016262823A1 (en) * 2015-05-18 2017-12-07 Universita' Degli Studi Di Trento Immunogenic compositions containing bacterial outer membrane vesicles and therapeutic uses thereof
IL305238A (en) 2015-12-16 2023-10-01 Gritstone Bio Inc Identification of neoantigens, preparation, and use
EP3692996A1 (en) * 2016-03-18 2020-08-12 Immune Sensor, LLC Cyclic di-nucleotide compounds and methods of use
US11440958B2 (en) 2016-11-22 2022-09-13 National University Of Singapore Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies
WO2019032916A1 (en) 2017-08-10 2019-02-14 National University Of Singapore CHIMERIC ANTIGEN RECEPTOR T CELL LYMPHOCYTES WITH LYMPHOCYTE T-RECEPTOR DEFICIENTS AND METHODS OF USE THEREOF
IL273255B1 (en) 2017-09-19 2024-06-01 Advaxis Inc Preparations and methods for lyophilization of bacterial strains and listeria
KR20200087143A (ko) 2017-10-10 2020-07-20 그릿스톤 온콜로지, 인코포레이티드 핫스팟을 이용한 신생항원 동정
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
KR20200130399A (ko) 2018-03-09 2020-11-18 어드박시스, 인크. 리스테리아 균주의 약독화 및 감염성을 평가하기 위한 조성물 및 방법
EP3536706A1 (en) 2018-03-09 2019-09-11 BiOMVis Srl Fusion proteins for the outer membrane vesicle (omv) delivery of heterologous polypeptides and immunogenic compositions thereof
CN110408634B (zh) 2018-04-27 2021-08-03 苏州若泰医药科技有限公司 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法
WO2019210034A1 (en) 2018-04-27 2019-10-31 Advaxis, Inc. Compositions and methods for evaluating potency of listeria-based immunotherapeutics
EP3725371A1 (en) 2019-04-18 2020-10-21 BiOMVis Srl Method for the production of outer membrane vesicles and immunogenic compositions thereof
CN110499324A (zh) * 2019-09-02 2019-11-26 中生康元生物科技(北京)有限公司 一种用于鉴定肿瘤新抗原的细菌表达载体及筛选鉴定肿瘤新抗原的方法

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Also Published As

Publication number Publication date
CA2888727A1 (en) 2014-07-03
EA201590397A8 (ru) 2016-08-31
WO2014106123A1 (en) 2014-07-03
AU2018203555A1 (en) 2018-06-07
WO2014106123A8 (en) 2016-06-16
KR102160322B1 (ko) 2020-09-25
JP2016503655A (ja) 2016-02-08
SG10201700916SA (en) 2017-03-30
CN104955835A (zh) 2015-09-30
AU2013370210B2 (en) 2018-06-14
US20140186387A1 (en) 2014-07-03
HK1215260A1 (zh) 2016-08-19
EA201590397A1 (ru) 2016-02-29
KR20150099738A (ko) 2015-09-01
AU2013370210A8 (en) 2016-06-23
SG11201502792TA (en) 2015-05-28
US9663557B2 (en) 2017-05-30
EP2938627A1 (en) 2015-11-04
EP2938627A4 (en) 2016-12-14
US20170253637A1 (en) 2017-09-07
JP6671408B2 (ja) 2020-03-25
AU2013370210A1 (en) 2015-06-18
EP2938627B1 (en) 2019-03-20
CN104955835B (zh) 2020-04-17
BR112015015076A2 (pt) 2018-10-30
JP2018135355A (ja) 2018-08-30

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