JP2010506855A5 - - Google Patents
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- Publication number
- JP2010506855A5 JP2010506855A5 JP2009532610A JP2009532610A JP2010506855A5 JP 2010506855 A5 JP2010506855 A5 JP 2010506855A5 JP 2009532610 A JP2009532610 A JP 2009532610A JP 2009532610 A JP2009532610 A JP 2009532610A JP 2010506855 A5 JP2010506855 A5 JP 2010506855A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- potassium phosphate
- phosphate buffer
- fenofibric acid
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 17
- 229960000701 fenofibric acid Drugs 0.000 claims 15
- MQOBSOSZFYZQOK-UHFFFAOYSA-N fenofibric acid Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1C(=O)C1=CC=C(Cl)C=C1 MQOBSOSZFYZQOK-UHFFFAOYSA-N 0.000 claims 15
- 239000008057 potassium phosphate buffer Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 238000009472 formulation Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000000872 buffer Substances 0.000 claims 3
- 238000004090 dissolution Methods 0.000 claims 3
- 229960002297 fenofibrate Drugs 0.000 claims 3
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 claims 3
- 229920001477 hydrophilic polymer Polymers 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000001509 sodium citrate Substances 0.000 claims 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000012738 dissolution medium Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82925506P | 2006-10-12 | 2006-10-12 | |
| PCT/US2007/081267 WO2008046052A1 (en) | 2006-10-12 | 2007-10-12 | Pharmaceutical formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010506855A JP2010506855A (ja) | 2010-03-04 |
| JP2010506855A5 true JP2010506855A5 (enExample) | 2010-09-30 |
Family
ID=38961056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009532610A Pending JP2010506855A (ja) | 2006-10-12 | 2007-10-12 | 医薬組成物 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP2081563A1 (enExample) |
| JP (1) | JP2010506855A (enExample) |
| KR (1) | KR20090119959A (enExample) |
| CN (1) | CN101677981A (enExample) |
| AU (1) | AU2007307641A1 (enExample) |
| CA (1) | CA2672686A1 (enExample) |
| CO (1) | CO6160302A2 (enExample) |
| EA (1) | EA200900531A1 (enExample) |
| EC (1) | ECSP099251A (enExample) |
| IL (1) | IL198160A0 (enExample) |
| MX (1) | MX2009003815A (enExample) |
| SG (1) | SG175570A1 (enExample) |
| WO (1) | WO2008046052A1 (enExample) |
| ZA (1) | ZA200902488B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102046153B (zh) * | 2008-05-30 | 2015-06-17 | Ucb医药有限公司 | 包含布立西坦的药物组合物 |
| CN102304103A (zh) * | 2011-06-03 | 2012-01-04 | 郑州泰基鸿诺药物科技有限公司 | 一种非诺贝特酸盐、制备方法、药物组合物及应用 |
| CN102659570B (zh) * | 2012-05-17 | 2014-05-28 | 安润医药科技（苏州）有限公司 | 二氟非诺贝特酸及其在药学上可接受的盐，以及它们的制备方法和应用 |
| FR3050112B1 (fr) * | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
| CN107496397A (zh) * | 2016-06-14 | 2017-12-22 | 重庆安格龙翔医药科技有限公司 | 一种二甲双胍与非诺贝酸的复合物及其制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1832285A1 (en) * | 2002-12-17 | 2007-09-12 | Abbott GmbH & Co. KG | Formulation comprising fenofibric acid or a physiologically acceptable salt thereof |
| US7259186B2 (en) * | 2002-12-17 | 2007-08-21 | Abbott Laboratories | Salts of fenofibric acid and pharmaceutical formulations thereof |
| AU2003290060A1 (en) * | 2002-12-17 | 2004-07-09 | Abbott Gmbh & Co. Kg | Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof |
| EP1559419A1 (en) * | 2004-01-23 | 2005-08-03 | Fournier Laboratories Ireland Limited | Pharmaceutical formulations comprising metformin and a fibrate, and processes for their obtention |
| UA100966C2 (ru) * | 2005-04-08 | 2013-02-25 | Эбботт Леборетриз | Фармацевтическая композиция на основе 2-[4-(4-хлорбензоил)фенокси]-2-метилпропионовой кислоты и ее солей |
-
2007
- 2007-10-12 SG SG2011070588A patent/SG175570A1/en unknown
- 2007-10-12 AU AU2007307641A patent/AU2007307641A1/en not_active Abandoned
- 2007-10-12 WO PCT/US2007/081267 patent/WO2008046052A1/en not_active Ceased
- 2007-10-12 EA EA200900531A patent/EA200900531A1/ru unknown
- 2007-10-12 CN CN200780045748A patent/CN101677981A/zh active Pending
- 2007-10-12 EP EP07844238A patent/EP2081563A1/en not_active Withdrawn
- 2007-10-12 MX MX2009003815A patent/MX2009003815A/es not_active Application Discontinuation
- 2007-10-12 JP JP2009532610A patent/JP2010506855A/ja active Pending
- 2007-10-12 CA CA002672686A patent/CA2672686A1/en not_active Abandoned
- 2007-10-12 ZA ZA200902488A patent/ZA200902488B/xx unknown
- 2007-10-12 KR KR1020097007466A patent/KR20090119959A/ko not_active Withdrawn
-
2009
- 2009-04-13 EC EC2009009251A patent/ECSP099251A/es unknown
- 2009-04-13 CO CO09036680A patent/CO6160302A2/es unknown
- 2009-04-16 IL IL198160A patent/IL198160A0/en unknown