JP2016199602A5 - - Google Patents
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- Publication number
- JP2016199602A5 JP2016199602A5 JP2016174293A JP2016174293A JP2016199602A5 JP 2016199602 A5 JP2016199602 A5 JP 2016199602A5 JP 2016174293 A JP2016174293 A JP 2016174293A JP 2016174293 A JP2016174293 A JP 2016174293A JP 2016199602 A5 JP2016199602 A5 JP 2016199602A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- pharmaceutical dosage
- tofacitinib
- cmax
- cmin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 24
- 239000004012 Tofacitinib Substances 0.000 claims 18
- UJLAWZDWDVHWOW-YPMHNXCESA-N tofacitinib Chemical compound C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)C1=NC=NC2=C1C=CN2 UJLAWZDWDVHWOW-YPMHNXCESA-N 0.000 claims 18
- 229960001350 tofacitinib Drugs 0.000 claims 18
- 239000011248 coating agent Substances 0.000 claims 7
- 238000000576 coating method Methods 0.000 claims 7
- 230000036470 plasma concentration Effects 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000001913 cellulose Substances 0.000 claims 6
- 229920002678 cellulose Polymers 0.000 claims 6
- 229920003176 water-insoluble polymer Polymers 0.000 claims 6
- 238000013268 sustained release Methods 0.000 claims 5
- 239000012730 sustained-release form Substances 0.000 claims 5
- 239000012528 membrane Substances 0.000 claims 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 240000007472 Leucaena leucocephala Species 0.000 claims 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229940070721 polyacrylate Drugs 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 1
- 239000008057 potassium phosphate buffer Substances 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 229940032147 starch Drugs 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361802479P | 2013-03-16 | 2013-03-16 | |
| US61/802,479 | 2013-03-16 | ||
| US201361864059P | 2013-08-09 | 2013-08-09 | |
| US61/864,059 | 2013-08-09 | ||
| US201461934428P | 2014-01-31 | 2014-01-31 | |
| US61/934,428 | 2014-01-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014045951A Division JP6041823B2 (ja) | 2013-03-16 | 2014-03-10 | トファシチニブの経口持続放出剤形 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018058176A Division JP2018100300A (ja) | 2013-03-16 | 2018-03-26 | トファシチニブの経口持続放出剤形 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016199602A JP2016199602A (ja) | 2016-12-01 |
| JP2016199602A5 true JP2016199602A5 (enExample) | 2017-04-13 |
| JP6314188B2 JP6314188B2 (ja) | 2018-04-18 |
Family
ID=50819757
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014045951A Active JP6041823B2 (ja) | 2013-03-16 | 2014-03-10 | トファシチニブの経口持続放出剤形 |
| JP2016174293A Active JP6314188B2 (ja) | 2013-03-16 | 2016-09-07 | トファシチニブの経口持続放出剤形 |
| JP2018058176A Pending JP2018100300A (ja) | 2013-03-16 | 2018-03-26 | トファシチニブの経口持続放出剤形 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014045951A Active JP6041823B2 (ja) | 2013-03-16 | 2014-03-10 | トファシチニブの経口持続放出剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018058176A Pending JP2018100300A (ja) | 2013-03-16 | 2018-03-26 | トファシチニブの経口持続放出剤形 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US9937181B2 (enExample) |
| EP (3) | EP2968155B1 (enExample) |
| JP (3) | JP6041823B2 (enExample) |
| KR (5) | KR20220151016A (enExample) |
| CN (2) | CN105101952B (enExample) |
| AU (2) | AU2014233850B2 (enExample) |
| BR (1) | BR112015020453B1 (enExample) |
| CA (2) | CA3037328C (enExample) |
| CY (1) | CY1124007T1 (enExample) |
| DK (1) | DK2968155T3 (enExample) |
| ES (1) | ES2865134T3 (enExample) |
| HU (1) | HUE053911T2 (enExample) |
| IL (3) | IL241400B (enExample) |
| MX (1) | MX2021000550A (enExample) |
| NZ (2) | NZ751227A (enExample) |
| PL (1) | PL2968155T3 (enExample) |
| PT (1) | PT2968155T (enExample) |
| SG (2) | SG11201506103UA (enExample) |
| SI (1) | SI2968155T1 (enExample) |
| TW (1) | TWI619516B (enExample) |
| WO (1) | WO2014147526A1 (enExample) |
| ZA (2) | ZA201505468B (enExample) |
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|---|---|---|---|---|
| JP2759924B2 (ja) | 1995-08-11 | 1998-05-28 | 株式会社ゼクセル | 燃料噴射装置の噴射時期検出装置 |
| JP6041823B2 (ja) | 2013-03-16 | 2016-12-14 | ファイザー・インク | トファシチニブの経口持続放出剤形 |
| GB201402070D0 (en) * | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| WO2015198225A1 (en) * | 2014-06-23 | 2015-12-30 | Sun Pharmaceutical Industries Limited | Oral pharmaceutical composition of tofacitinib |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| CN104622827A (zh) * | 2015-03-05 | 2015-05-20 | 重庆华邦制药有限公司 | 托法替布片剂及其制备方法 |
| EP4512394A3 (en) * | 2015-06-03 | 2025-10-22 | Triastek, Inc. | Dosage forms and use thereof |
| US12133911B2 (en) * | 2015-06-09 | 2024-11-05 | Capsugel Belgium Nv | Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules |
| WO2017010938A1 (en) * | 2015-07-16 | 2017-01-19 | National University Of Singapore | Printing drug tablets with fully customizable release profiles for personalized medicine |
| JP6507272B2 (ja) * | 2015-07-27 | 2019-04-24 | ユニケム ラボラトリーズ リミテッド | トファシチニブ口腔内崩壊錠 |
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| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| SG10201913999PA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
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| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
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| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| KR20180066296A (ko) * | 2016-12-07 | 2018-06-19 | 서울대학교산학협력단 | 토파시티닙을 포함하는 고염증 증상의 예방 또는 치료용 약학적 조성물 및 토파시티닙을 포함하는 고염증 증상의 예방 또는 개선용 건강기능식품 조성물 |
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