JP2008522989A5 - - Google Patents
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- JP2008522989A5 JP2008522989A5 JP2007544750A JP2007544750A JP2008522989A5 JP 2008522989 A5 JP2008522989 A5 JP 2008522989A5 JP 2007544750 A JP2007544750 A JP 2007544750A JP 2007544750 A JP2007544750 A JP 2007544750A JP 2008522989 A5 JP2008522989 A5 JP 2008522989A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- weight
- form according
- anionic
- meth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001577 copolymer Polymers 0.000 claims description 25
- 239000000178 monomer Substances 0.000 claims description 12
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 claims description 10
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 10
- 125000000129 anionic group Chemical group 0.000 claims description 10
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 239000008188 pellet Substances 0.000 claims description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 5
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims description 5
- 230000009477 glass transition Effects 0.000 claims description 5
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 3
- 229920002554 vinyl polymer Polymers 0.000 claims description 3
- 150000003254 radicals Chemical group 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 27
- 239000011159 matrix material Substances 0.000 claims 11
- 239000010410 layer Substances 0.000 claims 9
- 239000002105 nanoparticle Substances 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 230000003232 mucoadhesive effect Effects 0.000 claims 7
- 125000002091 cationic group Chemical group 0.000 claims 6
- 239000013543 active substance Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229920000642 polymer Polymers 0.000 claims 5
- 229920001661 Chitosan Polymers 0.000 claims 4
- 229920006318 anionic polymer Polymers 0.000 claims 3
- 239000007888 film coating Substances 0.000 claims 3
- 238000009501 film coating Methods 0.000 claims 3
- 238000005507 spraying Methods 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 102000053602 DNA Human genes 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- 229920006317 cationic polymer Polymers 0.000 claims 2
- 229920002301 cellulose acetate Polymers 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims 1
- 102000004856 Lectins Human genes 0.000 claims 1
- 108090001090 Lectins Proteins 0.000 claims 1
- 229920001800 Shellac Polymers 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 229920002807 Thiomer Polymers 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 claims 1
- 238000005054 agglomeration Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- -1 cationic lipid Chemical class 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims 1
- 239000011247 coating layer Substances 0.000 claims 1
- 238000013329 compounding Methods 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 210000003953 foreskin Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 1
- 210000004347 intestinal mucosa Anatomy 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 239000002523 lectin Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical group OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 125000001302 tertiary amino group Chemical group 0.000 claims 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims 1
- 125000005591 trimellitate group Chemical group 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229920003134 Eudragit® polymer Polymers 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004059792.8 | 2004-12-10 | ||
| DE102004059792A DE102004059792A1 (de) | 2004-12-10 | 2004-12-10 | Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
| PCT/EP2005/011864 WO2006061069A1 (de) | 2004-12-10 | 2005-11-05 | Multipartikuläre arzneiform, enthaltend mucoadhaesiv formulierte nukleinsäure-wirkstoffe, sowie ein verfahren zur herstellung der arzneiform |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008522989A JP2008522989A (ja) | 2008-07-03 |
| JP2008522989A5 true JP2008522989A5 (enExample) | 2011-09-01 |
| JP5578764B2 JP5578764B2 (ja) | 2014-08-27 |
Family
ID=35709359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544750A Expired - Lifetime JP5578764B2 (ja) | 2004-12-10 | 2005-11-05 | 核酸包含粘膜接着性作用物質を含有する多粒子投与形、および前記投与形を生成する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8568778B2 (enExample) |
| EP (1) | EP1824457B1 (enExample) |
| JP (1) | JP5578764B2 (enExample) |
| KR (1) | KR101319773B1 (enExample) |
| CN (1) | CN101060835B (enExample) |
| BR (1) | BRPI0515815B8 (enExample) |
| CA (1) | CA2586597C (enExample) |
| DE (1) | DE102004059792A1 (enExample) |
| ES (1) | ES2569354T3 (enExample) |
| HU (1) | HUE028793T2 (enExample) |
| IL (1) | IL183753A (enExample) |
| MX (1) | MX2007006343A (enExample) |
| PL (1) | PL1824457T3 (enExample) |
| SI (1) | SI1824457T1 (enExample) |
| TW (1) | TW200635617A (enExample) |
| WO (1) | WO2006061069A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8048413B2 (en) | 2006-05-17 | 2011-11-01 | Helene Huguet | Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules |
| EP2037888A2 (en) * | 2006-06-26 | 2009-03-25 | Mutual Pharmaceutical Company, Inc. | Active agent formulations, methods of making, and methods of use |
| US20110038939A1 (en) * | 2007-07-16 | 2011-02-17 | Northeastern University | Therapeutic stable nanoparticles |
| DE102008048729A1 (de) * | 2008-09-24 | 2010-03-25 | Add Technologies Ltd Advanced Drug Delivery | Multipartikuläre Tabletten und Verfahren zur deren Herstellung |
| WO2011090725A2 (en) * | 2009-12-29 | 2011-07-28 | Impax Laboratories, Inc. | Gastroretentive solid oral dosage forms with swellable hydrophilic polymer |
| AU2010346995B2 (en) | 2010-02-25 | 2014-12-04 | Evonik Operations Gmbh | Pharmaceutical or neutraceutical formulation |
| CN102250878B (zh) * | 2011-06-03 | 2013-01-23 | 吉林大学 | 一种基于固相介质表面电荷的反转提取dna的方法 |
| US9107851B2 (en) * | 2012-10-15 | 2015-08-18 | New Jersey Institute Of Technology | Solventless mixing process for coating pharmaceutical ingredients |
| JP6912876B2 (ja) * | 2016-10-06 | 2021-08-04 | 三洋化成工業株式会社 | アクリル系医薬固形製剤用添加剤 |
| US11033496B2 (en) * | 2017-03-17 | 2021-06-15 | The Regents Of The University Of Michigan | Nanoparticles for delivery of chemopreventive agents |
| WO2019226519A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| EP3801462A4 (en) | 2018-05-24 | 2022-03-16 | Celanese EVA Performance Polymers LLC | Implantable device for sustained release of a macromolecular drug compound |
| WO2019222856A1 (en) | 2018-05-24 | 2019-11-28 | Nureva Inc. | Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones |
| DE102020002360A1 (de) * | 2020-04-18 | 2021-10-21 | Friedrich-Schiller-Universität Jena | Nanopartikel enthaltend Komplexe aus Nukleinsäuren und kationischen Copolymeren, Verfahren zu deren Herstellung und deren Verwendung zum Gentransfer in Zellen |
| US20220175812A1 (en) | 2020-12-03 | 2022-06-09 | Battelle Memorial Institute | Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery |
| CN117120020A (zh) * | 2021-03-30 | 2023-11-24 | 塞拉尼斯伊娃高性能聚合物公司 | 用于递送核酸包封颗粒的植入式医疗器件 |
| JP2024516108A (ja) | 2021-04-07 | 2024-04-12 | バテル・メモリアル・インスティテュート | 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術 |
| JP2024515220A (ja) | 2021-04-26 | 2024-04-05 | セラニーズ・イーブイエイ・パフォーマンス・ポリマーズ・エルエルシー | 高分子薬剤化合物の持続放出用の埋め込み型デバイス |
| JPWO2023249087A1 (enExample) * | 2022-06-24 | 2023-12-28 | ||
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW209174B (enExample) | 1991-04-19 | 1993-07-11 | Takeda Pharm Industry Co Ltd | |
| AU7342296A (en) * | 1995-10-25 | 1997-05-15 | Octoplus Bv | Cationic polyacrylates and poly(alkyl) acrylates or the corresponding acrylamides for use in synthetic transfection or blocking systems |
| GB9700624D0 (en) | 1997-01-14 | 1997-03-05 | Danbiosyst Uk | Drug delivery composition |
| US6730735B2 (en) * | 1997-07-03 | 2004-05-04 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited | Conjugate of polyethylene glycol and chitosan |
| CA2378265C (en) | 1999-08-09 | 2007-11-20 | Dainippon Pharmaceutical Co., Ltd. | Solid preparations containing chitosan powder and process for producing the same |
| US7803392B2 (en) * | 2000-12-27 | 2010-09-28 | University Of Kentucky Research Foundation | pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules |
| AU2002319653A1 (en) * | 2001-07-20 | 2003-03-03 | Samir Mitragotri | Method for oral drug delivery |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| DE10332160A1 (de) * | 2003-07-15 | 2005-02-03 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
| DE10353196A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix |
| DE10353186A1 (de) * | 2003-11-13 | 2005-06-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform, enthaltend eine in Bezug auf die Wirkstoffabgabe modulatorisch wirkende Substanz |
| US20040224019A1 (en) | 2004-03-03 | 2004-11-11 | Adi Shefer | Oral controlled release system for targeted drug delivery into the cell and its nucleus for gene therapy, DNA vaccination, and administration of gene based drugs |
| DE102004036437A1 (de) * | 2004-07-27 | 2006-03-23 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
| DE102006035549A1 (de) * | 2006-07-27 | 2008-01-31 | Evonik Röhm Gmbh | Arzneiform mit mindestens zweischichtiger Trennschicht |
-
2004
- 2004-12-10 DE DE102004059792A patent/DE102004059792A1/de not_active Withdrawn
-
2005
- 2005-11-05 SI SI200532058A patent/SI1824457T1/sl unknown
- 2005-11-05 MX MX2007006343A patent/MX2007006343A/es unknown
- 2005-11-05 JP JP2007544750A patent/JP5578764B2/ja not_active Expired - Lifetime
- 2005-11-05 CN CN200580037293XA patent/CN101060835B/zh not_active Expired - Fee Related
- 2005-11-05 KR KR1020077012902A patent/KR101319773B1/ko not_active Expired - Fee Related
- 2005-11-05 EP EP05807707.4A patent/EP1824457B1/de not_active Expired - Lifetime
- 2005-11-05 BR BRPI0515815A patent/BRPI0515815B8/pt active IP Right Grant
- 2005-11-05 WO PCT/EP2005/011864 patent/WO2006061069A1/de not_active Ceased
- 2005-11-05 ES ES05807707.4T patent/ES2569354T3/es not_active Expired - Lifetime
- 2005-11-05 US US11/721,399 patent/US8568778B2/en not_active Expired - Fee Related
- 2005-11-05 CA CA2586597A patent/CA2586597C/en not_active Expired - Lifetime
- 2005-11-05 HU HUE05807707A patent/HUE028793T2/hu unknown
- 2005-11-05 PL PL05807707T patent/PL1824457T3/pl unknown
- 2005-11-16 TW TW094140339A patent/TW200635617A/zh unknown
-
2007
- 2007-06-07 IL IL183753A patent/IL183753A/en active IP Right Grant
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