JP2003502359A5 - - Google Patents
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- Publication number
- JP2003502359A5 JP2003502359A5 JP2001504358A JP2001504358A JP2003502359A5 JP 2003502359 A5 JP2003502359 A5 JP 2003502359A5 JP 2001504358 A JP2001504358 A JP 2001504358A JP 2001504358 A JP2001504358 A JP 2001504358A JP 2003502359 A5 JP2003502359 A5 JP 2003502359A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- core material
- alkaline
- form according
- omeprazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 description 23
- 239000011162 core material Substances 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 10
- 239000000654 additive Substances 0.000 description 7
- 239000004480 active ingredient Substances 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 229960000381 omeprazole Drugs 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 159000000011 group IA salts Chemical class 0.000 description 4
- 229920003176 water-insoluble polymer Polymers 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 230000027119 gastric acid secretion Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000009858 acid secretion Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 159000000003 magnesium salts Chemical group 0.000 description 1
- MQEUGMWHWPYFDD-UHFFFAOYSA-N magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical group [Mg].N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C MQEUGMWHWPYFDD-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000000634 powder X-ray diffraction Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9902386A SE9902386D0 (sv) | 1999-06-22 | 1999-06-22 | New formulation |
| SE9902386-3 | 1999-06-22 | ||
| PCT/SE2000/001310 WO2000078293A1 (en) | 1999-06-22 | 2000-06-20 | New formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003502359A JP2003502359A (ja) | 2003-01-21 |
| JP2003502359A5 true JP2003502359A5 (enExample) | 2007-08-09 |
Family
ID=20416209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001504358A Pending JP2003502359A (ja) | 1999-06-22 | 2000-06-20 | 新規製剤 |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1191926B1 (enExample) |
| JP (1) | JP2003502359A (enExample) |
| KR (1) | KR100717661B1 (enExample) |
| CN (1) | CN1243547C (enExample) |
| AT (1) | ATE291901T1 (enExample) |
| AU (1) | AU778158B2 (enExample) |
| BR (1) | BR0011894A (enExample) |
| CA (1) | CA2376226C (enExample) |
| CZ (1) | CZ20014579A3 (enExample) |
| DE (1) | DE60019116T2 (enExample) |
| DK (1) | DK1191926T3 (enExample) |
| EE (1) | EE200100693A (enExample) |
| ES (1) | ES2235912T3 (enExample) |
| HK (1) | HK1044480B (enExample) |
| HU (1) | HUP0201489A3 (enExample) |
| IL (2) | IL146818A0 (enExample) |
| IS (1) | IS6209A (enExample) |
| MX (1) | MXPA01012636A (enExample) |
| NO (1) | NO20016346L (enExample) |
| NZ (1) | NZ516186A (enExample) |
| PL (1) | PL352873A1 (enExample) |
| PT (1) | PT1191926E (enExample) |
| RU (1) | RU2240110C2 (enExample) |
| SE (1) | SE9902386D0 (enExample) |
| SK (1) | SK285326B6 (enExample) |
| TR (1) | TR200103693T2 (enExample) |
| UA (1) | UA73302C2 (enExample) |
| WO (1) | WO2000078293A1 (enExample) |
| ZA (1) | ZA200109803B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| EP1492511B3 (fr) | 2002-04-09 | 2012-05-02 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| SI21402A (sl) | 2003-02-12 | 2004-08-31 | LEK farmacevtska dru�ba d.d. | Obloženi delci in farmacevtske oblike |
| EP1605919A1 (en) * | 2003-02-28 | 2005-12-21 | Ranbaxy Laboratories, Ltd. | Stable pharmaceutical composition of rabeprazole and processes for their preparation |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| WO2005027876A1 (en) * | 2003-08-28 | 2005-03-31 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of benzimidazole and processes for their preparation |
| EP1660052A2 (en) * | 2003-09-03 | 2006-05-31 | Agi Therapeutics Limited | Proton pump inhibitor formulations, and methods of preparing and using such formulations |
| US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
| US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20080214618A1 (en) * | 2004-08-23 | 2008-09-04 | Auckland Uniservices Limited | Gastric Therapies Amd Compositions Therefor |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| FR2885526B1 (fr) * | 2005-05-13 | 2007-07-27 | Flamel Technologies Sa | Medicament oral a base d'inhibiteur de pompe a protons |
| CA2578626C (en) | 2005-06-27 | 2011-07-19 | Biovail Laboratories International S.R.L. | Modified-release formulations of a bupropion salt |
| MY151468A (en) * | 2005-12-28 | 2014-05-30 | Takeda Pharmaceutical | Controlled release solid preparation |
| US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
| AU2007278986B2 (en) | 2006-07-25 | 2010-09-16 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI |
| WO2008044236A2 (en) * | 2006-10-10 | 2008-04-17 | Dexcel Pharma Technologies Ltd. | Improved release of statins in the intestine |
| CA2736547C (en) | 2008-09-09 | 2016-11-01 | Pozen Inc. | Method for delivering a pharmaceutical composition to patient in need thereof |
| JP2012531409A (ja) | 2009-06-25 | 2012-12-10 | アストラゼネカ・アクチエボラーグ | Ｎｓａｉｄ関連潰瘍を発症するリスクがある患者の処置方法 |
| CA2835845C (en) * | 2011-05-13 | 2020-07-28 | Emotional Brain B.V. | Drug delivery system |
| EP2586429A1 (en) * | 2011-10-26 | 2013-05-01 | Freund Pharmatec Ltd. | Multi-unit drug delivery device for pulsatile or sustained release |
| EP2797600A4 (en) | 2011-12-28 | 2015-09-16 | Pozen Inc | IMPROVED COMPOSITIONS AND METHODS OF DISTRIBUTING OMEPRAZOLE AND ACETYL SALICYLIC ACID |
| WO2013122554A1 (en) | 2012-02-14 | 2013-08-22 | Mahmut Bilgic | Pellet formulations comprising esomeprazole |
| CN103127026B (zh) * | 2013-02-05 | 2017-02-15 | 悦康药业集团有限公司 | 一种奥美拉唑肠溶胶囊及其制备方法 |
| AU2014374361B9 (en) | 2013-12-31 | 2019-07-04 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
| EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| RU2614730C1 (ru) * | 2016-02-05 | 2017-03-28 | Игорь Юрьевич Чичерин | Антибактериальное средство и способ лечения кишечного иерсиниоза, или псевдотуберкулеза, или эшерихиоза |
| WO2017145146A1 (en) * | 2016-02-25 | 2017-08-31 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
| JP6426115B2 (ja) * | 2016-04-06 | 2018-11-21 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
| JP6462625B2 (ja) * | 2016-04-06 | 2019-01-30 | ニプロ株式会社 | カルシウムブロッカーを含有する錠剤 |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| CN109125282B (zh) * | 2018-09-05 | 2020-07-14 | 珠海润都制药股份有限公司 | 一种奥美拉唑肠溶胶囊及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| YU48263B (sh) * | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
| SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| ZA979937B (en) * | 1996-11-06 | 1999-05-18 | Sharmatek Inc | Delayed delivery system for acid-sensitive drugs |
| SE9702000D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Ab | New pharmaceutical formulation |
| US6328993B1 (en) * | 1997-12-08 | 2001-12-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral administration form for an acid liable active proton pump inhibitor |
| CA2340054C (en) * | 1998-08-12 | 2005-10-18 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral administration form for pyridin-2-ylmethylsulfinyl-1h-benzimidazoles |
-
1999
- 1999-06-22 SE SE9902386A patent/SE9902386D0/xx unknown
-
2000
- 2000-06-20 BR BR0011894-0A patent/BR0011894A/pt not_active Application Discontinuation
- 2000-06-20 ES ES00946614T patent/ES2235912T3/es not_active Expired - Lifetime
- 2000-06-20 EP EP00946614A patent/EP1191926B1/en not_active Expired - Lifetime
- 2000-06-20 EE EEP200100693A patent/EE200100693A/xx unknown
- 2000-06-20 UA UA2001128420A patent/UA73302C2/uk unknown
- 2000-06-20 CZ CZ20014579A patent/CZ20014579A3/cs unknown
- 2000-06-20 DK DK00946614T patent/DK1191926T3/da active
- 2000-06-20 NZ NZ516186A patent/NZ516186A/en unknown
- 2000-06-20 CA CA002376226A patent/CA2376226C/en not_active Expired - Fee Related
- 2000-06-20 HU HU0201489A patent/HUP0201489A3/hu unknown
- 2000-06-20 WO PCT/SE2000/001310 patent/WO2000078293A1/en not_active Ceased
- 2000-06-20 KR KR1020017016442A patent/KR100717661B1/ko not_active Expired - Fee Related
- 2000-06-20 PL PL00352873A patent/PL352873A1/xx unknown
- 2000-06-20 RU RU2001132861/15A patent/RU2240110C2/ru not_active IP Right Cessation
- 2000-06-20 SK SK1825-2001A patent/SK285326B6/sk not_active IP Right Cessation
- 2000-06-20 JP JP2001504358A patent/JP2003502359A/ja active Pending
- 2000-06-20 TR TR2001/03693T patent/TR200103693T2/xx unknown
- 2000-06-20 HK HK02106171.6A patent/HK1044480B/en not_active IP Right Cessation
- 2000-06-20 AU AU60344/00A patent/AU778158B2/en not_active Ceased
- 2000-06-20 AT AT00946614T patent/ATE291901T1/de not_active IP Right Cessation
- 2000-06-20 PT PT00946614T patent/PT1191926E/pt unknown
- 2000-06-20 DE DE60019116T patent/DE60019116T2/de not_active Expired - Lifetime
- 2000-06-20 IL IL14681800A patent/IL146818A0/xx active IP Right Grant
- 2000-06-20 MX MXPA01012636A patent/MXPA01012636A/es active IP Right Grant
- 2000-06-20 CN CNB008093369A patent/CN1243547C/zh not_active Expired - Fee Related
-
2001
- 2001-11-28 ZA ZA200109803A patent/ZA200109803B/en unknown
- 2001-11-29 IL IL146818A patent/IL146818A/en not_active IP Right Cessation
- 2001-12-21 NO NO20016346A patent/NO20016346L/no not_active Application Discontinuation
- 2001-12-21 IS IS6209A patent/IS6209A/is unknown
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