JP2005514386A5 - - Google Patents
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- Publication number
- JP2005514386A5 JP2005514386A5 JP2003552273A JP2003552273A JP2005514386A5 JP 2005514386 A5 JP2005514386 A5 JP 2005514386A5 JP 2003552273 A JP2003552273 A JP 2003552273A JP 2003552273 A JP2003552273 A JP 2003552273A JP 2005514386 A5 JP2005514386 A5 JP 2005514386A5
- Authority
- JP
- Japan
- Prior art keywords
- film
- modified release
- film coat
- vinyl acetate
- release pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims description 27
- 239000003381 stabilizer Substances 0.000 claims description 26
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 229920000642 polymer Polymers 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 12
- 239000002831 pharmacologic agent Substances 0.000 claims description 12
- 229920000058 polyacrylate Polymers 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000006185 dispersion Substances 0.000 claims description 11
- 239000007888 film coating Substances 0.000 claims description 11
- 238000009501 film coating Methods 0.000 claims description 11
- 229920001577 copolymer Polymers 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims 12
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 10
- 239000011324 bead Substances 0.000 claims 8
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 7
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 7
- 229920000847 nonoxynol Polymers 0.000 claims 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 3
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical group COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims 3
- RGHAZVBIOOEVQX-UHFFFAOYSA-N Metoprolol succinate Chemical group OC(=O)CCC(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 RGHAZVBIOOEVQX-UHFFFAOYSA-N 0.000 claims 2
- 239000004815 dispersion polymer Substances 0.000 claims 2
- 229960002237 metoprolol Drugs 0.000 claims 2
- 229960000939 metoprolol succinate Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229920003134 Eudragit® polymer Polymers 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 239000008199 coating composition Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical class OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0104328A SE0104328D0 (sv) | 2001-12-19 | 2001-12-19 | New film coating |
| SE0104327A SE0104327D0 (sv) | 2001-12-19 | 2001-12-19 | New film coating |
| PCT/GB2002/005739 WO2003051340A1 (en) | 2001-12-19 | 2002-12-18 | New film coating |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005514386A JP2005514386A (ja) | 2005-05-19 |
| JP2005514386A5 true JP2005514386A5 (enExample) | 2006-02-09 |
Family
ID=26655630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003552273A Withdrawn JP2005514386A (ja) | 2001-12-19 | 2002-12-18 | 新規フィルム・コーティング |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6827947B2 (enExample) |
| EP (2) | EP1355633B1 (enExample) |
| JP (1) | JP2005514386A (enExample) |
| KR (1) | KR20040065989A (enExample) |
| CN (1) | CN100341491C (enExample) |
| AT (1) | ATE287259T1 (enExample) |
| AU (2) | AU2002361447B2 (enExample) |
| BR (1) | BR0206441A (enExample) |
| CA (1) | CA2435729C (enExample) |
| CZ (1) | CZ20031970A3 (enExample) |
| DE (2) | DE60202662T2 (enExample) |
| DK (1) | DK1355633T3 (enExample) |
| ES (1) | ES2233876T3 (enExample) |
| HU (1) | HUP0303886A3 (enExample) |
| IL (1) | IL156998A0 (enExample) |
| IS (1) | IS6863A (enExample) |
| MX (1) | MXPA03007156A (enExample) |
| NO (1) | NO320358B1 (enExample) |
| NZ (1) | NZ526926A (enExample) |
| PL (1) | PL362378A1 (enExample) |
| PT (1) | PT1355633E (enExample) |
| RU (1) | RU2323717C2 (enExample) |
| SI (1) | SI1355633T1 (enExample) |
| SK (1) | SK9132003A3 (enExample) |
| WO (1) | WO2003051340A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100200D0 (sv) * | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
| SI1355633T1 (en) * | 2001-12-19 | 2005-06-30 | Astrazeneca Ab | NEW FILM COATING containing an ethyl acrylate/methyl methacrylate copolymer and polyvinyl acetate |
| ES2377729T3 (es) | 2002-02-21 | 2012-03-30 | Valeant International (Barbados) Srl | Formulaciones de liberación modificada de al menos una forma de tramadol |
| SE0201110D0 (sv) * | 2002-04-12 | 2002-04-12 | Astrazeneca Ab | New film coating |
| SE0202353D0 (sv) * | 2002-08-01 | 2002-08-01 | Astrazeneca Ab | New film coating |
| US7080545B2 (en) * | 2002-10-17 | 2006-07-25 | Advanced Technology Materials, Inc. | Apparatus and process for sensing fluoro species in semiconductor processing systems |
| EP1677766B1 (de) * | 2003-10-31 | 2012-03-14 | Hexal AG | Pharmazeutische wirkstoffhaltige formulierung mit überzug |
| WO2005084636A2 (en) * | 2004-02-27 | 2005-09-15 | Ranbaxy Laboratories Limited | A process for the preparation of controlled-release pharmaceutical composition of metoprolol |
| JP2005306778A (ja) * | 2004-04-21 | 2005-11-04 | Basf Ag | 徐放性製剤及びその製造方法 |
| US7838031B2 (en) * | 2004-05-21 | 2010-11-23 | Lawrence Solomon | Method of administering a partial dose using a segmented pharmaceutical tablet |
| DE102004035936A1 (de) * | 2004-07-23 | 2006-03-16 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
| NZ565649A (en) * | 2005-07-28 | 2011-03-31 | Shire Llc | Pharmaceutical formulations/composition of guanfacine suitable for single dose form administration daily |
| JP5259413B2 (ja) * | 2005-11-18 | 2013-08-07 | エーシーシーユー−ブレイク テクノロジーズ，インク． | セグメント化した薬の剤形 |
| DE102005060393A1 (de) | 2005-12-16 | 2007-06-21 | Add Advanced Drug Delivery Technologies Ltd. | Orales Präparat mit kontrollierter Freisetzung |
| US20080118570A1 (en) * | 2006-11-20 | 2008-05-22 | Zhi Liu | Polymer coated drug-ion exchange resins and methods |
| US20100303920A1 (en) * | 2009-05-27 | 2010-12-02 | Johan Hjartstam | Aqueous Film Coating Composition / 841 |
| WO2011017389A1 (en) | 2009-08-05 | 2011-02-10 | Idenix Pharmaceuticals, Inc. | Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv |
| WO2011056764A1 (en) | 2009-11-05 | 2011-05-12 | Ambit Biosciences Corp. | Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles |
| RU2554087C2 (ru) | 2009-12-18 | 2015-06-27 | Айденикс Фармасьютикалз, Инк. | 5,5-конденсированные ариленовые или гетероариленовые ингибиторы вируса гепатита с |
| IL210279A0 (en) | 2009-12-25 | 2011-03-31 | Dexcel Pharma Technologies Ltd | Extended release compositions for high solubility, high permeability acdtive pharmaceutical ingredients |
| WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| WO2011112689A2 (en) | 2010-03-11 | 2011-09-15 | Ambit Biosciences Corp. | Saltz of an indazolylpyrrolotriazine |
| WO2012030917A1 (en) | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
| US8633209B2 (en) | 2010-09-01 | 2014-01-21 | Ambit Biosciences Corporation | Hydrobromide salts of a pyrazolylaminoquinazoline |
| JP2014500275A (ja) | 2010-12-06 | 2014-01-09 | フォリカ，インコーポレイテッド | 禿頭症を治療するため、および毛髪の成長を促進するための方法 |
| WO2012080050A1 (en) | 2010-12-14 | 2012-06-21 | F. Hoffmann-La Roche Ag | Solid forms of a phenoxybenzenesulfonyl compound |
| WO2012106299A1 (en) | 2011-01-31 | 2012-08-09 | Celgene Corporation | Pharmaceutical compositions of cytidine analogs and methods of use thereof |
| US9353100B2 (en) | 2011-02-10 | 2016-05-31 | Idenix Pharmaceuticals Llc | Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections |
| US20120252721A1 (en) | 2011-03-31 | 2012-10-04 | Idenix Pharmaceuticals, Inc. | Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor |
| WO2012171884A1 (en) * | 2011-06-17 | 2012-12-20 | Evonik Röhm Gmbh | Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
| CA2839689C (en) * | 2011-06-17 | 2018-05-01 | Evonik Roehm Gmbh | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
| JP6120941B2 (ja) | 2012-03-16 | 2017-04-26 | アクシキン ファーマシューティカルズ インコーポレーテッド | ３，５−ジアミノピラゾールキナーゼ阻害剤 |
| JP2016507576A (ja) | 2013-02-13 | 2016-03-10 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツングＥｖｏｎｉｋ Ｒｏｅｈｍ ＧｍｂＨ | 多数の２種類のペレットを含む多粒子医薬組成物 |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| EP3046924A1 (en) | 2013-09-20 | 2016-07-27 | IDENIX Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
| JP5846185B2 (ja) | 2013-11-21 | 2016-01-20 | 大日本印刷株式会社 | 貫通電極基板及び貫通電極基板を用いた半導体装置 |
| US20170066779A1 (en) | 2014-03-05 | 2017-03-09 | Idenix Pharmaceuticals Llc | Solid forms of a flaviviridae virus inhibitor compound and salts thereof |
| KR102409739B1 (ko) | 2014-03-20 | 2022-06-17 | 카펠라 테라퓨틱스, 인크. | 암 치료용의 ｅｒｂｂ 티로신 키나제 억제제로서의 벤즈이미다졸 유도체 |
| EP3922630A1 (en) | 2014-03-20 | 2021-12-15 | Capella Therapeutics, Inc. | Benzimidazole derivatives as erbb tyrosine kinase inhibitors for the treatment of cancer |
| EP3166599B1 (en) * | 2014-07-09 | 2025-05-14 | Sun Pharmaceutical Industries Ltd | Capsule dosage form of metoprolol succinate |
| WO2016042565A1 (en) * | 2014-09-16 | 2016-03-24 | Suresh Pareek | Extended release 'formulation of metoprolol |
| KR102034202B1 (ko) | 2014-12-23 | 2019-10-18 | 에스엠에이 세라퓨틱스 아이엔씨. | 3,5-디아미노피라졸 키나제 억제제 |
| KR102411925B1 (ko) * | 2016-06-30 | 2022-06-22 | 베크만 컬터, 인코포레이티드 | 화학발광 기질 |
| EP3768378B1 (en) | 2018-03-22 | 2025-08-06 | InCarda Therapeutics, Inc. | A novel method to slow ventricular rate |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (31)
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|---|---|---|---|---|
| GB878234A (en) | 1958-12-18 | 1961-09-27 | Roehm & Haas Gmbh | Pharmaceutical coating compositions |
| DE1228757B (de) | 1962-06-28 | 1966-11-17 | Haessle Ab | Verfahren zur Herstellung eines in Wasser und Magensaft rasch zerfallenden UEberzuges auf festen Arzneiformen |
| US3341338A (en) | 1965-05-28 | 1967-09-12 | Union Carbide Corp | Polysiloxane polish formulations |
| DE2031871C3 (de) | 1970-06-27 | 1974-06-27 | Roehm Gmbh, 6100 Darmstadt | Überzugsmasse für Arzneiformen |
| US4330338A (en) * | 1978-10-02 | 1982-05-18 | Purdue Research Foundation | Pharmaceutical coating composition, and preparation and dosages so coated |
| US4916171A (en) | 1984-07-25 | 1990-04-10 | Rohm And Haas Company | Polymers comprising alkali-insoluble core/alkali-soluble shell and copositions thereof |
| SE8404467D0 (sv) * | 1984-09-06 | 1984-09-06 | Ferrosan Ab | Controlled-release medical preparations |
| SE450087B (sv) | 1985-10-11 | 1987-06-09 | Haessle Ab | Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial |
| SE455836B (sv) | 1985-10-11 | 1988-08-15 | Haessle Ab | Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning |
| US5246714A (en) | 1985-10-11 | 1993-09-21 | Aktiebolaget Hassle | Drug preparation |
| US4975283A (en) | 1985-12-12 | 1990-12-04 | Bristol-Myers Squibb Company | Stabilized enteric coated aspirin granules and process for preparation |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| US4874613A (en) * | 1987-03-06 | 1989-10-17 | Baker Cummins Pharmaceuticals, Inc. | Taste concealing pharmaceutical dosage unit |
| US4871546A (en) * | 1987-06-29 | 1989-10-03 | Sandoz Pharm. Corp. | Gastrointestinal protective coating formulations |
| JP2782691B2 (ja) | 1987-09-29 | 1998-08-06 | ワーナー−ランバート・コンパニー | 腸溶製剤の安定化 |
| US5292522A (en) * | 1989-06-20 | 1994-03-08 | Rohm Gmbh | Aqueous film coating agent for solid medicaments |
| FR2655266B1 (fr) | 1989-12-05 | 1992-04-03 | Smith Kline French Lab | Compositions pharmaceutiques a base de cimetidine. |
| GB9200607D0 (en) | 1992-01-13 | 1992-03-11 | Ethical Pharma Ltd | Pharmaceutical compositions containing nifedipine and process for the preparation thereof |
| US5376384A (en) | 1992-12-23 | 1994-12-27 | Kinaform Technology, Inc. | Delayed, sustained-release pharmaceutical preparation |
| DE69425453T2 (de) | 1993-04-23 | 2001-04-12 | Novartis Ag, Basel | Wirkstoffabgabevorrichtung mit gesteuerter Freigabe |
| CA2117546A1 (en) * | 1993-08-27 | 1995-02-28 | Takateru Muraoka | Medical adhesive sheet |
| DE4444051A1 (de) | 1994-12-10 | 1996-06-13 | Rhone Poulenc Rorer Gmbh | Pharmazeutische, oral anwendbare Zubereitung |
| US5871776A (en) | 1995-01-31 | 1999-02-16 | Mehta; Atul M. | Controlled-release nifedipine |
| DE19615812A1 (de) * | 1996-04-20 | 1997-10-23 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation |
| US6046177A (en) | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
| SE0100200D0 (sv) * | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
| SI1355633T1 (en) * | 2001-12-19 | 2005-06-30 | Astrazeneca Ab | NEW FILM COATING containing an ethyl acrylate/methyl methacrylate copolymer and polyvinyl acetate |
| US20030175342A1 (en) * | 2002-03-14 | 2003-09-18 | Karl Kolter | Coated pharmaceutical single-unit delayed-release forms, based on polyvinyl acetate |
| SE0201110D0 (sv) * | 2002-04-12 | 2002-04-12 | Astrazeneca Ab | New film coating |
| SE0202353D0 (sv) | 2002-08-01 | 2002-08-01 | Astrazeneca Ab | New film coating |
-
2002
- 2002-12-18 SI SI200230088T patent/SI1355633T1/xx unknown
- 2002-12-18 BR BR0206441-3A patent/BR0206441A/pt not_active IP Right Cessation
- 2002-12-18 US US10/450,794 patent/US6827947B2/en not_active Expired - Fee Related
- 2002-12-18 RU RU2003125371/15A patent/RU2323717C2/ru active
- 2002-12-18 PL PL36237802A patent/PL362378A1/xx not_active Application Discontinuation
- 2002-12-18 AT AT02796920T patent/ATE287259T1/de not_active IP Right Cessation
- 2002-12-18 MX MXPA03007156A patent/MXPA03007156A/es active IP Right Grant
- 2002-12-18 DK DK02796920T patent/DK1355633T3/da active
- 2002-12-18 CA CA002435729A patent/CA2435729C/en not_active Expired - Fee Related
- 2002-12-18 SK SK913-2003A patent/SK9132003A3/sk unknown
- 2002-12-18 AU AU2002361447A patent/AU2002361447B2/en not_active Ceased
- 2002-12-18 WO PCT/GB2002/005739 patent/WO2003051340A1/en not_active Ceased
- 2002-12-18 CZ CZ20031970A patent/CZ20031970A3/cs unknown
- 2002-12-18 EP EP02796920A patent/EP1355633B1/en not_active Expired - Lifetime
- 2002-12-18 PT PT02796920T patent/PT1355633E/pt unknown
- 2002-12-18 DE DE60202662T patent/DE60202662T2/de not_active Expired - Lifetime
- 2002-12-18 DE DE20220902U patent/DE20220902U1/de not_active Expired - Lifetime
- 2002-12-18 NZ NZ526926A patent/NZ526926A/en unknown
- 2002-12-18 ES ES02796920T patent/ES2233876T3/es not_active Expired - Lifetime
- 2002-12-18 JP JP2003552273A patent/JP2005514386A/ja not_active Withdrawn
- 2002-12-18 IL IL15699802A patent/IL156998A0/xx unknown
- 2002-12-18 EP EP04019487A patent/EP1477163A1/en not_active Withdrawn
- 2002-12-18 KR KR10-2003-7010812A patent/KR20040065989A/ko not_active Ceased
- 2002-12-18 HU HU0303886A patent/HUP0303886A3/hu unknown
- 2002-12-18 CN CNB028084683A patent/CN100341491C/zh not_active Expired - Lifetime
-
2003
- 2003-07-01 IS IS6863A patent/IS6863A/is unknown
- 2003-08-18 NO NO20033653A patent/NO320358B1/no not_active IP Right Cessation
-
2004
- 2004-09-16 US US10/942,407 patent/US7815938B2/en not_active Expired - Lifetime
-
2008
- 2008-08-28 AU AU2008207594A patent/AU2008207594A1/en not_active Abandoned
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