DE60202662T2 - NEUE FILMBESCHICHTUNG enthaltend ein Äthylacrylate/Methylmethacrylate-copolymer und Polyvinylacetat - Google Patents
NEUE FILMBESCHICHTUNG enthaltend ein Äthylacrylate/Methylmethacrylate-copolymer und Polyvinylacetat Download PDFInfo
- Publication number
- DE60202662T2 DE60202662T2 DE60202662T DE60202662T DE60202662T2 DE 60202662 T2 DE60202662 T2 DE 60202662T2 DE 60202662 T DE60202662 T DE 60202662T DE 60202662 T DE60202662 T DE 60202662T DE 60202662 T2 DE60202662 T2 DE 60202662T2
- Authority
- DE
- Germany
- Prior art keywords
- film coating
- modified release
- formulation
- vinyl acetate
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007888 film coating Substances 0.000 title claims abstract description 92
- 238000009501 film coating Methods 0.000 title claims abstract description 92
- 229920001577 copolymer Polymers 0.000 title claims description 23
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 title claims description 22
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 title claims description 16
- 229920002689 polyvinyl acetate Polymers 0.000 title claims description 12
- 239000011118 polyvinyl acetate Substances 0.000 title claims description 9
- 239000000203 mixture Substances 0.000 claims abstract description 73
- 239000006185 dispersion Substances 0.000 claims abstract description 66
- 229920000642 polymer Polymers 0.000 claims abstract description 35
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 238000000576 coating method Methods 0.000 claims abstract description 28
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 23
- 239000011248 coating agent Substances 0.000 claims abstract description 22
- 239000003381 stabilizer Substances 0.000 claims description 47
- 238000009472 formulation Methods 0.000 claims description 33
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 30
- 229960002237 metoprolol Drugs 0.000 claims description 29
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 21
- 229940083575 sodium dodecyl sulfate Drugs 0.000 claims description 16
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 16
- 239000002245 particle Substances 0.000 claims description 15
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 15
- 239000013543 active substance Substances 0.000 claims description 13
- 230000008569 process Effects 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 239000004815 dispersion polymer Substances 0.000 claims description 8
- 229920000847 nonoxynol Polymers 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 8
- 229920003163 Eudragit® NE 30 D Polymers 0.000 claims description 6
- RGHAZVBIOOEVQX-UHFFFAOYSA-N Metoprolol succinate Chemical group OC(=O)CCC(O)=O.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 RGHAZVBIOOEVQX-UHFFFAOYSA-N 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 6
- 229960000939 metoprolol succinate Drugs 0.000 claims description 6
- 239000002831 pharmacologic agent Substances 0.000 claims description 6
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- 150000001558 benzoic acid derivatives Chemical class 0.000 claims description 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 2
- 229940095064 tartrate Drugs 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 239000008199 coating composition Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 abstract description 29
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical group CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 20
- 239000003814 drug Substances 0.000 description 20
- 229940079593 drug Drugs 0.000 description 19
- 239000011162 core material Substances 0.000 description 18
- 229920003134 Eudragit® polymer Polymers 0.000 description 14
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 14
- -1 polypropylene Polymers 0.000 description 13
- 229940075507 glyceryl monostearate Drugs 0.000 description 10
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 10
- 230000035699 permeability Effects 0.000 description 10
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- 230000008033 biological extinction Effects 0.000 description 5
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- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 4
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- 239000000126 substance Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004809 Teflon Substances 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000181 anti-adherent effect Effects 0.000 description 3
- 239000003833 bile salt Substances 0.000 description 3
- 229940093761 bile salts Drugs 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 3
- 238000000921 elemental analysis Methods 0.000 description 3
- 238000009505 enteric coating Methods 0.000 description 3
- 239000002702 enteric coating Substances 0.000 description 3
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 3
- 238000013265 extended release Methods 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 229940033134 talc Drugs 0.000 description 3
- 239000001069 triethyl citrate Substances 0.000 description 3
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 3
- 235000013769 triethyl citrate Nutrition 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 102220570135 Histone PARylation factor 1_L30D_mutation Human genes 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- JPNZKPRONVOMLL-UHFFFAOYSA-N azane;octadecanoic acid Chemical class [NH4+].CCCCCCCCCCCCCCCCCC([O-])=O JPNZKPRONVOMLL-UHFFFAOYSA-N 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
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- NXWGWUVGUSFQJC-GFCCVEGCSA-N (2r)-1-[(2-methyl-1h-indol-4-yl)oxy]-3-(propan-2-ylamino)propan-2-ol Chemical compound CC(C)NC[C@@H](O)COC1=CC=CC2=C1C=C(C)N2 NXWGWUVGUSFQJC-GFCCVEGCSA-N 0.000 description 1
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- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Paints Or Removers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Piezo-Electric Transducers For Audible Bands (AREA)
- Surface Treatment Of Glass Fibres Or Filaments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0104328A SE0104328D0 (sv) | 2001-12-19 | 2001-12-19 | New film coating |
| SE0104328 | 2001-12-19 | ||
| SE0104327A SE0104327D0 (sv) | 2001-12-19 | 2001-12-19 | New film coating |
| SE0104327 | 2001-12-19 | ||
| PCT/GB2002/005739 WO2003051340A1 (en) | 2001-12-19 | 2002-12-18 | New film coating |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60202662D1 DE60202662D1 (de) | 2005-02-24 |
| DE60202662T2 true DE60202662T2 (de) | 2006-01-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| DE60202662T Expired - Lifetime DE60202662T2 (de) | 2001-12-19 | 2002-12-18 | NEUE FILMBESCHICHTUNG enthaltend ein Äthylacrylate/Methylmethacrylate-copolymer und Polyvinylacetat |
| DE20220902U Expired - Lifetime DE20220902U1 (de) | 2001-12-19 | 2002-12-18 | Neuer Filmüberzug |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE20220902U Expired - Lifetime DE20220902U1 (de) | 2001-12-19 | 2002-12-18 | Neuer Filmüberzug |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6827947B2 (enExample) |
| EP (2) | EP1355633B1 (enExample) |
| JP (1) | JP2005514386A (enExample) |
| KR (1) | KR20040065989A (enExample) |
| CN (1) | CN100341491C (enExample) |
| AT (1) | ATE287259T1 (enExample) |
| AU (2) | AU2002361447B2 (enExample) |
| BR (1) | BR0206441A (enExample) |
| CA (1) | CA2435729C (enExample) |
| CZ (1) | CZ20031970A3 (enExample) |
| DE (2) | DE60202662T2 (enExample) |
| DK (1) | DK1355633T3 (enExample) |
| ES (1) | ES2233876T3 (enExample) |
| HU (1) | HUP0303886A3 (enExample) |
| IL (1) | IL156998A0 (enExample) |
| IS (1) | IS6863A (enExample) |
| MX (1) | MXPA03007156A (enExample) |
| NO (1) | NO320358B1 (enExample) |
| NZ (1) | NZ526926A (enExample) |
| PL (1) | PL362378A1 (enExample) |
| PT (1) | PT1355633E (enExample) |
| RU (1) | RU2323717C2 (enExample) |
| SI (1) | SI1355633T1 (enExample) |
| SK (1) | SK9132003A3 (enExample) |
| WO (1) | WO2003051340A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0100200D0 (sv) * | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
| SI1355633T1 (en) * | 2001-12-19 | 2005-06-30 | Astrazeneca Ab | NEW FILM COATING containing an ethyl acrylate/methyl methacrylate copolymer and polyvinyl acetate |
| ES2377729T3 (es) | 2002-02-21 | 2012-03-30 | Valeant International (Barbados) Srl | Formulaciones de liberación modificada de al menos una forma de tramadol |
| SE0201110D0 (sv) * | 2002-04-12 | 2002-04-12 | Astrazeneca Ab | New film coating |
| SE0202353D0 (sv) * | 2002-08-01 | 2002-08-01 | Astrazeneca Ab | New film coating |
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-
2002
- 2002-12-18 SI SI200230088T patent/SI1355633T1/xx unknown
- 2002-12-18 BR BR0206441-3A patent/BR0206441A/pt not_active IP Right Cessation
- 2002-12-18 US US10/450,794 patent/US6827947B2/en not_active Expired - Fee Related
- 2002-12-18 RU RU2003125371/15A patent/RU2323717C2/ru active
- 2002-12-18 PL PL36237802A patent/PL362378A1/xx not_active Application Discontinuation
- 2002-12-18 AT AT02796920T patent/ATE287259T1/de not_active IP Right Cessation
- 2002-12-18 MX MXPA03007156A patent/MXPA03007156A/es active IP Right Grant
- 2002-12-18 DK DK02796920T patent/DK1355633T3/da active
- 2002-12-18 CA CA002435729A patent/CA2435729C/en not_active Expired - Fee Related
- 2002-12-18 SK SK913-2003A patent/SK9132003A3/sk unknown
- 2002-12-18 AU AU2002361447A patent/AU2002361447B2/en not_active Ceased
- 2002-12-18 WO PCT/GB2002/005739 patent/WO2003051340A1/en not_active Ceased
- 2002-12-18 CZ CZ20031970A patent/CZ20031970A3/cs unknown
- 2002-12-18 EP EP02796920A patent/EP1355633B1/en not_active Expired - Lifetime
- 2002-12-18 PT PT02796920T patent/PT1355633E/pt unknown
- 2002-12-18 DE DE60202662T patent/DE60202662T2/de not_active Expired - Lifetime
- 2002-12-18 DE DE20220902U patent/DE20220902U1/de not_active Expired - Lifetime
- 2002-12-18 NZ NZ526926A patent/NZ526926A/en unknown
- 2002-12-18 ES ES02796920T patent/ES2233876T3/es not_active Expired - Lifetime
- 2002-12-18 JP JP2003552273A patent/JP2005514386A/ja not_active Withdrawn
- 2002-12-18 IL IL15699802A patent/IL156998A0/xx unknown
- 2002-12-18 EP EP04019487A patent/EP1477163A1/en not_active Withdrawn
- 2002-12-18 KR KR10-2003-7010812A patent/KR20040065989A/ko not_active Ceased
- 2002-12-18 HU HU0303886A patent/HUP0303886A3/hu unknown
- 2002-12-18 CN CNB028084683A patent/CN100341491C/zh not_active Expired - Lifetime
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- 2003-07-01 IS IS6863A patent/IS6863A/is unknown
- 2003-08-18 NO NO20033653A patent/NO320358B1/no not_active IP Right Cessation
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2004
- 2004-09-16 US US10/942,407 patent/US7815938B2/en not_active Expired - Lifetime
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