AU2013370210B2 - Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof - Google Patents

Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof Download PDF

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Publication number
AU2013370210B2
AU2013370210B2 AU2013370210A AU2013370210A AU2013370210B2 AU 2013370210 B2 AU2013370210 B2 AU 2013370210B2 AU 2013370210 A AU2013370210 A AU 2013370210A AU 2013370210 A AU2013370210 A AU 2013370210A AU 2013370210 B2 AU2013370210 B2 AU 2013370210B2
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AU
Australia
Prior art keywords
sequence
pct
polynucleotide
acta
listerial
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2013370210A
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English (en)
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AU2013370210A8 (en
AU2013370210A1 (en
Inventor
Dirk Brockstedt
Thomas W. Dubensky Jr.
Marcella Fasso
William G. Hanson
Peter M. Lauer
Meredith Lai Ling Leong
Justin Skoble
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Chinook Therapeutics Inc
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Aduro Biotech Inc
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Publication of AU2013370210A1 publication Critical patent/AU2013370210A1/en
Publication of AU2013370210A8 publication Critical patent/AU2013370210A8/en
Priority to AU2018203555A priority Critical patent/AU2018203555A1/en
Application granted granted Critical
Publication of AU2013370210B2 publication Critical patent/AU2013370210B2/en
Ceased legal-status Critical Current
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013370210A 2012-12-27 2013-12-27 Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof Ceased AU2013370210B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018203555A AU2018203555A1 (en) 2012-12-27 2018-05-21 Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261746237P 2012-12-27 2012-12-27
US61/746,237 2012-12-27
US201361780744P 2013-03-13 2013-03-13
US61/780,744 2013-03-13
PCT/US2013/078119 WO2014106123A1 (en) 2012-12-27 2013-12-27 Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof

Related Child Applications (1)

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AU2018203555A Division AU2018203555A1 (en) 2012-12-27 2018-05-21 Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof

Publications (3)

Publication Number Publication Date
AU2013370210A1 AU2013370210A1 (en) 2015-06-18
AU2013370210A8 AU2013370210A8 (en) 2016-06-23
AU2013370210B2 true AU2013370210B2 (en) 2018-06-14

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AU2013370210A Ceased AU2013370210B2 (en) 2012-12-27 2013-12-27 Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof
AU2018203555A Abandoned AU2018203555A1 (en) 2012-12-27 2018-05-21 Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof

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US (2) US9663557B2 (enExample)
EP (1) EP2938627B1 (enExample)
JP (2) JP2016503655A (enExample)
KR (1) KR102160322B1 (enExample)
CN (1) CN104955835B (enExample)
AU (2) AU2013370210B2 (enExample)
BR (1) BR112015015076A2 (enExample)
CA (1) CA2888727A1 (enExample)
EA (1) EA201590397A8 (enExample)
MX (1) MX2015008329A (enExample)
SG (2) SG10201700916SA (enExample)
WO (1) WO2014106123A1 (enExample)

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US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US10016617B2 (en) 2009-11-11 2018-07-10 The Trustees Of The University Of Pennsylvania Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers
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MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
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ES2929628T3 (es) * 2016-03-18 2022-11-30 Immune Sensor Llc Compuestos de dinucleótidos cíclicos y métodos de uso
AU2017363278B2 (en) 2016-11-22 2022-10-27 National University Of Singapore Blockade of CD7 expression and chimeric antigen receptors for immunotherapy of T-cell malignancies
CA3071282A1 (en) 2017-08-10 2019-02-14 National University Of Singapore T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
US11179339B2 (en) 2017-09-19 2021-11-23 Advaxis, Inc. Compositions and methods for lyophilization of bacteria or listeria strains
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
KR20200090855A (ko) 2017-11-22 2020-07-29 그릿스톤 온콜로지, 인코포레이티드 신생항원에 대한 접합 에피토프 제시 감소
US20210003558A1 (en) 2018-03-09 2021-01-07 Advaxis, Inc. Compositions and methods for evaluating attenuation and infectivity of listeria strains
EP3536706A1 (en) 2018-03-09 2019-09-11 BiOMVis Srl Fusion proteins for the outer membrane vesicle (omv) delivery of heterologous polypeptides and immunogenic compositions thereof
CN110408634B (zh) 2018-04-27 2021-08-03 苏州若泰医药科技有限公司 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法
EP3785029A1 (en) 2018-04-27 2021-03-03 Advaxis, Inc. Compositions and methods for evaluating potency of listeria-based immunotherapeutics
CA3100386A1 (en) 2018-05-23 2019-11-28 National University Of Singapore Blockade of cd2 surface expression and expression of chimeric antigen receptors for immunotherapy of t-cell malignancies
EP3725371A1 (en) 2019-04-18 2020-10-21 BiOMVis Srl Method for the production of outer membrane vesicles and immunogenic compositions thereof
CN110499324A (zh) * 2019-09-02 2019-11-26 中生康元生物科技(北京)有限公司 一种用于鉴定肿瘤新抗原的细菌表达载体及筛选鉴定肿瘤新抗原的方法
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Also Published As

Publication number Publication date
SG11201502792TA (en) 2015-05-28
MX2015008329A (es) 2016-03-01
EA201590397A1 (ru) 2016-02-29
JP2018135355A (ja) 2018-08-30
AU2013370210A8 (en) 2016-06-23
WO2014106123A1 (en) 2014-07-03
WO2014106123A8 (en) 2016-06-16
AU2013370210A1 (en) 2015-06-18
KR20150099738A (ko) 2015-09-01
BR112015015076A2 (pt) 2018-10-30
EP2938627A4 (en) 2016-12-14
CA2888727A1 (en) 2014-07-03
SG10201700916SA (en) 2017-03-30
JP2016503655A (ja) 2016-02-08
HK1215260A1 (zh) 2016-08-19
EA201590397A8 (ru) 2016-08-31
US20140186387A1 (en) 2014-07-03
EP2938627A1 (en) 2015-11-04
US20170253637A1 (en) 2017-09-07
CN104955835B (zh) 2020-04-17
US9663557B2 (en) 2017-05-30
EP2938627B1 (en) 2019-03-20
JP6671408B2 (ja) 2020-03-25
AU2018203555A1 (en) 2018-06-07
KR102160322B1 (ko) 2020-09-25
CN104955835A (zh) 2015-09-30

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Free format text: IN VOL 29 , NO 23 , PAGE(S) 3440 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME ADURO BIOTECH, INC., APPLICATION NO. 2013370210, UNDER INID (72), CORRECT THE CO-INVENTOR TO DUBENSKY JR., THOMAS W.

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